المؤلفون: Marinaro, Federica, Silva, Joana Maria Marques, Barros, Alexandre António Antunes, Aroso, Ivo Manuel Ascensão, Gómez-Blanco, Juan C., Jardin, Isaac, Lopez, Jose J., Pulido, María, Pedro, María Ángeles de, Reis, R. L., Sánchez-Margallo, Francisco Miguel, Casado, Javier G., López, Esther

مصطلحات موضوعية: Surgical mesh, Fibrin sealant, Coating, Fibrin, Cell therapy, Menstrual blood-derived stromal cell, menstrual blood-derived stromal cells, Science & Technology

الوصف: Polypropylene (PP) mesh is well-known as a gold standard of all prosthetic materials of choice for the reinforcement of soft tissues in case of hernia, organ prolapse, and urinary incontinence. The adverse effects that follow surgical mesh implantation remain an unmet medical challenge. Herein, it is outlined a new approach to allow viability and adhesion of human menstrual blood-derived mesenchymal stromal cells (MenSCs) on PP surgical meshes. A multilayered fibrin coating, based on fibrinogen and thrombin from a commercial fibrin sealant, was optimized to guarantee a homogeneous and stratified film on PP mesh. MenSCs were seeded on the optimized fibrin-coated meshes and their adhesion, viability, phenotype, gene expression, and immunomodulatory capacity were fully evaluated. This coating guaranteed MenSC viability, adhesion and did not trigger any change in their stemness and inflammatory profile. Additionally, MenSCs seeded on fibrin-coated meshes significantly decreased CD4+ and CD8+ T cell proliferation, compared to in vitro stimulated lymphocytes ( p < 0.0001). Hence, the proposed fibrin coating for PP surgical meshes may allow the local administration of stromal cells and the reduction of the exacerbated inflammatory response following mesh implantation surgery. Reproducible and easy to adapt to other cell types, this method undoubtedly requires a multidisciplinary and translational approach to be improved for future clinical uses. ; This work was supported by: SANTANDER BANK: “Convenio de colaboración empresarial en actividades de interés general” to F.M.; FUNDAÇÃO PARA A CIÊNCIA E A TECNOLOGIA (FCT): post-doctoral contract CEECIND/01026/2018 to J.M.S.; INSTITUTO DE SALUD CARLOS III (ISCIII): a “PFIS” contract (FI19/00041) to M.Á.P., a “Sara Borrell” grant (CD19/00048) to E.L.; a “Miguel Servet I” grant (MS17/00021), co-funded by the European Social Fund (ESF) “Investing in your future”, and projects CP17/00021 and PI18/0911, co-funded by the European Regional Development Fund (ERDF) “A way to make ...

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01026%2F2018%2FCP1581%2FCT0016/PT; https://www.mdpi.com/1422-0067/22/24/13385Test; Marinaro, F.; Silva, J.M.; Barros, A.A.; Aroso, I.M.; Gómez-Blanco, J.C.; Jardin, I.; Lopez, J.J.; Pulido, M.; de Pedro, M.Á.; Reis, R.L.; Sánchez-Margallo, F.M.; Casado, J.G.; López, E. A Fibrin Coating Method of Polypropylene Meshes Enables the Adhesion of Menstrual Blood-Derived Mesenchymal Stromal Cells: A New Delivery Strategy for Stem Cell-Based Therapies. Int. J. Mol. Sci. 2021, 22, 13385. https://doi.org/10.3390/ijms222413385Test; https://hdl.handle.net/1822/77927Test; 13385

الإتاحة: https://doi.org/10.3390/ijms222413385Test
https://hdl.handle.net/1822/77927Test

المؤلفون: Silva, J. C., Aroso, Ivo Manuel Ascensão, Mano, F., Sá-Nogueira, I., Barreiros, S., Reis, R. L., Paiva, Alexandre, Duarte, Ana Rita C.

المساهمون: Universidade do Minho

مصطلحات موضوعية: Drug delivery systems, Green chemistry, Therapeutic deep eutectic solvents, Ciências Médicas::Biotecnologia Médica, Science & Technology

الوصف: In recent years, deep eutectic solvents (DES) have emerged as a sustainable alternative to ionic liquids mainly due to their lower production costs and higher biodegradability/ biocompatibility(1). DES are defined as a mixture of organic compounds with a melting point significantly lower than that of either individual component(2). When based in natural compounds such as aminoacids, organic acids, sugars or choline derivatives, DES are so called natural deep eutectic solvents (NADES) which fully comply with green technology principles(3). NADES constituted by bioactive substances or active pharmaceutical ingredients (APIs), which we define as therapeutic deep eutectic solvents (THEDES), are a promising source for several pharmaceutical and biomedical applications due to their increased ability to dissolve model drugs by increasing their solubility, permeation and absorption. In this work, we synthetized several THEDES based in choline chloride (ChCl) or menthol conjugated with three different APIs: acetylsalicylic acid (AA), benzoic acid (BA) and phenylacetic acid (PA) with different molar ratios (ChCl:AA 1:1, ChCl:PA 1:1, Menthol:AA 3:1, Menthol:BA 3:1, Menthol:PA 2:1, Menthol:PA 3:1). All THEDES produced were characterized by differential scanning calorimetry and polarized optical microscopy. Dissolution studies performed in PBS for 24 hours shown that THEDES increased significantly the dissolution of all APIs studied compared to the control (APIs only). This increased solubility was even more noticeable for the cases of THEDES with menthol in their composition. In overall, our results suggest the great promise of using THEDES as solubility enhancers in the development of novel and more effective drug delivery systems.

وصف الملف: application/pdf

العلاقة: Silva J. C., Aroso I. M., Mano F., Sá-Nogueira I., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Therapeutic deep eutectic solvents as solubility enhancers for different active pharmaceutical ingredients, Tissue Engineering Part A, doi:10.1089/ten.tea.2015.5000.abstracts, 2015; 1937-3341

الإتاحة: http://hdl.handle.net/1822/38328Test

المؤلفون: Aroso, Ivo Manuel Ascensão, Craveiro, Rita, Dionisio, Madalena, Barreiros, Susana, Reis, R. L., Paiva, Alexandre, Duarte, Ana Rita C.

المساهمون: Universidade do Minho

مصطلحات موضوعية: Deep Eutectic Solvents, Properties

الوصف: When combined at particular molar fractions, sugars, aminoacids or organic acids a present a high melting point depression, becoming liquids at room temperature. These are called Natural Deep Eutectic Solvents – NADES and are envisaged to play a major role on the chemical engineering processes of the future. Nonetheless, there is a significant lack of knowledge of its fundamental and basic properties, which is hindering their industrial applications. For this reason it is important to extend the knowledge on these systems, boosting their application development [1]. In this work, we have developed and characterized NADES based on choline chloride, organic acids, amino acids and sugars. Their density, thermal behavior, conductivity and polarity were assessed for different compositions. The conductivity was measured from 0 to 40 °C and the temperature effect was well described by the Vogel-Fulcher-Tammann equation. The morphological characterization of the crystallizable materials was done by polarized optical microscopy that provided also evidence of homogeneity/phase separation. Additionally, the rheological and thermodynamic properties of the NADES and the effect of water content were also studied. The results show these systems have Newtonian behavior and present significant viscosity decrease with temperature and water content, due to increase on the molecular mobility. The anhydrous systems present viscosities that range from higher than 1000Pa.s at 20°C to less than 1Pa.s at 70°C. DSC characterization confirms that for water content as high as 1:1:1 molar ratio, the mixture retains its single phase behavior. The results obtained demonstrate that the NADES properties can be finely tunned by careful selection of its constituents. NADES present the necessary properties for use as extraction solvents. They can be prepared from inexpensive raw materials and tailored for the selective extraction of target molecules. The data produced in this work is hereafter importance for the selection of the most promising candidates avoiding a time consuming and expensive trial and error phase providing also data for the development of models able to predict their properties and the mechanisms that allow the formation of the deep eutectic mixtures.

الوصف (مترجم): Rita Craveiro and Alexandre Paiva are grateful for financial support from Fundação para a Ciência e a Tecnologia (FCT) through the grants PTDC/EQUEPR/12191/2010/ENIGMA and SFRH/BPD/44946/2008. The research leading to these results has received funding from through the projects ENIGMA - PTDC/EQU-EPR/121491/2010, PTDC/QUI-QUI/119210/2010, PTDC/EQUEQU/122106/2010, PEst-C/EQB/LA0006/2013 from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° REGPOT-CT2012-316331-POLARIS and from Project “Novel smart and biomimetic materials for innovative regenerative medicine approaches (Ref.: RL1 - ABMR - NORTE-01-0124-FEDER-000016)” co-financed by North Portugal Regional Operational Programme (ON.2 – O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).

وصف الملف: application/pdf

العلاقة: Aroso I. M., Craveiro R., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Fundamental studies on natural deep eutectic sol-vents: physico-chemical, thermal and rheological properties, NWBC 2015 - The 6th Nordic Wood Biorefinery Conference, 2015

الإتاحة: http://hdl.handle.net/1822/40945Test

المؤلفون: Aroso, Ivo Manuel Ascensão, Craveiro, R., Rocha, Â., Dionisio, M., Barreiros, S., Reis, R. L., Paiva, Alexandre, Duarte, Ana Rita C.

المساهمون: Universidade do Minho

مصطلحات موضوعية: Drug delivery, Green chemistry, Ibuprofen, Polycaprolactone, Starch, Supercritical fluids, Therapeutic deep eutectic solvents, Biomaterial, Biomedical engineering, Materials Science, Engenharia e Tecnologia::Biotecnologia Industrial, Science & Technology

الوصف: Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications.

وصف الملف: application/pdf

العلاقة: Aroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems, Tissue Engineering Part A, Vol. 21, Issue S1, pp. S-1-S-413, doi:10.1089/ten.tea.2015.5000.abstracts, 2015; 1937-3341

الإتاحة: http://hdl.handle.net/1822/38099Test

المؤلفون: Barros, Alexandre António Antunes, Aroso, Ivo Manuel Ascensão, Silva, Tiago H., Mano, J. F., Duarte, Ana Rita C., Reis, R. L.

المساهمون: Universidade do Minho

مصطلحات موضوعية: Bioceramics, Marine biomaterials, Sponges, Science & Technology

الوصف: Publicado em "Journal of tissue engineering and regenerative medicine". Vol. 8, suppl. s1 (2014)

الوصف (مترجم): Introduction: The use of biostructures and bioceramics derived from the marine environment for several application has been proposed in the last years by different authors. Examples are the use of different marine species like coral skeletons, sea urchins and sponges as three dimensional biomatrices1-3.We have focused on the potential of bioce- ramics obtained from three marine sponges, Petrosia ficidormis (PET), Agelas oroides (AG) and Chondrosia reniformis (CR) for biomedical applications. In vitro bioactivity studies promote the precipitation of crystals of calcium phosphate (e.g. hydroxyapatite) on the surface of marine sponge derived bioceramics suggesting these as a new source of bioactive ceramics for tissue engineering and regenerative medicine (TERM) applications. Materials and methods: In these work, Sponge samples were collected in Mediterranean Sea, namely in Spanish north east coast (Petrosia fici- formis. and Agelas oroides) and Israeli coast (Chondrosia reniformis). Bi- oceramics were obtained, after sponge calcination in a furnace at 750 C for 6 hours. In vitro bioactivity of the bioceramics was evaluated by immersion in simulated body fluid (SBF), for 14 and 21 days. The structures were observed by SEM and the chemical composition was evaluated by energy dispersive x-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR). Cytotoxicity studies were also performed, using the commercial Bioglass 45S5 as reference. Results: The bioceramics structures obtained after calcination present different morphological and chemical compositions, as observed by SEM-EDS (FIG. 1). PET skeleton is a 3D architecture, composed of SiO2 groups. On the other hand the inorganic part of AG and CR is a powder mainly composed of silicates. However, they also contain Ca and Mg. The microscopic observation of the ceramics crystals after immersion in SBF solution for 14 and 21 days disclosed surface crystals, with the typ- ical cauliflower-like shape characteristic of hydroxyapatite, in case of AG and CR. These crystals are composed of Ca, P and Mg as demon- strated by EDS analysis. PET on the other hand, did not reveal any crys- tal precipitation, suggesting no inherent bioactivity. FTIR confirmed the presence of characteristics peaks of carbonates and phosphates of hydroxyapatite, nxCO3 and nxPO4, after immersion of the marine ori- gin ceramics in SBF solution. XRD analysis confirms the crystallo- graphic planes of hydroxyapatite and some intermediate crystals. Finally, in vitro test results demonstrate that bioceramics from these sponges are non-cytotoxic to L929 Cells. Discussion and conclusions: The results show that bioceramics obtained from PET sponges do not possess inherent bioactivity on the contrary of AG and CR, which establish, after 14 days and 21 days of immersion in SBF solution, the formation of hydroxyapatite crystals on their surface. Observing the chemical composition of the sponges after calcination, bioactivity can be explained by the presence of calcium and magnesium groups, which allow nucleation of crystals. CR and AG ceramics show, hereafter a bioactive behavior with potential use in TERM applications, namely towards bone tissues.
Alexandre Barros is grateful for financial support of FCT through grant EXP/QEQ-EPS/0745/2012, project SWIMS. The research leading to these results has received funding from EU FP7 under grant agreement n°KBBE-2010-266033 (project SPECIAL).

وصف الملف: application/pdf

العلاقة: Barros A. A., Aroso I. M., Silva T. H., Mano J. F., Duarte A. R. C., Reis R. L. Bioactive ceramics for tissue engineering and regenerative medicine derived from marine sponges, Tissue Engineering And Regenerative Medicine, Vol. 8, pp. 39-206, doi: 10.1002/term.1931, 2014; 1937-3341

الإتاحة: http://hdl.handle.net/1822/40947Test

المؤلفون: Barros, Alexandre A., Aroso, Ivo Manuel Ascensão, Silva, Tiago H., Mano, J. F., Duarte, Ana Rita C., Reis, R. L.

المساهمون: Universidade do Minho

مصطلحات موضوعية: Bioactive, Marine sponges, Tissue engineering and regenerative medicine

الوصف: Publicado em : "Journal of Tissue Engineering and Regenerative Medicine", vol, 7, supp. 1 (2013)

الوصف (مترجم): Marine organisms are exceptionally rich in natural products and present huge prospective for biomedical applications. In this work we have studied the potential of bioceramics from different sponge species, namely Petrosia ficidormis, Agelas oroides and Chondrosia reniformis, for novel biomedical applications. Studies reported in the literature have already demonstrated the potential of carbonate corals as a source of bioceramics. However, similar studies directed towards the valorization of marine sponge skeletons are still missing. The bioceramics, exempt of organic components, were obtained after calcination of the sponges at 750°C for 6 hours in a furnace. The powder was recovered and Scanning electron microscopy (SEM) was used to observe the morphology and gain insight of the elements spatial arrangement. Spectroscopic elemental analysis (EDS) was used to determine the chemical composition and has shown that Petrosia ficidormis skeleton is constituted mainly by silicate, while Chondrosia reniformis spicules are mostly calcium carbonates. On the other hand, the ceramics obtained from Agelas oroides present a combination of silicate and calcium salts. In vitro bioactivity of the bioceramics was evaluated in simulated body fluid (SBF), after 3, 7 and 14 days of incubation. Observation of the bioceramics by SEM, coupled with EDS, has shown that it is possible to induce the precipitation of calcium-phosphate crystals, consistent with similar to hydroxyapatite (HA) coating. The determination of Ca/P ratio, together with the infrared spectrum by Fourier transform infrared spectroscopy (FTIR) and x-Ray diffraction (XRD) pattern, has confirmed the deposition of HA. Cytotoxicity of developed bioceramics materials was also assessed, comparing their behaviour with synthetized bioactive glass as reference. Results obtained thus far have shown the potential of bioceramics from marine sponges for its use in biomedical applications, namely in tissue regeneration approaches

وصف الملف: application/pdf

العلاقة: Barros A. A., Aroso I. M., Silva T. H., Mano J. F., Duarte A. R. C., Reis R. L. Marine sponges – a new source of bioactive ceramics for tissue engineering and regenerative medicine applications, Journal of Tissue Engineering and Regenerative Medicine, Vol. 7, Issue 10, pp. 46, doi:10.1002/term.1822, 2013

الإتاحة: http://hdl.handle.net/1822/36584Test

المؤلفون: Fernandes, E. M., Aroso, Ivo Manuel Ascensão, Pires, R. A., Correlo, V. M., Pitkänen, P., Koskimies, S., Mano, J. F., Reis, R. L.

المساهمون: Universidade do Minho

مصطلحات موضوعية: Cork, Grafting agent, Mechanical properties, Polymer-matrix composites, Suberin, Cork powder, Functionalized, Interfacial adhesions, Reactive extrusion process, Reactive extrusion, Adhesion, Composite materials, Coupling agents, Compression molding, Extrusion

الوصف: New functionalized composite structures were prepared using low-density polyethylene (LDPE), cork powder and different suberins extracted from cork and birch outer bark as coupling agents to promote interfacial adhesion. The compounding was performed under reactive extrusion and samples processed by compression moulding. The morphology of the functionalized composites showed good adhesion between cork and the polymeric phase. The mechanical results confirm that the addition of suberin acts as coupling agent improving the strength and leads to cork-polymer composite materials with improved strain and lower modulus. When the suberin was added to the composition a slight increase on the composite density occurred. The new cork-polymer composites demonstrated that this technological approach is industrially appealing.

الوصف (مترجم): QREN FCOMP-01-0202-FEDER-003107 finance support on the project ”NovelComp”.
Portuguese Foundation for Science and Technology (FCT).
European project FP6 of Wacheup: New concepts for upgrading pulp and cork mill waste streams to value-added chemicals.
Corticeira Amorim S.G.P.S. on the development of new products based in/with cork and for the supply of cork materials.

وصف الملف: application/pdf

العلاقة: 9781617829604; http://www.plasticsengineering.orgTest/

الإتاحة: http://hdl.handle.net/1822/19488Test

المؤلفون: Silva, João C., Barros, Alexandre António Antunes, Aroso, Ivo Manuel Ascensão, Fassini, Dario, Silva, Tiago José Quinteiros Lopes Henriques, Reis, R. L., Duarte, Ana Rita C.

مصطلحات موضوعية: CO2 extraction, Collagen, Gelatin, Marine sponges, Science & Technology

الوصف: Marine sponges are a rich source of natural bioactive compounds. One of the most abundant valuable products is collagen/gelatin, and therefore, presents an interesting alternative source for pharmaceutical and biomedical applications. We have previously proposed an innovative green technology for the extraction of collagen/gelatin from marine sponges based in water acidified with carbon dioxide. In this work, we have optimized the process operating conditions towards high yields and collagen quality as well as to reduce extraction procedure duration and energy consumption. The process extraction efficiency is higher than 50%, corresponding to a yield of approximately 10% of the sponge dry mass, obtained for mild operating conditions 10 bars and 3h. The extracted material was characterized by Scanning Electron Microscopy (SEM), Rheology, Fourier Transformed Infrared Spectroscopy (FTIR), Circular Dichroism (CD), Aminoacid Analysis and SDS-PAGE. The extracts were found to be composed of highly pure mixtures of collagen and gelatin with similar properties of collagen isolated from other marine sources. The cytotoxicity evaluation, performed with L929 cells, has proven the biocompatibility of the material extracted. Overall, the results obtained demonstrate the efficiency of this approach and the high industrial potential of this technology to obtain marine collagen/gelatin with properties suitable for biomedical applications. ; FCT through Grant EXP/QEQ-EPS/0745/2012, SWIMS (Subcritical Water Isolation of compounds from Marine Sponges) ; European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement numbers REGPOT-CT2012-316331-POLARIS and KBBE-2010-266033 (project SPECIAL) ; European Regional Development Fund (ERDF) under the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” RL1-ABMR-NORTE-01- 0124-FEDER-000016), cofinanced by North Portugal Regional Operational Programme (ON.2, O Novo Norte), under the National Strategic Reference Framework (NSRF) ...

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/EC/FP7/316331/EU; info:eu-repo/grantAgreement/EC/FP7/266033/EU; info:eu-repo/grantAgreement/EC/FP7/321266/EU; info:eu-repo/grantAgreement/FCT/5876-PPCDTI/127219/PT; info:eu-repo/grantAgreement/FCT/COMPETE/127219/PT; Silva J. C., Barros A. A., Aroso I. M., Fassini D., Silva T. H., Reis R. L., Duarte A. R. C. Extraction of Collagen/Gelatin from the Marine Demosponge Chondrosia reniformis (Nardo, 1847) using Water Acidified with Carbon Dioxide – Process Optimization, Industrial & Engineering Chemistry Research , doi:10.1021/acs.iecr.6b00523, 2016; http://hdl.handle.net/1822/42487Test

الإتاحة: https://doi.org/10.1021/acs.iecr.6b00523Test
http://hdl.handle.net/1822/42487Test

المؤلفون: Mano, Francisca, Aroso, Ivo Manuel Ascensão, Barreiros, Susana, Borges, João Paulo, Reis, R. L., Duarte, Ana Rita C., Paiva, Alexandre

مصطلحات موضوعية: Electrospinning, Natural Deep-eutectic solvents, Poly(vinyl alcohol), Ciências Médicas::Biotecnologia Médica

الوصف: Functionalized electrospun fibers are of great interest for biomedical applications such as in the design of drug delivery systems. Nevertheless, in some cases the molecules of interest have poor solubility in water or have high melting temperatures. These drawbacks can be overcome using deep eutectic solvents. In this work, poly(vinyl alcohol) (PVA), a common biodegradable biopolymer, was used to produce new functionalized fibers with the eutectic mixture choline chloride:citric acid in a molar ratio of (1:1) ChCl:CA (1:1), which was used as a model system. Fibers were produced from an aqueous solution with 7.8% (w/v) and 9.8% (w/v) of 95% hydrolyzed PVA and a 2% (v/v) of ChCl:CA (1:1). Smooth, uniform fibers with an average diameter of 0.4 μm were obtained with a content of 19.8 wt % of ChCl:CA (1:1) encapsulated ; FCT/MEC through the project ENIGMA - PTDC/EQU-EPR/121491/2010, and the project PEst-C/EQB/LA0006/2013. European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n°REGPOT-CT2012-316331-POLARIS, and from the Project “Novel smart andbiomimetic materials for innovative regenerative medicine approaches (Ref.: RL1 - ABMR - NORTE-01-0124-FEDER-000016) ”cofinanced by the North Portugal Regional Operational Programme (ON.2 − O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). This work was also partly funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT - Portuguese Foundation for Science and Technology under the project UID/CTM/50025/2013.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/EC/FP7/316331/EU; info:eu-repo/grantAgreement/FCT/5876-PPCDTI/121491/PT; info:eu-repo/grantAgreement/FCT/COMPETE/132972/PT; info:eu-repo/grantAgreement/FCT/COMPETE/121491/PT; info:eu-repo/grantAgreement/FCT/5876/147333/PT; Mano F., Aroso I. M., Barreiros S., Borges J. P., Reis R. L., Duarte A. R. C., Paiva A. Production of Poly(vinyl alcohol) (PVA) Fibers with Encapsulated Natural Deep Eutectic Solvent (NADES) Using Electrospinning , ACS Sustainable Chemistry & Engineering, doi: DOI:10.1021/acssuschemeng.5b00613 , 2015; https://hdl.handle.net/1822/38366Test

الإتاحة: https://doi.org/10.1021/acssuschemeng.5b00613Test
https://hdl.handle.net/1822/38366Test

المؤلفون: Aroso, Ivo Manuel Ascensão, Fernandes, E. M., Pires, R. A., Mano, J. F., Reis, R. L.

مصطلحات موضوعية: Composites, Cork, Oxidation induction time, Oxidation onset temperature, Polypropylene, Thermo-oxidation, Science & Technology

الوصف: The thermo-oxidative stability of polypropylene (PP) in composites containing 15 wt.% of cork and the performance of selected cork extracts as stabilizing additives for PP was evaluated by Oxidation Induction Time (OIT) and by Oxidation Onset Temperature (OOT). The results showed that cork increases the OIT of PP in the composite and it was identified that the cork extractives fraction is responsible for such behavior. Selected cork extracts with high antioxidant capacity (determined by dpph radical scavenging and oxygen reactive absorbance capacity assays) were compounded by extrusion with PP in 0.5 and 1.5 wt.%. It was found that the ethanol extract is the most effective as thermo-oxidative stabilizer for PP. At the loading level of 1.5%, the OIT increases from 3.8 (neat PP) to 29.7 min at 200 °C and from 1.2 (neat PP) to 9.0 min at 220 °C. The OOT also increases from 216 °C (neat PP) to 247 °C. Mechanical tests, performed on PP loaded with the cork extracts, showed that the presence of these extracts has no significant effect on the polymer mechanical performance. The results demonstrate the suitability of cork as a source of thermo-oxidative stabilizing additives for the formulation of polyolefins, and enable the exploitation of new routes of cork valorization. ; The authors are grateful to Amorim Cork Composites for providing the cork powder raw material. Ivo Aroso and Emanuel Fernandes are grateful for financial support of FCT through grants SFRH/BD/42273/2007 and SFRH/BPD/96197/2013, respectively. Funding was also granted from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no REGPOT-CT2012-316331-POLARIS and from Project "Novel smart and biomimetic materials for innovative regenerative medicine approaches (Ref.: RL1-ABMR-NORTE-01-0124-FEDER-000016)" co-financed by North Portugal Regional Operational Programme (ON.2 - O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/EC/FP7/316331/EU; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F42273%2F2007/PT; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F96197%2F2013/PT; http://www.sciencedirect.com/science/article/pii/S0141391015000889Test; https://hdl.handle.net/1822/35027Test

الإتاحة: https://doi.org/10.1016/j.polymdegradstab.2015.03.006Test
https://hdl.handle.net/1822/35027Test