المؤلفون: Fourgeaud, Jacques, Magny, Jean-François, Couderc, Sophie, Garcia, Patricia, Maillotte, Anne-Marie, Benard, Melinda, Pinquier, Didier, Minodier, Philippe, Astruc, Dominique, Patural, Hugues, Ugolin, Melissa, Parat, Sophie, Guillois, Bernard, Garenne, Armelle, Guilleminot, Tiffany, Parodi, Marine, Bussières, Laurence, Ville, Yves, Leruez-Ville, Marianne

المساهمون: Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS Poissy, Hôpital de la Conception CHU - APHM (LA CONCEPTION), Hôpital Archet 2 Nice (CHU), Service Néonatologie CHU Toulouse, Pôle Enfants CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de Pédiatrie Néonatale et Réanimation – Neuropédiatrie CHU Rouen, Hôpital Charles Nicolle Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Nord CHU - APHM, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Service de Réanimation pédiatrique et Néonatalogie CHU Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre d'Investigation Clinique Rennes (CIC), Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Maternité Port-Royal CHU Cochin, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin AP-HP, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire de Virologie CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP

المصدر: ISSN: 0022-3476.

مصطلحات موضوعية: MESH: Cytomegalovirus / genetics, MESH: Cytomegalovirus Infections* / complications, MESH: DNA, Viral / analysis, MESH: Infant, Newborn, Diseases, MESH: Pregnancy, MESH: Real-Time Polymerase Chain Reaction, MESH: Saliva / chemistry, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics

الوصف: International audience ; Objective: To evaluate cytomegalovirus (CMV) viral load dynamics in blood and saliva during the first two years of life in symptomatic and asymptomatic infected infants and to identify whether these kinetics could have practical clinical implications.Study design: The Cymepedia cohort prospectively included 256 congenitally infected neonates followed for two years. Whole blood and saliva were collected at inclusion, months 4 and 12, and saliva at months 18 and 24. Real-time CMV PCR was performed, results expressed as log10 IU/mL in blood and in copies/mL in saliva.Results: Viral load in saliva progressively decreased from 7.5 log10 at birth to 3.3 log10 at month 24. CMV PCR in saliva was positive in 100% and 96% of infants at 6 and 12 months, respectively. In the first month of life, neonatal saliva viral load <5 log10 was related to a late CMV transplacental passage. Detection in blood was positive in 92% (147/159) of neonates in the first month of life. No viral load threshold values in blood or saliva could be associated with a high risk of sequelae. Neonatal blood viral load <3 log10 IU/ml had a 100% negative predictive value (NPV) for long-term sequelae.Conclusions: Viral loads in blood and saliva by CMV PCR testing in congenital infection fall over the first 24 months. In this study of infants affected mainly after primary maternal infection during pregnancy, all salivary samples were positive in the first 6 months of life and sequelae were not seen in infants with neonatal blood viral load <3 log10 IU/mL.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36181870; hal-03903498; https://univ-rennes.hal.science/hal-03903498Test; https://univ-rennes.hal.science/hal-03903498/documentTest; https://univ-rennes.hal.science/hal-03903498/file/Fourgeaud%20et%20al.%20-%202022%20-%20Clinical%20value%20of%20serial%20quantitative%20analysis%20of%20.pdfTest; PUBMED: 36181870

الإتاحة: https://doi.org/10.1016/j.jpeds.2022.09.040Test
https://univ-rennes.hal.science/hal-03903498Test
https://univ-rennes.hal.science/hal-03903498/documentTest
https://univ-rennes.hal.science/hal-03903498/file/Fourgeaud%20et%20al.%20-%202022%20-%20Clinical%20value%20of%20serial%20quantitative%20analysis%20of%20.pdfTest

المؤلفون: Passini, Loïc, Le Bouedec, Stephane, Dassieu, Gilles, Reynaud, Audrey, Jung, Camille, Keller, Marie-Laurence, Lefebvre, Aline, Katty, Therese, Baleyte, Jean-Marc, Layese, Richard, Audureau, Etienne, Caeymaex, Laurence, SEPREVEN Study Group, Astruc, Dominique, Biran, Valérie, Marcus, Leila, Beghin, Laurent, Guillois, Bernard, Remichi, Radia, Harbi, Faiza, Durrmeyer, Xavier, Casagrande, Florence, Lesaché, Nolwenn, Todorova, Darina, Bilal, Ali, Olivier, Damien, Jacquin, Cécile, Roze, Jean-Christophe, Danan, Claude, Decobert, Fabrice

مصطلحات موضوعية: Original research

الوصف: Importance Surveys based on hypothetical situations suggest that health-care providers agree that disclosure of errors and adverse events to patients and families is a professional obligation but do not always disclose them. Disclosure rates and reasons for the choice have not previously been studied. Objective To measure the proportion of errors disclosed by neonatal intensive care unit (NICU) professionals to parents and identify motives for and barriers to disclosure. Design Prospective, observational study nested in a randomised controlled trial (Study on Preventing Adverse Events in Neonates (SEPREVEN); ClinicalTrials.gov). Event disclosure was not intended to be related to the intervention tested. Setting 10 NICUs in France with a 20-month follow-up, starting November 2015. Participants n=1019 patients with NICU stay ≥2 days with ≥1 error. Exposure Characteristics of errors (type, severity, timing of discovery), patients and professionals, self-reported motives for disclosure and non-disclosure. Main outcome and measures Rate of error disclosure reported anonymously and voluntarily by physicians and nurses; perceived parental reaction to disclosure. Results Among 1822 errors concerning 1019 patients (mean gestational age: 30.8±4.5 weeks), 752 (41.3%) were disclosed. Independent risk factors for non-disclosure were nighttime discovery of error (OR 2.40; 95% CI 1.75 to 3.30), milder consequence (for moderate consequence: OR 1.85; 95% CI 0.89 to 3.86; no consequence: OR 6.49; 95% CI 2.99 to 14.11), a shorter interval between admission and error, error type and fewer beds. The most frequent reported reasons for non-disclosure were parental absence at its discovery and a perceived lack of serious consequence. Conclusion and relevance In the particular context of the SEPREVEN randomised controlled trial of NICUs, staff did not disclose the majority of errors to parents, especially in the absence of moderate consequence for the infant. Trial registration number NCT02598609 .

وصف الملف: text/html

العلاقة: http://qualitysafety.bmj.com/cgi/content/short/32/10/589Test; http://dx.doi.org/10.1136/bmjqs-2022-015247Test

الإتاحة: https://doi.org/10.1136/bmjqs-2022-015247Test
http://qualitysafety.bmj.com/cgi/content/short/32/10/589Test

المؤلفون: Nakhleh-Philippe, Pauline, Zores, Claire, Stern-Delfils, Amélie, Escande, Benoît, Astruc, Dominique, Severac, François, Kuhn, Pierre

المصدر: Frontiers in Pediatrics ; volume 11 ; ISSN 2296-2360

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الوصف: Objectives We aimed to evaluate (1) whether sedation analgesia (SA) used during therapeutic hypothermia (TH) was efficient to support the wellbeing of neonates with hypoxic-ischemic encephalopathy, (2) the SA level and its adjustment to clinical pain scores, and (3) the impact of inadequate SA on short-term neonatal outcomes evaluated at discharge. Methods This was an observational retrospective study performed between 2011 and 2018 in two level III centers in Alsace, France. We analyzed the wellbeing of infants by using the COMFORT-Behavior (COMFORT-B) clinical score and SA level during TH, according to which we classified infants into four groups: those with excess SA, adequate SA, lack of SA, and variability of SA. We analyzed the variations in doses of SA and their justification. We also determined the impact of inadequate SA on neonatal outcomes at discharge by multivariate analyses with multinomial regression, with adequate SA as the reference. Results A total of 110 patients were included, 89 from Strasbourg university hospital and 21 from Mulhouse hospital. The COMFORT-B score was assessed 95.5% of the time. Lack of SA was mainly found on the first day of TH (15/110, 14%). In all, 62 of 110 (57%) infants were in excess of SA over the entire duration of TH. Most dose variations were related to clinical pain scores. Inadequate SA was associated with negative short-term consequences. Infants with excess of SA had a longer duration of mechanical ventilation [mean ratio 1.46, 95% confidence interval (CI), 1.13–1.89, p = 0.005] and higher incidence of abnormal neurological examination at discharge (odds ratio 2.61, 95% CI, 1.10–6.18, p = 0.029) than infants with adequate SA. Discussion Adequate SA was not easy to achieve during TH. Close and regular monitoring of SA level may help achieve adequate SA. Excess of SA can be harmful for newborns with hypoxic-ischemic encephalopathy who are undergoing TH.

الإتاحة: https://doi.org/10.3389/fped.2023.1057724Test

المؤلفون: Fourgeaud, Jacques, Magny, Jean-François, Couderc, Sophie, Garcia, Patricia, Maillotte, Anne-Marie, Benard, Melinda, Pinquier, Didier, Minodier, Philippe, Astruc, Dominique, Patural, Hugues, Parat, Sophie, Guillois, Bernard, Garenne, Armelle, Guilleminot, Tiffany, Parodi, Marine, Bussières, Laurence, Ghout, Idir, Ville, Yves, Leruez-Ville, Marianne

المصدر: Pediatrics; Apr2024, Vol. 153 Issue 4, p1-9, 9p

المؤلفون: Caeymaex, Laurence, Astruc, Dominique, Biran, Valérie, Marcus, Leila, Flamein, Florence, Le Bouedec, Stephane, Guillois, Bernard, Remichi, Radia, Harbi, Faiza, Durrmeyer, Xavier, Casagrande, Florence, Le Saché, Nolwenn, Todorova, Darina, Bilal, Ali, Olivier, Damien, Reynaud, Audrey, Jacquin, Cécile, Rozé, Jean-Christophe, Layese, Richard, Danan, Claude, Jung, Camille, Decobert, Fabrice, Audureau, Etienne

المصدر: The Lancet ; volume 399, issue 10322, page 384-392 ; ISSN 0140-6736

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/s0140-6736Test(21)01899-7
https://api.elsevier.com/content/article/PII:S0140673621018997?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0140673621018997?httpAccept=text/plainTest

المؤلفون: Klein, Valérie, Zores-Koenig, Claire, Dillenseger, Laurence, Langlet, Claire, Escande, Benoît, Astruc, Dominique, Le Ray, Isabelle, Kuhn, Pierre

المصدر: Frontiers in Pediatrics ; volume 9 ; ISSN 2296-2360

الوصف: Introduction: Many studies have evaluated the Neonatal Individualized Developmental Care and Assessment Program (NIDCAP), but few studies have assessed changes in infant- and family-centered developmental care (IFCDC) practices during its implementation. Objectives: The primary objective of this single center study was to investigate the impact of the implementation of the NIDCAP program on IFCDC practices used for management of extremely preterm infants (EPIs). The secondary objective was to determine during implementation the impact of this program on the short-term medical outcomes of all EPIs hospitalized at our center. Methods: All EPIs (<28 weeks gestational age) who were hospitalized at Strasbourg University Hospital from 2007 to 2014 were initially included. Outborn infants were excluded. The data of EPIs were compared for three time periods: 2007 to 2008 (pre-NIDCAP), 2010 to 2011, and 2013 to 2014 (during-NIDCAP implementation) using appropriate statistical tests. The clinical and caring procedures used during the first 14 days of life were analyzed, with a focus on components of individualized developmental care (NIDCAP observations), infant pain management (number of painful procedures, clinical pain assessment), skin-to-skin contact (SSC; frequency, day of initiation, and duration), and family access and involvement in the care of their children (duration of parental presence, parental participation in care). The short-term mortality and morbidity at discharge were evaluated. Results: We examined 228 EPIs who received care during the three time periods. Over time, painful procedures decreased, but pain evaluations, parental involvement in care, individualized observations, and SSC increased (all p < 0.01). In addition, the first SSC was performed earlier ( p = 0.03) and lasted longer ( p < 0.01). There were no differences in mortality and morbidity, but there were reductions in the duration of mechanical ventilation ( p = 0.02) and the time from birth to first extubation ( p = ...

الإتاحة: https://doi.org/10.3389/fped.2021.718813Test

المؤلفون: Danion, François, Duval, Céline, Séverac, François, Bachellier, Philippe, Candolfi, Ermanno, Castelain, Vincent, Clere-Jehl, Raphaël, Denis, Julie, Dillenseger, Laurence, Epailly, Eric, Gantzer, Justine, Guffroy, Blandine, Hansmann, Yves, Herbrecht, Jean-Etienne, Letscher-Bru, Valérie, Leyendecker, Pierre, Le Van Quyen, Pauline, Ludes, Pierre-Olivier, Morel, Guillaume, Moulin, Bruno, Paillard, Catherine, Renaud-Picard, Benjamin, Roche, Anne-Claude, Sabou, Marcela, Schneider, Francis, Solis, Morgane, Talagrand-Reboul, Emilie, Veillon, Francis, Ledoux, Marie-Pierre, Simand, Célestine, Herbrecht, Raoul, Addeo, Pietro Francesco, Astruc, Dominique, Baldacini, Mathieu, Bilger, Karin, Chenard, Marie-Pierrette, Collange, Olivier, Degot, Tristan, Dhif, Nadia, Dicop, Elise, Fafi-Kremer, Samira, Fornecker, Luc-Matthieu, Fuseau, Charline, Guillot, Max, Harlay, Mary-Line, Janssen-Langenstein, Ralf, Jaulhac, Benoît, Kaeuffer, Charlotte, Kessler, Romain, Kummerlen, Christine

المصدر: Clinical Microbiology and Infection ; volume 27, issue 11, page 1644-1651 ; ISSN 1198-743X

مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), General Medicine

الإتاحة: https://doi.org/10.1016/j.cmi.2021.02.021Test
https://api.elsevier.com/content/article/PII:S1198743X21001038?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1198743X21001038?httpAccept=text/plainTest

المؤلفون: Durand, Benjamin, Stoetzel, Corinne, Schaefer, Elise, Calmels, Nadège, Scheidecker, Sophie, Kempf, Nadine, De Melo, Charlie, Guilbert, Anne-Sophie, Timbolschi, Dana, Donato, Leonardo, Astruc, Dominique, Sauer, Arnaud, Antal, Maria Cristina, Dollfus, Hélène, El Chehadeh, Salima

المصدر: European Journal of Medical Genetics ; volume 63, issue 4, page 103857 ; ISSN 1769-7212

مصطلحات موضوعية: Genetics (clinical), Genetics, General Medicine

الإتاحة: https://doi.org/10.1016/j.ejmg.2020.103857Test
https://api.elsevier.com/content/article/PII:S1769721219306731?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1769721219306731?httpAccept=text/plainTest

المؤلفون: Dillenseger, Laurence, Langlet, Claire, Iacobelli, Silvia, Lavaux, Thomas, Ratomponirina, Charline, Labenne, Marc, Astruc, Dominique, Severac, Francois, Gouyon, Jean-Bernard, Kuhn, Pierre

المساهمون: Hôpital de Hautepierre Strasbourg, CHU Sud Saint Pierre Ile de la Réunion, Centre d'Études Périnatales de l'Océan Indien (CEPOI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Hôpital de la Timone CHU - APHM (TIMONE), Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS)

المصدر: ISSN: 2296-2360 ; Frontiers in Pediatrics ; https://hal.univ-reunion.fr/hal-02015117Test ; Frontiers in Pediatrics, 2018, 6, pp.346. ⟨10.3389/fped.2018.00346⟩.

مصطلحات موضوعية: Late-onset neonatal sepsis, newborn infant, C-reactive protein, Procalcitonin, Interleukin 6, Interleukin 8, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Background: Early diagnosis is essential to improve the treatment and prognosis of newborn infants with nosocomial bacterial infections. Although cytokines and procalcitonin (PCT) have been evaluated as early inflammatory markers, their diagnostic properties have rarely been compared.Objectives: This study evaluated and compared the ability of individual inflammatory markers available for clinician (PCT, semi-quantitative determination of IL-8) and of combinations of markers (CRPi plus IL-6 or quantitative or semi-quantitative determination of IL-8) to diagnose bacterial nosocomial infections in neonates.Methods: This prospective two-center study included neonates suspected of nosocomial infections from September 2008 to January 2012. Inflammatory markers were measured initially upon suspicion of nosocomial infection, and CRP was again measured 12–24 h later. Newborns were retrospectively classified into two groups: those who were infected (certainly or probably) and uninfected (certainly or probably).Results: The study included 130 infants of median gestational age 28 weeks (range, 24–41 weeks). Of these, 34 were classified as infected and 96 as uninfected. The sensitivity, specificity, positive and negative predictive values (PPV and NPV), and positive and negative likelihood ratios (LR+ and LR-) for PCT were 59.3% (95% confidence interval [CI], 38.8–77.6%), 78.5% (95% CI, 67.8–86.9%), 48.5% (95% CI, 30.8–66.5%), 84.9% (95% CI, 74.6–92.2%), 2.7 (95% CI, 1.6–4.9), and 0.5 (95% CI, 0.3–0.8), respectively. Semi-quantitative IL-8 had the highest specificity (92.19%; 95% CI, 82.70–97.41%), PPV (72.22%; 95% CI, 46.52–90.30%) and LR+ (6.17, 95% CI, 2.67–28.44), but had low specificity (48.15%; 95% CI, 28.67–68.05%). Of all markers tested, the combination of IL-6 and CRPi had the highest sensitivity (78.12%; 95% CI, 60.03–90.72%), NPV (91.3%; 95% CI, 82.38–96.32%) and LR- (0.29; 95% CI, 0.12–0.49). The combination of IL-6 and CRPi had a higher area under the curve than PCT, but with borderline ...

العلاقة: hal-02015117; https://hal.univ-reunion.fr/hal-02015117Test; https://hal.univ-reunion.fr/hal-02015117/documentTest; https://hal.univ-reunion.fr/hal-02015117/file/2018%20Dillenseger%20L.%20Early%20inflammatory%20markers%20for%20the%20diagnosis.pdfTest

الإتاحة: https://doi.org/10.3389/fped.2018.00346Test
https://hal.univ-reunion.fr/hal-02015117Test
https://hal.univ-reunion.fr/hal-02015117/documentTest
https://hal.univ-reunion.fr/hal-02015117/file/2018%20Dillenseger%20L.%20Early%20inflammatory%20markers%20for%20the%20diagnosis.pdfTest

المؤلفون: Gallais, Floriane, Denis, Julie, Koobar, Olfa, Dillenseger, Laurence, Astruc, Dominique, Herbrecht, Raoul, Candolfi, Ermanno, Letscher-Bru, Valérie, Sabou, Marcela

المصدر: BMC Infectious Diseases ; volume 17, issue 1 ; ISSN 1471-2334

مصطلحات موضوعية: Infectious Diseases

الإتاحة: https://doi.org/10.1186/s12879-017-2646-8Test