المؤلفون: Ashot M. Mkrtumyan

المصدر: Терапевтический архив, Vol 96, Iss 4, Pp 419-428 (2024)

مصطلحات موضوعية: prediabetes, carbohydrate metabolism early disorders, impaired glucose tolerance, type 2 diabetes mellitus, insulin resistance, subetta®, metformin, Medicine

الوصف: In the contemporary reality pharmacological correction of the early carbohydrate metabolism disorders is the main method for the type 2 diabetes prevention. Taking into account the main role of insulin resistance in the prediabetes development it can be supposed that pharmacological agents directly activating the insulin receptor are the pathogenic-base therapy for prediabetes treatment. Such kind of this pathogenic therapy is Subetta® – a representative of the class of biological drugs created using the based graduated technology. Due to the absent of the direct comparative trials of Subetta® versus metformin in the efficacy of the type 2 diabetes prevention in prediabetes patients, was performed an analysis of the effectiveness of these two drugs using the adjusted indirect comparison method of the results of the randomized double-blind placebo-controlled clinical trial of Subetta® efficacy and safety in impaired glucose tolerance patients with the results of several metformin studies similar in inclusion and efficacy criteria. The results indicate greater Subetta® efficacy in the treatment of glucose intolerance and metformin's – in the impaired fasting glucose treatment, which can be explained by the differences in the action mechanisms of these two drugs for prediabetes treatment.

وصف الملف: electronic resource

العلاقة: https://ter-arkhiv.ru/0040-3660/article/viewFile/631557/146969Test; https://doaj.org/toc/0040-3660Test; https://doaj.org/toc/2309-5342Test

الوصول الحر: https://doaj.org/article/31675a1739eb4f31b3271eab13538c6cTest

المؤلفون: Igor V. Maev, Ashot M. Mkrtumyan, Luiza G. Bektemirova, Dmitry N. Andreev, Diana T. Dicheva

المصدر: Терапевтический архив, Vol 94, Iss 2, Pp 209-215 (2022)

مصطلحات موضوعية: helicobacter pylori infection, eradication therapy, diabetes mellitus, efficacy of eradication therapy, simultaneous therapy, Medicine

الوصف: Aim. Evaluation of the efficacy and safety of eradication therapy of infection Helicobacter pylori in patients with H. pylori- associated pathology of the upper gastrointestinal tract and concomitant type 2 diabetes mellitus (DM). Materials and methods. The prospective randomized study involving 180 patients (87 men and 93 women) with H. pylori- associated pathology of the upper gastrointestinal tract was carried out. The patients were divided into four groups of 45 people: 1 patients without diabetes who received the classic triple eradication therapy; 2 patients with type 2 DM who received the classic triple eradication therapy; 3 patients without DM who underwent quadrotherapy with bismuth preparations; 4 patients with type 2 DM who underwent quadrotherapy with bismuth preparations. Eradication therapy was carried out for 14 days. Evaluation of the effectiveness of eradication using a breath test was carried out 4 weeks after completion of the course of treatment. Eradication success was assessed separately for ITT and PP analyzes. Results. The effectiveness of classical triple eradication therapy in patients with concomitant type 2 DM is 64.4% in the ITT group and 69.05% in the PP: quadrotherapy 73.34 and 80.49%, respectively. The effectiveness of first line eradication therapy is higher in patients without DM compared with groups of patients with concomitant type 2 DM: ITT 83.33%, PP 88.23% and ITT 68.89%, PP 74.70%, respectively. The incidence of side effects in patients with type 2 DM: with the use of classical triple therapy 22.23%, quadrotherapy 31.12%. Conclusion. The data of the study of the efficacy and safety of line I eradication therapy make it possible to recommend the four-component therapy based on bismuth for use in clinical practice, especially in patients with DM.

وصف الملف: electronic resource

العلاقة: https://ter-arkhiv.ru/0040-3660/article/viewFile/105560/79976Test; https://doaj.org/toc/0040-3660Test; https://doaj.org/toc/2309-5342Test

الوصول الحر: https://doaj.org/article/90086d93d5204a3ba3c7ccc8b030d636Test

المؤلفون: Ivan I. Dedov, Marina V. Shestakova, Alexander Y. Mayorov, Minara S. Shamkhalova, Olga Yu. Sukhareva, Gagik R. Galstyan, Alla Y. Tokmakova, Tatiana V. Nikonova, Elena V. Surkova, Irina V. Kononenko, Daria N. Egorova, Lyudmila I. Ibragimova, Ekaterina A. Shestakova, Inna I. Klefortova, Igor A. Sklyanik, Ivona Ya. Yarek-Martynova, Anastasia S. Severina, Sergey A. Martynov, Olga K. Vikulova, Viktor Y. Kalashnikov, Irina Z. Bondarenko, Irina S. Gomova, Elena G. Starostina, Alexander S. Ametov, Mikhail B. Antsiferov, Tatiana P. Bardymova, Irina A. Bondar, Farida V. Valeeva, Tatiana Y. Demidova, Ashot M. Mkrtumyan, Nina A. Petunina, Lyudmila A. Ruyatkina, Lyudmila A. Suplotova, Olga V. Ushakova, Yurii Sh. Khalimov

المصدر: Сахарный диабет, Vol 23, Iss 2S, Pp 4-102 (2020)

مصطلحات موضوعية: type 2 diabetes mellitus, adults, clinical guidlines, Nutritional diseases. Deficiency diseases, RC620-627

الوصف: Public organization “Russian Association of Endocrinologists”. Clinical guidelines.

وصف الملف: electronic resource

العلاقة: https://www.dia-endojournals.ru/jour/article/view/12507Test; https://doaj.org/toc/2072-0351Test; https://doaj.org/toc/2072-0378Test

الوصول الحر: https://doaj.org/article/294c9e40a2044186a97a78a328cbab76Test

المؤلفون: Ivan I. Dedov, Marina V. Shestakova, Alexander Y. Mayorov, Minara S. Shamkhalova, Tatiana V. Nikonova, Olga Y. Sukhareva, Elena V. Pekareva, Lyudmila I. Ibragimova, Margarita S. Mikhina, Gagik R. Galstyan, Alla Y. Tokmakova, Elena V. Surkova, Dmitry N. Laptev, Irina V. Kononenko, Daria N. Egorova, Inna I. Klefortova, Igor A. Sklyanik, Ivona Ya. Yarek-Martynova, Anastasia S. Severina, Sergey A. Martynov, Olga K. Vikulova, Viktor Y. Kalashnikov, Irina S. Gomova, Dmitry V. Lipatov, Elena G. Starostina, Alexander S. Ametov, Mikhail B. Antsiferov, Tatiana P. Bardymova, Irina A. Bondar, Farida V. Valeeva, Tatiana Y. Demidova, Vadim V. Klimontov, Ashot M. Mkrtumyan, Nina A. Petunina, Lyudmila A. Suplotova, Olga V. Ushakova, Yurii Sh. Khalimov, Lyudmila A. Ruyatkina

المصدر: Сахарный диабет, Vol 23, Iss 1S, Pp 42-114 (2020)

مصطلحات موضوعية: type 1 diabetes mellitus, adults, clinical guidlines, Nutritional diseases. Deficiency diseases, RC620-627

الوصف: Public organization “Russian Association of Endocrinologists”. Clinical guidlines.

وصف الملف: electronic resource

العلاقة: https://www.dia-endojournals.ru/jour/article/view/12505Test; https://doaj.org/toc/2072-0351Test; https://doaj.org/toc/2072-0378Test

الوصول الحر: https://doaj.org/article/ea1852a3176049e3be057b302d59ae6fTest

المؤلفون: Ivan I. Dedov, Galina A. Mel'nichenko, Marina V. Shestakova, Ekaterina A. Troshina, Natalya V. Mazurina, Ekaterina A. Shestakova, Yuriy I. Yashkov, Alexander E. Neimark, Elena V. Biryukova, Irina Z. Bondarenko, Natalia S. Bordan, Fatima H. Dzgoeva, Ekaterina V. Ershova, Kseniya A. Komshilova, Ashot M. Mkrtumyan, Nina A. Petunina, Tatiana I. Romantsova, Elena G. Starostina, Leonid G. Strongin, Ludmila A. Suplotova, Valentin V. Fadeyev

المصدر: Ожирение и метаболизм, Vol 15, Iss 1, Pp 53-70 (2018)

مصطلحات موضوعية: arterial hypertension, gastric banding, bariatric / metabolic surgery, biliopancreatic diversion (bpd), hypocaloric nutrition, gastric bypass, liraglutide, morbid obesity, obesity, orlistat, sleeve gastrectomy, type 2 diabetes, sibutramin, obstructive sleep apnoe, physical activity, Physiology, QP1-981, Biochemistry, QD415-436

الوصف: The presented paper is a third revision of the clinical recommendations for the treatment of morbid obesity in adults. Morbid obesity is a condition with body mass index (BMI) ≥40 kg / m2 or a BMI ≥35 kg / m2 in the presence of serious complications associated with obesity. The recommendations provide data on the prevalence of obesity, its etiology and pathogenesis, as well as on associated complications. The necessary methods for laboratory and instrumental diagnosis of obesity are described in detail. In this revision of the recommendations, the staging of prescribing conservative and surgical methods for the treatment of obesity are determined. For the first time, a group of patients with obesity and type 2 diabetes mellitus is selected, in whom metabolic surgery allows a long-term improvement in the control of glycemia or remission of diabetes mellitus.

وصف الملف: electronic resource

العلاقة: https://www.omet-endojournals.ru/jour/article/view/9629Test; https://doaj.org/toc/2071-8713Test; https://doaj.org/toc/2306-5524Test

الوصول الحر: https://doaj.org/article/659e495a1c7f47e9829c1bd752e45492Test

المؤلفون: Ashot M. Mkrtumyan, Lilit V. Egshatyan

المصدر: Ожирение и метаболизм, Vol 14, Iss 3, Pp 19-24 (2017)

مصطلحات موضوعية: testosterone, androgen deficiency, obesity, metabolic malfunctions, diabetes mellitus, insulinresistance, Physiology, QP1-981, Biochemistry, QD415-436

الوصف: The article provides an overview of the current literature integrating clinical data on the role of androgen deficiency in pathogenesis of metabolic malfunctions and diabetes mellitus. The combination of androgen deficiency and diabetes mellitus is a risk factor of cardiovascular diseases. Due to the fact that general physicians, endocrinologist don’t have knowledge of this problem most of androgen deficiency cases are not only remained without treatment but also not revealed.

وصف الملف: electronic resource

العلاقة: https://www.omet-endojournals.ru/jour/article/view/9446Test; https://doaj.org/toc/2071-8713Test; https://doaj.org/toc/2306-5524Test

الوصول الحر: https://doaj.org/article/cff46f5c9f3f4c8eaf8e0cddcf3bc0b1Test

المؤلفون: Irina P. Balmasova, Evgenii I. Olekhnovich, Ksenia M. Klimina, Anna A. Korenkova, Maria T. Vakhitova, Elmar A. Babaev, Leyla A. Ovchinnikova, Yakov A. Lomakin, Ivan V. Smirnov, Victor N. Tsarev, Ashot M. Mkrtumyan, Alexey A. Belogurov, Alexander G. Gabibov, Elena N. Ilina, Sergey D. Arutyunov

المصدر: Pathogens, Vol 10, Iss 5, p 504 (2021)

مصطلحات موضوعية: oral microbiome, type 2 diabetes mellitus, periodontitis, 16S rRNA gene sequencing, metagenomics, Medicine

الوصف: Since periodontitis and type 2 diabetes mellitus are complex diseases, a thorough understanding of their pathogenesis requires knowing the relationship of these pathologies with other disorders and environmental factors. In this study, the representability of the subgingival periodontal microbiome of 46 subjects was studied by 16S rRNA gene sequencing and shotgun sequencing of pooled samples. We examined 15 patients with chronic periodontitis (CP), 15 patients with chronic periodontitis associated with type 2 diabetes mellitus (CPT2DM), and 16 healthy subjects (Control). The severity of generalized chronic periodontitis in both periodontitis groups of patients (CP and CPT2DM) was moderate (stage II). The male to female ratios were approximately equal in each group (22 males and 24 females); the average age of the subjects was 53.9 ± 7.3 and 54.3 ± 7.2 years, respectively. The presence of overweight patients (Body Mass Index (BMI) 30–34.9 kg/m2) and patients with class 1–2 obesity (BMI 35–45.9 kg/m2) was significantly higher in the CPT2DM group than in patients having only chronic periodontitis or in the Control group. However, there was no statistically significant difference in all clinical indices between the CP and CPT2DM groups. An analysis of the metagenomic data revealed that the alpha diversity in the CPT2DM group was increased compared to that in the CP and Control groups. The microbiome biomarkers associated with experimental groups were evaluated. In both groups of patients with periodontitis, the relative abundance of Porphyromonadaceae was increased compared to that in the Control group. The CPT2DM group was characterized by a lower relative abundance of Streptococcaceae/Pasteurellaceae and a higher abundance of Leptotrichiaceae compared to those in the CP and Control groups. Furthermore, the CP and CPT2DM groups differed in terms of the relative abundance of Veillonellaceae (which was decreased in the CPT2DM group compared to CP) and Neisseriaceae (which was increased in the CPT2DM group compared to CP). In addition, differences in bacterial content were identified by a combination of shotgun sequencing of pooled samples and genome-resolved metagenomics. The results indicate that there are subgingival microbiome-specific features in patients with chronic periodontitis associated with type 2 diabetes mellitus.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-0817/10/5/504Test; https://doaj.org/toc/2076-0817Test

الوصول الحر: https://doaj.org/article/f0365e816eb84d42b61522990f44b106Test

المؤلفون: Sergey V. Kakorin, Ruben A. Iskandaryan, Ashot M. Mkrtumyan

المصدر: Сахарный диабет, Vol 19, Iss 3, Pp 221-228 (2016)

مصطلحات موضوعية: type 2 diabetes mellitus, chronic heart failure (chf), cardiovascular mortality, cardiovascular disease (cvd), acute myocardial infarction, hyperglycemia, glycated hemoglobin, metformin, sulfonylurea derivates, insulin, dpp-4 inhibitors, sglt-2 inhibitors, Nutritional diseases. Deficiency diseases, RC620-627

الوصف: The use of modern pharmaceuticals and cardiovascular disease (CVD) treatment methods has increased life expectancy and improved the quality of life of both patients with normal carbohydrate metabolism and diabetes mellitus (DM). This study provides a review of the literature on glycaemic control and choice of glucose-lowering therapy in patients with type 2 DM (T2DM) and CVD. According to the latest recommendations for the prevention of CVD, the target level of glycated haemoglobin (HbA1c) should be less than 7.0% and 7.5%–8.0% in older patients to decrease the risk of hypoglycaemia. The target blood glucose level is 7.7–10 mmol/L. The results of randomized clinical trials (RCTs) revealed that the adverse effects of second-generation sulfonylureas include critical hypoglycaemia episodes and increases in CVD-associated complications and mortality. Metformin reduces the risk of CVD in comparison with second-generation sulfonylurea derivates and insulin. Thiazolidinediones are not currently used for patients with CVD, and the safety of GLP-1 analogues and SGLT-2 inhibitors is still under investigation. When metformin therapy is ineffective, DPP-4 inhibitors should be prescribed and renal function should be monitored. Metformin is contra-indicated in patients with severe chronic heart failure (CHF) and acute myocardial infarction (AMI) because of the risk of lactic acidosis with tissue hypoxia. Thus, insulin is the drug of choice for glycaemic control in CVD patients with chronic kidney disease, severe heart failure or other acute clinical conditions.

وصف الملف: electronic resource

العلاقة: https://www.dia-endojournals.ru/jour/article/view/7564Test; https://doaj.org/toc/2072-0351Test; https://doaj.org/toc/2072-0378Test

الوصول الحر: https://doaj.org/article/81527a880f0446f399dd85522567b619Test

المؤلفون: Sergey V. Kakorin, Ruben A. Iskandaryan, Ashot M. Mkrtumyan

المصدر: Сахарный диабет, Vol 19, Iss 2, Pp 141-149 (2016)

مصطلحات موضوعية: type 2 diabetes mellitus, chronic heart failure, cardiovascular mortality, hyperglycemia, glycated hemoglobin, insulin resistance, risk factors, epidemiology of cardiovascular disease, Nutritional diseases. Deficiency diseases, RC620-627

الوصف: A review of the scientific literature was conducted to investigate reducing mortality from acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM). This included a review of literature comparing cardiovascular disease (CVD) treatment methods for AMI patients who have T2DM and those with normal carbohydrate metabolism. These treatments increase the life expectancy and greatly improve the quality of life of patients with acute myocardial infarction in both groups of patients. However, the risk of cardiovascular mortality in patients with T2DM compared with people with normal carbohydrate metabolism remains unchanged. The rapidly growing population of patients with T2DM will soon change our attitude towards the possibility of improving the prognosis and treatment of those with CVD.

وصف الملف: electronic resource

العلاقة: https://www.dia-endojournals.ru/jour/article/view/7563Test; https://doaj.org/toc/2072-0351Test; https://doaj.org/toc/2072-0378Test

الوصول الحر: https://doaj.org/article/bb8f588030c447b9920ad02bf807fdf2Test

المؤلفون: Ashot M. Mkrtumyan, Larissa A. Zvenigorodskaya, Mikhail V. Shinkin

المصدر: Terapevticheskii arkhiv. 94:957-962

مصطلحات موضوعية: Glycated Hemoglobin, History, Microcirculation, Endocrinology, Diabetes and Metabolism, Laser-Doppler Flowmetry, Diabetes Mellitus, Humans, Hypoglycemic Agents, General Medicine, Family Practice, Diabetic Foot, Metformin

الوصف: To assess the state of the microvasculature, tissue metabolism and its reserve capabilities for the purpose of early intervention for the prevention of diabetic foot syndrome.Thirty patients were examined. The patients were divided into three groups depending on the hypoglycemic therapy (metformin, empagliflozin, dapagliflozin). The comparison group consisted of 12 volunteers who did not have carbohydrate metabolism disorders.It was found: the HbA1c indicator significantly decreased in all three groups; significant dynamics in the state of the microvasculature was not observed in any of the three groups; in all groups, there was an improvement in tissue metabolism, however, in this case, no significant dynamics were observed in any of the 3 groups, which indicates the need for provocative tests.For this purpose, the authors recommend the method of combined use of laser Doppler flowmetry and laser fluorescence spectroscopy. This technique allows diagnosing the state of the microvasculature and tissue metabolism and its reserve capabilities, using thermal and cold tests.Цель. Оценить состояние микроциркуляции и тканевого метаболизма в нижних конечностях у больных сахарным диабетом 2-го типа методами лазерной допплеровской флоуметрии и лазерной флуоресцентной спектроскопии с проведением провокационных проб (тепловой и холодовой). Материалы и методы. Обследованы 30 пациентов. Больные разделены на 3 группы в зависимости от проводимой сахароснижающей терапии (метформин, эмпаглифлозин, дапаглифлозин). Группу сравнения составляли 12 волонтеров, не имевших нарушений углеводного обмена. Результаты. Выявлено: показатель гликированного гемоглобина достоверно снизился во всех 3 группах; значительной динамики в состоянии микроциркуляторного русла не наблюдалось ни в одной из 3 групп; во всех группах отмечалось улучшение показателей тканевого метаболизма, однако и в данном случае значительной динамики не наблюдалось ни в одной из 3 групп, что свидетельствует о необходимости проведения провокационных проб. Заключение. Проведение нагрузочных проб позволяет выявить адаптивные возможности тканей (тепловая проба) и скрытые нарушения тканевого метаболизма (холодовая проба).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59123b4b4a1bd8d3955fa8dd06ae63bcTest
https://doi.org/10.26442/00403660.2022.08.201789Test