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المؤلفون: Fao, P., Ky-Zerbo, O., Gouem, C., Somda, P., Hien, H., Ouedraogo, P. E., Kania, D., Sanou, A., Kossiwavi, I. A., Sanogo, B., Ouedraogo, M., Siribie, I., Valea, D., Ouedraogo, S., Some, R., Rouet, F., Rollins, N., McFetridge, L., Naidu, K., Luchters, S., Reyners, M., Irungu, E., Katingima, C., Mwaura, M., Ouattara, G., Mandaliya, K., Wambua, S., Thiongo, M., Nduati, R., Kose, J., Njagi, E., Mwaura, P., Newell, M. L., Mepham, S., Viljoen, J., Bland, R., Mthethwa, L., Bazin, B., Rekacewicz, C., Taylor, A., Flowers, N., Thigpen, M., Fowler, M. G., Jamieson, D., Mofenson, L. M., Read, J. S., Bork, Kirsten, Cames, Cécile, Cournil, Amandine, Claeys, P., Temmerman, M., Van de Perre, P., Becquart, Pierre, Foulongne, V., Segondy, M., de Vincenzi, I., Gaillard, P., Farley, T., Habib, N., Landoulsi, S.
مصطلحات موضوعية: immune system diseases, virus diseases
الوصف: Background. Antiretroviral (ARV) prophylaxis effectively reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV). However, it is unclear whether stopping ARVs after breastfeeding cessation affects maternal HIV disease progression. We assessed 18-24-month postpartum disease progression risk among women in a randomized trial assessing efficacy and safety of prophylactic maternal ARVs. Methods. From 2005 to 2008, HIV-infected pregnant women with CD4(+) counts of 200-500/mm(3) were randomized to receive either triple ARV (zidovudine, lamivudine, and lopinavir/ritonavir during pregnancy and breastfeeding) or AZT/sdNVP (zidovudine until delivery with single-dose nevirapine without postpartum prophylaxis). Maternal disease progression was defined as the combined endpoint of death, World Health Organization clinical stage 4 disease, or CD4(+) counts of = 350/mm(3) progressed. Conclusions. Interrupting prolonged triple ARV prophylaxis had no effect on HIV progression following cessation (compared with AZT/sdNVP). However, women on triple ARV prophylaxis had lower progression risk during the time on triple ARV. Given the high rate of progression among women with CD4(+) cells of
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______932::5c8c3af6ddccc5372fb27a583b51a9e1Test
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المؤلفون: Nkoghe, D., Padilla, C., Becquart, Pierre, Wauquier, N., Moussavou, G., Akué, J. P., Ollomo, B., Pourrut, Xavier, Souris, Marc, Kazanji, M., Gonzalez, Jean-Paul, Leroy, Eric
الوصف: Methods. Blood samples and clinical and sociodemographic data were collected from 4349 adults and 362 children in a random sample of 220 villages in the 9 provinces of Gabon. An enzyme-linked immunosorbent assay was used to detect Zaire ebolavirus (ZEBOV)-specific IgG, and thin blood smears were used to detect parasites. Logistic regression was implemented using Stata software (Stata), and a probability level of
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______932::8a91407db1ce17cb7008c7ccba8e52bdTest
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المؤلفون: Low, A.J., Clayton, T., Konate, I., Nagot, N., Ouedraogo, A., Huet, C., Didelot-Rousseau, M., Segondy, M., Van de Perre, P., Mayaud, P., Yérélon Cohort Study Group (collab.), Becquart, Pierre (collab.)
مصطلحات موضوعية: virus diseases
الوصف: Background: Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology. Methods: A prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in Burkina Faso. Logistic and Cox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including HIV-1 serostatus, CD4+ count, and concurrent sexually transmitted infections. In a subset of 306 women, cervical HPV DNA was tested at enrolment. Results: Genital wart prevalence at baseline was 1.6% (8/492) among HIV-uninfected and 7.0% (19/273) among HIV-1 seropositive women. Forty women (5.2%) experienced at least one incident GW episode. Incidence was 1.1 per 100 person-years among HIV-uninfected women, 7.4 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count >200 cells/mu L and 14.6 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count
وصف الملف: text/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______932::72069922fde313d15a7d2d803a240624Test
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المؤلفون: Kesho Bora Study Group, Becquart, Pierre (collab.)
مصطلحات موضوعية: SIDA, TRANSMISSION, virus diseases, PROTECTION MATERNELLE ET INFANTILE, PREVENTION SANITAIRE, MILIEU URBAIN
الوصف: o evaluate strategies to reduce HIV-1 transmission through breastfeeding, a multicentre study including a nested randomized controlled trial was implemented in five research sites in West. East and South Africa (The Kesho Bora Study). The aim was to optimize the use of antiretroviral (ARV) drugs during pregnancy, delivery and breastfeeding to prevent mother-to-child transmission of HIV-1 (PMTCT) and to preserve the health of the HIV-1-infected mother. The study included long-term ARV treatment for women with advanced disease, and short-course ARV prophylaxis stopped at delivery for women with early disease. Women with intermediate disease participated in a randomized controlled trial to compare safety and efficacy of triple-ARV prophylaxis prolonged during breastfeeding with short-course ARV prophylaxis stopped at delivery. Between January 2005 and August 2008 a total of 1140 women were enrolled. This paper describes the study design, interventions and protocol amendments introduced to adapt to evolving scientific knowledge, international guidelines and availability of ARV treatment. The paper highlights the successes and challenges during the conduct of the trial. The Kesho Bora Study included one of the few randomized controlled trials to assess safety and efficacy of ARV prophylaxis continued during breastfeeding and the only randomized trial to assess maternal prophylaxis started during pregnancy. The findings have been important for informing international and national guidelines on MTCT prevention in developing countries where, due to poverty, lack of reliable and affordable supply of replacement feed and stigma associated with HIV/AIDS, HIV-infected women have little or no option other than to breastfeed their infants.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______932::5b712b4a0db498b9bea2de3061f89df9Test
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المؤلفون: Yalcindag, Erhan, Rougeron, Virginie, Elguero, Eric, Arnathau, Céline, Durand, Patrick, Brisse, Sylvain, Diancourt, Laure, Aubouy, Agnes, Becquart, Pierre, D'Alessandro, Umberto, Fontenille, Didier, Gamboa, Dionicia, Maestre, Amanda, Ménard, Didier, Musset, Lise, Noya, Oscar, Veron, Vincent, Wide, Albina, Carme, Bernard, Legrand, Eric, Chevillon, Christine, Ayala, Francisco J., Renaud, François, Prugnolle, Franck
المصدر: 10.5061/dryad.59645 ; oai:easy.dans.knaw.nl:easy-dataset:85228 ; oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:85228 ; 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 ; re3data_____::r3d100000044 ; 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f ; 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 ; 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 ; 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2
مصطلحات موضوعية: Life sciences, medicine and health care, envir, stat
الوصف: Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization of South America from Africa Plasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations (Amerindian and populations of mixed origins), that likely exerted new selective pressures on the parasite's genome. Among the genes that might have experienced strong selective pressures in response to these environmental changes, the eba genes (erythrocyte binding antigens genes), which are involved in the invasion of the human red blood cells, constitute good candidates. In this study, we analyzed, in South America, the polymorphism of three eba genes (eba-140, eba-175, eba-181) and compared it to the polymorphism observed in African populations. The aim was to determine whether these genes faced selective pressures in South America distinct from what they experienced in Africa. Patterns of genetic variability of these genes were compared to the patterns observed at two housekeeping genes (adsl and serca) and 272 SNPs to separate adaptive effects from demographic effects. We show that, conversely to Africa, eba-140 seemed to be under stronger diversifying selection in South America than eba-175. In contrast, eba-181 did not show any sign of departure from neutrality. These changes in the patterns of selection on the eba genes could be the consequence of changes in the host immune response, the host receptor polymorphisms, and / or the ability of the parasite to silence or express differentially its invasion proteins. 272 SNP dataset_South America_Yalcindag272 SNPs from South American populationsadsl_sequencesSequences alignment of adsl geneserca_sequencesSequences alignment of serca geneeba140_sequencesSequences alignment of eba-140 geneeba175_sequencesSequences alignment of eba-175 geneeba181_sequencesSequences alignment of eba-181 geneSupp ...
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المؤلفون: Rouet, F., Foulongne, V., Viljoen, J., Steegen, K., Becquart, Pierre, Valéa, D., Danaviah, S., Segondy, M., Verhofsted, C., Van de Perre, P., Kesho Bora Study Group
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______932::6d9e6445b125a1ad4eb7ec8f581b93f7Test
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مصطلحات موضوعية: ARN, DIAGNOSTIC, SIDA, GROSSESSE, PROTECTION MATERNELLE ET INFANTILE, PCR.REACTION DE POLYMERISATION EN CHAINE
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______932::2556c853988dffe20d30d0ff2b0a0551Test
http://www.documentation.ird.fr/hor/fdi:010070128Test -
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المؤلفون: Nagot, Nicolas, Ouédraogo, Abdoulaye, Foulongne, Vincent, Konaté, Issouf, Weiss, Helen A, Vergne, Laurence, Defer, Marie-Christine, Djagbaré, Didier, Sanon, Anselme, Andonaba, Jean-Baptiste, Becquart, Pierre, Segondy, Michel, Vallo, Roselyne, Sawadogo, Adrien, Van de Perre, Philippe, Mayaud, Philippe, ANRS 1285 Study Group
الوصف: BACKGROUND: Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of HSV suppressive therapy with valacyclovir (at a dose of 500 mg twice daily) in Burkina Faso among women who were seropositive for HIV-1 and HSV-2; all were ineligible for highly active antiretroviral therapy. The patients were followed for 24 weeks (12 weeks before and 12 weeks after randomization). Regression models were used to assess the effect of valacyclovir on the presence and quantity of genital and plasma HIV-1 RNA and genital HSV-2 DNA during treatment, adjusting for baseline values, and to evaluate the effect over time. RESULTS: A total of 140 women were randomly assigned to treatment groups; 136 were included in the analyses. At enrollment, the median CD4 cell count was 446 cells per cubic millimeter, and the mean plasma viral load was 4.44 log10 copies per milliliter. With the use of summary-measures analysis, valacyclovir therapy was found to be associated with a significant decrease in the frequency of genital HIV-1 RNA (odds ratio, 0.41; 95% confidence interval [CI], 0.21 to 0.80) and in the mean quantity of the virus (log(10) copies per milliliter, -0.29; 95% CI, -0.44 to -0.15). However, there was no significant decrease in detection of HIV (risk ratio, 0.93; 95% CI, 0.81 to 1.07). HSV suppressive therapy also reduced the mean plasma HIV-1 RNA level by 0.53 log(10) copy per milliliter (95% CI, -0.72 to -0.35). Repeated-measures analysis showed that these effects became significantly stronger during the 3 months of follow-up. CONCLUSIONS: HSV suppressive therapy significantly reduces genital and plasma HIV-1 RNA levels in dually infected women. This finding may have important implications for HIV control. (ClinicalTrials.gov number, NCT00158509 [ClinicalTrials.gov].).
وصف الملف: text
العلاقة: https://researchonline.lshtm.ac.uk/id/eprint/10291/1/nejmoa062607.pdfTest; Nagot, Nicolas; Ouédraogo, Abdoulaye; Foulongne, Vincent; Konaté, Issouf; Weiss, Helen A ; Vergne, Laurence; Defer, Marie-Christine; Djagbaré, Didier; Sanon, Anselme; Andonaba, Jean-Baptiste; +7 more. Becquart, Pierre; Segondy, Michel; Vallo, Roselyne; Sawadogo, Adrien; Van de Perre, Philippe; Mayaud, Philippe ; ANRS 1285 Study Group; (2007) Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. The New England journal of medicine, 356 (8). pp. 790-799. ISSN 0028-4793 DOI: https://doi.org/10.1056/NEJMoa062607Test
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100دورية أكاديمية
المؤلفون: Chomont, Nicolas, Hocini, Hakim, Grésenguet, Gérard, Brochier, Céline, Bouhlal, Hicham, Andréoletti, Laurent, Becquart, Pierre, Charpentier, Charlotte, de Dieu Longo, Jean, Si-Mohamed, Ali, Kazatchkine, Michel D, Bélec, Laurent
المصدر: AIDS ; volume 21, issue 2, page 153-162 ; ISSN 0269-9370
الإتاحة: https://doi.org/10.1097/qad.0b013e328011f94bTest
http://journals.lww.com/00002030-200701110-00004Test
