نتائج البحث - "Barry R, Davies"

91

Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models

المؤلفون: Phillippa Dudley, Neil H. James, Claire Crafter, John Vincent, Barry R. Davies, Teresa Klinowska, Eric Tang

المصدر: International Journal of Oncology

مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Receptor, ErbB-2, feedback, Breast Neoplasms, Pharmacology, Biology, Receptor tyrosine kinase, combination therapy, Mice, Trastuzumab, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, PI3K/AKT/mTOR, Animals, Humans, Pyrroles, HER2-amplified breast cancer, skin and connective tissue diseases, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Cell growth, Gene Amplification, Cancer, Drug Synergism, Articles, medicine.disease, Xenograft Model Antitumor Assays, AZD5363, Pyrimidines, Oncology, Drug Resistance, Neoplasm, MCF-7 Cells, Quinazolines, biology.protein, Phosphorylation, Female, Proto-Oncogene Proteins c-akt, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16a0e9136df3078b9af2fd2524426a6Test
https://doi.org/10.3892/ijo.2015.3062Test

92

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

المصدر: Molecular Cancer Therapeutics. 14:48-58

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0de79ea05648a8f13f0ac9f05b31f90Test
https://doi.org/10.1158/1535-7163.mct-14-0406Test

93

Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL

المصدر: Blood. 130(3)

مصطلحات موضوعية: 0301 basic medicine, Apoptosis, Pharmacology, Biochemistry, Tyrosine-kinase inhibitor, chemistry.chemical_compound, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Piperidines, hemic and lymphatic diseases, Agammaglobulinaemia Tyrosine Kinase, Phosphoinositide-3 Kinase Inhibitors, Oxadiazoles, biology, NF-kappa B, Drug Synergism, Hematology, Protein-Tyrosine Kinases, Gene Expression Regulation, Neoplastic, Drug Combinations, Organ Specificity, 030220 oncology & carcinogenesis, Ibrutinib, Lymphoma, Large B-Cell, Diffuse, Signal transduction, Signal Transduction, medicine.drug_class, Immunology, Antineoplastic Agents, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, medicine, Animals, Humans, Pyrroles, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide 3-kinase, Akt inhibitor AZD5363, Adenine, PTEN Phosphohydrolase, Germinal center, Cell Biology, Xenograft Model Antitumor Assays, 030104 developmental biology, Pyrimidines, chemistry, biology.protein, Cancer research, Pyrazoles, Drug Screening Assays, Antitumor, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b7729777f360eff7908ecbecbfbd4dTest
https://pubmed.ncbi.nlm.nih.gov/28729335Test

94

A pharmacokinetic-pharmacodynamic model predicting tumour growth inhibition after intermittent administration with the mTOR kinase inhibitor AZD8055

المؤلفون: James W T, Yates, Sarah V, Holt, Armelle, Logie, Kirsty, Payne, Karen, Woods, Robert W, Wilkinson, Barry R, Davies, Sylvie M, Guichard

المصدر: British journal of pharmacology. 174(16)

مصطلحات موضوعية: Morpholines, Ribosomal Protein S6 Kinases, TOR Serine-Threonine Kinases, Mice, Nude, Antineoplastic Agents, Models, Biological, Research Papers, Tumor Burden, Cell Line, Tumor, Neoplasms, Animals, Humans, Female, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d1fa9a6e9530284c20dc58908ceba490Test
https://pubmed.ncbi.nlm.nih.gov/28556895Test

95

Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors

المؤلفون: Michael Ittmann, Peter S. Nelson, Paul D. Smith, Barry R. Davies, Shu Feng, Longjiang Shao, Ilsa Coleman, Patricia Castro

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, STAT3 Transcription Factor, medicine.medical_specialty, kinase inhibitor, Mice, SCID, Fibroblast growth factor, Piperazines, 03 medical and health sciences, Internal medicine, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Pyrroles, Receptor, Fibroblast Growth Factor, Type 1, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Kinase, business.industry, Fibroblast growth factor receptor 1, AKT, fibroblast growth factors, Prostatic Neoplasms, prostate cancer, Xenograft Model Antitumor Assays, 3. Good health, Tumor Burden, 030104 developmental biology, Endocrinology, Pyrimidines, Oncology, Fibroblast growth factor receptor, Benzamides, Cancer research, Pyrazoles, Signal transduction, business, Proto-Oncogene Proteins c-akt, signal transduction, Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a286cbf59b00d90c15d81932e9cb0d4eTest
https://pubmed.ncbi.nlm.nih.gov/28008155Test

96

Abstract 3506: AZD7648, a potent and selective inhibitor of DNA-PK, potentiates activity of the PARP inhibitor olaparib resulting in sustained anti-tumour activity in xenograft and PDX models

المؤلفون: Neil H. James, Valeria Follia, Ankur Karmokar, Barry R. Davies, Jacqueline H. L. Fok, Emma Dean, Mercedes Vazquez-Chantada, Simon J. Hollingsworth, Antonio Ramos-Montoya, Lenka Oplustil O'Connor, Paul W. G. Wijnhoven, Anna Staniszewska, Elaine Cadogan

المصدر: Cancer Research. 79:3506-3506

مصطلحات موضوعية: Protein kinase complex, Cancer Research, Chemistry, Kinase, Cell growth, DNA damage, Cell, Olaparib, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, PARP inhibitor, medicine, Cancer research, Growth inhibition

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fed19919befdfb163b13b2d262815543Test
https://doi.org/10.1158/1538-7445.am2019-3506Test

97

Abstract 3505: AZD7648: A potent and selective inhibitor of DNA-PK with pharmacodynamic and monotherapy anti-tumor activity

المؤلفون: Emma Dean, Antonio Ramos-Montoya, Elaine Cadogan, Jacqueline H. L. Fok, Lenka Oplustil O'Connor, Barry R. Davies, Neil H. James, Paul Winjhoven, Valeria Follia, Ankur Karmokar, Anna Staniszewska, Mercedes Vazquez-Chantada, Simon J. Hollingsworth

المصدر: Cancer Research. 79:3505-3505

مصطلحات موضوعية: Protein kinase complex, A549 cell, Cancer Research, chemistry.chemical_compound, Oncology, DNA damage, Chemistry, Kinase, DNA repair, Poly ADP ribose polymerase, Cancer research, Growth inhibition, Olaparib

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d3da36654f442068097cfc48c3d5f6e7Test
https://doi.org/10.1158/1538-7445.am2019-3505Test

98

Abstract 4996: A real-time PCR-based approach to quantitatively assess tumor immune profiles and immune responses

المؤلفون: Barry R. Davies, Yurie Kura, Kazuto Nishio, Kazuko Sakai, Marco A. De Velasco, Yasunori Mori, Kazuhiro Yoshimura, Kazuhiro Yoshikawa, Noriko Sato, Naomi Ando, Masahiro Nozawa, Hirotsugu Uemura

المصدر: Cancer Research. 79:4996-4996

مصطلحات موضوعية: Cancer Research, business.industry, medicine.medical_treatment, Antigen presentation, Cancer, Immunotherapy, medicine.disease, Immune checkpoint, Prostate cancer, Immune system, Oncology, Cancer cell, medicine, Cancer research, Biomarker (medicine), business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b545e5eece9d0b6bad54b4078c7e8332Test
https://doi.org/10.1158/1538-7445.am2019-4996Test

99

Abstract 3512: AZD7648, a potent and selective inhibitor of DNA-PK, potentiates the activity of ionising radiation and doxorubicin in vitro and causes tumour regression in xenograft models

المؤلفون: Jacqueline H. Fok, Antonio Ramos-Montoya, Neil James, Mercedes Vazquez-Chantada, Valeria Follia, Ankur Karmokar, Anna Staniszewska, Lenka Oplustil O’Connor, Emma Dean, Simon J. Hollingsworth, Barry R. Davies, Elaine B. Cadogan

المصدر: Cancer Research. 79:3512-3512

مصطلحات موضوعية: Cancer Research, Oncology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4e92698a7e998e59daac156d42fee2e5Test
https://doi.org/10.1158/1538-7445.am2019-3512Test

100

Abstract 321: Genome-wide CRISPR screens identify combination strategies for Capivasertib (AZD5363; AKT) and AZD8186 (PI3Kβ/δ) in PTEN-null breast cancer

المؤلفون: Beverley Isherwood, Shanade Dunn, Yan Zi Au, Albert Gris-Oliver, Barry R. Davies, Violeta Serra, James Pilling, Anna Staniszewsla, Jason S. L. Yu, Simon T. Barry, Natalie Cureton, Philip Hopcroft, Kosuke Yusa, Urs Yelland, Swee Hoe Ong, James T. Lynch

المصدر: Cancer Research. 79:321-321

مصطلحات موضوعية: Cancer Research, biology, DDIT4, Cancer, medicine.disease, DEPDC5, Breast cancer, Oncology, medicine, biology.protein, Cancer research, PTEN, CRISPR, Protein kinase B, PI3K/AKT/mTOR pathway

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3437552b1e3468122a9010d0e4739c4dTest
https://doi.org/10.1158/1538-7445.am2019-321Test

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