-
1
المؤلفون: Jean-Philippe Jais, Benedicte Michaud, Lucienne Chatenoud, Jean-Jacques Robert, Alix Besançon, Michel Polak, Jacques Beltrand, Tania Goncalves
المصدر: Pediatric Diabetes. 18:772-776
مصطلحات موضوعية: Type 1 diabetes, medicine.medical_specialty, medicine.diagnostic_test, Autoimmune Gastritis, Atrophic gastritis, Anemia, business.industry, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Iron deficiency, medicine.disease, Autoimmune thyroiditis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Iron-deficiency anemia, Internal medicine, Pediatrics, Perinatology and Child Health, Internal Medicine, medicine, Serum iron, 030211 gastroenterology & hepatology, business
الوصف: Objective Assess the frequency of anti-H+ /K+ adenosine triphosphatase (ATPase) autoantibodies (AAB) and symptoms of autoimmune gastritis in children and adolescents with type 1 diabetes (T1D). Research design and methods Anti-H+ /K+ ATPase AAB were measured in 402 children and adolescents (210 boys and 192 girls, 11.1 ± 4.5 years) treated for T1D (screened positive for β-cell AAB), along with search of symptoms of anemia (hemoglobin, serum iron, and ferritin levels) and gastric pain. The AAB specific for thyroperoxydase, thyroglobulin, and transglutaminase were also measured. Results Anti-H+ /K+ ATPase AAB were present in 6.5% of children. Their frequency increased with age: 4% at 10 years, 10% at 15 years, and 20% at 20 years. Iron deficiency (45% vs 3.8%), iron deficiency anemia (36% vs 3.8%), antithyroid AAB (24% vs 9.7%), and family history of Graves' disease (25% vs 5.6%) were more frequent in patients with anti-H+ /K+ ATPase AAB. Two patients, a 13-year-old girl and a 11-year-old boy, experienced symptoms (iron deficiency anemia and epigastric pain) which led to diagnosis of autoimmune gastritis confirmed upon fibroscopy. Both showed high levels of anti-H+ /K+ ATPase AAB and atrophic gastritis. Conclusions Autoimmune gastritis presents an age-dependent frequency in children and adolescents with T1D but is rarely symptomatic. Screening for anti-H+ /K+ ATPase AAB should thus target patients with iron deficiency, anemia, epigastralgia, autoimmune thyroiditis, or age over 15 years.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9f1ca885e497b352f6a1d27461eebdd2Test
https://doi.org/10.1111/pedi.12482Test -
2
المؤلفون: Yamina Hamel, Roland Kratzer, Emmanuelle Énée, Lucienne Chatenoud, Benedicte Michaud, Peter van Endert, Émilie Barilleau, Christophe Marchi, Jean-Jacques Robert, Jean-Baptiste Arnoux, Jacques Beltrand
المساهمون: U 1013, Institut National de la Santé et de la Recherche Médicale (INSERM), Faculté de Médecine, Université de Ngozi, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), ProdInra, Migration
المصدر: Diabetes
Diabetes, American Diabetes Association, 2012, 61 (7), pp.1779-1784. ⟨10.2337/db12-0071⟩مصطلحات موضوعية: Male, Enzyme-Linked Immunospot Assay, AUTOIMMUNITY, Endocrinology, Diabetes and Metabolism, CD8-Positive T-Lymphocytes, LYMPHOCYTES, Autoantigens, Epitope, Mice, TRANSGENIC NOD MICE, 0302 clinical medicine, POTENTIAL CLINICAL-RELEVANCE, Cytotoxic T cell, Child, Cation Transport Proteins, 0303 health sciences, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ELISPOT, 3. Good health, Child, Preschool, Female, Adult, Adolescent, Population, Mice, Transgenic, PERIPHERAL-BLOOD, Young Adult, 03 medical and health sciences, AGE, Antigen, HLA-A2 Antigen, Internal Medicine, medicine, Animals, Humans, education, Autoantibodies, 030304 developmental biology, Type 1 diabetes, business.industry, Autoantibody, medicine.disease, ZINC TRANSPORTER 8, LONG, Diabetes Mellitus, Type 1, ANTIBODIES, Immunology, Immunology and Transplantation, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, CD8, RESPONSES, 030215 immunology
الوصف: Type 1 diabetes results from the destruction of β-cells by an autoimmune T-cell response assisted by antigen-presenting B cells producing autoantibodies. CD8+ T-cell responses against islet cell antigens, thought to play a central role in diabetes pathogenesis, can be monitored using enzyme-linked immunosorbent spot (ELISpot) assays. However, such assays have been applied to monitoring of adult patients only, leaving aside the large and increasing pediatric patient population. The objective of this study was twofold: 1) to develop a CD8+ T-cell interferon-γ ELISpot assay for pediatric patients and 2) to determine whether zinc transporter 8 (ZnT8), a recently described target of autoantibodies in a majority of patients, is also recognized by autoreactive CD8+ T cells. Using DNA immunization of humanized mice, we identified nine HLA-A2–restricted ZnT8 epitopes. Among 36 HLA-A2+ children with diabetes, 29 responded to ZnT8 epitopes, whereas only 3 of 16 HLA-A2+ control patients and 0 of 17 HLA-A2− control patients responded. Some single ZnT8 epitopes performed as well as the group of epitopes in discriminating between patients and control individuals. Thus, ZnT8 is a major CD8+ T-cell autoantigen, and ELISpot assays display similar performance in adult and pediatric type 1 diabetes.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d0d4fb27bb983dffbf199765b0e712Test
https://doi.org/10.2337/db12-0071Test -
3
المؤلفون: Diana Colson, Christophe Dupont, Nicolas Kalach, Pascale Soulaines, Benedicte Michaud, Lucienne Chatenoud
المساهمون: Nutritia Nutrition Clinique, Institut Catholique de Lille (ICL), Université catholique de Lille (UCL), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Tolérance immunitaire et présentation antigénique: impact en auto-immunité et en transplantation, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), BMC, Ed., Institut Catholique de Lille ( ICL ), Université catholique de Lille ( UCL ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )
المصدر: Clinical and Translational Allergy
Food Allergy and Anaphylaxis Meeting (FAAM 2013)
Food Allergy and Anaphylaxis Meeting (FAAM 2013), Feb 2013, Nice, France. pp.P4
Food Allergy and Anaphylaxis Meeting (FAAM 2013), Feb 2013, Nice, France. 3 (Suppl 3), pp.P4, 2013مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Allergy, [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, Treatment sequence, Immunoglobulin E, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Elimination diet, medicine, Immunology and Allergy, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, 030223 otorhinolaryngology, Eosinophilic esophagitis, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, biology, business.industry, medicine.disease, 3. Good health, Titer, 030228 respiratory system, Poster Presentation, Cohort, biology.protein, Blood eosinophils, [SDV.IMM]Life Sciences [q-bio]/Immunology, business
الوصف: Background The use of dietary treatment in eosinophilic esophagitis (EoE) in children is regularly described in literature. The aim of the study was to evaluate anthropomorphic and biological parameters in EoE children before and after elimination diet. Methods A cohort of 87 consecutive patients with EoE (>15 eosinophils/hpf in esophageal biopsies) was retrospectively analyzed. All children followed the so-called modified six-food elimination diet (SFED), excluding 6 main offending foods retrieved together with those eliciting positive SPT and APT, supplemented with a nutritional support by an amino acid formula. Patients had the following treatment sequence: endoscopy/clinical/biological assessment, 3 months elimination diet and second endoscopy/clinical/ biological assessment. Results Analysis included 49 patients. At enrolment, BMI was significantly lower in females than in males (p
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167c1e1c501b0827414287b3215fd1caTest
https://www.hal.inserm.fr/inserm-00848073/file/2045-7022-3-S3-P4.pdfTest -
4دورية أكاديمية
المؤلفون: Bénédicte Michaud, Pr Franck Pagès………………………président, Pr Lucienne Chatenoud………………directeur De Thèse
المساهمون: The Pennsylvania State University CiteSeerX Archives
الوصف: présentée et soutenue publiquement par
وصف الملف: application/pdf
-
5دورية أكاديمية
المؤلفون: Bénédicte Michaud, Pr Franck Pagès………………………président, Pr Lucienne Chatenoud………………directeur De Thèse
المساهمون: The Pennsylvania State University CiteSeerX Archives
الوصف: présentée et soutenue publiquement par
وصف الملف: application/pdf
-
6
المؤلفون: Lucienne Chatenoud, Jacques Beltrand, Tania Goncalves, Benedicte Michaud, A. Besançon-Bénézet, J.-J. Robert, Sophie Candon
المصدر: Diabetes & Metabolism. 39:A17
مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, General Medicine
الوصف: Objectif Le depistage des autoanticorps anti-H+/K+ ATPase n’est pas couramment recommande chez les jeunes ayant un diabete de type 1 (DT1) et leur presence est generalement asymptomatique. Nous rapportons les resultats de la recherche de ces anticorps chez des jeunes DT1, ainsi que deux cas ou des symptomes cliniques ont conduit au diagnostic de gastrite auto-immune. Patients et methodes Differents autoanticorps ont ete recherches chez 337 enfants et adolescents DT1 : autoanticorps specifiques de la cellule beta (ICA, anti-IAA, anti-GAD, anti-IA2, anti-ZnT8), antithyroperoxydase (TPO), antithyroglobuline (TG), anti-H+/K+ ATPase, anti-transglutaminase, anti-Saccharomyces Cerevisiae (ASCA), anti-cytoplasme des polynucleaires neutrophiles (ANCA), anti-AIE 75 (enteropathie auto-immune). Resultats Sur 337 patients (garcons/filles, 51/49 %) ayant au moins un anticorps specifique de la cellule beta, 23 (6,8 %) presentaient des autoanticorps anti-H+/K+ ATPase (garcons/filles, 35,6/68,4 %). Huit patients (35 %) presentaient au moins un autre autoanticorps : anti-TPO et/ou anti-TG chez 22 %, anti-transglutaminase chez 4,4 %, anti-ASCA dans deux cas. Chez deux patients, les anticorps anti-H+/K+ ATPase ont ete trouves associes a des symptomes cliniques. Un garcon de 11 ans (HLA DQB0201), presentant un DT1 depuis 5,5 ans, des anticorps anti-GAD et anti-ZnT8, a developpe des douleurs epigastriques evoquant une gastrite. Chez la 2e patiente de 13 ans (HLA DR 4–4), presentant un DT1 depuis 4,5 ans, des anticorps anti-GAD, anti-IA2 et antithyroide (TSH 4,3 mU/l), une anemie ferriprive a ete decouverte fortuitement et la fibroscopie a montre des signes de gastrite auto-immune. Conclusion La gastrite auto-immune associee au DT1 est generalement asymptomatique (marquee seulement par la presence d’autoanticorps anti-H+/K+ ATPase), mais peut parfois etre revelee par des douleurs epigastriques ou une anemie ferriprive. L’association de multiples autoanticorps reflete une perte de tolerance immunitaire vis-a-vis d’un large repertoire d’autoantigenes et pourrait permettre de definir des sous-populations differentes de patients presentant un DT1.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::400edda087ad5a28a18682f2b1d422b9Test
https://doi.org/10.1016/s1262-3636Test(13)71681-1 -
7
المؤلفون: Lucienne Chatenoud, Christophe Dupont, Diana Colson, Benedicte Michaud, Pascale Soulaines, N. Kalach
المصدر: Journal of Allergy and Clinical Immunology. 131:AB181
مصطلحات موضوعية: business.industry, Elimination diet, Immunology, Immunology and Allergy, Physiology, Medicine, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::65c98c720d2c58cde381dadfe396324bTest
https://doi.org/10.1016/j.jaci.2012.12.1311Test -
8
المؤلفون: Lucienne Chatenoud, Sophie Candon, Marie-Alexandra Alyanakian, Benedicte Michaud, Diana Colson, Christophe Dupont, Pascale Soulaines, Jocelyne Just
المصدر: Journal of Allergy and Clinical Immunology. 131:AB131
مصطلحات موضوعية: biology, business.industry, medicine.medical_treatment, Immunology, food and beverages, Immunotherapy, Basophil, Immunoglobulin E, medicine.disease, Slit, Basophil activation, medicine.anatomical_structure, Antigen, medicine, biology.protein, Immunology and Allergy, business, Eosinophilic esophagitis, Desensitization (medicine)
الوصف: S U N D A Y 471 Development of Tolerance Following Peanut Immunotherapy Is Associated with Basophil Hyporesponsiveness and Low Peanut-IgE:IgG4 Ratio Michael D. Kulis, Jr, , PhD, Rishu Guo, PhD, Edwin Kim, MD, MS, Brian P. Vickery, MD, A. Wesley Burks, MD FAAAAI; University of North Carolina at Chapel Hill, Chapel Hill, NC. RATIONALE: Peanut allergic patients can be desensitized with both oral (OIT) and sublingual (SLIT) immunotherapy, however once therapy is withdrawn only a subset of subjects will remain tolerant. We examined basophil responses and peanut-specific immunoglobulins to determine if these parameters were indicative of tolerance development. METHODS: Subjects enrolled in peanut OIT or SLIT protocols underwent double-blind placebo-controlled food challenges (DBPCFCs) with peanut to assess desensitization while continuing daily therapy. Subjects passing the DBPCFC were instructed to cease daily therapy and avoid all peanut products for 4 weeks, at which time a second DBPCFC was administered to assess tolerance. Basophil activation to peanut antigens, as well as serum peanut-specific IgE and IgG4 were measured at the time of desensitization DBPCFC. RESULTS: Tolerance was achieved in 5 of 12 (41.7%) subjects receiving SLIT, whereas 18 of 27 (66.7%) subjects were tolerant after receiving OIT. Basophil responses were significantly lower in the SLIT group that developed tolerance than in the non-tolerant SLIT group for each of 4 log-fold dilutions of peanut antigen used in the assay (p
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::394568dcc081a67dfb19342049773262Test
https://doi.org/10.1016/j.jaci.2012.12.1136Test -
9
المؤلفون: Diana Colson, Christophe Dupont, Pascale Soulaines, Benedicte Michaud
المصدر: Journal of Allergy and Clinical Immunology. 131:AB98
مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, business.industry, Immunology, medicine.disease, Hydrolysate, Telephone survey, Infant formula, Food allergy, Cohort, medicine, Retrospective analysis, Immunology and Allergy, Iron status, business
الوصف: Methods Retrospective analysis of consecutive (2004-2010) patients diagnosed with CMPA (digestive/cutaneous/ respiratory symptoms) in a food allergy reference center (Cohort Arsene,n°DC-2009-955), through a telephone survey (Nov2011–Feb2012). Children were enrolled if having adhered to dietetic recommendations, and fed with ≥500mL/day of AAF (Neocate) or extensive whey hydrolysate-based formula (eWHF, Pepti-Junior) for ≥6mo, starting either before age 6 months (AAF1, eWHF1)), between ages >6 and 12 months (AAF2) or after age 12 (AAF3).
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ff7fde4c07bc4659cd53974664623ffaTest
https://doi.org/10.1016/j.jaci.2012.12.1018Test
