المؤلفون: Chorão, Pedro, Montoro, Juan, Balaguer-Roselló, Aitana, Guerreiro, Manuel, Villalba, Marta, Facal, Ana, Solves, Pilar, Gómez-Segui, Inés, Pasquini, Marcelo C., Granados, Pablo, Bataller, Ana, Louro, Alberto, de la Rubia, Javier, Sanz, Miguel A., Sanz, Jaime

المصدر: Transplantation and Cellular Therapy ; volume 29, issue 5, page 322.e1-322.e5 ; ISSN 2666-6367

مصطلحات موضوعية: Transplantation, Cell Biology, Hematology, Molecular Medicine, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jtct.2023.01.016Test
https://api.elsevier.com/content/article/PII:S2666636723000374?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666636723000374?httpAccept=text/plainTest

المؤلفون: Cordón, Lourdes, Chorão, Pedro, Martín-Herreros, Beatriz, Montoro, Juan, Balaguer, Aitana, Guerreiro, Manuel, Villalba, Marta, Facal, Ana, Asensi, Pedro, Solves, Pilar, Gómez, Inés, Santiago, Marta, Lamas, Brais, Bataller, Ana, Granados, Pablo, Sempere, Amparo, Sanz, Guillermo F., Sanz, Miguel A., Sanz, Jaime

المصدر: Annals of Hematology; Jul2024, Vol. 103 Issue 7, p2475-2484, 10p

مستخلص: This study aimed to investigate the kinetics of immune recovery following umbilical cord blood transplantation (UCBT) in adults who received a myeloablative conditioning (MAC) regimen and antithymocyte globulin (ATG). While the immune recovery kinetics has been extensively studied in pediatric UCBT recipients, limited data exist for adults. We conducted a comprehensive analysis of 221 consecutive adult patients who underwent UCBT with MAC and ATG at a single institution. Our objective was to evaluate the influence of patient, disease, and transplant factors, along with acute graft-versus-host disease (aGVHD), on immune reconstitution and overall survival. Our findings confirm a delayed recovery of T cells, while B and NK cell reconstitution exhibited rapid progress, with NK cell counts reaching normal levels within 3 months post-transplantation and B cells within 6 months. Within CD3⁺ T cells, CD8⁺ T cells also experienced a delayed recovery (12 months), but to a lesser extent compared to CD4⁺ T cells (18 months). Delayed immune recovery of T-cell subsets was associated with the development of aGVHD grade II-IV, older age, CMV negativity, and a female donor. Patients with lymphoproliferative diseases showed slower NK cell recovery. Our study demonstrates that adult patients undergoing MAC with ATG and receiving a single unit UCBT for hematologic malignancies experienced rapid reconstitution of NK and B cells. However, T cell recovery, particularly CD4⁺ T cells, was significantly delayed. To enhance T cell recovery, it may be crucial to consider UCB units with higher cellularity and optimize ATG doses in conditioning. [ABSTRACT FROM AUTHOR]

: Copyright of Annals of Hematology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Solves, Pilar^1,2 (AUTHOR) bataller_anaalf@gva.es, Bataller, Ana¹ (AUTHOR) galvez_anarui@gva.es, Gálvez, Ana Belén¹ (AUTHOR) asensi_ped@gva.es, Asensi Cantó, Pedro¹ (AUTHOR) santiago_marbal@gva.es, Santiago, Marta^1,2 (AUTHOR) gomez_ine@gva.es, Moreno, María José³ (AUTHOR) moreno_marjos@gva.es, Gómez-Seguí, Inés^1,2 (AUTHOR) delarubia_jav@gva.es, de la Rubia, Javier^1,2,4 (AUTHOR)

المصدر: Hemato. Jun2024, Vol. 5 Issue 2, p109-114. 6p.

مستخلص: Background: Selective IgA deficiency (IgA-D) has been historically considered a high-risk entity for developing allergic/anaphylactic reactions after blood transfusion (AATRs). However, it has been suggested that the IgA-D-related anaphylactic transfusion reaction is not evidence-based. Methods: We conducted three different approaches to collect evidence about epidemiology, AATRs, and transfusion management of patients with IgA-D at La Fe University Hospital. Firstly, we analysed the prevalence of IgA-D in a population of patients diagnosed with acute leukaemia, The second approach consisted of collecting transfusion data from IgA-D patients. Finally, we reviewed the IgA levels of patients recorded in the hemovigilance system suffering an AATR. Results: IgA-D prevalence was 1 in 334 patients. At least one blood component was transfused to 23 patients diagnosed with IgA-D. Plasma was transfused to eight IgA-D patients, while six patients received red blood cells, platelets, and plasma. No adverse reactions were reported in any patient. AATRs occurred in 325 men and 264 women with a median age of 52 years. Severe reactions occurred in 56 patients (1/14,520 components). Mean IgA levels were 215 mg/dL (4–5570) for mild reactions and 214 mg/dL (14–824) for severe reactions (p = ns). Washed platelets were administered to two patients who developed severe and repeated AATRs. Both had normal IgA levels. Conclusions: Since the AATRs related to IgA-D are extremely low, as reported in current hemovigilance systems, IgA-D should not be considered a high-risk entity to develop AATRs. On the contrary, our findings support standard transfusion management of IgA-D patients. [ABSTRACT FROM AUTHOR]

المؤلفون: Chorão, Pedro, Henriques, Marta, Villalba, Marta, Montoro, Juan, Balaguer-Roselló, Aitana, González, Eva María, Gómez, María Dolores, Gómez, Inés, Solves, Pilar, Santiago, Marta, Asensi, Pedro, Lamas, Brais, Bataller, Ana, Granados, Pablo, Eiris, Juan, Martínez, David, Louro, Alberto, Rebollar, Paula, Perla, Aurora, Salavert, Miguel, de la Rubia, Javier, Sanz, Miguel Ángel, Sanz, Jaime

المصدر: Transplantation and Cellular Therapy; May 2024, Vol. 30 Issue: 5 p538.e1-538.e10, 48430p

مستخلص: • First CMV reactivations in HSCT with PTCy without letermovir prophylaxis occurred in 46% of patients.• The reactivation rate was 73% for CMV seropositive recipients and 49% for CMV-seropositive donors.• Risk factors for reactivation were CMV seropositivity, haploidentical HSCT, older patient, and grade II-IV acute GVHD.• Second and third CMV reactivations occurred in 13% and 4.4% of patients, independent of donor type.

المؤلفون: Sanz, Miguel Ángel, Montoro, Juan, Balaguer-Roselló, Aitana, Chorão, Pedro, Villalba, Marta, Gómez, Inés, Solves, Pilar, Santiago, Marta, Asensi, Pedro, Lamas, Brais, Bataller, Ana, Granados, Pablo, Eiris, Juan, Martinez, David, Lloret, Pilar, Louro, Alberto, Rebollar, Paula, Perla, Aurora, de la Rubia, Javier, Sanz, Jaime

المصدر: Bone Marrow Transplant ; ISSN:1476-5365

الوصف: This 45-year study (1978-2022) at a single institution evaluated HSCT outcomes and complications, emphasizing recent advances, with to provide insights into HSCT's evolving field and ongoing efforts to enhance patient outcomes. Involving 1707 patients, the study revealed an initial phase (1978-1987) with a limited activity that yielded modest outcomes, a nearly three-decade span (1988-2016) with a substantial increase in transplant activity, emphasizing umbilical cord blood transplantation (UCBT) for patients lacking a suitable matched sibling donor. In addition to a gradual increase in recipient age, significant improvement in outcomes emerged in the recent period (2017-2022), marked by UCBT replacement with haploidentical transplants, introduction of PTCY-based GVHD prophylaxis for all type of transplants, and increased use of conditioning regimens with thiotepa, busulfan, and fludarabine. In this period, reductions in GVHD, non-relapse mortality, and relapse rates significantly contributed to improved overall survival, event-free survival, and GVHD-free/relapse-free survival. The study identified specific factors, including GVHD prophylaxis and donor selection changes, associated with these positive trends. This four-decade study provides a unique perspective on allogeneic HSCT, showcasing the dynamic evolution of transplantation practices and their impact on outcomes, offering valuable insights for personalized treatment approaches and emphasizing continual innovation in this critical therapeutic modality.

العلاقة: https://doi.org/10.1038/s41409-024-02319-xTest; https://pubmed.ncbi.nlm.nih.gov/38918495Test

الإتاحة: https://doi.org/10.1038/s41409-024-02319-xTest
https://pubmed.ncbi.nlm.nih.gov/38918495Test

المؤلفون: Balaguer-Roselló, Aitana, Gil-Perotín, Sara, Montoro, Juan, Bataller, Luis, Lamas, Brais, Villalba, Marta, Facal, Ana, Guerreiro, Manuel, Chorão, Pedro, Bataller, Ana, Granados, Pablo, Gómez, Inés, Solves, Pilar, Louro, Alberto, de la Rubia, Javier, Sanz, Miguel Ángel, Sanz, Jaime

المصدر: Transplantation and Cellular Therapy ; volume 29, issue 10, page 610.e1-610.e12 ; ISSN 2666-6367

مصطلحات موضوعية: Transplantation, Cell Biology, Hematology, Molecular Medicine, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jtct.2023.07.008Test
https://api.elsevier.com/content/article/PII:S2666636723014161?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666636723014161?httpAccept=text/plainTest

المؤلفون: Gonzalo-Skok, Oliver, Tous-Fajardo, Julio, Valero-Campo, Carlos, Berzosa, César, Bataller, Ana Vanessa, Arjol-Serrano, José Luis, Moras, Gerard, Mendez-Villanueva, Alberto

المصدر: International Journal of Sports Physiology & Performance; Aug2017, Vol. 12 Issue 7, p951-958, 8p, 1 Diagram, 1 Chart, 1 Graph

مصطلحات موضوعية: COMPARATIVE studies, EXERCISE tests, HEALTH outcome assessment, STATISTICAL sampling, EFFECT sizes (Statistics), PHYSICAL training & conditioning, BODY movement, TEAM sports, RESISTANCE training

مستخلص: Purpose: To analyze the effects of 2 different eccentric-overload training (EOT) programs, using a rotational conical pulley, on functional performance in team-sport players. A traditional movement paradigm (ie, squat) including several sets of 1 bilateral and vertical movement was compared with a novel paradigm including a different exercise in each set of unilateral and multi-directional movements. Methods: Forty-eight amateur or semiprofessional team-sport players were randomly assigned to an EOT program including either the same bilateral vertical (CBV, n = 24) movement (squat) or different unilateral multidirectional (VUMD, n = 24) movements. Training programs consisted of 6 sets of 1 exercise (CBV) or 1 set of 6 exercises (VUMD) x 6-10 repetitions with 3 min of passive recovery between sets and exercises, biweekly for 8 wk. Functional-performance assessment included several change-of-direction (COD) tests, a 25-m linear-sprint test, unilateral multidirectional jumping tests (ie, lateral, horizontal, and vertical), and a bilateral vertical-jump test. Results: Within-group analysis showed substantial improvements in all tests in both groups, with VUMD showing more robust adaptations in pooled COD tests and lateral/horizontal jumping, whereas the opposite occurred in CBV respecting linear sprinting and vertical jumping. Between-groups analyses showed substantially better results in lateral jumps (ES = 0.21), left-leg horizontal jump (ES = 0.35), and 10-m COD with right leg (ES = 0.42) in VUMD than in CBV. In contrast, left-leg countermovement jump (ES = 0.26) was possibly better in CBV than in VUMD. Conclusions: Eight weeks of EOT induced substantial improvements in functional-performance tests, although the force-vector application may play a key role to develop different and specific functional adaptations. [ABSTRACT FROM AUTHOR]

: Copyright of International Journal of Sports Physiology & Performance is the property of Human Kinetics Publishers, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Bataller, Ana, Alcántara Alcover, Enrique

المصدر: Revista de biomecánica, ISSN 1575-5622, Nº. 24, 1999, pags. 19-21

الوصف: LA INTRODUCCIÓN DEL PROTOTIPADO RÁPIDO EN EL CICLO DE desarrollo de productos supone una mejora en la calidad e innovación del producto final, a la vez que reduce el tiempo y el coste necesarios para su puesta en el mercado, proporcionando una clara ventaja competitiva. ; The introduction of Rapid Prototyping in the Product Development cycle is a clear improvement in terms of quality and innovation of the final product, while reducing the time and cost necessary for product marketing, giving thus a clear competitive advantage.

وصف الملف: application/pdf

العلاقة: http://dialnet.unirioja.es/servlet/oaiart?codigo=4846407Test; (Revista) ISSN 1575-5622

الإتاحة: http://dialnet.unirioja.es/servlet/oaiart?codigo=4846407Test

المؤلفون: Nicolas Bataller, Ana

الوصول الحر: https://www.europeana.eu/item/2020801/dmglib_handler_docum_24960009?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCaTest

المؤلفون: Nicolas Bataller, Ana

الإتاحة: http://www.dmg-lib.org/dmglib/handler?docum=24960009Test