المؤلفون: Vahermaa, Vesa, Aydogan, Dogu Baran, Raij, Tuukka, Armio, Reetta-Liina, Laurikainen, Heikki, Saramäki, Jari, Suvisaari, Jaana

المساهمون: Clinicum, HUS Helsinki and Uusimaa Hospital District, HUS Psychiatry

مصطلحات موضوعية: Freesurfer, Mri, Neuroimaging, Psychosis, Quality control, 3112 Neurosciences, 3124 Neurology and psychiatry, 3126 Surgery, anesthesiology, intensive care, radiology

الوصف: We have studied the effects of manual quality control of brain Magnetic Resonance Imaging (MRI) images processed with Freesurfer. T1 images of first episode psychosis patients (N = 60) and healthy controls (N = 41) were inspected for gray matter boundary errors. The errors were fixed, and the effects of error correction on brain volume, thickness, and surface area were measured. It is commonplace to apply quality control to Freesurfer MRI recordings to ensure that the edges of gray and white matter are detected properly, as incorrect edge detection leads to changes in variables such as volume, cortical thickness, and cortical surface area. We find that while Freesurfer v7.1.1. does regularly make mistakes in identifying the edges of cortical gray matter, correcting these errors yields limited changes in the commonly measured variables listed above. We further find that the software makes fewer gray matter boundary errors when processing female brains. The results suggest that manually correcting gray matter boundary errors may not be worthwhile due to its small effect on the measurements, with potential exceptions for studies that focus on the areas that are more commonly affected by errors: the areas around the cerebellar tentorium, paracentral lobule, and the optic nerves, specifically the horizontal segment of the middle cerebral artery. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Vahermaa , V , Aydogan , D B , Raij , T , Armio , R-L , Laurikainen , H , Saramäki , J & Suvisaari , J 2023 , ' FreeSurfer 7 quality control : Key problem areas and importance of manual corrections ' , NeuroImage , vol. 279 , 120306 . https://doi.org/10.1016/j.neuroimage.2023.120306Test; cb769bf9-1eff-4a52-87ba-0c4e59cec3b5; http://hdl.handle.net/10138/565319Test; 001053594000001

الإتاحة: http://hdl.handle.net/10138/565319Test

المؤلفون: Walta, Maija, Laurikainen, Heikki, Armio, Reetta-Liina, From, Tiina, Tolvanen, Arvi, Salokangas, Raimo K.R., Hietala, Jarmo

المصدر: Schizophrenia Research ; volume 246, page 235-240 ; ISSN 0920-9964

مصطلحات موضوعية: Biological Psychiatry, Psychiatry and Mental health

الإتاحة: https://doi.org/10.1016/j.schres.2022.06.022Test
https://api.elsevier.com/content/article/PII:S0920996422002572?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0920996422002572?httpAccept=text/plainTest

المؤلفون: Turtonen, Otto, Saarinen, Aino, Nummenmaa, Lauri, Tuominen, Lauri, Tikka, Maria, Armio, Reetta-Liina, Hautamäki, Airi, Laurikainen, Heikki, Raitakari, Olli, Keltikangas-Järvinen, Liisa, Hietala, Jarmo

المساهمون: Department of Psychology and Logopedics, Swedish School of Social Science Subunit, Medicum

مصطلحات موضوعية: 6162 Cognitive science, 515 Psychology

الوصف: BACKGROUND: Secure attachment is important in maintaining an individual's health and well-being. Attachment disturbances increase the risk for developing psychiatric disorders such as affective disorders. Yet, the neurobiological correlates of human attachment are poorly understood at the neurotransmitter level. We investigated whether adult attachment style is linked to functioning of the opioid and serotonergic systems in the human brain. METHODS: We used positron emission tomography with radioligands [C-11]carfentanil and [C-11]MADAM to quantify mu opioid receptor (n = 39) and serotonin transporter (n = 37) availability in volunteers with no current psychiatric disorders. Attachment style was determined according to the Dynamic-Maturational Model of Attachment and Adaptation with the structured Adult Attachment Interview. RESULTS: Secure attachment was associated with higher mu opioid receptor availability in the hippocampus, amygdala, thalamus, and prefrontal cortex when compared with insecure (i.e., avoidant or ambivalent groups combined) attachment. In contrast, attachment style was not associated with serotonin transporter availability. CONCLUSIONS: Our results provide preliminary in vivo evidence that the opioid system may be involved in the neurocircuits associated with individual differences in adult attachment behavior. The results suggest that variation in mu opioid receptor availability may be linked with the individuals' social relationships and psychosocial well-being and thus contributes to risk for psychiatric morbidity. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Turtonen , O , Saarinen , A , Nummenmaa , L , Tuominen , L , Tikka , M , Armio , R-L , Hautamäki , A , Laurikainen , H , Raitakari , O , Keltikangas-Järvinen , L & Hietala , J 2021 , ' Adult Attachment System Links With Brain Mu Opioid Receptor Availability In Vivo ' , Biological Psychiatry: Cognitive Neuroscience and Neuroimaging , vol. 6 , no. 3 , pp. 360-369 . https://doi.org/10.1016/j.bpsc.2020.10.013Test; ORCID: /0000-0002-7977-3852/work/92660505; ORCID: /0000-0003-2936-2120/work/92661741; ORCID: /0000-0003-4495-8360/work/92662730; a40fa9de-8bd0-4c3a-afe3-794a2bb620cd; http://hdl.handle.net/10138/335867Test; 000631895800013

الإتاحة: http://hdl.handle.net/10138/335867Test

المؤلفون: Salokangas, Raimo K. R., From, Tiina, Ilonen, Tuula, Luutonen, Sinikka, Heinimaa, Markus, Armio, Reetta-Liina, Laurikainen, Heikki, Walta, Maija, Paju, Janina, Toivonen, Anna, Jalo, Päivi, Tuominen, Lauri, Hietala, Jarmo

المصدر: BMC Psychiatry ; volume 21, issue 1 ; ISSN 1471-244X

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: Background Functional recovery of patients with clinical and subclinical psychosis is associated with clinical, neuropsychological and developmental factors. Less is known about how these factors predict functional outcomes in the same models. We investigated functional outcomes and their predictors in patients with first-episode psychosis (FEP) or a confirmed or nonconfirmed clinical high risk of psychosis (CHR-P vs. CHR-N). Methods Altogether, 130 patients with FEP, 60 patients with CHR-P and 47 patients with CHR-N were recruited and extensively examined at baseline (T0) and 9 (T1) and 18 (T2) months later. Global Assessment of Functioning (GAF) at T0, T1 and T2 and psychotic, depression, and anxiety symptoms at T1 and T2 were assessed. Functional outcomes were predicted using multivariate repeated ANOVA. Results During follow-up, the GAF score improved significantly in patients with FEP and CHR-P but not in patients with CHR-N. A single marital status, low basic education level, poor work situation, disorganization symptoms, perceptual deficits, and poor premorbid adjustment in patients with FEP, disorganization symptoms and poor premorbid adjustment in patients with CHR-P, and a low basic education level, poor work situation and general symptoms in patients with CHR-N predicted poor functional outcomes. Psychotic symptoms at T1 in patients with FEP and psychotic and depression symptoms at T1 and anxiety symptoms at T2 in patients with CHR-P were associated with poor functioning. Conclusions In patients with FEP and CHR-P, poor premorbid adjustment and disorganization symptomatology are common predictors of the functional outcome, while a low education level and poor work situation predict worse functional outcomes in patients with FEP and CHR-N. Interventions aimed at improving the ability to work and study are most important in improving the functioning of patients with clinical or subclinical psychosis.

الإتاحة: https://doi.org/10.1186/s12888-021-03516-4Test

المؤلفون: Laurikainen, Heikki, Vuorela, Arja, Toivonen, Anna, Reinert-Hartwall, Linnea, Trontti, Kalevi, Lindgren, Maija, Keinanen, Jaakko, Mäntylä, Teemu, Paju, Janina, Ilonen, Tuula, Armio, Reetta-Liina, Walta, Maija, Tuisku, Jouni, Helin, Semi, Marjamäki, Päivi, Hovatta, Iiris, Therman, Sebastian, Vaarala, Outi, Linnaranta, Outi, Kieseppä, Tuula, Salokangas, Raimo K. R., Honkanen, Jarno, Hietala, Jarmo, Suvisaari, Jaana

المساهمون: Clinicum, University of Helsinki, SLEEPWELL Research Program, Medicum, Department of Psychology and Logopedics, Iiris Hovatta / Principal Investigator, Genetics, HUS Children and Adolescents, CAMM - Research Program for Clinical and Molecular Metabolism, Research Programs Unit, HUS Psychiatry, Department of Psychiatry, Mind and Matter

مصطلحات موضوعية: PROTEIN 18 KDA, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, MACROPHAGE-DERIVED CHEMOKINE, TRANSLOCATOR PROTEIN, BENZODIAZEPINE-RECEPTOR, SCHIZOPHRENIA, MICROGLIA, CYTOKINES, TSPO, RADIOLIGAND, 3124 Neurology and psychiatry

الوصف: Several lines of research support immune system dysregulation in psychotic disorders. However, it remains unclear whether the immunological marker alterations are stable and how they associate with brain glial cell function. This longitudinal study aimed at investigating whether peripheral immune functions are altered in the early phases of psychotic disorders, whether the changes are associated with core symptoms, remission, brain glial cell function, and whether they persist in a one-year follow-up. Two independent cohorts comprising in total of 129 first-episode psychosis (FEP) patients and 130 controls were assessed at baseline and at the one-year follow-up. Serum cyto-/chemokines were measured using a 38-plex Luminex assay. The FEP patients showed a marked increase in chemokine CCL22 levels both at baseline (p <0.0001; Cohen's d = 0.70) and at the 12-month follow-up (p = 0.0007) compared to controls. The group difference remained significant (p = 0.0019) after accounting for relevant covariates including BMI, smoking, and antipsychotic medication. Elevated serum CCL22 levels were significantly associated with hallucinations (rho = 0.20) and disorganization (rho = 0.23), and with worse verbal performance (rho = -0.23). Brain glial cell activity was indexed with positron emission tomography and the translocator protein radiotracer [C-11]PBR28 in subgroups of 15 healthy controls and 14 FEP patients with serum CCL22/CCL17 measurements. The distribution volume (V-T) of [C-11]PBR28 was lower in patients compared to controls (p = 0.026; Cohen's d = 0.94) without regionally specific effects, and was inversely associated with serum CCL22 and CCL17 levels (p = 0.036). Our results do not support the over-active microglia hypothesis of psychosis, but indicate altered CCR4 immune signaling in early psychosis with behavioral correlates possibly mediated through cross-talk between chemokine networks and dysfunctional or a decreased number of glial cells. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: This study was supported by the Academy of Finland grant nos. 278155, 278171 and 323035. We thank Paivi Jalo, Akseli Makela and the personnel at the Turku PET centre for their assistance.; Laurikainen , H , Vuorela , A , Toivonen , A , Reinert-Hartwall , L , Trontti , K , Lindgren , M , Keinanen , J , Mäntylä , T , Paju , J , Ilonen , T , Armio , R-L , Walta , M , Tuisku , J , Helin , S , Marjamäki , P , Hovatta , I , Therman , S , Vaarala , O , Linnaranta , O , Kieseppä , T , Salokangas , R K R , Honkanen , J , Hietala , J & Suvisaari , J 2020 , ' Elevated serum chemokine CCL22 levels in first-episode psychosis : associations with symptoms, peripheral immune state and in vivo brain glial cell function ' , Translational Psychiatry , vol. 10 , no. 1 , 94 . https://doi.org/10.1038/s41398-020-0776-zTest; ORCID: /0000-0002-5990-7892/work/72776035; ORCID: /0000-0002-1645-2883/work/72781425; ORCID: /0000-0001-9987-1903/work/90908545; 74a7a25d-e947-4343-9d75-71cac561db60; http://hdl.handle.net/10138/314191Test; 000521106000001

الإتاحة: http://hdl.handle.net/10138/314191Test

المؤلفون: Walta, Maija, Laurikainen, Heikki, Armio, Reetta-Liina, From, Tiina, Salokangas, Raimo K R, Hietala, Jarmo

المصدر: Schizophrenia Bulletin ; volume 46, issue Supplement_1, page S85-S86 ; ISSN 0586-7614 1745-1701

مصطلحات موضوعية: Psychiatry and Mental health

الوصف: Background Attrition rates and sampling bias in controlled clinical studies are a concern when evaluating the relevance of the results to a specific patient population in a real-life clinical / treatment setting. Dropout rates in studies on psychotic disorders are high and many eligibility criteria may lead to bias in study samples. We wanted to analyze how representative are the patient samples typically included in first-episode psychosis studies such as the Turku Early Psychosis (TEPS) study by using a platform of 3772 consecutive admissions to clinical psychiatric services of Turku Psychiatry. Methods TEPS study was started in 2011 as a part of a larger study on psychosis treatment processes in Turku Psychiatric services. Each patient, inpatient and outpatient, went through initial clinical screening by the treatment group which was followed by a structured evaluation if the screen for first-episode psychosis was positive. Between Oct 2011 and June 2016 there were 195 patients with first-episode psychosis (FEP) suitable to the TEPS study. Of them 102 were willing and 93 were not willing to participate or were not reached in a baseline structured evaluation. Using patient records, we compared if these two groups differed in terms of clinical variables, treatment or prognosis during a 1-year follow-up. Time of hospital stay, involuntary vs. voluntary admission, coercive measures during the hospital care, re-hospitalizations and drop-out from the clinical care during the follow-up were used as outcomes. Results Non-participating (NTP) group had higher rate of involuntary care than participating (TP) group (70 % vs 62 %) as well as higher rate of coercion during the treatment and higher rate of re-admissions during the follow-up than the TP group (36 % vs 22 % and 41 % vs 34 %, respectively) but these differences did not reach statistical significance. During the one-year follow-up NTP group had a significantly higher rate of dropping out from the clinical care than participating TP group (48 % vs 30 %, ...

الإتاحة: https://doi.org/10.1093/schbul/sbaa031.198Test
http://academic.oup.com/schizophreniabulletin/article-pdf/46/Supplement_1/S85/33288809/sbaa031.198.pdfTest

المؤلفون: Laurikainen, Heikki, Tuominen, Lauri, Tikka, Maria, Merisaari, Harri, Armio, Reetta-Liina, Sormunen, Elina, Borgan, Faith, Veronese, Mattia, Howes, Oliver, Haaparanta-Solin, Merja, Solin, Olof, Hietala, Jarmo

المصدر: Laurikainen , H , Tuominen , L , Tikka , M , Merisaari , H , Armio , R-L , Sormunen , E , Borgan , F , Veronese , M , Howes , O , Haaparanta-Solin , M , Solin , O & Hietala , J 2018 , ' Sex difference in brain CB1 receptor availability in man ' , NeuroImage . https://doi.org/10.1016/j.neuroimage.2018.10.013Test

مصطلحات موضوعية: Endocannabinoid, cb1 receptor, Sex difference, Working memory

الوصف: The endocannabinoid system (ECS) has a widespread neuromodulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. Animal studies convincingly show an interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference have yielded discrepant findings. Gender differences in CB1R availability were investigated in vivo in 11 male and 11 female healthy volunteers using a specific CB1R tracer [18F]FMPEP-d2 and positron emission tomography (PET). Regional [18F]FMPEP-d2 distribution volume was used as a proxy for CB1R availability. In addition, we explored whether CB1R availability is linked to neuropsychological functioning. Relative to females, CB1R availability was on average 41% higher in males (p = 0.002) with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices (p = 0.001). Inter-subject variability in CB1R availability was similar in both groups. Voxel-based analyses revealed an inverse association between CB1R availability and visuospatial working memory task performance in both groups (p

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.neuroimage.2018.10.013Test
https://kclpure.kcl.ac.uk/portal/en/publications/efef9d7b-e4bb-43db-8d68-27b6b6f3e75eTest
https://kclpure.kcl.ac.uk/ws/files/101792126/Sex_difference_in_brain_TUOMINEN_Firstonline5October2018_GREEN_AAM_CC_BY_NC_ND_.pdfTest

المؤلفون: Armio, Reetta-Liina, Laurikainen, Heikki, Salokangas, Raimo, Tuominen, Lauri, Hietala, Jarmo

المصدر: Schizophrenia Bulletin ; volume 44, issue suppl_1, page S391-S391 ; ISSN 0586-7614 1745-1701

مصطلحات موضوعية: Psychiatry and Mental health

الإتاحة: https://doi.org/10.1093/schbul/sby018.957Test
http://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S391/25467149/sby018.957.pdfTest

المؤلفون: Vahermaa, Vesa, Aydogan, Baran, T. Raij, Tuukka, Armio, Reetta-Liina, Laurikainen, Heikki, Saramäki, Jari, Suvisaari, Jaana

مصطلحات موضوعية: education, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, human activities, GeneralLiterature_MISCELLANEOUS, health care economics and organizations

الوصف: This poster is related to manual quality control of MRI images processed by the Freesurfer 7.1 software suite.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441945ce0839cd63e356f54f60102846Test

المؤلفون: Salokangas, Raimo K. R., From, Tiina, Ilonen, Tuula, Luutonen, Sinikka, Heinimaa, Markus, Armio, Reetta-Liina, Laurikainen, Heikki, Walta, Maija, Tuominen, Lauri, Hietala, Jarmo

المصدر: Nordic Journal of Psychiatry ; volume 75, issue sup1, page S12-S12 ; ISSN 0803-9488 1502-4725

الإتاحة: https://doi.org/10.1080/08039488.2021.2019919Test