المؤلفون: LEYROLLE, Quentin, DECOEUR, Fanny, DEJEAN, Cyril, BRIERE, Marie-Galadriel, LEON, Stephane, BAKOGIANNIS, Ioannis, BAROUX, Emilie, STERLEY, Tony‐Lee, BOSCH BOUJU, Clementine, MOREL, Lydie, AMADIEU, Camille, LECOURS, Cynthia, ST‐PIERRE, Marie‐Kim, BORDELEAU, Maude, DE SMEDT-PEYRUSSE, Veronique, SERE, Alexandra, SCHWENDIMANN, Leslie, GREGOIRE, Stephane, BRETILLON, Lionel, ACAR, Niyazi, JOFFRE, Corinne, FERREIRA, Guillaume, URICARU, Raluca, THEBAULT, Patricia, GRESSENS, Pierre, TREMBLAY, Marie‐Eve, LAYE, Sophie, NADJAR, Agnes

المصدر: crossref

مصطلحات موضوعية: Clemastine, Cognition, Hippocampus, Myelin, N-3 PUFA, Neurodevelopement, Oligodendrocyte, Omega-3, Prefrontal cortex, Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]

الوصف: Westernization of dietary habits has led to a progressive reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental disorders, conditions in which myelination processes are abnormal, leading to defects in brain functional connectivity. Only little is known about the role of n-3 PUFAs in oligodendrocyte physiology and white matter development. Here, we show that lifelong n-3 PUFA deficiency disrupts oligodendrocytes maturation and myelination processes during the postnatal period in mice. This has long-term deleterious consequences on white matter organization and hippocampus-prefrontal functional connectivity in adults, associated with cognitive and emotional disorders. Promoting developmental myelination with clemastine, a first-generation histamine antagonist and enhancer of oligodendrocyte precursor cell differentiation, rescues memory deficits in n-3 PUFA deficient animals. Our findings identify a novel mechanism through which n-3 PUFA deficiency alters brain functions by disrupting oligodendrocyte maturation and brain myelination during the neurodevelopmental period.

العلاقة: oai:crossref.org:10.1002/glia.24088; https://oskar-bordeaux.fr/handle/20.500.12278/112232Test

الإتاحة: https://doi.org/20.500.12278/112232Test
https://doi.org/10.1002/glia.24088Test
https://oskar-bordeaux.fr/handle/20.500.12278/112232Test
https://hdl.handle.net/20.500.12278/112232Test

المؤلفون: Leyrolle, Quentin, Decoeur, Fanny, Dejean, Cyril, Briere, Marie-Galadriel, Leon, Stephane, Bakogiannis, Ioannis, Baroux, Emilie, Sterley, Tony‐lee, Bosch-Bouju, Clémentine, Morel, Lydie, Amadieu, Camille, Lecours, Cynthia, St‐pierre, Marie‐kim, Bordeleau, Maude, de Smedt-Peyrusse, Veronique, Sere, Alexandra, Schwendimann, Leslie, Grégoire, Stéphane, Brétillon, Lionel, Acar, Niyazi, Joffre, Corinne, Ferreira, Guillaume, Uricaru, Raluca, Thebault, Patricia, Gressens, Pierre, Tremblay, Marie‐eve, Layé, Sophie, Nadjar, Agnes

المساهمون: Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), University of Calgary, Université Laval Québec (ULaval), University of Victoria Canada (UVIC), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté COMUE (UBFC), University of Northern British Columbia Prince George (UNBC), ANR-10-LABX-0057,TRAIL,Translational Research and Advanced Imaging Laboratory(2010)

المصدر: ISSN: 0894-1491.

مصطلحات موضوعية: clemastine, cognition, hippocampus, MRI, myelin, n-3 PUFA, neurodevelopement, oligodendrocyte, omega-3, prefrontal cortex, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: This article corrects the following:N-3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain developmentQuentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony-Lee Sterley, Clémentine Bosch-Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie-Kim St-Pierre, Maude Bordeleau, Helene Roumes, Véronique De Smedt-Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie-Eve Tremblay, Sophie Layé, Agnes Nadjar Volume 70Issue 1Glia pages: 50-70 First Published online: September 14, 2021 ; International audience

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36511441; hal-03998738; https://hal.science/hal-03998738Test; PUBMED: 36511441; WOS: 000898549300001

الإتاحة: https://doi.org/10.1002/glia.24321Test
https://hal.science/hal-03998738Test

المؤلفون: Leyrolle, Quentin, Decoeur, Fanny, Dejean, Cyril, Briere, Marie-Galadriel, Leon, Stephane, Bakogiannis, Ioannis, Baroux, Emilie, Sterley, Tony‐lee, Bosch-Bouju, Clémentine, Morel, Lydie, Amadieu, Camille, Lecours, Cynthia, St‐pierre, Marie‐kim, Bordeleau, Maude, de Smedt-Peyrusse, Veronique, Sere, Alexandra, Schwendimann, Leslie, Grégoire, Stéphane, Brétillon, Lionel, Acar, Niyazi, Joffre, Corinne, Ferreira, Guillaume, Uricaru, Raluca, Thebault, Patricia, Gressens, Pierre, Tremblay, Marie‐eve, Layé, Sophie, Nadjar, Agnes

المساهمون: Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), University of Calgary, Université Laval Québec (ULaval), University of Victoria Canada (UVIC), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté COMUE (UBFC), University of Northern British Columbia Prince George (UNBC), Fondation de France, Fondation pour la Recherche Médicale, Institut National de la Recherche Agronomique, Institut National de la Santé et de la Recherche Médicale

المصدر: ISSN: 0894-1491.

مصطلحات موضوعية: Clemastine, Cognition, Hippocampus, Myelin, N-3 PUFA, Neurodevelopement, Oligodendrocyte, Omega-3, Prefrontal cortex, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Westernization of dietary habits has led to a progressive reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental disorders, conditions in which myelination processes are abnormal, leading to defects in brain functional connectivity. Only little is known about the role of n-3 PUFAs in oligodendrocyte physiology and white matter development. Here, we show that lifelong n-3 PUFA deficiency disrupts oligodendrocytes maturation and myelination processes during the postnatal period in mice. This has long-term deleterious consequences on white matter organization and hippocampus-prefrontal functional connectivity in adults, associated with cognitive and emotional disorders. Promoting developmental myelination with clemastine, a first-generation histamine antagonist and enhancer of oligodendrocyte precursor cell differentiation, rescues memory deficits in n-3 PUFA deficient animals. Our findings identify a novel mechanism through which n-3 PUFA deficiency alters brain functions by disrupting oligodendrocyte maturation and brain myelination during the neurodevelopmental period.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34519378; hal-03347586; https://hal.science/hal-03347586Test; PUBMED: 34519378; WOS: 000695519900001

الإتاحة: https://doi.org/10.1002/glia.24088Test
https://hal.science/hal-03347586Test