المؤلفون: EPOS Study Grp, van Geloven, Thomas P. G., van der Heijden, Lizz, Laitinen, Minna K., Campanacci, Domenico A., Doering, Kevin, Dammerer, Dietmar, Badr, Ismail T., Haara, Mikko, Beltrami, Giovanni, Hobusch, Gerhard M., Kraus, Tanja, Scheider, Philipp, Soto-Montoya, Camilo, Umer, Masood, Saeed, Javeria, Funovics, Phillipp T., Fiocco, Marta, van de Sande, Michiel A. J., de Witte, Pieter Bas

المساهمون: HUS Musculoskeletal and Plastic Surgery, I kirurgian klinikka (Töölö), Department of Surgery, HUS Children and Adolescents, Children's Hospital

مصطلحات موضوعية: Simple bone cysts, Minimally invasive, Simple bone cyst treatment, Unicameral bone cyst, Weight-bearing, 3123 Gynaecology and paediatrics, 3126 Surgery, anesthesiology, intensive care, radiology

الوصف: Purpose: Simple bone cysts are among the most prevalent benign cystic tumor-like lesions in children. Proximal femoral simple bone cysts may require specific treatment because of increased fracture risk. With limited literature available on this specific localization, consensus regarding optimal treatment is lacking. We present a large international multicenter retrospective cohort study on proximal femoral simple bone cysts.Methods: All consecutive pediatric patients with proximal femoral simple bone cyst from 10 tertiary referral centers for musculoskeletal oncology were included (2000-2021). Demographics, primary treatment, complications, and re-operations were evaluated. Primary outcomes were time until full weight-bearing and failure-free survival.Results: Overall, 74 simple bone cyst patients were included (median age 9 years (range = 2-16), 56 (76%) male). Median follow-up was 2.9 years (range = 0.5-21). Index procedure was watchful waiting (n = 6), percutaneous procedure (n = 12), open procedure (n = 50), or osteosynthesis alone (n = 6). Median time until full weight-bearing was 8 weeks (95% confidence interval = 0.1-15.9) for watchful waiting, 9.5 (95% confidence interval = 3.7-15.3) for percutaneous procedure, 11 (95% confidence interval = -0.7 to 13.7) for open procedure, and 6.5 (95% confidence interval = 5.9-16.1) for osteosynthesis alone (p = 0.58). Failure rates were 33%, 58%, 29%, and 0%, respectively (p = 0.069). Overall failure-free survival at 1, 2, and 5 years was 77.8% (95% confidence interval = 68.2-87.4), 69.5% (95% confidence interval = 58.5-80.5), and 62.0% (95% confidence interval = 47.9-76.1), respectively.Conclusion: A preferred treatment for proximal femoral simple bone cysts remains unclear, with comparable failure rates and times until full weight-bearing. Watchful waiting may be successful in certain cases. If not feasible, osteosynthesis alone can be considered. Treatment goals should be cyst control, minimizing complications and swift return to normal activities. Therefore, an ...

وصف الملف: application/pdf

العلاقة: EPOS Study Grp , van Geloven , T P G , van der Heijden , L , Laitinen , M K , Campanacci , D A , Doering , K , Dammerer , D , Badr , I T , Haara , M , Beltrami , G , Hobusch , G M , Kraus , T , Scheider , P , Soto-Montoya , C , Umer , M , Saeed , J , Funovics , P T , Fiocco , M , van de Sande , M A J & de Witte , P B 2024 , ' As simple as it sounds? The treatment of simple bone cysts in the proximal femur in children and adolescents: Retrospective multicenter EPOS study of 74 patients ' , Journal of Children's Orthopaedics , vol. 18 , no. 1 , pp. 85-95 . https://doi.org/10.1177/18632521231221553Test; ORCID: /0000-0002-9975-0121/work/154556385; dee96114-96b4-4a42-b472-d85283579db1; http://hdl.handle.net/10138/571898Test; 001159149500004

الإتاحة: http://hdl.handle.net/10138/571898Test

المؤلفون: van Geloven, Thomas PG, van der Heijden, Lizz, Laitinen, Minna K, Campanacci, Domenico A, Döring, Kevin, Dammerer, Dietmar, Badr, Ismail T, Haara, Mikko, Beltrami, Giovanni, Hobusch, Gerhard M, Kraus, Tanja, Scheider, Philipp, Soto-Montoya, Camilo, Umer, Masood, Saeed, Javeria, Funovics, Phillipp T, Fiocco, Marta, van de Sande, Michiel AJ, de Witte, Pieter Bas

المصدر: Journal of Children's Orthopaedics ; volume 18, issue 1, page 85-95 ; ISSN 1863-2521 1863-2548

مصطلحات موضوعية: Orthopedics and Sports Medicine, Pediatrics, Perinatology and Child Health

الوصف: Purpose: Simple bone cysts are among the most prevalent benign cystic tumor-like lesions in children. Proximal femoral simple bone cysts may require specific treatment because of increased fracture risk. With limited literature available on this specific localization, consensus regarding optimal treatment is lacking. We present a large international multicenter retrospective cohort study on proximal femoral simple bone cysts. Methods: All consecutive pediatric patients with proximal femoral simple bone cyst from 10 tertiary referral centers for musculoskeletal oncology were included (2000–2021). Demographics, primary treatment, complications, and re-operations were evaluated. Primary outcomes were time until full weight-bearing and failure-free survival. Results: Overall, 74 simple bone cyst patients were included (median age 9 years (range = 2–16), 56 (76%) male). Median follow-up was 2.9 years (range = 0.5–21). Index procedure was watchful waiting (n = 6), percutaneous procedure (n = 12), open procedure (n = 50), or osteosynthesis alone (n = 6). Median time until full weight-bearing was 8 weeks (95% confidence interval = 0.1–15.9) for watchful waiting, 9.5 (95% confidence interval = 3.7–15.3) for percutaneous procedure, 11 (95% confidence interval = −0.7 to 13.7) for open procedure, and 6.5 (95% confidence interval = 5.9–16.1) for osteosynthesis alone (p = 0.58). Failure rates were 33%, 58%, 29%, and 0%, respectively (p = 0.069). Overall failure-free survival at 1, 2, and 5 years was 77.8% (95% confidence interval = 68.2–87.4), 69.5% (95% confidence interval = 58.5–80.5), and 62.0% (95% confidence interval = 47.9–76.1), respectively. Conclusion: A preferred treatment for proximal femoral simple bone cysts remains unclear, with comparable failure rates and times until full weight-bearing. Watchful waiting may be successful in certain cases. If not feasible, osteosynthesis alone can be considered. Treatment goals should be cyst control, minimizing complications and swift return to normal activities. Therefore, ...

الإتاحة: https://doi.org/10.1177/18632521231221553Test

المؤلفون: Campanacci, Domenico Andrea, Scanferla, Roberto, Marsico, Mariagrazia, Scolari, Federico, Scoccianti, Guido, Beltrami, Giovanni, Delcroix, Luca, Innocenti, Marco, Capanna, Rodolfo

المصدر: Clinical Orthopaedics & Related Research ; ISSN 0009-921X 1528-1132

الوصف: Background Reconstruction with vascularized fibula grafts (VFG) after intercalary resection of sarcoma may offer longevity by providing early graft-host union and fracture healing. The ability of the fibula to hypertrophy under mechanical stress, as well as vascularized bone in the area, may also be advantageous, given that soft tissues may be compromised because of resection, chemotherapy, or radiation therapy. VFG with a massive allograft combines the primary mechanical stability of the graft with the biological potential of the vascularized fibula; however, complications and the durability of this combined reconstruction are not well described. Questions/purposes (1) What was the proportion of complications after reconstruction with VFG, with or without allografts? (2) What was the functional result after surgical treatment as assessed by the Musculoskeletal Tumor Society (MSTS) score? (3) What was the survivorship of these grafts free from revision and graft removal? Methods Between 1988 and 2021, 219 patients were treated at our institution for a primary malignant or aggressive benign bone tumor of the tibia with en bloc resection. Of those, 54% (119 of 219) had proximal tibial tumors with epiphyseal involvement and were treated with either intra-articular resection and reconstruction with an osteoarticular allograft, allograft-prosthesis composite (APC), or modular prosthesis according to age, diagnosis, and preoperative or postoperative radiotherapy. Nine percent (20) of patients had distal tibial tumors that were treated with intra-articular resection and reconstruction with ankle arthrodesis using allogenic or autologous grafts, and 0.5% (1 patient) underwent total tibial resection for extensive tumoral involvement of the tibia and reconstruction with an APC. Thirty-six percent (79) of patients had a metadiaphyseal bone tumor of the tibia and were treated with intercalary joint-sparing resection. We routinely use reconstruction with VFG after intercalary tibial resection for primary malignant or ...

الإتاحة: https://doi.org/10.1097/corr.0000000000003007Test

المؤلفون: the EPOS Study Group, van Geloven, Thomas P. G., van der Heijden, Lizz, Laitinen, Minna K., Campanacci, Domenico A., Doring, Kevin, Dammerer, Dietmar, Badr, Ismail T., Haara, Mikko, Beltrami, Giovanni, Kraus, Tanja, Scheider, Philipp, Soto-Montoya, Camilo, Umer, Masood, Fiocco, Marta, Coppa, Valentino, de Witte, Pieter B., van de Sande, Michiel A. J.

المساهمون: University of Helsinki, Department of Surgery, I kirurgian klinikka (Töölö), HUS Musculoskeletal and Plastic Surgery, HUS Children and Adolescents, Children's Hospital, Lastenkirurgian yksikkö

مصطلحات موضوعية: Abc, Bearing, Benign bone tumor, Hip, Pediatric, Percutaneous treatment, Survival, Weight, 3126 Surgery, anesthesiology, intensive care, radiology, 3123 Gynaecology and paediatrics

الوصف: Background:Aneurysmal bone cysts (ABC) are rare benign cystic bone tumors, generally diagnosed in children and adolescents. Proximal femoral ABCs may require specific treatment strategies because of an increased pathologic fracture risk. As few reports are published on ABCs, specifically for this localization, consensus regarding optimal treatment is lacking. We present a large retrospective study on the treatment of pediatric proximal femoral ABCs. Methods:All eligible pediatric patients with proximal femoral ABC were included, from 11 tertiary referral centers for musculo-skeletal oncology (2000-2021). Patient demographics, diagnostics, treatments, and complications were evaluated. Index procedures were categorized as percutaneous/open procedures and osteosynthesis alone. Primary outcomes were: time until full weight-bearing and failure-free survival. Failure was defined as open procedure after primary surgery, >3 percutaneous procedures, recurrence, and/or fracture. Risk factors for failure were evaluated. Results:Seventy-nine patients with ABC were included [mean age, 10.2 (+/- SD4.0) y, n=56 male]. The median follow-up was 5.1 years (interquartile ranges=2.5 to 8.8).Index procedure was percutaneous procedure (n=22), open procedure (n=35), or osteosynthesis alone (n=22). The median time until full weight-bearing was 13 weeks [95% confidence interval (CI)=7.9-18.1] for open procedures, 9 weeks (95% CI=1.4-16.6) for percutaneous, and 6 weeks (95% CI=4.3-7.7) for osteosynthesis alone (P=0.1). Failure rates were 41%, 43%, and 36%, respectively. Overall, 2 and 5-year failure-free survival was 69.6% (95% CI=59.2-80.0) and 54.5% (95% CI=41.6-67.4), respectively. Risk factors associated with failure were age younger than 10 years [hazard ratios (HR)=2.9, 95% CI=1.4-5.8], cyst volume >55 cm(3) (HR=1.7, 95% CI=0.8-2.5), and fracture at diagnosis (HR=1.4, 95% CI=0.7-3.3). Conclusions:As both open and percutaneous procedures along with osteosynthesis alone seem viable treatment options in this weight-bearing ...

وصف الملف: application/pdf

العلاقة: the EPOS Study Group , van Geloven , T P G , van der Heijden , L , Laitinen , M K , Campanacci , D A , Doring , K , Dammerer , D , Badr , I T , Haara , M , Beltrami , G , Kraus , T , Scheider , P , Soto-Montoya , C , Umer , M , Fiocco , M , Coppa , V , de Witte , P B & van de Sande , M A J 2023 , ' Do's and Don'ts in Primary Aneurysmal Bone Cysts of the Proximal Femur in Children and Adolescents : Retrospective Multicenter EPOS Study of 79 Patients ' , Journal of Pediatric Orthopaedics , vol. 43 , no. 1 , pp. 37-45 . https://doi.org/10.1097/BPO.0000000000002267Test; ORCID: /0000-0002-9975-0121/work/131065514; 7658fe90-2214-4acf-b043-dbb5ebf2e4ba; http://hdl.handle.net/10138/356267Test; 000920190900013

الإتاحة: http://hdl.handle.net/10138/356267Test

المؤلفون: Campanacci, Domenico Andrea, Scanferla, Roberto, Innocenti, Matteo, Muratori, Francesco, Puccini, Serena, Scoccianti, Guido, Beltrami, Giovanni, Capanna, Rodolfo, Innocenti, Marco

المصدر: Clinical Orthopaedics & Related Research ; volume 481, issue 11, page 2185-2197 ; ISSN 0009-921X 1528-1132

الوصف: Background A vascularized fibula graft (VFG) is the vascular autograft most frequently used to restore large segmental long bone defects, particularly in the upper limb. Because the use of a vascularized fibula involves an operation in an uninvolved extremity with potential morbidity, it is important to document that this type of reconstruction is successful in restoring function to the humerus. However, the long-term results of VFG after intercalary resection of the humeral diaphysis for bone tumors are still unknown. Questions/purposes (1) What was the complication rate of reconstruction? (2) What was the functional result after surgical treatment, as assessed by the Musculoskeletal Tumor Society (MSTS) score, the American Shoulder and Elbow Society (ASES) score, and Constant score? (3) What was the survivorship of these grafts free from revision and graft removal at 5, 10, and 15 years? Methods Between 1987 and 2021, 127 patients were treated at our institution with en bloc resection for a primary malignant or an aggressive benign bone tumor of the humerus; we excluded patients treated with extra-articular resection or amputation. Of those, 14% (18 of 127) were treated with intercalary resection of the humeral diaphysis for primary bone tumors and reconstruction with VFG, with or without a bulk allograft, and were analyzed in this retrospective study. Generally, our indications for reconstruction with VFG are intercalary resection of the humerus for primary malignant or aggressive benign bone tumors in patients with long life expectancy and high functional demands, in whom adequate bone stock of the proximal and distal epiphysis can be preserved. In 13 patients, VFG was used alone, whereas in five patients, a massive allograft was used. Our policy was to use VFG combined with a massive allograft in patients undergoing juxta-articular joint-sparing resections in which proximal osteotomy was performed close to the anatomic neck of the humerus to obtain more stable fixation and better tendinous ...

الإتاحة: https://doi.org/10.1097/corr.0000000000002739Test

المؤلفون: Scanferla, Roberto, Scolari, Federico, Muratori, Francesco, Tamburini, Angela, Delcroix, Luca, Scoccianti, Guido, Beltrami, Giovanni, Innocenti, Marco, Campanacci, Domenico Andrea

المصدر: Cancers; May2024, Vol. 16 Issue 9, p1672, 13p

مصطلحات موضوعية: PREVENTION of surgical complications, TIBIA surgery, OSTEOSARCOMA, LIFE expectancy, HOMOGRAFTS, TREATMENT effectiveness, DESCRIPTIVE statistics, KNEE joint, BONE grafting, LIMB salvage, REOPERATION, PLASTIC surgery, SURVIVAL analysis (Biometry)

مستخلص: Simple Summary: Osteosarcoma most frequently affects the metaphyseal region of the distal femur and proximal tibia; in around 20% of patients, the epiphyseal bone is not affected and an intercalary joint-sparing resection can be safely performed, preserving the native joint and ligament insertions. In young patients, according to their high functional expectations and potential long-life expectancy, the objective of reconstruction is to restore lower limb function with a low risk of reoperation and implant removal at long-term follow-up. VFG combined with massive allograft is one of the possible reconstructive options after intercalary resection around the knee. In the present study, we aimed to investigate the long-term results of this technique in patients treated for osteosarcoma around the knee with a joint-sparing resection. (1) Background: We aim to address the following questions. What was the complication rate of vascularized fibula graft (VFG) combined with massive allograft in patients treated with joint-sparing resection around the knee for a high-grade osteosarcoma? What was the long-term survivorship of VFG free from revision and graft removal? What were the functional results as assessed by the Musculoskeletal Tumor Society (MSTS) score? (2) Methods: 39 patients treated in our unit for osteosarcoma around the knee with intercalary resection and reconstruction with VFG combined with massive allograft were included; 26 patients underwent intercalary tibial resection, while 13 underwent intercalary femoral resection. (3) Results: Mean Follow-Up was 205 months (28 to 424). Complications that required surgery were assessed in requiring surgical revision in 19 patients (49%) after a mean of 31 months (0 to 107), while VFG removal was necessary in three patients (8%). The revision-free survival of the reconstructions was 59% at 5 years and 50% at 10 to 30 years. The overall survival of the reconstructions was 95% at 5 to 15 years and 89% at 20 to 30 years. The mean MSTS score was 29.3 (23 to 30). (4) Conclusions: VFG represents an effective reconstructive option after joint-sparing intercalary resection around the knee for osteosarcoma. [ABSTRACT FROM AUTHOR]

: Copyright of Cancers is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Abu‐Rumeileh, Sarah, Beltrami, Giovanni, Di Maurizio, Marco, Indolfi, Giuseppe, Trapani, Sandra

المصدر: Clinical Case Reports ; volume 10, issue 10 ; ISSN 2050-0904 2050-0904

الوصف: Bartonella henselae is an unusual and rarely suspected osteomyelitis etiologic agent. We present a case of low back‐pain in a 10‐year‐old female which lead to a challenging diagnostic work‐up due to subtle imaging findings. The diagnosis was Bartonella henselae vertebral osteomyelitis mimicking bone tumor.

الإتاحة: https://doi.org/10.1002/ccr3.6117Test

المؤلفون: van Geloven, Thomas P.G., van der Heijden, Lizz, Laitinen, Minna K., Campanacci, Domenico A., Döring, Kevin, Dammerer, Dietmar, Badr, Ismail T., Haara, Mikko, Beltrami, Giovanni, Kraus, Tanja, Scheider, Philipp, Soto-Montoya, Camilo, Umer, Masood, Fiocco, Marta, Coppa, Valentino, de Witte, Pieter B., van de Sande, Michiel A.J.

المصدر: Journal of Pediatric Orthopaedics ; volume 43, issue 1, page 37-45 ; ISSN 0271-6798

الوصف: Background: Aneurysmal bone cysts (ABC) are rare benign cystic bone tumors, generally diagnosed in children and adolescents. Proximal femoral ABCs may require specific treatment strategies because of an increased pathologic fracture risk. As few reports are published on ABCs, specifically for this localization, consensus regarding optimal treatment is lacking. We present a large retrospective study on the treatment of pediatric proximal femoral ABCs. Methods: All eligible pediatric patients with proximal femoral ABC were included, from 11 tertiary referral centers for musculo-skeletal oncology (2000-2021). Patient demographics, diagnostics, treatments, and complications were evaluated. Index procedures were categorized as percutaneous/open procedures and osteosynthesis alone. Primary outcomes were: time until full weight-bearing and failure-free survival. Failure was defined as open procedure after primary surgery, >3 percutaneous procedures, recurrence, and/or fracture. Risk factors for failure were evaluated. Results: Seventy-nine patients with ABC were included [mean age, 10.2 (±SD4.0) y, n=56 male]. The median follow-up was 5.1 years (interquartile ranges=2.5 to 8.8). Index procedure was percutaneous procedure (n=22), open procedure (n=35), or osteosynthesis alone (n=22). The median time until full weight-bearing was 13 weeks [95% confidence interval (CI)=7.9-18.1] for open procedures, 9 weeks (95% CI=1.4-16.6) for percutaneous, and 6 weeks (95% CI=4.3-7.7) for osteosynthesis alone ( P =0.1). Failure rates were 41%, 43%, and 36%, respectively. Overall, 2 and 5-year failure-free survival was 69.6% (95% CI=59.2-80.0) and 54.5% (95% CI=41.6-67.4), respectively. Risk factors associated with failure were age younger than 10 years [hazard ratios (HR)=2.9, 95% CI=1.4-5.8], cyst volume >55 cm 3 (HR=1.7, 95% CI=0.8-2.5), and fracture at diagnosis (HR=1.4, 95% CI=0.7-3.3). Conclusions: As both open and percutaneous procedures along with osteosynthesis alone seem viable treatment options in this weight-bearing ...

الإتاحة: https://doi.org/10.1097/bpo.0000000000002267Test

المؤلفون: Nozzoli, Filippo, Lazar, Alexander J., Castiglione, Francesca, Campanacci, Domenico Andrea, Beltrami, Giovanni, De Logu, Francesco, Caporalini, Chiara, Massi, Daniela, Roviello, Giandomenico

المصدر: Pathology and Oncology Research ; volume 28 ; ISSN 1532-2807

مصطلحات موضوعية: Cancer Research, Oncology, General Medicine, Pathology and Forensic Medicine

الوصف: Undifferentiated round cell sarcomas (URCS) of soft tissue and bone and tumours of uncertain differentiation (TUD) are commonly ascribed to a subset of neoplasms with low frequency of NTRK gene fusions. However, more recently NTRK-rearranged round and spindle cell tumours have been noted in case reports and in limited or heterogeneous cohorts. The aim of our study was to investigate the presence of NTRK gene fusions in a large retrospective cohort of paediatric URCS and TUD after a systematic review of the diagnosis, according to the recently updated WHO classification scheme. One-hundred and five patients with diagnosis of URCS or TUD, involving the bone or soft tissue, were retrospectively evaluated. After the case selection and the histopathological review of the case cohort, pan-Trk immunohistochemistry (IHC) testing was performed on formalin-fixed paraffin-embedded (FFPE) tissues. Tumour RNA was extracted from FFPE tissue and subjected to next-generation sequencing (NGS) library preparation, using a 10-gene NGS fusion panel, sequenced on an Illumina MiSeq. The NGS-positive cases were further confirmed by real-time PCR. On immunohistochemical screening, 12/105 (11.4%) cases were positive using the pan-Trk antibody, showing three different staining patterns with the cytoplasmic distribution being most common. Molecular analysis using NGS and confirmed by the real-rime PCR detected two positive cases for the ETV6-NTRK3 fusion. The histological pattern of the two positive cases, together with the demonstration of the NTRK rearrangement, leaded to re-classify these previously not otherwise specified sarcomas with uncertain differentiation into the emerging category of NTRK-rearranged neoplasms. In addition, we found the two NTRK fused neoplasms showing a clinical indolent course, in contrast with literature.

الإتاحة: https://doi.org/10.3389/pore.2022.1610237Test

المؤلفون: Mangoni, Monica, Sottili, Mariangela, Salvatore, Giulia, Meattini, Icro, Desideri, Isacco, Greto, Daniela, Loi, Mauro, Becherini, Carlotta, Garlatti, Pietro, Paoli, Camilla Delli, Dominici, Luca, Gerini, Chiara, Scoccianti, Silvia, Bonomo, Pierluigi, Silvano, Angela, Beltrami, Giovanni, Campanacci, Domenico, Livi, Lorenzo

المصدر: Radiation Research, 2018 Nov 01. 190(5), 464-472.

الوصول الحر: https://www.jstor.org/stable/48570516Test