المؤلفون: Beavers, Kristen M, Avery, Allison E, Shankaran, Mahalakshmi, Evans, William J, Lynch, S Delanie, Dwyer, Caitlyn, Howard, Marjorie, Beavers, Daniel P, Weaver, Ashley A, Lenchik, Leon, Cawthon, Peggy M

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Aging, Nutrition, Prevention, Obesity, Physical Rehabilitation, Rehabilitation, Clinical Trials and Supportive Activities, Clinical Research, Musculoskeletal, Deuterated creatine (D3Cr) dilution, Muscle mass, Sarcopenia, Weight loss, Physiology, Human Movement and Sports Sciences, Clinical sciences, Allied health and rehabilitation science, Sports science and exercise

الوصف: BackgroundTraditionally, weight loss (WL) trials utilize dual energy X-ray absorptiometry (DXA) to measure lean mass. This method assumes lean mass, as the sum of all non-bone and non-fat tissue, is a reasonable proxy for muscle mass. In contrast, the D3 -creatine (D3 Cr) dilution method directly measures whole body skeletal muscle mass, although this method has yet to be applied in the context of a geriatric WL trial. The purpose of this project was to (1) describe estimates of change and variability in D3 Cr muscle mass in older adults participating in an intentional WL intervention and (2) relate its change to other measures of body composition as well as muscle function and strength.MethodsThe INVEST in Bone Health trial (NCT04076618), used as a scaffold for this ancillary pilot project, is a three-armed, 12-month randomized, controlled trial designed to determine the effects of resistance training or weighted vest use during intentional WL on a battery of musculoskeletal health outcomes among 150 older adults living with obesity. A convenience sample of 24 participants (n = 8/arm) are included in this analysis. At baseline and 6 months, participants were weighed, ingested a 30 mg D3 Cr tracer dose, provided a fasted urine sample 3-6 days post-dosage, underwent DXA (total body fat and lean masses, appendicular lean mass) and computed tomography (mid-thigh and trunk muscle/intermuscular fat areas) scans, and performed 400-m walk, stair climb, knee extensor strength, and grip strength tests.ResultsParticipants were older (68.0 ± 4.4 years), mostly White (75.0%), predominantly female (66.7%), and living with obesity (body mass index: 33.8 ± 2.7 kg/m2 ). Six month total body WL was -10.3 (95% confidence interval, CI: -12.7, -7.9) kg. All DXA and computed tomography-derived body composition measures were significantly decreased from baseline, yet D3 Cr muscle mass did not change [+0.5 (95% CI: -2.0, 3.0) kg]. Of muscle function and strength measures, only grip strength significantly changed [+2.5 (95% CI: 1.0, 4.0) kg] from baseline.ConclusionsAmong 24 older adults, significant WL with or without weighted vest use or resistance training over a 6-month period was associated with significant declines in all bioimaging metrics, while D3 Cr muscle mass and muscle function and strength were preserved. Treatment assignment for the trial remains blinded; therefore, full interpretation of these findings is limited. Future work in this area will assess change in D3 Cr muscle mass by parent trial treatment group assignment in all study participants.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/94m0c56jTest

المؤلفون: Petkus, Andrew J, Resnick, Susan M, Wang, Xinhui, Beavers, Daniel P, Espeland, Mark A, Gatz, Margaret, Gruenewald, Tara, Millstein, Joshua, Chui, Helena C, Kaufman, Joel D, Manson, JoAnn E, Wellenius, Gregory A, Whitsel, Eric A, Widaman, Keith, Younan, Diana, Chen, Jiu-Chiuan

مصطلحات موضوعية: Pollution and Contamination, Biological Psychology, Epidemiology, Environmental Sciences, Health Sciences, Psychology, Clinical Research, Mental Health, Biomedical Imaging, Brain Disorders, Neurosciences, Climate-Related Exposures and Conditions, Depression, Behavioral and Social Science, Aging, 2.2 Factors relating to the physical environment, Aetiology, Mental health, Neurological, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Cross-Sectional Studies, Environmental Exposure, Female, Humans, Nitrogen Dioxide, Particulate Matter, Prefrontal Cortex, Prospective Studies, Air pollution, Brain aging, Structural magnetic resonance imaging

الوصف: Exposures to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) have been associated with the emergence of depressive symptoms in older adulthood, although most studies used cross-sectional outcome measures. Elucidating the brain structures mediating the adverse effects can strengthen the causal role between air pollution and increasing depressive symptoms. We evaluated whether smaller volumes of brain structures implicated in late-life depression mediate associations between ambient air pollution exposure and changes in depressive symptoms. This prospective study included 764 community-dwelling older women (aged 81.6 ± 3.6 in 2008-2010) from the Women's Health Initiative Memory Study (WHIMS) Magnetic Resonance Imaging study (WHIMS-MRI; 2005-06) and WHIMS-Epidemiology of Cognitive Health Outcomes (WHIMS-ECHO; 2008-16). Three-year average annual mean concentrations (scaled by interquartile range [IQR]) of ambient PM2.5 (in μg/m3; IQR = 3.14 μg/m3) and NO2 (in ppb; IQR = 7.80 ppb) before WHIMS-MRI were estimated at participants' addresses via spatiotemporal models. Mediators included structural brain MRI-derived grey matter volumes of the prefrontal cortex and structures of the limbic-cortical-striatal-pallidal-thalamic circuit. Depressive symptoms were assessed annually by the 15-item Geriatric Depression Scale. Structural equation models were constructed to estimate associations between exposure, structural brain volumes, and depressive symptoms. Increased exposures (by each IQR) were associated with greater annual increases in depressive symptoms (βPM2.5 = 0.022; 95% Confidence Interval (CI) = 0.003, 0.042; βNO2 = 0.019; 95% CI = 0.001, 0.037). The smaller volume of prefrontal cortex associated with exposures partially mediated the associations of increased depressive symptoms with NO2 (8%) and PM2.5 (13%), and smaller insula volume associated with NO2 contributed modestly (13%) to the subsequent increase in depressive symptoms. We demonstrate the first evidence that the smaller volumes of the prefrontal cortex and insula may mediate the subsequent increases in depressive symptoms associated with late-life exposures to NO2 and PM2.5.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/16g5s54bTest

المؤلفون: Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J.

المصدر: Messier , S P , Callahan , L F , Losina , E , Mihalko , S L , Guermazi , A , Ip , E , Miller , G D , Katz , J N , Loeser , R F , Pietrosimone , B G , Soto , S , Cook , J L , Newman , J J , DeVita , P , Spindler , K P , Runhaar , J , Armitano-Lago , C , Duong , V , Selzer , F , Hill , R , Love , M , Beavers , D P , ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ≥ 30 kg/m 2 ) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA. Trial registration: ClinicalTrials.gov Identifier: NCT05946044.

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100418Test
https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test
https://pure.eur.nl/ws/files/124162103/The_osteoarthritis_prevention_study_TOPS_-_A_randomized_controlled_trial_of_diet_and_exercise_to_prevent_Knee_Osteoarthritis.pdfTest
http://www.scopus.com/inward/record.url?scp=85179044965&partnerID=8YFLogxKTest

المؤلفون: Messier, Stephen P., Gill, Malia E., Mihalko, Shannon L., Beavers, Daniel P., Queen, Kate, Miller, Gary D., Losina, Elena, Katz, Jeffrey N., Loeser, Richard F., DeVita, Paul, Hunter, David J., Quandt, Sara A., Lyles, Mary F., Hudson, David, Callahan, Leigh F.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Arthritis Care & Research ; volume 76, issue 4, page 503-510 ; ISSN 2151-464X 2151-4658

الوصف: Objective The purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category. Methods This cross‐sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications (overweight or class I, body mass index [BMI] 27.0–34.9; class II, BMI 35.0–39.9; class III BMI ≥40.0). Results Patients with class III obesity had worse Western Ontario McMasters Universities Arthritis Index knee pain (0–20) than the overweight or class I (mean 8.6 vs 7.0; difference 1.5; 95% confidence interval [CI] 1.0–2.1; P < 0.0001) and class II (mean 8.6 vs 7.4; difference 1.1; 95% CI 0.6–1.7; P = 0.0002) obesity groups. The Short Form 36 physical HRQL measure was lower in the class III obesity group compared to the overweight or class I (mean 31.0 vs 37.3; difference −6.2; 95% CI −7.8 to −4.7; P < 0.0001) and class II (mean 31.0 vs 35.0; difference −3.9; 95% CI −5.6 to −2.2; P < 0.0001) obesity groups. The class III obesity group had a base of support (cm) during gait that was wider than that for the overweight or class I (mean 14.0 vs 11.6; difference 3.3; 95% CI 2.6–4.0; P < 0.0001) and class II (mean 14.0 vs 11.6; difference 2.4; 95% CI 1.6–3.2; P < 0.0001) obesity groups. Conclusion Among adults with knee OA, those with class III obesity had significantly higher pain levels and worse physical HRQL and gait characteristics compared to adults with overweight or class I or class II obesity. image

الإتاحة: https://doi.org/10.1002/acr.25265Test

المؤلفون: Jiang, Xiaotong, Nelson, Amanda E., Cleveland, Rebecca J., Beavers, Daniel P., Schwartz, Todd A., Arbeeva, Liubov, Alvarez, Carolina, Callahan, Leigh F., Messier, Stephen, Loeser, Richard, Kosorok, Michael R.

مصطلحات موضوعية: Statistics - Machine Learning, Computer Science - Machine Learning, Statistics - Applications

الوصف: We provide additional statistical background for the methodology developed in the clinical analysis of knee osteoarthritis in "A Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight Loss Treatments for Overweight and Obese Adults with Knee Osteoarthritis" (Jiang et al. 2020). Jiang et al. 2020 proposed a pipeline to learn optimal treatment rules with precision medicine models and compared them with zero-order models with a Z-test. The model performance was based on value functions, a scalar that predicts the future reward of each decision rule. The jackknife (i.e., leave-one-out cross validation) method was applied to estimate the value function and its variance of several outcomes in IDEA. IDEA is a randomized clinical trial studying three interventions (exercise (E), dietary weight loss (D), and D+E) on overweight and obese participants with knee osteoarthritis. In this report, we expand the discussion and justification with additional statistical background. We elaborate more on the background of precision medicine, the derivation of the jackknife estimator of value function and its estimated variance, the consistency property of jackknife estimator, as well as additional simulation results that reflect more of the performance of jackknife estimators. We recommend reading Jiang et al. 2020 for clinical application and interpretation of the optimal ITR of knee osteoarthritis as well as the overall understanding of the pipeline and recommend using this article to understand the underlying statistical derivation and methodology.

الوصول الحر: http://arxiv.org/abs/2001.09930Test

المؤلفون: Petkus, Andrew J, Wang, Xinhui, Beavers, Daniel P, Chui, Helena C, Espeland, Mark A, Gatz, Margaret, Gruenewald, Tara, Kaufman, Joel D, Manson, JoAnn E, Resnick, Susan M, Stewart, James D, Wellenius, Gregory A, Whitsel, Eric A, Widaman, Keith, Younan, Diana, Chen, Jiu-Chiuan

مصطلحات موضوعية: Epidemiology, Environmental Sciences, Pollution and Contamination, Health Sciences, Mind and Body, Climate-Related Exposures and Conditions, Aging, Behavioral and Social Science, Mental Health, Clinical Research, Mental health, Good Health and Well Being, Adult, Aged, Air Pollutants, Air Pollution, Cognition, Environmental Exposure, Female, Humans, Nitrogen Dioxide, Particulate Matter, Psychological Distress, Air pollution, Emotional distress

الوصف: The interrelationships among long-term ambient air pollution exposure, emotional distress and cognitive decline in older adulthood remain unclear. Long-term exposure may impact cognitive performance and subsequently impact emotional health. Conversely, exposure may initially be associated with emotional distress followed by declines in cognitive performance. Here we tested the inter-relationship between global cognitive ability, emotional distress, and exposure to PM2.5 (particulate matter with aerodynamic diameter

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4jx4p3jjTest

المؤلفون: Petkus, Andrew J, Younan, Diana, Wang, Xinhui, Beavers, Daniel P, Espeland, Mark A, Gatz, Margaret, Gruenewald, Tara L, Kaufman, Joel D, Chui, Helena C, Manson, JoAnn E, Resnick, Susan M, Wellenius, Gregory A, Whitsel, Eric A, Widaman, Keith, Chen, Jiu‐Chiuan

المصدر: Journal of the American Geriatrics Society. 69(2)

مصطلحات موضوعية: Epidemiology, Health Services and Systems, Health Sciences, Climate-Related Exposures and Conditions, Brain Disorders, Behavioral and Social Science, Clinical Research, Depression, Aging, Mental Health, Good Health and Well Being, Aged, 80 and over, Air Pollution, Cognition, Environmental Exposure, Female, Geriatric Assessment, Humans, Independent Living, Memory Disorders, Memory, Episodic, Mental Status Schedule, Particulate Matter, Risk Assessment, Risk Factors, United States, depressive symptoms, episodic memory, air pollution, oldest‐, old, oldest-old, Medical and Health Sciences, Geriatrics, Biomedical and clinical sciences, Health sciences, Psychology

الوصف: Background/objectivesExposure to air pollution may contribute to both increasing depressive symptoms and decreasing episodic memory in older adulthood, but few studies have examined this hypothesis in a longitudinal context. Accordingly, we examined the association between air pollution and changes in depressive symptoms (DS) and episodic memory (EM) and their interrelationship in oldest-old (aged 80 and older) women.DesignProspective cohort data from the Women's Health Initiative Memory Study-Epidemiology of Cognitive Health Outcomes.SettingGeographically diverse community-dwelling population.ParticipantsA total of 1,583 dementia-free women aged 80 and older.MeasurementsWomen completed up to six annual memory assessments (latent composite of East Boston Memory Test and Telephone Interview for Cognitive Status) and the 15-item Geriatric Depression Scale (GDS-15). We estimated 3-year average exposures to regional particulate matter with aerodynamic diameter below 2.5 μm (PM2.5 ) (interquartile range [IQR] = 3.35 μg/m3 ) and gaseous nitrogen dioxide (NO2 ) (IQR = 9.55 ppb) at baseline and during a remote period 10 years earlier, using regionalized national universal kriging.ResultsLatent change structural equation models examined whether residing in areas with higher pollutant levels was associated with annual changes in standardized EM and DS while adjusting for potential confounders. Remote NO2 (β = .287 per IQR; P = .002) and PM2.5 (β = .170 per IQR; P = .019) exposure was significantly associated with larger increases in standardized DS, although the magnitude of the difference, less than 1 point on the GDS-15, is of questionable clinical significance. Higher DS were associated with accelerated EM declines (β = -.372; P = .001), with a significant indirect effect of remote NO2 and PM2.5 exposure on EM declines mediated by DS. There were no other significant indirect exposure effects.ConclusionThese findings in oldest-old women point to potential adverse effects of late-life exposure to air pollution on subsequent interplay between DS and EM, highlighting air pollution as an environmental health risk factor for older women.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/53b1s7jhTest

المؤلفون: Petkus, Andrew J, Younan, Diana, Wang, Xinhui, Beavers, Daniel P, Espeland, Mark A, Gatz, Margaret, Gruenewald, Tara, Kaufman, Joel D, Chui, Helena C, Millstein, Joshua, Rapp, Stephen R, Manson, JoAnn E, Resnick, Susan M, Wellenius, Gregory A, Whitsel, Eric A, Widaman, Keith, Chen, Jiu-Chiuan

المصدر: Journal of Alzheimer's Disease. 84(4)

مصطلحات موضوعية: Clinical Research, Behavioral and Social Science, Aging, Neurosciences, Basic Behavioral and Social Science, Aged, Air Pollutants, Air Pollution, Brain, Cognition, Environmental Exposure, Female, Humans, Neuropsychological Tests, Nitrogen Dioxide, Particulate Matter, Cognitive aging, latent class analysis, nitrogen dioxide, particulate matter, women, women, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery

الوصف: BackgroundElucidating associations between exposures to ambient air pollutants and profiles of cognitive performance may provide insight into neurotoxic effects on the aging brain.ObjectiveWe examined associations between empirically derived profiles of cognitive performance and residential concentrations of particulate matter of aerodynamic diameter

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/88v5905gTest

المؤلفون: Younan, Diana, Petkus, Andrew J, Widaman, Keith F, Wang, Xinhui, Casanova, Ramon, Espeland, Mark A, Gatz, Margaret, Henderson, Victor W, Manson, JoAnn E, Rapp, Stephen R, Sachs, Bonnie C, Serre, Marc L, Gaussoin, Sarah A, Barnard, Ryan, Saldana, Santiago, Vizuete, William, Beavers, Daniel P, Salinas, Joel A, Chui, Helena C, Resnick, Susan M, Shumaker, Sally A, Chen, Jiu-Chiuan

المصدر: Brain : a journal of neurology. 143(1)

مصطلحات موضوعية: Alzheimer’s disease, air pollution, episodic memory, fine particulate matter, neuroimaging, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery

الوصف: Evidence suggests exposure to particulate matter with aerodynamic diameter

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8v0012vnTest

المؤلفون: Beavers, Kristen M., Avery, Allison E., Shankaran, Mahalakshmi, Evans, William J., Lynch, S. Delanie, Dwyer, Caitlyn, Howard, Marjorie, Beavers, Daniel P., Weaver, Ashley A., Lenchik, Leon, Cawthon, Peggy M.

المساهمون: National Institute on Aging

المصدر: Journal of Cachexia, Sarcopenia and Muscle ; volume 14, issue 5, page 2350-2358 ; ISSN 2190-5991 2190-6009

الوصف: Background Traditionally, weight loss (WL) trials utilize dual energy X‐ray absorptiometry (DXA) to measure lean mass. This method assumes lean mass, as the sum of all non‐bone and non‐fat tissue, is a reasonable proxy for muscle mass. In contrast, the D 3 ‐creatine (D 3 Cr) dilution method directly measures whole body skeletal muscle mass, although this method has yet to be applied in the context of a geriatric WL trial. The purpose of this project was to (1) describe estimates of change and variability in D 3 Cr muscle mass in older adults participating in an intentional WL intervention and (2) relate its change to other measures of body composition as well as muscle function and strength. Methods The INVEST in Bone Health trial (NCT04076618), used as a scaffold for this ancillary pilot project, is a three‐armed, 12‐month randomized, controlled trial designed to determine the effects of resistance training or weighted vest use during intentional WL on a battery of musculoskeletal health outcomes among 150 older adults living with obesity. A convenience sample of 24 participants ( n = 8/arm) are included in this analysis. At baseline and 6 months, participants were weighed, ingested a 30 mg D 3 Cr tracer dose, provided a fasted urine sample 3–6 days post‐dosage, underwent DXA (total body fat and lean masses, appendicular lean mass) and computed tomography (mid‐thigh and trunk muscle/intermuscular fat areas) scans, and performed 400‐m walk, stair climb, knee extensor strength, and grip strength tests. Results Participants were older (68.0 ± 4.4 years), mostly White (75.0%), predominantly female (66.7%), and living with obesity (body mass index: 33.8 ± 2.7 kg/m 2 ). Six month total body WL was −10.3 (95% confidence interval, CI: −12.7, −7.9) kg. All DXA and computed tomography‐derived body composition measures were significantly decreased from baseline, yet D 3 Cr muscle mass did not change [+0.5 (95% CI: −2.0, 3.0) kg]. Of muscle function and strength measures, only grip strength significantly changed ...

الإتاحة: https://doi.org/10.1002/jcsm.13322Test