المؤلفون: Tuğba Altun Ensari, Sadiman Kiykac Altinbas, Ayse Gulcin Bastemur, Elif Gülşah Diktaş, Nazan Vanlı Tonyalı, Gizem Aktemur, Mehmet Ünsal, Uğurcan Zorlu

المصدر: Hitit Medical Journal, Vol 5, Iss 3, Pp 185-189 (2023)

مصطلحات موضوعية: cesarean section, pregnancy, robson ten-group classification., robson on grup sınıflandırması, gebelik, sezaryen, Medicine

الوصف: Amaç: Üçüncü basamak bir doğum hastanesinde bir yılda gerçekleşen sezaryen doğumların Robson On Gruplu Sınıflandırma Sistemi kullanılarak analiz edilmesi amaçlanmıştır. Gereç ve Yöntem: 1 Ocak 2019 - 31 Aralık 2019 tarihleri arasında hastanemiz doğum salonuna kabul edilip, hastanemizde doğum yapmış olan ve herhangi bir obstetrik risk faktö rü olmayan gebeler çalışmaya dahil edilmiştir. Çalışmamız retrospektif olarak dizayn edilmiştir. Bulgular: Çalışmada 10781 doğuma ait veriler incelendi. Bu doğumların 4391’i sezaryen doğum ile gerçekleşmiştir. Tüm doğumlar içerisinde sezaryen doğum oranı %40,7’dir. Sezaryen doğum yapan gebelerin %9,3’lük kısmı Robson sınıflandırmasına göre birinci grupta, %13,6’sı Robson sınıflandırılmasına göre ikinci grupta yer almıştır. Sezaryen doğum yapan gebelerin %12,1’lik kısmı Robson sınıflandırmasına göre üçüncü grupta, %10,8’i dördüncü gruptadır. Grup 5, grup 6 ve grup 7’nin tüm sezaryen doğumlardaki oranları sırasıyla % 47,7, %2,5 ve %2,6’dır. Robson sınıflandırmasına göre Grup 9 ’un tüm sezaryen doğumlar arasındaki oranı ise %1,4’tür. Sonuç: Sonuç olarak, hastanelerin yıllık Robson On Gruplu Sınıflandırma Sistemi Formundaki yüzdelere gö re sezaryen doğumlarının izlenmesi ve değerlendirilmesi, kendi sezaryen eylem planlarını hazırlamaları ve belirledikleri sezaryen hedefine gö re kalite notlarının değerlendirilmesi de sezaryen oranının azaltılması hedefine katkı sağlayacaktır.

وصف الملف: electronic resource

العلاقة: https://dergipark.org.tr/tr/download/article-file/3170492Test; https://doaj.org/toc/2687-4717Test

الوصول الحر: https://doaj.org/article/2255415cdaad4a9aadcc0313846d069cTest

المؤلفون: Ercan Yilmaz, Mehmet Gul, Rauf Melekoglu, Ebru Inci Coskun, Nurhan Sahin, Semir Gul, Ayse Gulcin Bastemur, Baris Ciplak

المصدر: Journal of International Medical Research, Vol 46 (2018)

مصطلحات موضوعية: Medicine (General), R5-920

الوصف: Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n = 23), patients with endometrial hyperplasia (Group 2, n = 21) and patients with endometrial cancer (Group 3, n = 20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0300-0605Test; https://doaj.org/toc/1473-2300Test

الوصول الحر: https://doaj.org/article/8b667f222ec146be9b940818893eb929Test

المؤلفون: Harun Karaağaç, Aslıhan Kara, Yaprak Engin Üstün, Ayse Ozcan, Ertan Akpinar, Ayse Gulcin Bastemur, Müjde Can Ibanoğlu, Omer Lutfi Tapisiz

المصدر: Türk Kadın Sağlığı ve Neonatoloji Dergisi. 3:50-52

مصطلحات موضوعية: Pneumonia, Pregnancy, medicine.medical_specialty, business.industry, Obstetrics, General Mathematics, Medicine, business, medicine.disease, medicine.disease_cause, Coronavirus

الوصف: İlk olarak Çin'in Wuhan kentinde tanımlanan yeni tip koronavirüs hastalığı (COVID-19), küresel bir halk sağlığı sorunu olan, bir çeşit solunum yolu enfeksiyonudur. Vaka raporları ve küçük kohort çalışmalarından oluşan, gebelikte COVID-19 ile ilgili veriler sınırlıdır. Doğum sonrası ürosepsis de küresel olarak yaygın bir hastalıktır ve pekçok yayın bulunmaktadır. Sepsis bulguları olan postpartum hastalar, salgın sırasında; halk sağlığı ve hastanın kendi iyiliği açısından COVID-19 için test edilmelidir. Ürosepsisin klinik özellikleri, doğum sonrası hastalarda COVID-19 hastalığına benzer olabilir. Bu olgu sunumu ile; postpartum dönemde ani akut solunum bozukluğu ve septik şok bulguları geliştiren bir vakada COVID-19 enfeksiyonu ve ürosepsis ayırıcı tanısının ve tedavisinin nasıl yönetildiğini anlatmak amaçlanmıştır.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::800e17a43845ad18a324d00128c9f944Test
https://doi.org/10.46969/ezh.835911Test

المؤلفون: Ayse Gulcin BASTEMUR, Barış ÇIPLAK, Rauf MELEKOĞLU, Serhat TOPRAK, Cemalettin KOÇ, Eda A ŞAHİN, Işıl KÖLELİ, Hanifi ŞAHİN, Ercan YILMAZ

المصدر: Volume: 6, Issue: 4 465-469
Journal of Surgery and Medicine

مصطلحات موضوعية: Ovarian cancer,Pelvic mass,RMI,ROMA,CA 125,HE4,Morphological index, Obstetrics and Gynecology, Kadın Hastalıkları ve Doğum

الوصف: Background/Aim: Ovarian cancer is the second most common gynecologic malignancy worldwide and is the deadliest among gynecological cancers. It is important that this cancer, which is usually diagnosed in advanced stages, is referred to a gynecologist oncologist without delay. An ideal screening method does not yet exist. Although CA 125 is still the most used tumor marker, it cannot detect early-stage ovarian cancer. Also, CA 125 is not specific for ovarian malignancy. Therefore, new serum markers, such as HE4, and more complex algorithms, like ROMA and RMI, have emerged. Here we evaluate the preoperative potential of patients with adnexal mass to have a malignant or benign mass with morphological index, CA 125, HE4, RMI, and ROMA tests. Methods: This study is a prospective cohort study. A power analysis was done before starting the study. The sample size was at least 80 when the Type I error was set at 0.05, and the confidence interval was 95%. We included into the study 84 patients admitted to our clinic because of pelvic mass and underwent operation between March 2016 and October 2018. To homogenize the benign and malignant groups, 42 patients were collected from each group. CA 125 and HE4 levels of the samples were studied by the electrochemiluminescence method. ROMA and RMI values were calculated, and the data were entered into SPSS. Data were analyzed using SPSS 22.0 statistical package program. Results: Each of the CA 125 (P = 0.002), HE4 (P < 0.001), morphological index (P < 0.001), ROMA (P < 0.001), and RMI (P < 0.001) tests has been successful in differentiating malignant masses from benign masses. In the malignant-benign differentiation of adnexal masses preoperatively, CA 125 was the test with the lowest sensitivity, and RMI had the highest sensitivity. However, in the ROC analysis, the morphological index has a higher area under the curve.Conclusion: Although CA 125 is still the most frequently used marker in the preoperative evaluation of adnexal masses, it has low specificity and sensitivity, especially in premenopausal patients. The use of new tumor markers (e.g., HE4) and other algorithms (e.g., ROMA and RMI) is supported by our findings and the literature. However, here we show that an expert ultrasonographic evaluation with morphological index alone could be effective.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e9b7ff1bd913306cd5f9f644ff3538Test
https://dergipark.org.tr/tr/pub/josam/issue/69115/960550Test

المؤلفون: Sevil Eraslan, Ebru Celik, Rauf Melekoglu, Ayse Gulcin Bastemur, Harika Gözde Gözükara Bağ

المصدر: Perinatal Journal. 25:108-115

مصطلحات موضوعية: 03 medical and health sciences, Pediatrics, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, 0302 clinical medicine, Neonatal outcomes, business.industry, medicine, 030212 general & internal medicine, General Medicine, medicine.disease, business, Thrombocytopenic purpura

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a5ee2cfd3b8b7e98ba9650efcc0a751aTest
https://doi.org/10.2399/prn.17.0253004Test

المؤلفون: Osman Ciftci, Rauf Melekoglu, Ercan Nurcan Yilmaz, Ebru Celik, Ayse Gulcin Bastemur

مصطلحات موضوعية: amnion fluid analysis, Amniotic fluid, thrombospondin, Gastroenterology, Pregnancy, gestational age, tumor necrosis factor-alpha, amnion, clinical article, medicine.diagnostic_test, biology, Amnion, amnion fluid, disease course, pathogenesis, Obstetrics and Gynecology, Gestational age, karyotyping, cohort analysis, ADAMTS4 protein, human, gestational diabetes mellitus, TNF protein, human, Gestational diabetes, A Disintegrin and Metalloprotease Protein, medicine.anatomical_structure, female, pregnancy diabetes mellitus, Pregnancy Trimester, Second, Cohort, Amniocentesis, ADAMTS4 Protein, Female, ADAMTS5 protein, human, prospective study, Adult, medicine.medical_specialty, tumor necrosis factor, ADAMTS4 Protein/*metabolism, ADAMTS5 Protein/*metabolism, Amniotic Fluid/*chemistry, Diabetes, Gestational/*metabolism, Humans, Interleukin-6/*metabolism, Pregnancy Trimester, Second/*metabolism, Tumor Necrosis Factor-alpha/*metabolism, interleukin 6, IL6 protein, human, chemistry, Article, second trimester pregnancy, Internal medicine, medicine, aggrecanase 1, controlled study, human, Interleukin 6, business.industry, Interleukin-6, Tumor Necrosis Factor-alpha, aggrecanase 2, case control study, medicine.disease, Amniotic Fluid, body mass, Diabetes, Gestational, age, biology.protein, amniocentesis, ADAMTS5 Protein, business, Body mass index, metabolism

الوصف: Aim: To test the hypothesis that altered A Disintegrin and Metalloproteinase Domains with Thrombospondins motifs (ADAMTS) is implicated in the etiopathogenesis of gestational diabetes mellitus (GDM). Methods: All pregnant women who underwent elective amniocentesis for karyotype analysis between January 1, 2016, and January 1, 2018, were included in this study. From this cohort, the study group consisting of 20 patients diagnosed with GDM was selected and compared against a control group consisting of 20 age- and body mass index (BMI)-matched patients without GDM. ADAMTS4, ADAMTS5, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels were compared in the second trimester amniotic fluid of patients with GDM and normoglycemic pregnant women. Results: No significant differences were observed between GDM and control groups regarding age, BMI, gestational age at amniocentesis and indication for amniocentesis. Mean amniotic fluid ADAMTS4 and ADAMTS5 levels were significantly increased in the GDM group compared with the control group (253.5 ± 18.7 pg/mL and 188.5 ± 21.3 pg/mL, P < 0.001; 192.9 ± 16.4 pg/mL and 154.8 ± 19.9 pg/mL, P = 0.021, respectively). Significant increases in IL-6 and TNF-α levels were also detected in the amniotic fluid of GDM patients relative to controls (136.2 ± 17.3 pg/mL and 98.3 ± 11.5 pg/mL, P < 0.001; 154.2 ± 12.5 pg/mL and 86.2 ± 10.8 pg/mL, P < 0.001, respectively). Conclusion: The data presented here suggest that increased levels of ADAMTS4, ADAMTS5, IL-6 and TNF-α may play an important role in the progression of GDM. © 2019 Japan Society of Obstetrics and Gynecology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d970e0e847e97fe40e45e72ba775f41Test

المؤلفون: Nurhan Şahin, Rauf Melekoglu, Ayse Gulcin Bastemur, Mehmet Gul, Ebru Inci Coskun, Semir Gul, Ercan Yilmaz, Barış Çıplak

المساهمون: ŞAHİN, NURHAN

المصدر: Journal of International Medical Research, Vol 46 (2018)

مصطلحات موضوعية: Adult, 0301 basic medicine, Medicine (General), Nedd4 Ubiquitin Protein Ligases, Gene Expression, a new biomarker in the pathophysiology of endometrial cancer-, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.46, ss.3709-3716, 2018 [YILMAZ E., GÜL M., MELEKOĞLU R., Coskun E. I. , Sahin N., GÜL S., BAŞTEMUR A. G. , Ciplak B., -Neural precursor cell-expressed developmentally down-regulated 4-like], Adenocarcinoma, medicine.disease_cause, Biochemistry, 03 medical and health sciences, R5-920, Polyps, 0302 clinical medicine, Ubiquitin, Precursor cell, medicine, Humans, Aged, Retrospective Studies, Uterine Diseases, NEDD4L, biology, business.industry, Endometrial cancer, Biochemistry (medical), Cancer, Cell Biology, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Endometrial Neoplasms, Cell biology, Endometrial hyperplasia, 030104 developmental biology, 030220 oncology & carcinogenesis, Endometrial Hyperplasia, biology.protein, Biomarker (medicine), Female, Carcinogenesis, business

الوصف: Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n = 23), patients with endometrial hyperplasia (Group 2, n = 21) and patients with endometrial cancer (Group 3, n = 20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e4377433247063a37897e598ff34d8Test
http://hdl.handle.net/20.500.12645/24743Test