المؤلفون: Jha, Rajiv, Shrestha, Rajendra, Rajbhandari, Binod, Bhattarai, Sushil Mohan, Aryal, Sameer, Gautam, Sindhu, Jha, Binit, Karki, Anuj Jung

المصدر: Nepal Journal of Neuroscience; Vol. 21 No. 1 (2024): March; 24-28 ; 1813-1956 ; 1813-1948

مصطلحات موضوعية: Vestibular Schwannoma, CP angle, Facial nerve, Retrosigmoid, Retromastoid

جغرافية الموضوع: Nepal

الوصف: Background: Preservation of facial nerve injury is a key important factor in vestibular schwannoma surgery as facial paralysis has devastating functional and psychological consequences for patients. Objective: To correlate different factors resulting in facial nerve preservation in vestibular schwannoma surgery by retro mastoid retro sigmoid approach. Method: This is a retrospective analysis of facial nerve status of 212 cases of vestibular schwannoma microsurgery through Retrosigmoid Retromastoid (RSRM) approach. This study was carried out in National Neurosurgical Referral Center(NNRC), National Academy Of Medical Sciences (NAMS), Bir hospital between January 2016 to December 2022.Preoperative and post operative details of facial nerve function status compared according to House and Brackmann (H and B) grading system, and factors influencing outcome in facial nerve preservation were analyzed. Recurrent and residual tumors were excluded. Results: A total of 212 cases of vestibular schwannoma were operated during the study period. The average age of presentation was 47 years. Most common affected age group was 51-60 years. Female to male ratio was 3:2.5. The most common clinical symptoms for vestibular schwannoma were sensorineural hearing loss followed by headache and difficulty in limb coordination. Tumor size and consistency was most important indicator of facial nerve function outcome. Conclusion: The incidence of post operative facial palsy is found to be correlated to tumor size and consistency. Improvement of the facial nerve outcome is detected in patients undergone simultaneous intraoperative monitoring (IONM).

وصف الملف: application/pdf

العلاقة: https://www.nepjol.info/index.php/NJN/article/view/61342/49155Test; https://www.nepjol.info/index.php/NJN/article/view/61342Test

الإتاحة: https://www.nepjol.info/index.php/NJN/article/view/61342Test

المؤلفون: Aryal, Sameer, Longo, Francesco, Klann, Eric

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2021 May 01. 118(18), 1-11.

الوصول الحر: https://www.jstor.org/stable/27040362Test

المؤلفون: Farsi, Zohreh, Nicolella, Ally, Simmons, Sean, Aryal, Sameer, Shepard, Nate, Brenner, Kira, Lin, Sherry, Herzog, Linnea, Shin, Wangyong, Gazestani, Vahid, Song, Bryan, Bonanno, Kevin, Keshishian, Hasmik, Carr, Steven, Macosko, Evan, Datta, Sandeep, Dejanovic, Borislav, Kim, Eunjoon, Levin, Joshua, Sheng, Morgan

الوصف: Schizophrenia disease mechanisms remain poorly understood, in large part due to a lack of valid animal models. Rare heterozygous loss-of-function mutations in GRIN2A, encoding a subunit of the NMDA (N-methyl-d-aspartate) receptor, greatly increase the risk of schizophrenia. By transcriptomic, proteomic, electroencephalogram (EEG) recording and behavioral analysis, we report that heterozygous Grin2a mutant mice show: (i) large-scale gene expression changes across multiple brain regions and in neuronal (excitatory and inhibitory) and non-neuronal cells (astrocytes, oligodendrocytes); (ii) evidence of reduced activity in prefrontal cortex and increased activity in hippocampus and striatum; (iii) elevated dopamine signaling in striatum; (iv) altered cholesterol biosynthesis in astrocytes; (v) reduction of glutamatergic receptor signalin g proteins in the synapse; (iv) heightened gamma oscillation power in EEG; (vi) aberrant locomotor behavioral pattern opposite of that induced by antipsychotic drugs. These findings reveal potential pathophysiologic mechanisms, provide support for both the “hypo-glutamate” and “hyper-dopamine” hypotheses of schizophrenia, and underscore the utility of Grin2a-deficient mice as a new genetic model of schizophrenia.

العلاقة: https://zenodo.org/record/8145320Test; https://doi.org/10.5281/zenodo.8145320Test; oai:zenodo.org:8145320

الإتاحة: https://doi.org/10.5281/zenodo.8145320Test
https://doi.org/10.5281/zenodo.8145319Test
https://zenodo.org/record/8145320Test

المؤلفون: Paudel, Kumar, Rai, Prahasan, Khadka, Namrata, Bhattarai, Sushil Mohan, Rajbhandari, Binod, Aryal, Sameer, Shrestha, Rajendra, Jha, Rajiv

المصدر: Nepal Journal of Neuroscience; Vol. 20 No. 4 (2023): December; 69-71 ; 1813-1956 ; 1813-1948

مصطلحات موضوعية: Microsurgery, Brainstem, Cavernoma, Outcomes

الوصف: Cavernous malformation of brainstem is at increased risk of hemorrhage compared to supratentorial cavernomas. Increased morbidity associated with brainstem cavernoma (BCs) is defined by the inherent eloquence of the surrounding structures. At present watchful waiting, microsurgical resection and gamma knife surgery are the treatment modalities for symptomatic brainstem cavernoma. However, in the resource limited settings microsurgical excision by selecting an appropriate corridor can help in gross total removal in the meantime improving the neurological deficit and patient satisfaction. In this case series we have reviewed cavernomas of midbrain and pons, the technical difficulty with its management and its outcomes.

وصف الملف: application/pdf

العلاقة: https://www.nepjol.info/index.php/NJN/article/view/60640/46660Test; https://www.nepjol.info/index.php/NJN/article/view/60640Test

الإتاحة: https://www.nepjol.info/index.php/NJN/article/view/60640Test

المؤلفون: Longo, Francesco, Aryal, Sameer, Anastasiades, Paul G., Maltese, Marta, Baimel, Corey, Albanese, Federica, Tabor, Joanna, Zhu, Jeffrey D., Oliveira, Mauricio M., Gastaldo, Denise, Bagni, Claudia, Santini, Emanuela, Tritsch, Nicolas X., Carter, Adam G., Klann, Eric

المساهمون: Abney Foundation, Gunvor and Josef Anér's Foundation, Swedish Research Council, Magnus Bergvalls Stiftelse, US Department of Defense, National Institutes of Health

المصدر: Cell Reports ; volume 42, issue 8, page 112901 ; ISSN 2211-1247

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.celrep.2023.112901Test
https://api.elsevier.com/content/article/PII:S2211124723009129?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211124723009129?httpAccept=text/plainTest

المؤلفون: Aryal, Sameer, Bonanno, Kevin, Song, Bryan, Mani, D.R., Keshishian, Hasmik, Carr, Steven A., Sheng, Morgan, Dejanovic, Borislav

المصدر: Cell Reports ; volume 42, issue 5, page 112497 ; ISSN 2211-1247

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.celrep.2023.112497Test
https://api.elsevier.com/content/article/PII:S2211124723005089?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211124723005089?httpAccept=text/plainTest

المؤلفون: Adhikari, Manoj, Jha, Kanistika, Aryal, Sameer, Adhikari, Galav

المصدر: International Journal of Surgery Case Reports ; volume 111, page 108826 ; ISSN 2210-2612

مصطلحات موضوعية: Surgery

الإتاحة: https://doi.org/10.1016/j.ijscr.2023.108826Test
https://api.elsevier.com/content/article/PII:S2210261223009550?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2210261223009550?httpAccept=text/plainTest

المؤلفون: Aryal, Sameer, Klann, Eric

المصدر: Science, 2018 Aug . 361(6403), 648-649.

الوصول الحر: https://www.jstor.org/stable/26498210Test

المؤلفون: Shah, Nitesh R., Aryal, Sameer, Wen, Yi, Cherry, Christopher R.

المساهمون: United States Department of Transportation Research and Innovative Technology Administration

المصدر: Journal of Safety Research ; volume 77, page 217-228 ; ISSN 0022-4375

الإتاحة: https://doi.org/10.1016/j.jsr.2021.03.005Test
https://api.elsevier.com/content/article/PII:S0022437521000384?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022437521000384?httpAccept=text/plainTest

المؤلفون: Longo, Francesco, Mancini, Maria, Ibraheem, Pierre L., Aryal, Sameer, Mesini, Caterina, Patel, Jyoti C., Penhos, Elena, Rahman, Nazia, Mamcarz, Maggie, Santini, Emanuela, Rice, Margaret E., Klann, Eric

المصدر: Molecular Psychiatry; 20240101, Issue: Preprints p1-24, 24p

مستخلص: Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been shown to activate the eIF2α kinase PERK to directly regulate translation initiation. Tight control of PERK-eIF2α signaling has been shown to be necessary for normal long-lasting synaptic plasticity and cognitive function, including memory. In contrast, chronic activation of PERK-eIF2α signaling has been shown to contribute to pathophysiology, including memory impairments, associated with multiple neurological diseases, making this pathway an attractive therapeutic target. Herein, using multiple genetic approaches we show that selective deletion of the PERK in mouse midbrain dopaminergic (DA) neurons results in multiple cognitive and motor phenotypes. Conditional expression of phospho-mutant eIF2α in DA neurons recapitulated the phenotypes caused by deletion of PERK, consistent with a causal role of decreased eIF2α phosphorylation for these phenotypes. In addition, deletion of PERK in DA neurons resulted in altered de novo translation, as well as changes in axonal DA release and uptake in the striatum that mirror the pattern of motor changes observed. Taken together, our findings show that proper regulation of PERK-eIF2α signaling in DA neurons is required for normal cognitive and motor function in a non-pathological state, and also provide new insight concerning the onset of neuropsychiatric disorders that accompany UPR failure.