المؤلفون: ZHENG Guang⁃yao, BAO Xu⁃dong, LU Lin, FENG Ming, ZHU Hui⁃juan, YAO Yong, WANG Ren⁃zhi

المصدر: Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 21, Iss 3, Pp 170-176 (2021)

مصطلحات موضوعية: cushing syndrome, multiple endocrine neoplasia, acth syndrome, ectopic, diagnosis, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective To summarize the clinical features of adrenocorticotropic hormone (ACTH)⁃dependent Cushing's syndrome (CS) with multiple endocrine neoplasia (MEN). Methods Based on the pituitary tumor database of Peking Union Medical College Hospital of China Pituitary Disease Register Network (CPDRN), 18 patients with ACTH ⁃ dependent CS complicated with MEN from January 1984 to September 2020 were collected. The clinical manifestations, involved other endocrine glands, laboratorial and imageological examinations were analyzed. Results Among 18 patients, 13 cases were Cushing's disease and 5 cases were ectopic ACTH syndrome (EAS); 15 cases were MEN1 type, 2 cases were MEN2 type and one case was MEN4 type. The clinical manifestations were subclinical CS in 6 cases and overt CS in 12 cases. All cases had osteopenia or osteoporosis. Urolithiasis accounted for 11/18 cases. Regarding the involved endocrine glands, pituitary ACTH adenoma accounted for 13/18 cases, prolactinoma accounted for 4/18 cases, hyperparathyroidism accounted for 15/18 cases, pancreatic neuroendocrine tumors accounted for 13/18 cases and adrenal adenomas and hyperplasia accounted for 10/18 cases. Laboratorial examinations showed the average morning serum cortisol was (652.90 ± 254.90) nmol/L, the morning ACTH was (13.38 ± 8.73) pmol/L and the 24 h urinary free cortisol was 446.35 (233.08, 531.10) µg. Serum prolactin was elevated in 2 cases, parathyroid hormone was elevated in 13 cases and serum calcium was elevated in 11 cases. In imageological examinations, there were pituitary microadenoma in 12 cases, pituitary macroadenoma in 3 cases, adrenal adenoma in 8 cases, thickened adrenal in 4 cases, adrenal pheochromocytoma in 2 cases, and paraganglioma in one case. Genetic test showed 3 cases had MEN1 gene mutation including c.1183C ＞ T, c.1579C ＞ T and c.1174G ＞ T. Conclusions ACTH⁃dependent CS with MEN is a rare disease with complex manifestations. The most common symptom is osteopenia/osteoporosis. The most common cause of CS is pituitary microadenoma. MEN1 is the most common MEN type, and primary hyperparathyroidism is the most common type of affected endocrine glands, followed by pancreatic neuroendocrine tumors. doi：10.3969/j.issn.1672⁃6731.2021.03.008

وصف الملف: electronic resource

العلاقة: http://www.cjcnn.org/index.php/cjcnn/article/view/2292Test; https://doaj.org/toc/1672-6731Test

الوصول الحر: https://doaj.org/article/831bbf38a74348b19cd95ffc17a8e23fTest

المؤلفون: Bao, Xu-dong, Lu, Lin, Zhu, Hui-juan, Yao, Yong, Feng, Ming, Wang, Ren-zhi, Zhai, Xiao, Fu, Yong, Gong, Feng-ying, Lu, Zhao-lin

المساهمون: The National Key Research and Development Program of China, CAMS Innovation Fund for Medical Science

المصدر: BMC Endocrine Disorders ; volume 22, issue 1 ; ISSN 1472-6823

مصطلحات موضوعية: General Medicine, Endocrinology, Diabetes and Metabolism

الوصف: Background Cushing’s disease (CD) is rare in pediatric patients. It is characterized by elevated plasma adrenocorticotropic hormone (ACTH) from pituitary adenomas, with damage to multiple systems and development. In recent years, genetic studies have shed light on the etiology and several mutations have been identified in patients with CD. Case presentation A girl presented at the age of 10 years and 9 months with facial plethora, hirsutism and acne. Her vision and eye movements were impaired. A quick weight gain and slow growth were also observed. Physical examination revealed central obesity, moon face, buffalo hump, supra-clavicular fat pads and bruising. Her plasma ACTH level ranged between 118 and 151 pg/ml, and sella enhanced MRI showed a giant pituitary tumor of 51.8 × 29.3 × 14.0 mm. Transsphenoidal pituitary debulk adenomectomy was performed and immunohistochemical staining confirmed an ACTH-secreting adenoma. Genetic analysis identified a novel germline GPR101 (p.G169R) and a somatic USP8 (p. S719del) mutation. They were hypothesized to impact tumor growth and function, respectively. Conclusions We reported a rare case of pediatric giant pituitary ACTH adenoma and pointed out that unusual concurrent mutations might contribute to its early onset and large volume.

الإتاحة: https://doi.org/10.1186/s12902-022-01058-8Test

المؤلفون: Tang, Hui, Li, Tian, Lin, Yu Bing, Li, Yu, Bao, Xu Dong

المصدر: Journal of X-Ray Science & Technology; 2023, Vol. 31 Issue 5, p965-979, 15p

مصطلحات موضوعية: PRINTED circuits, IMAGE reconstruction algorithms, TOMOSYNTHESIS, IMAGE reconstruction, ALGORITHMS, NONDESTRUCTIVE testing

مستخلص: Digital tomosynthesis (DTS) technology has attracted much attention in the field of nondestructive testing of printed circuit boards (PCB) due to its high resolution and suitability to thin slab objects. However, the traditional DTS iterative algorithm is computationally demanding, and its real-time processing of high-resolution and large volume reconstruction is infeasible. To address this issue, we in this study propose a multiple multi-resolution algorithm, including two multi-resolution strategies: volume domain multi-resolution and projection domain multi-resolution. The first multi-resolution scheme employs a LeNet-based classification network to divide the roughly reconstructed low-resolution volume into two sub-volumes namely, (1) the region of interest (ROI) with welding layers that necessitates high-resolution reconstruction, and (2) the remaining volume with unimportant information which can be reconstructed in low-resolution. When X-rays in adjacent projection angles pass through many identical voxels, information redundancy is prevalent between the adjacent image projections. Therefore, the second multi-resolution scheme divides the projections into non-overlapping subsets, using only one subset for each iteration. The proposed algorithm is evaluated using both the simulated and real image data. The results demonstrate that the proposed algorithm is approximately 6.5 times faster than the full-resolution DTS iterative reconstruction algorithm without compromising image reconstruction quality. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of X-Ray Science & Technology is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Tang, Hui, Lin, Yu Bing, Jiang, Su Dong, Li, Yu, Li, Tian, Bao, Xu Dong

المصدر: Physics in Medicine & Biology ; volume 68, issue 17, page 175016 ; ISSN 0031-9155 1361-6560

الوصف: Objective. Cone beam computed tomography (CBCT) has been wildly used in clinical treatment of dental diseases. However, patients often have metallic implants in mouth, which will lead to severe metal artifacts in the reconstructed images. To reduce metal artifacts in dental CBCT images, which have a larger amount of data and a limited field of view compared to computed tomography images, a new dental CBCT metal artifact reduction method based on a projection correction and a convolutional neural network (CNN) based image post-processing model is proposed in this paper . Approach. The proposed method consists of three stages: (1) volume reconstruction and metal segmentation in the image domain, using the forward projection to get the metal masks in the projection domain; (2) linear interpolation in the projection domain and reconstruction to build a linear interpolation (LI) corrected volume; (3) take the LI corrected volume as prior and perform the prior based beam hardening correction in the projection domain, and (4) combine the constructed projection corrected volume and LI-volume slice-by-slice in the image domain by two concatenated U-Net based models (CNN1 and CNN2). Simulated and clinical dental CBCT cases are used to evaluate the proposed method. The normalized root means square difference (NRMSD) and the structural similarity index (SSIM) are used for the quantitative evaluation of the method. Main results. The proposed method outperforms the frequency domain fusion method (FS-MAR) and a state-of-art CNN based method on the simulated dataset and yields the best NRMSD and SSIM of 4.0196 and 0.9924, respectively. Visual results on both simulated and clinical images also illustrate that the proposed method can effectively reduce metal artifacts. Significance . This study demonstrated that the proposed dual-domain processing framework is suitable for metal artifact reduction in dental CBCT images.

الإتاحة: https://doi.org/10.1088/1361-6560/acec29Test

المؤلفون: Tang, Hui, Dillenseger, Jean-Louis, Bao, Xu Dong, Luo, Li Min

المساهمون: Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Image Science and Technology Nanjing (LIST), Southeast University Jiangsu -School of Computer Science and Engineering, Centre de Recherche en Information Biomédicale sino-français (CRIBS), Université de Rennes (UR)-Southeast University Jiangsu -Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: ISSN: 0895-6111 ; Computerized Medical Imaging and Graphics ; https://www.hal.inserm.fr/inserm-00411983Test ; Computerized Medical Imaging and Graphics, 2009, 33 (8), pp.644-50. ⟨10.1016/j.compmedimag.2009.07.001⟩.

مصطلحات موضوعية: segmentation, Gaussian mixture model, vectorial image segmentation, image classification, MESH: Algorithms, MESH: Artificial Intelligence, MESH: Phantoms, Imaging, MESH: Reproducibility of Results, MESH: Sensitivity and Specificity, MESH: Subtraction Technique, MESH: Tomography, X-Ray Computed, MESH: Urography, MESH: Data Interpretation, Statistical, MESH: Humans, MESH: Image Enhancement, MESH: Image Interpretation, Computer-Assisted, MESH: Imaging, Three-Dimensional, MESH: Kidney, MESH: Normal Distribution, MESH: Pattern Recognition, Automated, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging

الوصف: International audience ; The CT uroscan consists of three to four time-spaced acquisitions of the same patient. After registration of these acquisitions, the data forms a volume in which each voxel contains a vector of elements corresponding to the information of the CT uroscan acquisitions. In this paper we will present a segmentation tool in order to differentiate the anatomical structures within the vectorial volume. Because of the partial volume effect (PVE), soft segmentation is better suited because it allows regions or classes to overlap. Gaussian mixture model is often used in statistical classifier to realize soft segmentation by getting classes probability distributions. But this model relies only on the intensity distributions, which will lead a misclassification on the boundaries and on inhomogeneous regions with noise. In order to solve this problem, a neighborhood weighted Gaussian mixture model is proposed in this paper. Expectation maximization algorithm is used as optimization method. The experiments demonstrate that the proposed method can get a better classification result and is less affected by the noise.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/19674872; inserm-00411983; https://www.hal.inserm.fr/inserm-00411983Test; https://www.hal.inserm.fr/inserm-00411983/documentTest; https://www.hal.inserm.fr/inserm-00411983/file/compMedImGraph09.pdfTest; PUBMED: 19674872

الإتاحة: https://doi.org/10.1016/j.compmedimag.2009.07.001Test
https://www.hal.inserm.fr/inserm-00411983Test
https://www.hal.inserm.fr/inserm-00411983/documentTest
https://www.hal.inserm.fr/inserm-00411983/file/compMedImGraph09.pdfTest

المؤلفون: Tang, Hui, Lin, Yu Bing, Sun, Guo Yan, Bao, Xu Dong

المصدر: Journal of X-Ray Science & Technology; 2021, Vol. 29 Issue 2, p245-257, 13p

مصطلحات موضوعية: COMPUTED tomography, REAR-screen projection, METALS, SIGNAL-to-noise ratio, IMAGE fusion, IMAGING phantoms

مستخلص: OBJECTIVE: To reduce secondary artifactes generated by the current interpolation-based metal artifact reduction (MAR) methods, this study proposes and tests a new Poisson fusion sinogram based metal artifact reduction (FS-MAR) method. METHODS: The proposed FS-MAR method consists of (1) generating the prior image, (2) forward projecting this prior image and applying the Poisson blending technique to seamlessly replace the metal-affected sinogram of the original projection in the metal projection region (MPR) by the prior image projection to get the corrected metal-free sinogram, and (3) performing the filtered back projection (FBP) on the corrected sinogram and filling the metal image back to the metal-free corrected image to get the final artifact reduced image. Simulated images are calculated by taking clinical metal-free CT images as phantoms and inserting metals during the simulated projection process to get the corresponding metal-affected images by the FBP. After the simulated images are processed by the proposed MAR method, two metrics structural similarity index (SSIM) and peak signal-to-noise ratio (PSNR) are used to evaluate image quality. Finally, visual evaluation is also performed using several real clinical metal-affected images obtained from the Revision Radiology group. RESULTS: In two testing samples, using FS-MAR method yields the highest SSIM and PSNR of 0.8912 and 30.6693, respectively. Visual evaluation results on both simulated and clinical images also show that using FS-MAR method generates less image artifacts than using the interpolation-based algorithm. CONCLUSIONS: This study demonstrated that with the same prior image, applying the proposed Poisson FS-MAR method can achieve the higher image quality than using the interpolation-based algorithm. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of X-Ray Science & Technology is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Tang, Hui, Dillenseger, Jean-Louis, Bao, Xu Dong, Luo, Li Min

المصدر: 2009 First International Conference on Information Science and Engineering

الإتاحة: https://doi.org/10.1109/icise.2009.77Test
http://xplorestaging.ieee.org/ielx5/5454173/5454428/05454828.pdf?arnumber=5454828Test

المؤلفون: Liang, Yu-Hong, Jiang, Lei-Meng, Jiang, Lan, Chen, Xiao-Bo, Liu, Ying-Yi, Tian, Fu-Cong, Bao, Xu-Dong, Gao, Xue-Jun, Versluis, Michel, Wu, Min-Kai, van der Sluis, Luc

المصدر: Liang , Y-H , Jiang , L-M , Jiang , L , Chen , X-B , Liu , Y-Y , Tian , F-C , Bao , X-D , Gao , X-J , Versluis , M , Wu , M-K & van der Sluis , L 2013 , ' Radiographic Healing after a Root Canal Treatment Performed in Single-rooted Teeth with and without Ultrasonic Activation of the Irrigant : A Randomized Controlled Trial ' , Journal of endodontics , vol. 39 , no. 10 , pp. 1218-1225 . https://doi.org/10.1016/j.joen.2013.06.024Test

مصطلحات موضوعية: Cone-beam computed tomography, irrigation, radiographic healing, root canal treatment, ultrasonic, BEAM COMPUTED-TOMOGRAPHY, OF-THE-LITERATURE, PERIAPICAL RADIOGRAPHY, ENDODONTIC TREATMENT, FOLLOW-UP, PART 2, DENTIN, INSTRUMENTATION, LESION, ROTARY

الوصف: Introduction: The aim of this study was to compare the outcome of a root canal treatment with and without additional ultrasonic activation of the irrigant. Methods: Single-rooted teeth with radiographic evidence of periapical bone loss were randomly assigned to 2 treatment groups. In both groups syringe irrigation was performed, and in one group the irrigant was also activated by ultrasound. Ten to 19 months after treatment, the teeth were examined by using periapical radiography (PA) and cone-beam computed tomography (CBCT). Area and volume of the periapical lesions were measured, and the outcome was presented in 4 categories: absence, reduction or enlargement of the radiolucency, or uncertain. Lesions were classified as reduced or enlarged when the change in size of the radiolucency was 20% or more. Results: The recall rate was 82%, and 84 teeth were analyzed. CBCT detected significantly more post-treatment lesions than PA (P = .038), but the percentages of absence and reduction of the radiolucency together revealed by CBCT and PA were similar (P = .383). The CBCT results showed that absence of the radiolucency was observed in 16 of 84 teeth (19%) and reduction of the radiolucency in 61 of 84 teeth (72.6%), but there was no significant difference between the results of the 2 groups (P = .470). Absence and reduction of the radiolucency together were observed in the ultrasonic group in 39 of 41 teeth (95.1%) and in the syringe group in 38 of 43 teeth (88.4%). Conclusions: Root canal treatments with and without additional ultrasonic activation of the irrigant contributed equally to periapical healing.

العلاقة: https://research.rug.nl/en/publications/7b7dae04-a363-48f2-b9e5-917d8501f5c6Test

الإتاحة: https://doi.org/10.1016/j.joen.2013.06.024Test
https://hdl.handle.net/11370/7b7dae04-a363-48f2-b9e5-917d8501f5c6Test
https://research.rug.nl/en/publications/7b7dae04-a363-48f2-b9e5-917d8501f5c6Test

المؤلفون: Bao Xu-dong, Yao Na, Guo Hui-jie, Zhang Cheng-fei, Yue Lin

المساهمون: Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

المصدر: PubMed

الوصف: To evaluate the disinfection efficacy of MTAD on Enterococcus faecalis biofilm and smear layer colonization in apical isthums of the root canal system.Fifteen extracted human maxillary first premolars with isthmus anatomic structure which confirmed by stereo-microscope were contaminated with E. faecalis in vitro and randomly divided into 5 groups: the first group was not treated serving as a baseline control, the second group was treated by normal saline (NS) serving as negative control, the third group was treated by MTAD , the forth group by 5.25% NaOCl, and the fifth group by 5.25% NaOCl + EDTA. All roots in the latter four groups were instrumented by Protaper rotary files and irrigated with respective irrigant, then the roots were split longitudinally and a scanning electron microscope was used to evaluate the antibacterial activity and smear layer cleaning ability of irrigants on isthmus.In the first group, E. faecalis colonized on the isthmus surface and aggregated together to form biofilm-like microorganism community, some bacteria also colonized in the dentinal tubules. When treated with NS, both smear layer and bacteria remained (median of smear layer score was 5). MTAD can remove partial smear layer, and have limited antibacterial activity, some bacteria embedded in smear layer (the median was 3) and were destroyed; In 5.25% NaOCl treatmentgroup, the smear layer was not removed (median of smear layer score was also 5), but all bacteria on the surface were extinguished. The combined use of 5.25% NaOCl and EDTA produced a cleaner isthmus surface and had marked antimicrobial effect, with the median of smear layer score being only 1.MTAD may permeate into the isthmus area of apical root canal system, but only performed a partial effect of disinfection and limited antibacterial activity. Sodium hypochlorite cooperated with EDTA can remove infection effectively in the isthmus area. ; PubMed ; 0 ; 1 ; 34-8 ; 44

العلاقة: Beijing da xue xue bao. Yi xue ban.2012,44,(1),34-8.; 661261; http://hdl.handle.net/20.500.11897/318484Test

الإتاحة: https://doi.org/20.500.11897/318484Test
https://hdl.handle.net/20.500.11897/318484Test

المؤلفون: Bao Xu-dong, Yue Lin, Gao Xue-jun

المساهمون: Yue, L (reprint author), Peking Univ, Sch Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China., Peking Univ, Sch Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China., Peking Univ, Hosp Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China.

المصدر: PubMed ; SCI

مصطلحات موضوعية: Streptococcus oligofermentans, lactate dehydrogenase, pyruvic acid, lactic acid, LACTATE-DEHYDROGENASE, FERMENTATION PRODUCTS, MUTANS, PLAQUE, H2O2

الوصف: Background Streptococcus (S.) oligofermentans is a newly identified bacteria with a yet to be defined mechanism of sucrose metabolism that results in acid production. This study aimed to investigate the biochemical mechanisms of S. oligoferm-entans glucose metaolism. Methods The S. oligofermentans LMG21532, Lactobacillus (L.) fermentum 38 and the S. mutans UA140 were used to characterize sucrose metabolism by measuring lactate dehydrogenase (LDH) activity and lactic acid production. Continuous dynamics and high performance capillary electrophoresis were used to determine LDH activity and lactic acid production, respectively, from bacteria collected at 0, 10 and 30 minutes after cultured in 10% sucrose. Results These analyses demonstrated that LDH activity of the three bacterial strains examined remained stable but significantly different throughout the sucrose fermentation process. The S. oligofermentans LDH activity ((0.61 +/- 0.05) U/mg) was significantly lower than that of L. ferment urn ((52.91 +/- 8.97) U/mg). In addition, the S. oligofermentans total lactate production ((0.048 +/- 0.021) mmol/L) was also significantly lower than that of L. fermentum ((0.958 +/- 0.201) mmol/L). Although the S. oligofermentans LDH production was almost double of that produced by S. mutans ((0.32 +/- 0.07) U/mg), lactic acid production was approximately one sixth that of S. mutans ((0.296 +/- 0.058) mmol/L). Additional tests examining pyruvic acid production (the LDH substrate) demonstrated that lactic acid concentrations correlated with pyruvic acid production. That is, pyruvic acid production by S. oligofermentans was undetectable following sucrose incubation, however, (0.074 +/- 0.024) and (0.175 +/- 0.098) mmol/L pyruvic acid were produced by S. mutans and L. fermentum, respectively. Conclusion S. oligofermentans is incapable of fermenting carbohydrates to produce enough pyruvic acid, which results in reduced lactic acid production. Chin Med J 2011;124(21):3499-3503 ...

العلاقة: CHINESE MEDICAL JOURNAL.2011,124,(21),3499-3503.; 664420; http://hdl.handle.net/20.500.11897/343868Test; WOS:000297658200013

الإتاحة: https://doi.org/20.500.11897/343868Test
https://doi.org/10.3760/cma.j.issn.0366-6999.2011.21.012Test
https://hdl.handle.net/20.500.11897/343868Test