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1دورية أكاديمية
المؤلفون: Leyla Köse Leba, Safiye Gül Kenar, Bülent Oğuz Genç
المصدر: Archives of Epilepsy, Vol 28, Iss 4, Pp 169-171 (2022)
مصطلحات موضوعية: epilepsy, sleep-related hypermotor epilepsy, video-eeg, Neurology. Diseases of the nervous system, RC346-429, Medicine
الوصف: Sleep-related hypermotor epilepsy is a subgroup of sleep-related epilepsies and is very rare among focal epilepsies. It is a type of epilepsy that can be confused with the primary diseases of sleep and is diagnosed late. Here, we present a case diagnosed with elect roenc ephal ograp hy (video-EEG) monitoring 13 years later.
وصف الملف: electronic resource
العلاقة: http://archepilepsy.org/archives/archive-detail/article-preview/sleep--related-hypermotor-epilepsy-a-rare-case/57763Test; https://doaj.org/toc/2792-0550Test
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2دورية أكاديمية
المؤلفون: Arife Çimen Atalar, Aynur Özge, Bengi Gül Türk, Esme Ekizoğlu, Duygu Kurt Gök, Betül Baykan, Semih Ayta, Füsun Ferda Erdoğan, Seher Naz Yeni, Bahar Taşdelen, IDEM Study Group, Sibel K. Velioğlu, Zuhal Yapıcı, İpek Midi, Saygı Serap, Çelebi Ulufer, Elif Sarıca Darol, Kadriye Ağan, Senem Ayç, Sibel Gazioğlu, Zeynep Vildan Okudan, Nermin Görkem Şirin, Nerses Bebek, Neşe Dericioğlu, İlknur Güçlü Altun, Ayşe Destina Yalçın, Reyhan Sürmeli, Oğuz Osman Erdinç, Abidin Erdal, Demet İlhan Algın, Gülnihal Kutlu, Semai Bek, Yüksel Erdal, Akçay Övünç Özön, Aylin Reyhani, Babürhan Güldiken, Barış Baklan, Bülent Oğuz Genç, Ebru Aykutlu Altindağ, Gökçen Karahan, Güray Koç, Handan Mısırlı, İbrahim Öztura, Kezban Aslan-Kara, Melodi Çakar Merve, Nur Türkmen, Onur Bulut, Karadaş Ömer, Özlem Kesim Çahin, Sevgi Ferik, Taylan Peköz Mehmet, Pınar Topaloğlu, Sibel Üstün Özek, Ülkühan Düzgün, Vildan Yayla, Yasemin Gömceli, Zeynep Ünlüsoy Acar
المصدر: Frontiers in Neurology, Vol 13 (2023)
مصطلحات موضوعية: migraine, idiopathic epilepsy, classification tree, headache, headache criteria, migraine without aura, Neurology. Diseases of the nervous system, RC346-429
الوصف: BackgroundMigraine without aura (MwoA) is a very frequent and remarkable comorbidity in patients with idiopathic/genetic epilepsy (I/GE). Frequently in clinical practice, diagnosis of MwoA may be challenging despite the guidance of current diagnostic criteria of the International Classification of Headache Disorders 3 (ICHD-3). In this study, we aimed to disclose the diagnostic gaps in the diagnosis of comorbid MwoA, using a zone concept, in patients with I/GEs with headaches who were diagnosed by an experienced headache expert.MethodsIn this multicenter study including 809 consecutive patients with a diagnosis of I/GE with or without headache, 163 patients who were diagnosed by an experienced headache expert as having a comorbid MwoA were reevaluated. Eligible patients were divided into three subgroups, namely, full diagnosis, zone I, and zone II according to their status of fulfilling the ICHD-3 criteria. A Classification and Regression Tree (CART) analysis was performed to bring out the meaningful predictors when evaluating patients with I/GEs for MwoA comorbidity, using the variables that were significant in the univariate analysis.ResultsLonger headache duration (
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fneur.2022.1103541/fullTest; https://doaj.org/toc/1664-2295Test
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3دورية أكاديمية
المؤلفون: Nur Türkmen, Ahmet Buğrul, Bülent Oğuz Genç
المصدر: Türk Nöroloji Dergisi, Vol 27, Iss s1, Pp 26-30 (2021)
مصطلحات موضوعية: covid-19, electroencephalography, epilepsy, Medicine, Neurology. Diseases of the nervous system, RC346-429
الوصف: Objective: Neurological manifestations associated with coronavirus disease-2019 (COVID-19) are broad and heterogeneous. Although the predominant clinical presentation is respiratory dysfunction, concerns have been raised about the neurological hallmarks. Many reports suggest some findings on electroencephalography (EEG) can be relevant to COVID-19. Materials and Methods: Patients with COVID-19 admitted to hospital and referred for EEG from March 1, 2020 to February 15, 2021, were retrospectively enrolled. When research databases were queried with the terms “COVID-19 (ICD code: 10: U07.3) and “EEG”, total number of patients obtained was 32. Number of patients excluded due to unconfirmed diagnose with COVID-19 was 12. Twenty adult patients with certain diagnose of COVID-19 who underwent 21-electrode routine EEG during the outbreak with neurological deterioration were identified. Results: Background abnormalities was evident in one of fourth patients (n=5, 25%). Mild diffuse slowing (n=3, 15%) and focal slowing (n=3, 15%) with left frontotemporal tendency (n=2, 10%) were observed. Epileptiform abnormalities and seizures were detected showing focal (n=4, 20%) or generalized onset (n=1, 5%). Conclusion: Here we performed a retrospective single-centre study to evaluate the electroencephalographic findings in patients diagnosed with COVID-19 since it remains unknown. it needs to be more clarified with increasing number of recordings
وصف الملف: electronic resource
العلاقة: https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-76329&look4Test=; https://doaj.org/toc/1309-2545Test
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4دورية أكاديمية
المؤلفون: Nur Türkmen, Bülent Oğuz Genç
المصدر: Archives of Epilepsy, Vol 26, Iss 3, Pp 207-212 (2020)
مصطلحات موضوعية: ictal turning, gelastic seizure, tuberosclerosis, Neurology. Diseases of the nervous system, RC346-429, Medicine
الوصف: Summary Gelastic seizures are typically associated with hypothalamic hamartoma. Given the rarity of gelastic seizures, pathways for the motor and emotional aspects of laughter have been hypothesized but remain unclear. Only few case reports of patients with tuberous sclerosis complex who developed gelastic epilepsy have been reported. In this case study, we report a case of TS that presented itself mainly with dermatologic manifestations and without any neurological findings other than gelastic seizures. Ictal EEG revealed an active epileptic activity on the right fronto-temporal region. Clinical and laboratory findings were consistent with gelastic epilepsy that originated from temporal and extra-temporal lobes. Seizures were controlled using carbamazepine and levetiracetam polytherapy. In our case, there is no evidence of cortical and subcortical tubers, subependymal glial nodules, giant cell astrocytomas or aneurysm.
وصف الملف: electronic resource
العلاقة: http://archepilepsy.org/archives/archive-detail/article-preview/a-case-of-gelastic-epilepsy-associated-with-tubero/54695Test; https://doaj.org/toc/2792-0550Test
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5دورية أكاديميةLacosamide add-on Treatment in Refractory Focal Epilepsy: The Experience of a Single Tertiary Center
المؤلفون: Aslı AKYOL GÜRSES, Emine GENÇ, Bülent Oğuz GENÇ
المصدر: Archives of Epilepsy, Vol 26, Iss 2, Pp 88-93 (2020)
مصطلحات موضوعية: refractory epilepsy, lacosamide, responder rate, Neurology. Diseases of the nervous system, RC346-429, Medicine
الوصف: Objectives:Lacosamide is a third-generation antiepileptic agent that selectively enhances slow inactivation of sodium channels that take part in generation and propagation of action potentials and results in the diminution of neuronal excitability. Because of this new mechanism of action, it is expected to be efficacious in patients with drug-resistant epilepsy. In this study, we aimed to assess the efficacy and tolerability of lacosamide add-on treatment in refractory epilepsy patients by presenting our experience in a tertiary referral center.Methods:Medical records of refractory focal epilepsy patients who were followed in epilepsy outpatient clinic between October 2014 and May 2017 were retrospectively reviewed in this study. Patients who were treated with add-on lacosamide and completed minimum of six months follow-up period were included. ≥50% reduction in seizure frequency was defined as treatment response.Results:In this study, 88 patients were included. The percentage of seizure-free patients after six months follow-up was 4.6% and the treatment response rate was 55.6%. We also evaluated the effect of concomitant use of sodium channel blockers, the presence of abnormal findings on magnetic resonance imaging and the introduction stage of lacosamide. No significant difference was observed in the response rate regarding the mentioned parameters. 19% of the patients reported side effects, the majority of which were dizziness, vertigo and somnolence. None of them discontinued treatment because of side effects.Conclusion:Our findings suggest that lacosamide add-on therapy is effective in refractory focal epilepsy and has an appropriate tolerability and safety profile since none of the patients stopped treatment due to side effects.
وصف الملف: electronic resource
العلاقة: http://archepilepsy.org/archives/archive-detail/article-preview/lacosamide-add-on-treatment-in-refractory-focal-ep/54758Test; https://doaj.org/toc/2792-0550Test
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6دورية أكاديمية
المؤلفون: Emine GENÇ, Bülent Oğuz GENÇ
المصدر: Archives of Epilepsy, Vol 24, Iss 1, Pp 6-9 (2018)
مصطلحات موضوعية: epilepsy, neurosteroids, estrogen, progesterone, sex hormones, testosterone, Neurology. Diseases of the nervous system, RC346-429, Medicine
الوصف: There is a mutual interaction between sex steroid hormones and epilepsy. Although female and male sex hormones and their metabolites access the brain via the blood brain barrier, they can also be synthesized de novo from cholesterol within the glia and neurones (neurosteroids). While estrogens enhance neuronal excitability, progesterone and its metabolites exert anticonvulsant effects. Testosterone, on the other hand, has a less consistent effect on seizure susceptibility, depending on the ratio of its conversion to estrogens. This paper focuses on the effects of neurosteroidal sex hormones on seizure susceptibility. Further study is required to identify the future role of their use in the treatment of epilepsy.
وصف الملف: electronic resource
العلاقة: http://archepilepsy.org/archives/archive-detail/article-preview/epilepsy-and-sex-hormones/54920Test; https://doaj.org/toc/2792-0550Test
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7دورية أكاديمية
المؤلفون: Ebru APAYDIN DOĞAN, Faik İLİK, Zeliha Esin ÇELİK, Bülent Oğuz GENÇ, Muhammed Nebil SELİMOĞLU
المصدر: Archives of Epilepsy, Vol 22, Iss 1, Pp 32-36 (2016)
مصطلحات موضوعية: lafora disease, perampanel, progressive myoclonic epilepsy, Neurology. Diseases of the nervous system, RC346-429, Medicine
الوصف: Lafora disease (LD) is a progressive myoclonus epilepsy with autosomal recessive inheritance. Clinical course is progressive and includes myoclonic, cerebellar, and extrapyramidal signs, generalized tonic-clonic seizures, and cognitive decline. Valproic acid, zonisamide, levetiracetam, clonazepam, and piracetam are among the treatment options. Carbamazepine (CBZ), oxcarbazepine, phenytoin, and lamotrigine (LM) should be avoided to prevent worsening of symptoms. Though evidence is limited, perampanel is the only drug to achieve sustained improvement in frequency of seizures, and effective control of neurological and cognitive decline in patients with LD. Described in the present report is a case of typical LD with clinical worsening on CBZ and LM treatment. Electroencephalographic and pathologic findings are reported.
وصف الملف: electronic resource
العلاقة: http://archepilepsy.org/archives/archive-detail/article-preview/lafora-disease-a-case-report/55060Test; https://doaj.org/toc/2792-0550Test
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8دورية أكاديمية
المؤلفون: Figen Güney, Hasan Hüseyin Kozak, Bülent Oğuz Genç, Esra Yetkin
المصدر: Türk Nöroloji Dergisi, Vol 14, Iss 1, Pp 41-44 (2008)
مصطلحات موضوعية: bilateral thalamic infarct, myelodysplastic syndrome, Medicine, Neurology. Diseases of the nervous system, RC346-429
الوصف: Scientific BACKGROUND: Bilateral thalamic infarct is quite rare and encountered at the rate of 0.6%. Emboly from an artery to another, cardioembolism, migrain and the existence of an only perforing artery are among the causes of bilateral thalamic infarct. During the course of many hematologic diseases, tendency to thrombosis increases, and therefore, stroke can also be witnessed. OBJECTIVE: Upon scanning the literature, concurrence of myelodysplastic syndrome and bilateral thalamic infarct have not been encountered. Thus, a subject with myelodysplastic syndrome was aimed to be discussed due to the development of bilateral thalamic infarct in the light of the literature. CASE: A 52 years old women was consulted with the complaint of headache and weakness on her right side as an inpatient in hematology unit. On the neurological examination of the patient followed by hematology unit for a decade with the diagnosis of myelodysplastic syndrome, right hemiparesis including her face was determined. On the sensorial examination, there was a decrease in all her sensorial modalities on the right, but there was only loss of sensorial vibration on the left. On cranial MRI, bilateral thalamic infarct was detected. No other pathologies except for myelodysplastic syndrome were found in the etiology. CONCLUSION: It should also be remembered that a blood disease such as myelodysplastic syndrome could be among the causes of bilateral thalamic infarct
وصف الملف: electronic resource
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9
المؤلفون: Esme Ekizoglu, Betül Baykan, Arife Çimen Atalar, Bengi Gül Türk, Duygu Kurt Gök, Pınar Topaloglu, Aynur Özge, Semih Ayta, Füsun Ferda Erdoğan, Seher Naz Yeni, Bahar Taşdelen, Sibel K. Velioğlu, Zuhal Yapıcı, İpek Midi, Serap Saygı, Ulufer Çelebi, Elif Sarıca Darol, Kadriye Ağan, Senem Ayça, Sibel Gazioğlu, Zeynep Vildan Okudan, Nermin Görkem Şirin, Nerses Bebek, Neşe Dericioğlu, İlknur Güçlü Altun, Ayşe Destina Yalçın, Reyhan Sürmeli, Oğuz Osman Erdinç, Abidin Erdal, Demet İlhan Algın, Gülnihal Kutlu, Semai Bek, Yüksel Erdal, Akçay Övünç Özön, Aylin Reyhani, Babürhan Güldiken, Barış Baklan, Bülent Oğuz Genç, Ebru Aykutlu Altındağ, Gökçen Karahan, Güray Koç, Handan Mısırlı, İbrahim Öztura, Kezban Aslan-Kara, Merve Melodi Çakar, Nur Türkmen, Onur Bulut, Ömer Karadaş, Özlem Kesim Şahin, Sevgi Ferik, Mehmet Taylan Peköz, Sibel Üstün Özek, Ülkühan Düzgün, Vildan Yayla, Yasemin Gömceli, Zeynep Ünlüsoy Acar
مصطلحات موضوعية: Behavioral Neuroscience, Neurology, Neurology (clinical)
الوصف: Objective: There are a handful of studies investigating peri-ictal headache (PIH) and its clinical associations in patients with idiopathic/genetic epilepsies (I/GE). This multi-center study aimed to investigate PIH, which is an ignored comorbid condition in patients with I/GE, by headache experts and epileptologists working together. Methods: The data were collected from a cross-sectional large study, using two structured questionnaires for headache and epilepsy features, fulfilled by neurologists. Headaches were classified according to the International Classification of Headache Disorders, third edition, whereas seizure and syndrome types were diagnosed according to International League Against Epilepsy criteria. The patients with a headache starting 24 hours before the onset of the seizure (preictal) or within 3 hours after the seizure (postictal) were defined as patients with PIH. We compared demographic and clinical differences between two groups of patients with and without PIH statistically and used ROC curves to determine a threshold of the total number of seizure triggers associated with the occurrence of PIH. Results: Among 809 (531 females, 65.6%) consecutive patients with I/GE, 105 (13%) patients reported PIH (22 preictal, 82 postictal headaches, and one with both types). Peri-ictal headache was more frequently reported by females and those having a family history of migraine or epilepsy, and it was significantly associated with lower rates of seizure freedom for more than five years, drug resistance, and use of polytherapy, remarkably. Moreover, ROC curves showed that having more than 3 seizure triggers was associated with the presence of PIH. Conclusion: Our findings revealed that PIH may be linked to poor outcomes in I/GEs and seems to be related to a lower ictal threshold precipitated by multiple triggers. Future prospective studies will illuminate the unknown underlying mechanisms and appropriate management strategies for PIH to improve the prognosis.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a0e2840ac7d4c2458b3dc21a85ed46Test
https://avesis.erciyes.edu.tr/publication/details/998d2ba4-74ce-4ddb-b7fa-27149ebf1142/oaiTest -
10صورة
المؤلفون: Arife Çimen Atalar (14369835), Aynur Özge (9516154), Bengi Gül Türk (14369838), Esme Ekizoğlu (9516148), Duygu Kurt Gök (14369841), Betül Baykan (9516163), Semih Ayta (9955249), Füsun Ferda Erdoğan (14369844), Seher Naz Yeni (14369847), Bahar Taşdelen (7855709), IDEM Study Group (14369850), Sibel K. Velioğlu (14369853), Zuhal Yapıcı (14369856), İpek Midi (14369859), Saygı Serap (14369862), Çelebi Ulufer (14369865), Elif Sarıca Darol (14369868), Kadriye Ağan (14369871), Senem Ayç (14369874), Sibel Gazioğlu (14369877), Zeynep Vildan Okudan (14369880), Nermin Görkem Şirin (14369883), Nerses Bebek (6316601), Neşe Dericioğlu (14369886), İlknur Güçlü Altun (14369889), Ayşe Destina Yalçın (14369892), Reyhan Sürmeli (14369895), Oğuz Osman Erdinç (14369898), Abidin Erdal (14369901), Demet İlhan Algın (14369904), Gülnihal Kutlu (14369907), Semai Bek (14369910), Yüksel Erdal (14369913), Akçay Övünç Özön (14369916), Aylin Reyhani (14369919), Babürhan Güldiken (14369922), Barış Baklan (14369925), Bülent Oğuz Genç (14369928), Ebru Aykutlu Altindağ (14369931), Gökçen Karahan (14369934), Güray Koç (14369937), Handan Mısırlı (14369940), İbrahim Öztura (14369943), Kezban Aslan-Kara (14369946), Melodi Çakar Merve (14369949), Nur Türkmen (14369952), Onur Bulut (14369955), Karadaş Ömer (14369958), Özlem Kesim Çahin (14369961), Sevgi Ferik (14369964), Taylan Peköz Mehmet (14369967), Pınar Topaloğlu (14369970), Sibel Üstün Özek (14369973), Ülkühan Düzgün (14369976), Vildan Yayla (8858300), Yasemin Gömceli (14369979), Zeynep Ünlüsoy Acar (14369982)
مصطلحات موضوعية: Neurology and Neuromuscular Diseases, Neurogenetics, migraine, idiopathic epilepsy, classification tree, headache, headache criteria, migraine without aura, ICHD-3 criteria
الوصف: Background Migraine without aura (MwoA) is a very frequent and remarkable comorbidity in patients with idiopathic/genetic epilepsy (I/GE). Frequently in clinical practice, diagnosis of MwoA may be challenging despite the guidance of current diagnostic criteria of the International Classification of Headache Disorders 3 (ICHD-3). In this study, we aimed to disclose the diagnostic gaps in the diagnosis of comorbid MwoA, using a zone concept, in patients with I/GEs with headaches who were diagnosed by an experienced headache expert. Methods In this multicenter study including 809 consecutive patients with a diagnosis of I/GE with or without headache, 163 patients who were diagnosed by an experienced headache expert as having a comorbid MwoA were reevaluated. Eligible patients were divided into three subgroups, namely, full diagnosis, zone I, and zone II according to their status of fulfilling the ICHD-3 criteria. A Classification and Regression Tree (CART) analysis was performed to bring out the meaningful predictors when evaluating patients with I/GEs for MwoA comorbidity, using the variables that were significant in the univariate analysis. Results Longer headache duration (<4 h) followed by throbbing pain, higher visual analog scale (VAS) scores, increase of pain by physical activity, nausea/vomiting, and photophobia and/or phonophobia are the main distinguishing clinical characteristics of comorbid MwoA in patients with I/GE, for being classified in the full diagnosis group. Despite being not a part of the main ICHD-3 criteria, the presence of associated symptoms mainly osmophobia and also vertigo/dizziness had the distinguishing capability of being classified into zone subgroups. The most common epilepsy syndromes fulfilling full diagnosis criteria (n = 62) in the CART analysis were 48.39% Juvenile myoclonic epilepsy followed by 25.81% epilepsy with generalized tonic-clonic seizures alone. Conclusion Longer headache duration, throbbing pain, increase of pain by physical activity, photophobia and/or ...
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