المؤلفون: Falsarella, Gláucia R, Coimbra, Ibsen B, Barcelos, Caroline C, Iartelli, Isabele, Montedori, Kedma T, Santos, Manuela NJ, Neri, Anita L, Coimbra, Arlete MV

مصطلحات موضوعية: Elderly, Muscle mass, Bone mass, Mobility

الوصف: Background The purpose of this study was to investigate the influence of muscle mass and bone mineral density on markers of mobility in dwelling elderly women. Methods This cross-sectional study included 99 elderly women, who were 65 years old or above, in Campinas-SP, Brazil. To collect data, we used sociodemographic data, the body mass index (BMI), health status, comorbidities, use of medications, mobility tests (TUG and gait speed) and examinations of the body composition (densitometry with dual-emission X-ray absorptiometry “DXA”). In order to examine the relationship between muscle and bone mass with mobility (gait speed and TUG), we applied the Spearman correlation coefficient. Also was applied the analysis of covariance (ANCOVA) adjusted for age and comorbidities. To identify the factors associated with mobility, we used the univariate and multivariate logistic regression analysis. The level of significance for statistical tests was P < 0.05. Results The correlation between sarcopenia and bone mineral density with mobility tests showed a significant relationship only between sarcopenia and TUG (r = 0.277, P = 0.006) in Spearman correlation coefficient. The result of the correlation analysis (ANCOVA) showed that sarcopenia was associated with gait speed (r 2 = 0.0636, P = 0.0018) and TUG (r 2 = 0.0898, P = 0.0027). The results of the multivariate analysis showed that age (P = 0.034, OR = 1.081) was associated with worse performance on gait speed. By highlighting the TUG test, the results of the multivariate analysis showed that the age (P = 0.004, OR = 1.111) and BMI in overweight (P = 0.011, OR = 7.83) and obese (P < 0.001, OR = 7.84) women were associated with lower performance of the functionality of the lower limbs. Conclusion The findings with regard to mobility tests which were analyzed in this study indicate the association of variables related to the aging process that contribute to the decline in physical performance, for example, age, BMI and sarcopenia.

العلاقة: http://www.biomedcentral.com/1471-2318/14/13Test

الإتاحة: http://www.biomedcentral.com/1471-2318/14/13Test

المؤلفون: Falsarella, Gláucia R, Coimbra, Ibsen B, Barcelos, Caroline C, Costallat, Lilian TL, Carvalho, Olga MF, Coimbra, Arlete MV

المصدر: Geriatrics & Gerontology International ; volume 13, issue 4, page 1043-1050 ; ISSN 1444-1586 1447-0594

الوصف: Aim In the elderly population, rheumatic conditions are major causes of pain that restrict participation in activities and mobility, and cause difficulties in the execution of self‐care tasks. The present study aimed to analyze the prevalence and factors associated with the self‐reported rheumatic diseases and chronic joint symptoms of the elderly. Methods This transversal epidemiological survey involved 2209 older adults (aged ≥60 years). The investigation included sociodemographic factors, anthropometrics, activities of daily living, chronic conditions, medication and quality of life. Univariate and multivariate regression analysis were used for statistical procedures, P ≤ 0.05. Results The prevalence of rheumatism was 22.7%. Multivariate analysis showed that rheumatism was correlated with the following: female sex ( OR = 1.91), high income ( OR = 2.34), cardiovascular disease ( OR = 1.42), cataracts ( OR = 1.39), glucocorticoids ( OR = 5.24), other anti‐inflammatory medications ( OR = 2.24) and pain ( OR = 0.983). After adjusting for age and glucocorticoids, an association between cataracts and rheumatism was detected ( OR = 1.32). The prevalence of symptoms was 45.6%. Multivariate regression results for symptoms included the following: female sex ( OR = 1.40), body mass index ≥30.0 kg/m 2 ( OR = 3.31), functional capacity ( OR = 0.990), general health ( OR = 0.993) and pain ( OR = 0.981). After adjustment for age and glucocorticoids, an association between cataracts and symptoms was detected ( OR = 1.26). Conclusion There was a significant association of rheumatism and symptoms with women and high incomes. Obesity was associated with joint symptoms, which in turn were associated with an impaired quality of life. Cataracts and cardiovascular disease were associated with rheumatism. The identification of these characteristics in the elderly will contribute to a better understanding of this systemic disease and should be used to plan effective preventive measures. Geriatr Gerontol Int 2013; 13: 1043–1050.

الإتاحة: https://doi.org/10.1111/ggi.12052Test

المؤلفون: Rubem-Mauro, Leandro, Rocha Jr, Dimas S., Barcelos, Caroline C., Costa Varca, Gustavo H., Andréo Filho, Newton, Barberato Fihlo, Silvio, Oshima-Franco, Yoko, Vila, Marta M. D. C.

مصطلحات موضوعية: Farmacia, Medicamento, antiepileptic drugs, neuromuscular junction, pharmacologic actions, Sistema Nervioso Central

الوصف: Phenobarbital and carbamazepine are antiepileptic drugs that act at the nervous central system by different mechanisms of action. In this work we investigated the pharmacological effects of these drugs on mouse phrenic nerve-diaphragm preparations through the myographic technique. Carbamazepine (0.105, 1.05, 2.1 and 4.2 mM, n = 8, 6, 6 and 6, respectively), induced a dose-dependent neuromuscular blockade, under indirect or direct muscle stimulation and the neurotransmission was reestablished after washing. Conversely, phenobarbital caused an unexpected facilitatory effect, under several formulations, such as the acid-extracted commercial tablets (1.05, 2.1 and 4.2 mM, n = 7, 6 and 7, respectively), commercial phenobarbital solution (4.2 mM, n = 7) or its correspondent pure active ingredient (4.2 and 2.1 mM, n = 6 each). Only at a higher concentration the acid-extracted phenobarbital performed a neuromuscular blockade (8.4 mM, n = 10). The different responses between carbamazepine (paralysis) and phenobarbital (facilitatory effect) evidentiated a new effect for phenobarbital until now concealed at the neuromuscular junction and may involve the glutamatergic regulation, since its role as an acetylcholine co-transmitter in motoneurons was already established. ; Colegio de Farmacéuticos de la Provincia de Buenos Aires

وصف الملف: 211-218

العلاقة: http://sedici.unlp.edu.ar/handle/10915/7748Test; http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_7_0F5VI3J8T0.pdfTest

الإتاحة: http://sedici.unlp.edu.ar/handle/10915/7748Test
http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_7_0F5VI3J8T0.pdfTest

المؤلفون: Falsarella, Gláucia R., Coimbra, Ibsen B., Barcelos, Caroline C., Iartelli, Isabele, Montedori, Kedma T., Santos, Manuela N. J., Neri, Anita L., Coimbra, Arlete M. V.

المصدر: BMC Geriatrics; 2014, Vol. 14 Issue 1, p1-14, 14p

مصطلحات موضوعية: BODY mass index, SCIENTIFIC observation, CROSS-sectional method, COMORBIDITY, BONE density, SOCIODEMOGRAPHIC factors, DUAL-energy X-ray absorptiometry

مستخلص: Background The purpose of this study was to investigate the influence of muscle mass and bone mineral density on markers of mobility in dwelling elderly women. Methods This cross-sectional study included 99 elderly women, who were 65 years old or above, in Campinas-SP, Brazil. To collect data, we used sociodemographic data, the body mass index (BMI), health status, comorbidities, use of medications, mobility tests (TUG and gait speed) and examinations of the body composition (densitometry with dual-emission X-ray absorptiometry "DXA"). In order to examine the relationship between muscle and bone mass with mobility (gait speed and TUG), we applied the Spearman correlation coefficient. Also was applied the analysis of covariance (ANCOVA) adjusted for age and comorbidities. To identify the factors associated with mobility, we used the univariate and multivariate logistic regression analysis. The level of significance for statistical tests was P < 0.05. Results The correlation between sarcopenia and bone mineral density with mobility tests showed a significant relationship only between sarcopenia and TUG (r = 0.277, P = 0.006) in Spearman correlation coefficient. The result of the correlation analysis (ANCOVA) showed that sarcopenia was associated with gait speed (r² = 0.0636, P = 0.0018) and TUG (r² = 0.0898, P = 0.0027). The results of the multivariate analysis showed that age (P = 0.034, OR = 1.081) was associated with worse performance on gait speed. By highlighting the TUG test, the results of the multivariate analysis showed that the age (P = 0.004, OR = 1.111) and BMI in overweight (P = 0.011, OR = 7.83) and obese (P < 0.001, OR = 7.84) women were associated with lower performance of the functionality of the lower limbs. Conclusion The findings with regard to mobility tests which were analyzed in this study indicate the association of variables related to the aging process that contribute to the decline in physical performance, for example, age, BMI and sarcopenia. [ABSTRACT FROM AUTHOR]

: Copyright of BMC Geriatrics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Braga, Angélica de Fátima de Assunção, Barcelos, Caroline Coutinho de, Braga, Franklin Sarmento da Silva, Fernandes, Samanta Cristina Antoniassi, Franco, Yoko Oshima, Mantovani, Mario, Simioni, Léa Rodrigues

المصدر: Acta Cirúrgica Brasileira. August 2008 23(4)

مصطلحات موضوعية: Phenobarbital, Neuromuscular Blocking Agents, Rats

الوصف: PURPOSE: To evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes. METHODS: Thirty rats were included in the study and distributed into 6 groups of 5 animals each. Rats were treated for seven days with phenobarbital (20 mg/kg) and the following parameters were evaluated: 1) the amplitude of muscle response in the preparation of rats exposed to phenobarbital; 2) rocuronium effect on rat preparation exposed or not to phenobarbital; 3) concentrations of cytochrome P450 and cytochrome b5 in hepatic microsomes isolated from rats exposed or not to phenobarbital. The concentration and dose of rocuronium used in vitro and in vivo experiments were 4 µg/mL and 0,6 mg/kg, respectively. RESULTS: Phenobarbital in vitro and in vivo did not alter the amplitude of muscle response. The neuromuscular blockade in vitro produced by rocuronium was significantly different (p=0.019) between exposed (20%) and not exposed (60%) rats; the blockade in vivo was significantly greater (p=0.0081) in treated rats (93.4%). The enzymatic concentrations were significantly greater in rats exposed to phenobarbital. CONCLUSIONS: Phenobarbital alone did not compromise neuromuscular transmission. It produced enzymatic induction, and neuromuscular blockade in vivo produced by rocuronium was potentiated by phenobarbital.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000400008Test

المؤلفون: Barcelos, Caroline Coutinho de, Braga, Angélica de Fátima de Assunção, Braga, Franklin Sarmento da Silva, Potério, Gloria Braga, Fernandes, Samanta Cristina Antoniassi, Franco, Yoko Oshima, Simioni, Léa Rodrigues

المصدر: Revista Brasileira de Anestesiologia. April 2008 58(2)

مصطلحات موضوعية: ANIMAIS: ratos, ANTICONVULSIVANTE: carbamazepina, BLOQUEADORES NEUROMUSCULARES, adespolarizante/atracúrio

الوصف: JUSTIFICATIVA E OBJETIVOS: Trata-se de um estudo experimental que investigou in vitro e in vivo o bloqueio neuromuscular produzido pelo rocurônio e atracúrio em ratos tratados com carbamazepina e determinou as concentrações de citocromo P450 e b5 redutase em microssomos hepáticos. MÉTODO: Ratos foram tratados por sete dias com carbamazepina (CBZ) - 40 mg.kg-1 pelo método de gavagem e sacrificados no oitavo dia sob anestesia com uretana. As preparações in vitro e in vivo foram montadas de acordo com as técnicas de Bulbring e de Leeuwin e Wolters, respectivamente. As concentrações e doses utilizadas dos bloqueadores nas preparações in vitro e in vivo foram, respectivamente, 20 µg.mL-1 e 0,5 mg.kg-1 para atracúrio (ATC); 4 µg.mL-1 e 0,6 mg.kg-1 para rocurônio (ROC). Cada protocolo teve um n = 5 e as respostas foram observadas por 60 minutos. Os efeitos do ATC e ROC foram avaliados nas preparações de ratos tratados (Cbz t) e comparados com os observados nas de ratos não-tratados (CBZst). As concentrações de citocromo P450 e b5 redutase foram determinadas em microssomos isolados de fígados de ratos tratados (CBZt) e comparadas com as obtidas em ratos não tratados (CBZst). RESULTADOS: A carbamazepina não alterou a amplitude das respostas musculares; in vitro e in vivo, não houve diferença entre o bloqueio neuromuscular produzido pelo atracúrio nas preparações CBZt versus CBZst; o bloqueio neuromuscular produzido pelo rocurônio nas preparações CBZt foi potencializado in vitro. A carbamazepina não alterou as concentrações de citocromo P450 e b5. CONCLUSÕES: O tratamento por sete dias com carbamazepina não influenciou no bloqueio produzido pelo atracúrio, e alterou in vitro os efeitos do rocurônio. O tempo de tratamento não foi suficiente para causar indução enzimática e diminuir a sensibilidade ao rocurônio.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942008000200006Test

المؤلفون: Fernandes, Samanta Cristina Antoniassi, Braga, Angélica de Fátima de Assunção, Braga, Franklin Sarmento da Silva, Loyola, Yolanda Christina S., Souza, Silmara Rodrigues de, Barcelos, Caroline Coutinho de

المصدر: Revista Brasileira de Anestesiologia. June 2007 57(3)

مصطلحات موضوعية: ANIMAIS/ratos, Estabilizadores do humor/Lítio, Bloqueadores neuromusculares, não despolarizantes/atracúrio, cisatracúrio

الوصف: JUSTIFICATIVA E OBJETIVOS: O lítio, fármaco amplamente utilizado nos distúrbios bipolares, pode interagir com os bloqueadores neuromusculares. Os mecanismos para explicar os seus efeitos na transmissão neuromuscular e a interação com bloqueadores neuromusculares são controversos. O objetivo deste trabalho foi avaliar, em diafragma de rato, os efeitos do lítio sobre a resposta muscular à estimulação indireta e a possível interação com os bloqueadores neuromusculares. MÉTODO: Utilizaram-se ratos com peso entre 250g e 300g, sacrificados sob anestesia com uretana. A preparação nervo frênico-diafragma foi montada de acordo com a técnica descrita por Bulbring. O diafragma foi mantido sob tensão, ligado a um transdutor isométrico e submetido à estimulação indireta de 0,1 Hz de freqüência. As contrações do diafragma foram registradas em fisiógrafo. Da análise da amplitude das respostas musculares avaliaram-se: os efeitos dos fármacos: lítio (1,5 mg.mL-1); atracúrio (20 µg.mL-1) e cisatracúrio (3 µg.mL-1) empregados isoladamente; da associação lítio-bloqueadores neuromusculares; e do lítio no bloqueio neuromuscular produzido pelo atracúrio (35 µg.mL-1) e cisatracúrio (5 µg.mL-1). Os efeitos foram avaliados antes e 45 minutos após a adição dos fármacos. Também foram estudados os efeitos do lítio nos potenciais de membrana (PM) e potenciais de placa terminal em miniatura (PPTM). RESULTADOS: O lítio isoladamente não alterou a amplitude das respostas musculares, mas diminuiu significativamente o bloqueio neuromuscular produzido pelo atracúrio e cisatracúrio. Não alterou o PM e ocasionou aumento inicial da freqüência dos PPTM. CONCLUSÕES: O lítio empregado isoladamente não comprometeu a transmissão neuromuscular e aumentou a resistência ao efeito do atracúrio e cisatracúrio. Não mostrou ação sobre a fibra muscular, sendo que as alterações nos potenciais de placa terminal em miniatura evidenciaram ação pré-sináptica.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942007000300007Test

المؤلفون: Barcelos, Caroline Coutinho de, 1982

مرشدي الرسالة: UNIVERSIDADE ESTADUAL DE CAMPINAS, Coimbra, Ibsen Bellini, 1959, Bonfiglioli, Rubens, Peixoto, Beatriz de Oliveira, Costa, Sandra Cecília Botelho, Guariento, Maria Elena

المصدر: Repositório Institucional da UnicampUniversidade Estadual de CampinasUNICAMP.

مصطلحات موضوعية: Osteoartrite, Idosos, Mulheres, Osteoarthritis, Elderly, Women

الوصف: Orientador: Ibsen Bellini Coimbra
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-24T17:23:25Z (GMT). No. of bitstreams: 1 Barcelos_CarolineCoutinhode_D.pdf: 1979405 bytes, checksum: cec79f3f27610781d0bff4ab161fc971 (MD5) Previous issue date: 2014
A osteoartrite (OA) é a enfermidade articular mais prevalente entre os idosos e pode causar incapacidades. Representa importante causa de morbidade, alto custo para o paciente e para a sociedade, além de afetar significativamente a qualidade de vida relacionada à saúde. O objetivo deste projeto foi estimar a influência da osteoartrite (OA) de joelhos no equilíbrio e a composição corporal do idoso. A amostra foi constituída por 94 idosas (188 joelhos) acima de 60 anos. As idosas foram submetidas a uma entrevista, radiografia de ambos os joelhos, densitometria corporal, avaliação do equilíbrio através de uma plataforma de força AMTI e antropometria; a dor no joelho foi graduada de 0 (sem dor) à 10 (dor máxima) através da Escala Visual Analógica e a caracterização da síndrome metabólica foi obtida por meio de auto relato das comorbidades. A análise dos resultados foi realizada por meio da ANOVA, regressão logística univariada e multivariada, Tukey e correlação linear de Spearman, tendo o nível de significância estabelecido em 5% (p
Osteoarthritis (OA), the most prevalent joint disorder causing disability in the elderly, represents an important cause of morbidity and significantly affects quality of life, leading to high costs for both patients and society. This work aimed to identify the influence of OA in the knees in balance and body composition in elderly. The sample comprised 94 elderly individuals (188 knees; all women) over 60 years of age. The subjects were interviewed and underwent PA radiography of both knees, total body densitometry, balance assessment using an AMTI force platform and anthropometry; knee pain was graded using a visual analogue scale and characterization of the metabolic syndrome was obtained through self-report of comorbidities. Statistical analysis of the results was performed using ANOVA, univariate and multivariate regression analyses, Tukey¿s test and Spearman¿s linear correlation coefficient, with a 5% significance level (p
Doutorado
Clinica Medica
Doutora em Clínica Médica

وصف الملف: 164 p. : il.; application/pdf

الإتاحة: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309640Test

المؤلفون: Barcelos, Caroline Coutinho de, 1982

مرشدي الرسالة: UNIVERSIDADE ESTADUAL DE CAMPINAS, Franco, Yoko Oshima, Simioni, Lea Rodrigues, 1942, Teixeira, Cleber Evandro, Ganem, Eliana Marisa

المصدر: Repositório Institucional da UnicampUniversidade Estadual de CampinasUNICAMP.

مصطلحات موضوعية: Atracurio, Rocurônio, Agentes não despolarizantes, Interações de medicamentos, Carbamazepina, Fenobarbital, Anticonvulsivantes, Atracurium, Rocuronium, Nondepolarizing agents, Drug interactions, Carbamazepine, Phenobarbital, Anticonvulsants

الوصف: Orientadores: Lea Rodrigues Simioni, Yoko Oshima Franco
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-09T02:12:41Z (GMT). No. of bitstreams: 1 Barcelos_CarolineCoutinhode_M.pdf: 1481920 bytes, checksum: 51a5dae81283795439bd5ed51ac09f60 (MD5) Previous issue date: 2007
Atracúrio (ATC) e rocurônio (ROC) são bloqueadores neuromusculares de ação intermediária. Neste estudo, seus efeitos neuromusculares foram investigados in vitro e in vivo em ratos pré-tratados, via gavagem (7d), com os anticonvulsivantes (AC) carbamazepina (CBZ, 40 mg/kg) e fenobarbital (FB, 20 mg/kg) e sacrificados no 8º dia, sob anestesia com uretana. Os resultados foram comparados com a condição-controle (ratos não tratados com AC). A exposição crônica a AC pode determinar a indução de enzimas microssomais responsáveis pela metabolização (oxidação) de fármacos. Para o controle desse fenômeno farmacológico foram determinadas as concentrações enzimáticas de citocromo P450 e b5 redutase, em microssomos hepáticos de ratos tratados com AC, e comparados aos controles. As preparações in vitro e in vivo foram montadas de acordo com as técnicas de Bulbring e de Leeuwin e Wolters, respectivamente. As concentrações utilizadas dos bloqueadores nas preparações in vitro e in vivo foram, respectivamente, 20 µg/mL e 0,5 mg/kg para atracúrio (ATC); 4 µg/mL e 0,6 mg/kg para rocurônio (ROC). Cada protocolo teve um n=5 e as respostas foram observadas por 60 min. Os resultados tanto in vitro quanto in vivo mostraram que o pré-tratamento com a carbamazepina reduziu a resposta contrátil em cerca de 30%. Sob sua vigência, não houve alteração do bloqueio produzido pelo atracúrio e pelo rocurônio, possivelmente porque o tempo de tratamento com a carbamazepina não foi suficiente para causar indução enzimática. Em relação ao fenobarbital, os resultados in vitro e in vivo mostraram nenhuma alteração significativa sob a resposta contrátil. Sob sua vigência, diminuiu a sensibilidade do ATC em produzir o bloqueio neuromuscular in vitro. Contudo, in vivo potencializou o bloqueio neuromuscular de ambos os bloqueadores estudados. Essas alterações observadas em ambos os modelos experimentais podem ser devidas à indução ocorrida com o fenobarbital, conforme comprovado pela concentração de citocromo P450 (0,69 nmol/mg proteína) e b5 redutase (0,62 nmol/mg proteína)
Atracurium (ATC) and rocuronium (ROC) are neuromuscular blockers of intermediate action. In this study, the neuromuscular effects had been investigated in vitro and in vivo in treated rats, by gavage (7d), with the anticonvulsantes (AC) carbamazepine (CBZ, 40 mg/kg) and phenobarbital (FB, 20 mg/kg) and sacrificed on the eight day, under anesthesia with urethane. The results had been compared with the control-condition (rats not treated AC). The chronic exposition the AC can determine the induction of microsomes enzyme for the responsible metabolization (oxidation) of drugs. For the control of this pharmacologic phenomenon the enzymatic concentrations of P450 and b5 cytochromes had been determined, in livers microsomes of rats treated with AC, and compared with the controls. The preparations in vitro and in vivo had been followed the Bulbring and Leeuwin and Wolters techniques, respectively. The in vitro and in vivo concentrations were 20 µg/ml and 0.5 mg/kg, respectively, for atracurium (ATC); and 4 µg/ml and 0.6 mg/kg for rocuronium (ROC). Each protocol presented n=5 and the answers were calculated during 60 minutes. The in vitro and in vivo results showed that treatment with carbamazepine reduced the extent of muscle response in about 30%. Under its validity, did not alter the extent of the muscle response block produced by atracurium and rocuronium possibly because the period of time of carbamazepine treatment was not enough to cause enzymatic induction. Regarding phenobarbital, the in vitro and in vivo results did not alter significant the extent of the muscle response block produced. Under its validity, reduced the ATC sensitivity the block neuromuscular in vitro produced. However, in vivo increased the neuromuscular block of both the blockers studied. These alterations observed in both the experimental models can have occured induction with the phenobarbital, as proven P450 (0,69 nmol/mg protein) and b5 (0,62 nmol/mg protein) of cytochrome concentration
Mestrado
Mestre em Farmacologia

وصف الملف: 75f. : il.; application/pdf

الإتاحة: http://repositorio.unicamp.br/jspui/handle/REPOSIP/310321Test