المؤلفون: Cammarota G., Vaschetto R., Azzolina D., De Vita N., Olivieri C., Ronco C., Longhini F., Bruni A., Colombo D., Pissaia C., Prato F., Maestrone C., Maestrone M., Vetrugno L., Bove T., Lemut F., Taretto E., Locatelli A., Barzaghi N., Cerrano M., Ravera E., Zanza C., Selva A. D., Blangetti I., Salvo F., Racca F., Longhitano Y., Boscolo A., Sguazzotti I., Bonato V., Grossi F., Crimaldi F., Perucca R., Boniolo E., Verdina F., Vignazia G. L., Santangelo E., Tarquini R., Zanoni M., Messina A., Marin M., Bacigalupo P., Sileci G., Sella N., De Robertis E., Corte F. D., Navalesi P.

المساهمون: Cammarota, G., Vaschetto, R., Azzolina, D., De Vita, N., Olivieri, C., Ronco, C., Longhini, F., Bruni, A., Colombo, D., Pissaia, C., Prato, F., Maestrone, C., Maestrone, M., Vetrugno, L., Bove, T., Lemut, F., Taretto, E., Locatelli, A., Barzaghi, N., Cerrano, M., Ravera, E., Zanza, C., Selva, A. D., Blangetti, I., Salvo, F., Racca, F., Longhitano, Y., Boscolo, A., Sguazzotti, I., Bonato, V., Grossi, F., Crimaldi, F., Perucca, R., Boniolo, E., Verdina, F., Vignazia, G. L., Santangelo, E., Tarquini, R., Zanoni, M., Messina, A., Marin, M., Bacigalupo, P., Sileci, G., Sella, N., De Robertis, E., Corte, F. D., Navalesi, P.

مصطلحات موضوعية: SARS-CoV-2, Noninvasive Ventilation, Hospital Mortality

الوصف: In patients intubated for hypoxemic acute respiratory failure (ARF) related to novel coronavirus disease (COVID-19), we retrospectively compared two weaning strategies, early extubation with immediate non-invasive ventilation (NIV) versus standard weaning encompassing spontaneous breathing trial (SBT), with respect to IMV duration (primary endpoint), extubation failures and reintubations, rate of tracheostomy, intensive care unit (ICU) length of stay and mortality (additional endpoints). All COVID-19 adult patients, intubated for hypoxemic ARF and subsequently extubated, were enrolled. Patients were included in two groups, early extubation followed by immediate NIV application, and conventionally weaning after passing SBT. 121 patients were enrolled and analyzed, 66 early extubated and 55 conventionally weaned after passing an SBT. IMV duration was 9 [6–11] days in early extubated patients versus 11 [6–15] days in standard weaning group (p = 0.034). Extubation failures [12 (18.2%) vs. 25 (45.5%), p = 0.002] and reintubations [12 (18.2%) vs. 22 (40.0%) p = 0.009] were fewer in early extubation compared to the standard weaning groups, respectively. Rate of tracheostomy, ICU mortality, and ICU length of stay were no different between groups. Compared to standard weaning, early extubation followed by immediate NIV shortened IMV duration and reduced the rate of extubation failure and reintubation.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34183764; info:eu-repo/semantics/altIdentifier/wos/WOS:000669978600009; volume:11; issue:1; firstpage:13418-1; lastpage:13418-9; numberofpages:9; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/11392/2486887Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85109691183; https://www.nature.com/articles/s41598-021-92960-zTest

الإتاحة: https://doi.org/10.1038/s41598-021-92960-zTest
https://hdl.handle.net/11392/2486887Test
https://www.nature.com/articles/s41598-021-92960-zTest

المؤلفون: Zadra, A. R., Ripellino, P., Barzaghi, N.

المصدر: Case Reports ; volume 2015, issue apr29 1, page bcr2014208787-bcr2014208787 ; ISSN 1757-790X

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1136/bcr-2014-208787Test

المؤلفون: Rossini, R, Masiero, G, Fruttero, C, Passamonti, E, Calvaruso, E, Cecconi, M, Carlucci, C, Barzaghi, N, Locatelli, A, Mojoli, M, Parodi, G, Talanas, G, Pierini, S, Angiolillo, D, Musumeci, G

المصدر: European Heart Journal ; volume 40, issue Supplement_1 ; ISSN 0195-668X 1522-9645

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Perioperative management of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients deemed at high thrombotic risk undergoing non-deferrable surgery remains poorly defined. Cangrelor represents a potential treatment option as a “bridge” from discontinuation of oral P2Y12 receptor antagonists to surgical procedures, but data in this setting are still scant. Purpose We sought to describe a real-world experience of a bridging protocol using cangrelor for patients referred to relevant bleeding risk surgery requiring withdrawal of DAPT. Methods We collected data from 7 Italian centers on patients with previous PCI, still on DAPT, undergoing non-deferrable surgery which required discontinuation of one or both antiplatelet agents. A standardized bridging protocol using cangrelor infusion before and eventually after surgery was applied (Figure 1). Results Between December 2017 and January 2019, a total of 18 patients (mean age 70±10 years; male 85%) were enrolled. In the majority (89%) of patients, the index PCI was performed due to acute coronary syndrome (ACS) and 2±1.7 stents per patient were implanted. All patients required non-deferrable, intermediate-high bleeding risk surgery as pulmonary lobectomy, colectomy, endoscopic bladder surgery, paranasal sinus surgery, coronary artery by-pass surgery and valvular repair, hip replacement, endoscopy sphincterotomy. High thrombotic risk categories included PCI time <1 month, SCA time <3 months, stent failure occurrence, previous Absorb BVS implantation. Due to the surgical bleeding risk, discontinuation of P2Y12 inhibitor was required 5 days before surgery (ticagrelor, n=13; prasugrel=1; clopidogrel, n=5). All patients but 1 maintained aspirin through the perioperative phase. Cangrelor infusion was started at a bridging dose (0.75 mcg/kg/min) 3 days before planned surgery and was discontinued 6.9±1.5 hours before. After surgery, drainages were left in all patients but 3. In 56% of patients, cangrelor was resumed ...

الإتاحة: https://doi.org/10.1093/eurheartj/ehz748.1127Test
http://academic.oup.com/eurheartj/article-pdf/40/Supplement_1/ehz748.1127/30203191/ehz748.1127.pdfTest

المؤلفون: Seminari, E, De Silvestri, A., Ravasio, V., Ludovisi, S., Utili, R., Petrosillo, N., Castelli, F., Barbaro, F., Grossi, P., Barzaghi, N., Rizzi, M., Minoli, L., BASSETTI, MATTEO

المساهمون: Seminari, E, De Silvestri, A., Ravasio, V., Ludovisi, S., Utili, R., Petrosillo, N., Castelli, F., Bassetti, Matteo, Barbaro, F., Grossi, P., Barzaghi, N., Rizzi, M., Minoli, L.

مصطلحات موضوعية: Adult, Aged, Endocarditis, Bacterial, Female, Hospital Mortality, Human, Italy, Liver Disease, Male, Middle Aged, Prognosi, Prospective Studie, Prosthesis-Related Infection, Retrospective Studie, Risk Factor, Staphylococcal Infection, Staphylococcus aureu, Staphylococcus epidermidi, Microbiology (medical), Infectious Diseases

الوصف: Few data have been published regarding the epidemiology and outcome of infective endocarditis (IE) in patients with chronic hepatic disease (CHD). A retrospective analysis of the Studio Endocarditi Italiano (SEI) database was performed to evaluate the epidemiology and outcome of CHD+ patients compared with CHD− patients. The diagnosis of IE was defined in accordance with the modified Duke criteria. Echocardiography, diagnosis, and treatment procedures were in accordance with current clinical practice. Among the 1722 observed episodes of IE, 300 (17.4 %) occurred in CHD+ patients. The cause of CHD mainly consisted of chronic viral infection. Staphylococcus aureus was the most common bacterial species in CHD+ patients; the frequency of other bacterial species (S. epidermidis, streptococci, and enterococci) were comparable among the two groups. The percentage of patients undergoing surgery for IE was 38.9 in CHD+ patients versus 43.7 in CHD− patients (p = 0.06). Complications were more common among CHD+ patients (77 % versus 65.3 %, p < 0.001); embolization (43.3 % versus 26.1 %, p < 0.001) and congestive heart failure (42 % versus 34.1 %, p = 0.01) were more frequent among CHD+ patients. Mortality was comparable (12.5 % in CHD− and 15 % in CHD+ patients). At multivariable analysis, factors associated with hospital-associated mortality were having an infection sustained by S. aureus, a prosthetic valve, diabetes and a neoplasia, and CHD. Being an intravenous drug user (IVDU) was a protective factor and was associated with a reduced death risk. CHD is a factor worsening the prognosis in patients with IE, in particular in patients for whom cardiac surgery was required.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000368813200017; volume:35; issue:2; firstpage:279; lastpage:284; numberofpages:6; journal:EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES; http://hdl.handle.net/11390/1101264Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84955461416; link.springer.de/link/service/journals/10096/index.htm

الإتاحة: https://doi.org/10.1007/s10096-015-2541-4Test
http://hdl.handle.net/11390/1101264Test

المؤلفون: Durante Mangoni E., Ravasio V., Stellini R., Barzaghi N., Del Bono V., Chinello P., Delle Foglie P., Di Caprio D., Tedesco A., Rizzi M., Suter F., Utili R., TRIPODI, MARIE FRANCOISE

المساهمون: Durante Mangoni, E., Ravasio, V., Tripodi, MARIE FRANCOISE, Stellini, R., Barzaghi, N., Del Bono, V., Chinello, P., Delle Foglie, P., Di Caprio, D., Tedesco, A., Rizzi, M., Suter, F., Utili, R.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000266284500079; ispartofbook:International journal of Antimicrobial Agents; 10th International Symposium on Modern Concepts in Endocarditis and Cardiovascular Infections; volume:Volume: 33; firstpage:S30; lastpage:S30; numberofpages:1; journal:INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS; http://hdl.handle.net/11386/3880427Test

الإتاحة: http://hdl.handle.net/11386/3880427Test

المؤلفون: DURANTE MANGONI, Emanuele, Ravasio V, Tripodi MF, Stellini R, Barzaghi N, Del Bono V, Chinello P, Delle Foglie P, Di Caprio D, Tedesco A, Rizzi M, Suter F, UTILI, Riccardo

المساهمون: DURANTE MANGONI, Emanuele, Ravasio, V, Tripodi, Mf, Stellini, R, Barzaghi, N, Del Bono, V, Chinello, P, Delle Foglie, P, Di Caprio, D, Tedesco, A, Rizzi, M, Suter, F, Utili, Riccardo

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000266284500079; ispartofbook:Supplement; 10th International Symposium on Modern Concepts in Endocarditis and Cardiovascular Infections; volume:33; issue:Suppl 2; firstpage:S30; lastpage:S30; numberofpages:1; journal:INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS; http://hdl.handle.net/11591/158729Test

الإتاحة: http://hdl.handle.net/11591/158729Test

المؤلفون: Rizzi, Marco, Ravasio, Veronica, Carobbio, Alessandra, Mattucci, Irene, Crapis, Massimo, Stellini, Roberto, Pasticci, Maria B., Chinello, Pierangelo, Falcone, Marco, Grossi, Paolo, Barbaro, Francesco, Pan, Angelo, Viale, Pierluigi, Durante Mangoni, Emanuele, Biglino A, Brusa MT, Crivelli P, Moglia R, Leone S, Ravasio V, Rizzi M, Suter F, Viale P, Mian P, Spoladore G, Castelli F, Magri S, Stellini R, Di Caprio D, Van Hauwermeiren E, Pan A, Zacchi F, Barzaghi N, Libanore M, Pantaleoni M, Del Bono V, Viscoli C, Gattuso G, Scalzini A, Villa MR, Bernardo M, Casillo R, Cuccurullo S, Dialetto G, Durante Mangoni E, Mattucci I, Ragone E, Tripodi MF, Utili R, Barbaro F, Erne E, Minoli L, Seminari EM, Martinelli L, Pallotto C, Pasticci MB, Canovari B, Stoppini L, Chinello P, Falcone M, Petrosillo N, Venditti M, Delle Foglie P, Giobbia M, Inoiosa W, Scotton G, Vaglia A, Crapis M, Venturini S, Dalla Gasperina D, Grossi P, Tebini A, Concia E, Del Bravo P, Tedesco A, Nicolin R, Pellizzer G., BASSETTI, MATTEO

المساهمون: Rizzi, Marco, Ravasio, Veronica, Carobbio, Alessandra, Mattucci, Irene, Crapis, Massimo, Stellini, Roberto, Pasticci, Maria B., Chinello, Pierangelo, Falcone, Marco, Grossi, Paolo, Barbaro, Francesco, Pan, Angelo, Viale, Pierluigi, Durante, Mangoni, Emanuele, Biglino, A, Brusa MT, Crivelli P, Moglia, R, Leone, S, Ravasio, V, Rizzi, M, Suter, F, Viale, P, Mian, P, Spoladore, G, Castelli, F, Magri, S, Stellini, R, Di Caprio, D, Van Hauwermeiren, E, Pan, A, Zacchi, F, Barzaghi, N, Libanore, M, Pantaleoni, M, Del Bono, V, Viscoli, C, Gattuso, G, Scalzini, A, Villa, Mr, Bernardo, M, Casillo, R, Cuccurullo, S, Dialetto, G, Durante Mangoni, E, Mattucci, I, Ragone, E, Tripodi, Mf, Utili, R, Barbaro, F, Erne, E, Minoli, L, Seminari, Em, Martinelli, L, Pallotto, C, Pasticci, Mb, Canovari, B, Stoppini, L, Chinello, P, Falcone, M, Petrosillo, N, Venditti, M, Delle Foglie, P, Giobbia, M, Inoiosa, W, Scotton, G, Vaglia, A, Bassetti, Matteo, Crapis, M, Venturini, S, Dalla Gasperina, D, Grossi, P, Tebini, A, Concia, E, Del Bravo, P, Tedesco, A, Nicolin, R, Pellizzer, G.

مصطلحات موضوعية: Embolism, Infective endocarditi, Risk score, Stroke, Adult, Aged, Endocarditis, Bacterial, Female, Human, Italy, Male, Middle Aged, Retrospective Studie, Risk Factor, Infectious Disease, Medicine (all)

الوصف: Background: Embolic events are a major cause of morbidity and mortality in patients with infective endocarditis. We analyzed the database of the prospective cohort study SEI in order to identify factors associated with the occurrence of embolic events and to develop a scoring system for the assessment of the risk of embolism.Methods: We retrospectively analyzed 1456 episodes of infective endocarditis from the multicenter study SEI. Predictors of embolism were identified. Risk factors identified at multivariate analysis as predictive of embolism in left-sided endocarditis, were used for the development of a risk score: 1 point was assigned to each risk factor (total risk score range: minimum 0 points; maximum 2 points). Three categories were defined by the score: low (0 points), intermediate (1 point), or high risk (2 points); the probability of embolic events per risk category was calculated for each day on treatment (day 0 through day 30).Results: There were 499 episodes of infective endocarditis (34%) that were complicated by ≥ 1 embolic event. Most embolic events occurred early in the clinical course (first week of therapy: 15.5 episodes per 1000 patient days; second week: 3.7 episodes per 1000 patient days). In the total cohort, the factors associated with the occurrence of embolism at multivariate analysis were prosthetic valve localization (odds ratio, 1.84), right-sided endocarditis (odds ratio, 3.93), Staphylococcus aureus etiology (odds ratio, 2.23) and vegetation size ≥ 13 mm (odds ratio, 1.86). In left-sided endocarditis, Staphylococcus aureus etiology (odds ratio, 2.1) and vegetation size ≥ 13 mm (odds ratio, 2.1) were independently associated with embolic events; the 30-day cumulative incidence of embolism varied with risk score category (low risk, 12%; intermediate risk, 25%; high risk, 38%; p < 0.001).Conclusions: Staphylococcus aureus etiology and vegetation size are associated with an increased risk of embolism. In left-sided endocarditis, a simple scoring system, which combines etiology and ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000336070300001; volume:14; issue:1; firstpage:230; journal:BMC INFECTIOUS DISEASES; http://hdl.handle.net/11390/1101107Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84900436055; http://www.biomedcentral.com/1471-2334/14/230Test

الإتاحة: https://doi.org/10.1186/1471-2334-14-230Test
http://hdl.handle.net/11390/1101107Test
http://www.biomedcentral.com/1471-2334/14/230Test

المؤلفون: Tripodi MF, Pasquariello T, Biglino A, Ravasio V, Carosi G, Barzaghi N, Gattuso G, UTILI, Riccardo, Brugnone R, Minoli L, Pasticci MB, Petrosillo N, Venditti M, Falcone M, Delle Foglie P, Inojaga W, Viale PL, Crapis M, Grossi P, Concia E., DURANTE MANGONI, Emanuele

المساهمون: Tripodi, Mf, Pasquariello, T, Biglino, A, Ravasio, V, Carosi, G, Barzaghi, N, Gattuso, G, Utili, Riccardo, DURANTE MANGONI, Emanuele, Brugnone, R, Minoli, L, Pasticci, Mb, Petrosillo, N, Venditti, M, Falcone, M, Delle Foglie, P, Inojaga, W, Viale, Pl, Crapis, M, Grossi, P, Concia, E.

العلاقة: ispartofbook:Atti del 6° Congresso Nazionale Società Italiana Malattie Infettive e Tropicali; 6° Congresso Nazionale SIMIT; http://hdl.handle.net/11591/207757Test

الإتاحة: http://hdl.handle.net/11591/207757Test

المؤلفون: Suter F, Rizzi M, Ravasio V, Biglino A, Carosi G, Barzaghi N, Gattuso G, UTILI, Riccardo, Tripodi MF, Minoli L, Pasticci MB, Petrosillo N, Venditti M, Falcone M, Delle Foglie P, Vaglia A, Viale PL, Crapis M, Grossi P, Concia E., DURANTE MANGONI, Emanuele

المساهمون: Suter, F, Rizzi, M, Ravasio, V, Biglino, A, Carosi, G, Barzaghi, N, Gattuso, G, Utili, Riccardo, DURANTE MANGONI, Emanuele, Tripodi, Mf, Minoli, L, Pasticci, Mb, Petrosillo, N, Venditti, M, Falcone, M, Delle Foglie, P, Vaglia, A, Viale, Pl, Crapis, M, Grossi, P, Concia, E.

العلاقة: ispartofbook:Supplement; 9th International Symposium on Endocarditis and Cardiovascular Infections; volume:96; firstpage:436; lastpage:436; numberofpages:1; journal:CLINICAL RESEARCH IN CARDIOLOGY; http://hdl.handle.net/11591/158750Test

الإتاحة: http://hdl.handle.net/11591/158750Test

المؤلفون: DURANTE MANGONI, Emanuele, Ravasio V, Tripodi MF, Rizzi M, Biglino A, Carosi G, Barzaghi N, Gattuso G, Iossa D, Minoli L, Pasticci MB, Petrosillo N, Venditti M, Falcone M, Delle Foglie P, Inojaga W, Viale PL, Crapis M, Grossi P, Concia E, UTILI, Riccardo, Suter F.

المساهمون: DURANTE MANGONI, Emanuele, Ravasio, V, Tripodi, Mf, Rizzi, M, Biglino, A, Carosi, G, Barzaghi, N, Gattuso, G, Iossa, D, Minoli, L, Pasticci, Mb, Petrosillo, N, Venditti, M, Falcone, M, Delle Foglie, P, Inojaga, W, Viale, Pl, Crapis, M, Grossi, P, Concia, E, Utili, Riccardo, Suter, F.

العلاقة: ispartofbook:Atti del 6° Congresso nazionale Società Italiana Malattie Infettive e Tropicali; 6° Congresso nazionale SIMIT; http://hdl.handle.net/11591/162068Test

الإتاحة: http://hdl.handle.net/11591/162068Test