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المؤلفون: Martin Pass, Sylvie Guichard, Graeme C.M. Smith, Matt Jacobsen, Richard Jenkins, Keith Menear, Karine Malagu, Marc Hummersone, Sharon Maguire, Lisa Smith, Gareth Hughes, Phillippa Dudley, Zoe Howard, Dominic James, Patrizia Sini, Darren Jones, Rebecca Ellston, John P. Vincent, Susan E. Critchlow, Sabina Cosulich, Tom Harding, Ian Hickson, Barry R. Davies, Christine M. Chresta
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f94cb2e112404bc4549d9a076de01bTest
https://doi.org/10.1158/0008-5472.c.6500190Test -
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المؤلفون: Martin Pass, Sylvie Guichard, Graeme C.M. Smith, Matt Jacobsen, Richard Jenkins, Keith Menear, Karine Malagu, Marc Hummersone, Sharon Maguire, Lisa Smith, Gareth Hughes, Phillippa Dudley, Zoe Howard, Dominic James, Patrizia Sini, Darren Jones, Rebecca Ellston, John P. Vincent, Susan E. Critchlow, Sabina Cosulich, Tom Harding, Ian Hickson, Barry R. Davies, Christine M. Chresta
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3384b989c01cabca3f7bf94f2d6d0f8fTest
https://doi.org/10.1158/0008-5472.22382397.v1Test -
63دورية أكاديمية
المؤلفون: Nicolas Floc'h, Maria Luisa Guerriero, Antonio Ramos-Montoya, Barry R. Davies, Jonathan Cairns, Natasha A. Karp
المصدر: Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
مصطلحات موضوعية: Patient-derived tumor xenografts, Population studies, Preclinical trial, Medicine, Pathology, RB1-214
وصف الملف: electronic resource
العلاقة: http://dmm.biologists.org/content/11/11/dmm036160Test; https://doaj.org/toc/1754-8403Test; https://doaj.org/toc/1754-8411Test
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المؤلفون: Shanade Dunn, Cath Eberlein, Jason Yu, Albert Gris-Oliver, Swee Hoe Ong, Urs Yelland, Natalie Cureton, Anna Staniszewska, Robert McEwen, Millie Fox, James Pilling, Philip Hopcroft, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Beverley Isherwood, Violeta Serra, Barry R. Davies, Simon T. Barry, James T. Lynch, Kosuke Yusa
المساهمون: Institut Català de la Salut, [Dunn S] Wellcome Sanger Institute, Cambridge, UK. Bioscience, Early Oncology, AstraZeneca, Cambridge, UK. [Eberlein C, Yelland U] Bioscience, Early Oncology, AstraZeneca, Alderley Park, UK. [Yu J] Wellcome Sanger Institute, Cambridge, UK. Molecular Biology of Metabolism Lab, The Francis Crick Institute, London, UK. [Gris-Oliver A, Serra V] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Ong SH] Wellcome Sanger Institute, Cambridge, UK, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
مصطلحات موضوعية: Cancer Research, Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm [PHENOMENA AND PROCESSES], Class I Phosphatidylinositol 3-Kinases, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], Medicaments antineoplàstics - Ús terapèutic, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Breast Neoplasms, Antineoplastic Agents, Mechanistic Target of Rapamycin Complex 1, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Genetics, Humans, Guanine Nucleotide Exchange Factors, Other subheadings::/therapeutic use [Other subheadings], Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Resistència als medicaments, fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos [FENÓMENOS Y PROCESOS], neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Otros calificadores::/uso terapéutico [Otros calificadores], TOR Serine-Threonine Kinases, PTEN Phosphohydrolase, acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos [COMPUESTOS QUÍMICOS Y DROGAS], Mama - Càncer - Tractament, Female, Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [CHEMICALS AND DRUGS], Proto-Oncogene Proteins c-akt
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e136f779ccbe55fa005a37d201d30Test
https://hdl.handle.net/11351/8698Test -
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المؤلفون: Paul Kinchesh, James M Thompson, Stuart Gilchrist, Barry R. Davies, Jennifer L. Martin, Mark J. O'Connor, Veerle Kersemans, Sean Smart, Yanyan Jiang, Anderson J. Ryan, Kay Shigemori, Maryam Alkadhimi, Mark A. Hill
المصدر: British Journal of Cancer
مصطلحات موضوعية: Thorax, Cancer Research, Radiation-Sensitizing Agents, Lung Neoplasms, Article, Piperazines, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Therapeutic index, Carcinoma, Non-Small-Cell Lung, medicine, Animals, Lung cancer, Cancer models, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, Radiotherapy, business.industry, Magnetic resonance imaging, Histology, medicine.disease, Disease Models, Animal, Therapeutic Index, Treatment Outcome, Oncology, chemistry, Tolerability, 030220 oncology & carcinogenesis, Toxicity, Phthalazines, Female, business, Nuclear medicine, Non-small-cell lung cancer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e600d6088887f3370444bc9ed4771b5bTest
http://europepmc.org/articles/PMC8144220Test -
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المؤلفون: Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis
المصدر: Clinical Cancer Research. 26:6535-6549
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Venetoclax, Chronic lymphocytic leukemia, Cancer, Myeloid leukemia, Bcl-xL, medicine.disease, 3. Good health, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Oncology, chemistry, In vivo, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, medicine, Cancer research, B cell
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::564420d79c6feacf9af617f03b6937bcTest
https://doi.org/10.1158/1078-0432.ccr-20-0863Test -
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المؤلفون: Frederick W. Goldberg, M. Raymond V. Finlay, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, Gail L. Wrigley, Marianne Schimpl, Martin R. Howard, Beth Williamson, Mercedes Vazquez-Chantada, Derek G. Barratt, Barry R. Davies, Elaine B. Cadogan, Antonio Ramos-Montoya, Emma Dean
المصدر: Journal of Medicinal Chemistry. 63:3461-3471
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6b43386329529371549eb2977979ceb2Test
https://doi.org/10.1021/acs.jmedchem.9b01684Test -
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المؤلفون: Kyoko Nakamura, Neil H. James, Paul Farrington, Ankur Karmokar, Susan J. Bickerton, Simon J. Dovedi, Gareth Hughes, Timothy M Illidge, Elaine Cadogan, Antonio Ramos-Montoya, Barry R. Davies, Viia Valge-Archer
المصدر: Nakamura, K, Karmokar, A, Farrington, P M, James, N H, Ramos-Montoya, A, Bickerton, S J, Hughes, G D, Illidge, T M, Cadogan, E B, Davies, B R, Dovedi, S J & Valge-Archer, V 2021, ' Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 27, no. 15, pp. 4353-4366 . https://doi.org/10.1158/1078-0432.CCR-20-3701Test
مصطلحات موضوعية: Cancer Research, Tumor microenvironment, Radiation-Sensitizing Agents, Combination therapy, Manchester Cancer Research Centre, Chemistry, DNA damage, ResearchInstitutes_Networks_Beacons/mcrc, DNA Repair Pathway, DNA-Activated Protein Kinase, Triazoles, Non-homologous end joining, Granzyme B, Mice, Immune system, Oncology, Purines, Cell Line, Tumor, Neoplasms, Interferon Type I, Cancer research, Animals, Protein Kinase Inhibitors, CD8, Pyrans
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361b99c301898bba1de98f81587a182cTest
https://research.manchester.ac.uk/en/publications/08e42339-29d6-407b-83fc-396678da590eTest -
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المؤلفون: Kunzah Jamal, Anna Staniszewska, Jacob Gordon, Shenghua Wen, Frank McGrath, Gregory Dowdell, Dominic Kabbabe, Giuditta illuzzi, Matthew Griffin, Barry R. Davies, Petra Hamerlik
المصدر: Cancer Research. 82:2609-2609
مصطلحات موضوعية: Cancer Research, Oncology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::728e8f30b4670d6c50328eb487e60996Test
https://doi.org/10.1158/1538-7445.am2022-2609Test -
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المؤلفون: Ammar Adam, David J. Owen, Justin Cidado, Claire Patterson, Matthew Skinner, Stuart Purbrick, Lorraine Graham, Petar Pop-Damkov, Michael Giannis, Srividya B. Balachander, Francis D. Gibbons, William McCoull, Marianne Ashford, Hill Kathryn Jane, Martin Wild, Eric Gangl, Stephen Fawell, Corinne Reimer, Sean Redmond, Paul D. Kemmitt, Barry R. Davies, Jamal Carlos Saeh, Shenghua Wen, J. Paul Secrist, Alwin Schuller, Edward J. Hennessy, Sonya Gales, Iain Grant, Alexander R. Harmer, Jeremy S. Parker, Brian Kelly
المصدر: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)مصطلحات موضوعية: Male, 0301 basic medicine, Drug, Dendrimers, QH301-705.5, media_common.quotation_subject, bcl-X Protein, Medicine (miscellaneous), Drug development, Antineoplastic Agents, Mice, SCID, Pharmacology, Conjugated system, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, Targeted therapies, Dogs, 0302 clinical medicine, Therapeutic index, Neoplasms, Dendrimer, Tumor Cells, Cultured, Animals, Humans, Medicine, Biology (General), Rats, Wistar, media_common, Haematological cancer, business.industry, Xenograft Model Antitumor Assays, Rats, Mice, Inbred C57BL, Therapeutic Index, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Tolerability, 030220 oncology & carcinogenesis, Drug delivery, Female, General Agricultural and Biological Sciences, business, Conjugate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f928851dba9fe7a39b683d8c12e8a5dTest
https://doi.org/10.1038/s42003-020-01631-8Test