المؤلفون: Lory Santarelli, Elisabetta Strafella, Sara Staffolani, Monica Amati, Monica Emanuelli, Davide Sartini, Valentina Pozzi, Damiano Carbonari, Massimo Bracci, Elettra Pignotti, Paola Mazzanti, Armando Sabbatini, Renzo Ranaldi, Stefano Gasparini, Jiri Neuzil, Marco Tomasetti

المصدر: PLoS ONE, Vol 6, Iss 4, p e18232 (2011)

مصطلحات موضوعية: Medicine, Science

الوصف: BackgroundImproved detection methods for diagnosis of malignant pleural mesothelioma (MPM) are essential for early and reliable detection as well as treatment. Since recent data point to abnormal levels of microRNAs (miRNAs) in tumors, we hypothesized that a profile of deregulated miRNAs may be a marker of MPM and that the levels of specific miRNAs may be used for monitoring its progress.Methods and resultsmiRNAs isolated from fresh-frozen biopsies of MPM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. Most of the tested miRNAs were downregulated in the malignant tissues compared with the normal tissues. Of eight significantly downregulated, three miRNAs were assayed in cancerous tissue and adjacent non-cancerous tissue sample pairs collected from 27 formalin-fixed, paraffin-embedded MPM tissues by quantitative RT-PCR. Among the miRNAs tested, only miR-126 significantly remained downregulated in the malignant tissues. Furthermore, the performance of the selected miR-126 as biomarker was evaluated in serum samples of asbestos-exposed subjects and MPM patients and compared with controls. MiR-126 was not affected by asbestos exposure, whereas it was found strongly associated with VEGF serum levels. Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MPM, SMRPs, correlate with subjects at high risk to develop MPM.Conclusions and significanceWe propose miR-126, in association with SMRPs, as a marker for early detection of MPM. The identification of tumor biomarkers used alone or, in particular, in combination could greatly facilitate the surveillance procedure for cohorts of subjects exposed to asbestos.

وصف الملف: electronic resource

العلاقة: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483773/?tool=EBITest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/8211c1807a0f4f0e97c1a9f27bbaaa8eTest

المؤلفون: Bongiolatti, Stefano, Gonfiotti, Alessandro, Viggiano, Domenico, Borgianni, Sara, Politi, Leonardo, Crisci, Roberto, Curcio, Carlo, Voltolini, Luca, Italian Vats Group, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano Di Rienzo, Camillo Lopez, Roberto Crisci, Duilio Divisi, Angelo Morelli, Alessandro Bertani, Francesco Londero, Lorenzo Rosso, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Andrea Droghetti, Andrea Giovanardi, Giuseppe Cardillo, Francesco Carleo, Luca Bertolaccini, Piergiorgio Solli, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco Pio Maniscalco, Desideria Argnani, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Mohsen Ibrahim, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera

المساهمون: Stefano, Bongiolatti, Alessandro, Gonfiotti, Domenico, Viggiano, Sara, Borgianni, Leonardo, Politi, Roberto, Crisci, Carlo, Curcio, Luca, Voltolini, Vats Group, Italian, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, Di Rienzo, Gaetano, Lopez, Camillo, Crisci, Roberto, Divisi, Duilio, Morelli, Angelo, Bertani, Alessandro, Londero, Francesco, Rosso, Lorenzo, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Droghetti, Andrea, Giovanardi, Andrea, Cardillo, Giuseppe, Carleo, Francesco, Bertolaccini, Luca, Solli, Piergiorgio, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco Pio Maniscalco, Giorgio, Argnani, Desideria, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Ibrahim, Mohsen, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Roberto Benvenuti, Mauro, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30706153; info:eu-repo/semantics/altIdentifier/wos/WOS:000500976900011; journal:SURGICAL ENDOSCOPY; http://hdl.handle.net/11573/1311323Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85066995436

الإتاحة: https://doi.org/10.1007/s00464-019-06878-9Test
http://hdl.handle.net/11573/1311323Test

المؤلفون: Bertani, Alessandro, Gonfiotti, Alessandro, Nosotti, Mario, Ferrari, Paolo Albino, De Monte, Lavinia, Russo, Emanuele, Di Paola, Gioacchino, Solli, Piero, Droghetti, Andrea, Bertolaccini, Luca, Crisci, Roberto, Italian Vats Group, Alessandro Bertani, Alessandro Gonfiotti, Mario Nosotti, Paolo Albino Ferrari, Lavinia De Monte, Emanuele Russo, Gioacchino Di Paola, Piergiorgio Solli, Andrea Droghetti, Luca Bertolaccini, Roberto Crisci, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano di Rienzo, Camillo Lopez, Angelo Morelli, Francesco Londero, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Giuseppe Cardillo, Francesco Carleo, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco, Pio Maniscalco, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Perkmann, Francesco Zaraca, Claudio Andreetti, Camilla Poggi, Felice Mucilli, MD Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre Alessandro Rinaldo, MD (Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera

المساهمون: Alessandro, Bertani, Alessandro, Gonfiotti, Mario, Nosotti, Paolo Albino, Ferrari, Lavinia, De Monte, Emanuele, Russo, Gioacchino, Di Paola, Piero, Solli, Andrea, Droghetti, Luca, Bertolaccini, Roberto, Crisci, Vats Group, Italian, Bertani, Alessandro, Gonfiotti, Alessandro, Nosotti, Mario, Albino Ferrari, Paolo, De Monte, Lavinia, Russo, Emanuele, Di Paola, Gioacchino, Solli, Piergiorgio, Droghetti, Andrea, Bertolaccini, Luca, Crisci, Roberto, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Zaraca, Francesco, Andreetti, Claudio, Poggi, Camilla, Mucilli, Felice, Pierpaolo Camplese, Md, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre Alessandro Rinaldo, Massimo, (Armando Sabbatini, Md, Refai, Majed, Roberto Benvenuti, Mauro, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco

الوصف: [This corrects the article DOI:10.21037/jtd.2017.06.12.].

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29268451; info:eu-repo/semantics/altIdentifier/wos/WOS:000417752900032; volume:9; issue:10; firstpage:E976; lastpage:E977; numberofpages:2; journal:JOURNAL OF THORACIC DISEASE; http://hdl.handle.net/11573/1311335Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85036540021

الإتاحة: https://doi.org/10.21037/jtd.2017.09.32Test
http://hdl.handle.net/11573/1311335Test

المؤلفون: Miriam Caramanti, Mariangela Torniai, Francesca Morgese, Francesca Bianchi, Azzurra Onofri, Armando Sabbatini, Gaia Goteri, Rossana Berardi, Silvia Rinaldi, Giulia Marcantognini, Majed Refai, Paola Mazzanti, Cecilia Pompili, Stefano Cascinu, Silvia Pagliaretta, Alessandro Brunelli, Vittorio Paolucci, Giulia Ricci

المساهمون: Berardi, R., Goteri, G., Brunelli, A., Pagliaretta, S., Paolucci, V., Caramanti, M., Rinaldi, S., Refai, M., Pompili, C., Morgese, F., Torniai, M., Marcantognini, G., Ricci, G., Mazzanti, P., Onofri, A., Bianchi, F., Sabbatini, A., Cascinu, S.

المصدر: Expert Opinion on Therapeutic Targets. 24:937-943

مصطلحات موضوعية: Adult, Male, PD-L1, 0301 basic medicine, Thymoma, Programmed Cell Death 1 Receptor, Clinical Biochemistry, B7-H1 Antigen, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Programmed cell death 1, Myasthenia Gravis, PD-1, Drug Discovery, medicine, Humans, Neoplasms, Glandular and Epithelial, RNA, Messenger, immune checkpoint, Thymic carcinoma, Aged, Aged, 80 and over, Pharmacology, biology, Age Factors, Thymus Neoplasms, Middle Aged, thymoma, Prognosis, medicine.disease, Ligand (biochemistry), Immunohistochemistry, Immune checkpoint, Gene Expression Regulation, Neoplastic, 030104 developmental biology, 030220 oncology & carcinogenesis, Disease Progression, biology.protein, Cancer research, Molecular Medicine, Female, thymic carcinoma, Programmed death

الوصف: Background: The aim of the study was to investigate Programmed cell Death protein 1 (PD-1) and Programmed Death-Ligand 1 (PD-L1) and their mRNA expression in thymic epithelial tumors (TETs). Research design and Methods: We analyzed 68 samples of formalin-fixed paraffin embedded tissue (63 thymomas and 5 thymic carcinomas). PD-1 and PD-L1 protein expression was evaluated by immunohistochemistry and mRNA expression was evaluated by Real Time-PCR. Results: M/F ratio was 33/35, and median age was 60.5 years. 20 patients had Myasthenia Gravis (MG). In the subgroup with large tumors (>5 cm), PD-L1 mRNA overexpression was significantly associated with worse prognosis vs. patients with no mRNA overexpression (p =0.0083) and simultaneous PD-L1 immunostaining (>1%); PD-L1 mRNA overexpression was significantly associated with worse prognosis, respect to patient with PD-L1 negative immunostaining and no PD-L1 mRNA overexpression (p = 0.0178). The elderly patients (> 60 years) with large tumors showed worse prognosis (p = 0.0395). PD-L1 immunostaining (>50%) resulted significantly associated with MG. Conclusions: Our data suggest the potential involvement of the PD-1 and PD-L1 pathway in TETs progression. According to our results, it may be helpful to design future trials with anti-PD-1 drugs to establish high-risk patients after surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40392c8d8e57c3d2d344bc62071be89Test
https://doi.org/10.1080/14728222.2020.1790529Test

المؤلفون: Stefano Bongiolatti, Alessandro Gonfiotti, Sara Borgianni, Roberto Crisci, Carlo Curcio, Luca Voltolini, Marco Alloisio, Dario Amore, Luca Ampollini, Claudio Andreetti, Desideria Argnani, Guido Baietto, Alessandro Bandiera, Cristiano Benato, Mauro Roberto Benvenuti, Alessandro Bertani, Luca Bertolaccini, Luigi Bortolotti, Edoardo Bottoni, Cristiano Breda, Pierpaolo Camplese, Paolo Carbognani, Giuseppe Cardillo, Caterina Casadio, Giorgio Cavallesco, Roberto Cherchi, Andrea Dell'Amore, Vittorio Della Beffa, Giampiero Dolci, Andrea Droghetti, Paolo A Ferrari, Diego Fontana, Gaetano Gargiulo, Roberto Gasparri, Diego Gavezzoli, Marco Ghisalberti, Michele Giovanardi, Francesco Guerrera, Andrea Imperatori, Maurizio Infante, Luciano Iurilli, Paolo Lausi, Fabio Lo Giudice, Francesco Londero, Luca Luzzi, Camillo Lopez, Maurizio Mancuso, Pio Maniscalco, Stefano Margaritora, Elisa Meacci, Giulio Melloni, Angelo Morelli, Felice Mucilli, Pamela Natali, Giampiero Negri, Samuele Nicotra, Mario Nosotti, Gianluca Pariscenti, Reinhold Perkmann, Fausto Pernazza, Emanuele Pirondini, Camilla Poggi, Francesco Puma, Majed Refai, Alessandro Rinaldo, Giovanna Rizzardi, Lorenzo Rosso, Nicola Rotolo, Emanuele Russo, Armando Sabbatini, Marco Scarci, Lorenzo Spaggiari, Alessandro Stefani, Piergiorgio Solli, Corrado Surrente, Alberto Terzi, Massimo Torre, Damiano Vinci, Andrea Viti, Gino Zaccagna, Francesco Zaraca

المساهمون: Bongiolatti, Stefano, Gonfiotti, Alessandro, Borgianni, Sara, Crisci, Roberto, Curcio, Carlo, Voltolini, Luca, Alloisio, Marco, Amore, Dario, Ampollini, Luca, Andreetti, Claudio, Argnani, Desideria, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Roberto Benvenuti, Mauro, Bertani, Alessandro, Bertolaccini, Luca, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Casadio, Caterina, Cavallesco, Giorgio, Cherchi, Roberto, Dell'Amore, Andrea, Della Beffa, Vittorio, Dolci, Giampiero, Droghetti, Andrea, A Ferrari, Paolo, Fontana, Diego, Gargiulo, Gaetano, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Iurilli, Luciano, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Luzzi, Luca, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Poggi, Camilla, Puma, Francesco, Refai, Majed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabbatini, Armando, Scarci, Marco, Spaggiari, Lorenzo, Stefani, Alessandro, Solli, Piergiorgio, Surrente, Corrado, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Zaccagna, Gino, Zaraca, Francesco

مصطلحات موضوعية: VATS-Lobectomy, Non-small cell lung cancer, Octogenarians, Complications, Quality of life

الوصف: Background: Thoracoscopic lobectomy (VATS-L) for non-small-cell lung cancer (NSCLC) is a well-established option for early stage NSCLC, but the evidences are limited for octogenarians. Objective: The objectives of this multi-institutional study were to evaluate the post-operative outcomes of VATS-L in octogenarians and to estimate the post-operative quality of life (QoL) using a validated questionnaire (EuroQoL5D). Methods: Data from patients underwent VATS-L between 2014 and 2019 were analysed and divided into two groups: Group A (younger patients) and Group B (octogenarians). To define predictors for complications, univariate and multivariable logistic regression analysis were performed. Results: 7023 patients underwent VATS-L and 329 (4.6%) were octogenarians. 30-day and 90-day post-operative mortality were similar (0.95% vs 0.91%, p = 0.84 and 1.3% vs 1.2%, p = 0.58), whereas the percentage of patients who suffered from any complication (25.5% vs 31.9%, p = 0.012) and the complication rate (31.6% vs 45.2%, p=<0.01) were higher for octogenarians. At discharge, the values of EuroQoL5D were worse in group B, but after one month these levels became similar. Age >80 years had a significant influence on morbidity on both univariate and multivariable analyses (p = 0.025). Conclusions: VATS-L for NSCLC can be performed in selected octogenarians without increased risk of post- operative death, acceptable not-life-threatening complications and a moderate impact on QoL.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33548589; info:eu-repo/semantics/altIdentifier/wos/WOS:000670223300006; volume:37; firstpage:1; lastpage:6; numberofpages:6; journal:SURGICAL ONCOLOGY; https://hdl.handle.net/11383/2169171Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100402668

الإتاحة: https://doi.org/10.1016/j.suronc.2021.101530Test
https://hdl.handle.net/11383/2169171Test

المؤلفون: Bongiolatti, Stefano, Gonfiotti, Alessandro, Viggiano, Domenico, Borgianni, Sara, Politi, Leonardo, Crisci, Roberto, Curcio, Carlo, Voltolini, Luca, Italian Vats Group, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano Di Rienzo, Camillo Lopez, Roberto Crisci, Duilio Divisi, Angelo Morelli, Alessandro Bertani, Francesco Londero, Lorenzo Rosso, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Andrea Droghetti, Andrea Giovanardi, Giuseppe Cardillo, Francesco Carleo, Luca Bertolaccini, Piergiorgio Solli, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco Pio Maniscalco, Desideria Argnani, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Mohsen Ibrahim, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera

المساهمون: Stefano, Bongiolatti, Alessandro, Gonfiotti, Domenico, Viggiano, Sara, Borgianni, Leonardo, Politi, Roberto, Crisci, Carlo, Curcio, Luca, Voltolini, Vats Group, Italian, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, Di Rienzo, Gaetano, Lopez, Camillo, Crisci, Roberto, Divisi, Duilio, Morelli, Angelo, Bertani, Alessandro, Londero, Francesco, Rosso, Lorenzo, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Droghetti, Andrea, Giovanardi, Andrea, Cardillo, Giuseppe, Carleo, Francesco, Bertolaccini, Luca, Solli, Piergiorgio, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco Pio Maniscalco, Giorgio, Argnani, Desideria, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Ibrahim, Mohsen, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Roberto Benvenuti, Mauro, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco

مصطلحات موضوعية: Video-assisted thoracic surgery · Lobectomy · Lung cancer · Conversion · Complications

الوصف: Objective The objective of the study is to analyse the causes and impact of conversion from VATS to thoracotomy identifying any possible pre-operative risk factors and related consequences. Methods Data from patient who underwent VATS lobectomy (VATS-L) for NSCLC at VATS Group participating centres were retrospectively analysed and divided in two groups: patients treated with VATS-L and patients who suffered from conversion. Predictors of conversion were assessed with univariate and multivariable exact logistic regression. Complications were evaluated as dependent variables of conversion in a Cox multivariable logistic regression model. Results A total of 4629 patients underwent planned VATS-L for NSCLC and of these, 432 (9.3%) required conversion; the most frequent causes were bleeding (30.4%) and fibro-calcified hilar lymph nodes (23.9%). The independent risk factors at multivariable analysis model were sex male (OR 1.458, p < 0.01), age older than 70 years (OR 1.248, p = 0.036) and the clinically node-positive disease (OR 2.258, p < 0.01). The mortality rate was similar, but the percentage of patients who suffered from any complication (41.7% vs 24.4%, p < 0.01), the complication rate (65% vs 32.2%, p < 0.01), chest tube duration (p < 0.01) and the hospitalisation rate (p < 0.01) were higher for patients converted. Atrial fibrillation (OR 1.471, p = 0.019), prolonged air leak (OR 1.403, p = 0.043), blood transfusions (OR 4.820, p < 0.01), sputum retention (OR 1.80, p = 0.027) and acute kidney failure (OR 2.758, p = 0.03) were significantly associated with conversion at multivariable analysis. Conclusions Conversion is associated with increased surgical morbidity, blood loss and hospital stay. Sex male, old age and the clinical involvement of lymph nodes were the strongest predictors of conversion.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30706153; info:eu-repo/semantics/altIdentifier/wos/WOS:000500976900010; numberofpages:10; journal:SURGICAL ENDOSCOPY; http://hdl.handle.net/11573/1311321Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060955519

الإتاحة: https://doi.org/10.1007/s00464-019-06682-5Test
http://hdl.handle.net/11573/1311321Test

المؤلفون: Francesco Xiumé, Roberto Palloni, Michele Salati, Armando Sabbatini, Majed Refai, Alessandro Brunelli, Michela Tiberi, Cecilia Pompili, Marco Monteverde

المصدر: European Journal of Cardio-Thoracic Surgery. 51:1177-1182

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Vital capacity, medicine.medical_specialty, medicine.medical_treatment, VATS lobectomy, 030204 cardiovascular system & hematology, Pulmonary function testing, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, DLCO, medicine, Humans, Prospective Studies, Thoracotomy, Pneumonectomy, Aged, Thoracic Surgery, Video-Assisted, business.industry, Recovery of Function, General Medicine, Middle Aged, respiratory system, Respiratory Function Tests, Surgery, 030228 respiratory system, Video assisted thoracic surgery, Propensity score matching, Observational study, Cardiology and Cardiovascular Medicine, business, human activities

الوصف: OBJECTIVES The objective of the present study was to compare functional loss [forced expiratory volume in one second to forced vital capacity ratio (FEV1), DLCO and VO2max reduction] after VATS versus open lobectomies. METHODS We performed a prospective observational study on 195 patients who had a pulmonary lobectomy from June 2010 to November 2014 and who were able to complete a 3-months functional evaluation follow-up program. Since the VATS technique was our first choice for performing lobectomies from January 2012, we divided the patients into two groups: the OPEN group (112 patients) and the VATS group (83 patients). The open approach was intended as a muscle sparing/nerve sparing lateral thoracotomy. Fourteen baseline factors were used to construct a propensity score to match the VATS-group patients with their OPEN-group counterparts. These two matched groups were then compared in terms of reduction of FEV1, DLCO and VO2max (Mann-Whitney test). RESULTS The propensity score analysis yielded 83 well-matched pairs of OPEN and VATS patients. In both groups, 3 months postoperatively, we found a reduction in FEV1, DLCO and VO2max values (OPEN patients: FEV1-10%, DLCO -11.9%, VO2max - 5.5%; VATS patients: FEV1-7.2%, DLCO-10.6%, VO2max-6.9%). The reductions in FEV1, DLCO and VO2max were similar to those in the two matched groups, with a Cohen effect size

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82022a3eeb3aad3421bc239041e11dd3Test
https://doi.org/10.1093/ejcts/ezx013Test

المؤلفون: Armando Sabbatini, Matteo Valentino, Monica Amati, Simona Gaetani, Jiri Neuzil, Federica Alessandrini, Lory Santarelli, Adriano Tagliabracci, Marco Tomasetti, Federica Monaco, Massimo Bracci

المصدر: The international journal of biochemistrycell biology. 121

مصطلحات موضوعية: 0301 basic medicine, Male, Mesothelioma, Lung Neoplasms, Inflammation, Biology, medicine.disease_cause, Biochemistry, Chromatin remodeling, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, medicine, Humans, Epigenetics, Carcinogen, Aged, Mesothelioma, Malignant, Asbestos, Cell Biology, medicine.disease, MicroRNAs, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Carcinogens, medicine.symptom, Carcinogenesis

الوصف: MiR-222 and miR-126 are associated with asbestos exposure and the ensuing malignancy, but the mechanism(s) of their regulation remain unclear. We evaluated the mechanism by which asbestos regulates miR-222 and miR-126 expression in the context of cancer etiology. An 'in vitro' model of carcinogen-induced cell transformation was used based on exposing bronchial epithelium BEAS-2B cells to three different carcinogens including asbestos. Involvement of the EGFR pathway and the role of epigenetics have been investigated in carcinogen-transformed cells and in malignant mesothelioma, a neoplastic disease associated with asbestos exposure. Increased expression of miR-222 and miR-126 were found in asbestos-transformed cells, but not in cells exposed to arsenic and chrome. Asbestos-mediated activation of the EGFR pathway and macrophages-induced inflammation resulted in miR-222 upregulation, which was reversed by EGFR inhibition. Conversely, asbestos-induced miR-126 expression was affected neither by EGFR modulation nor inflammation. Rather than methylation of the miR-126 host gene EGFL7, epigenetic mechanism involving DNMT1- and PARP1-mediated chromatin remodeling was found to upregulate of miR-126 in asbestos-exposed cells, while miR-126 was downregulated in malignant cells. Analysis of MM tissue supported the role of PARP1 in miR-126 regulation. Therefore, activation of the EGFR pathway and the PARP1-mediated epigenetic regulation both play a role in asbestos-induced miRNA expression, associated with in asbestos-induced carcinogenesis and tumor progression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1599a7f4d311401c55a71c6628cfaf95Test
https://pubmed.ncbi.nlm.nih.gov/32006662Test

المؤلفون: Nunzia Zanotta, Massimo Bovenzi, Armando Sabbatini, Matteo Valentino, Monica Amati, Manola Comar, Corrado Rubini, Ernesto Pasquini, Massimo Bracci, Federica Monaco, Jiri Neuzil, Simona Gaetani, Lory Santarelli, Marco Tomasetti

المساهمون: Santarelli, Lory, Gaetani, Simona, Monaco, Federica, Bracci, Massimo, Valentino, Matteo, Amati, Monica, Rubini, Corrado, Sabbatini, Armando, Pasquini, Ernesto, Zanotta, Nunzia, Comar, Manola, Neuzil, Jiri, Tomasetti, Marco, Bovenzi, Massimo

مصطلحات موضوعية: Male, Mesothelioma, 0301 basic medicine, Lung Neoplasms, Epidemiology, Population, medicine.disease_cause, Sensitivity and Specificity, 03 medical and health sciences, asbestos exposure, 0302 clinical medicine, Blood serum, non-small cell lung cancer, malignant pleural mesothelioma, miRNAs, biomarker, Carcinoma, Non-Small-Cell Lung, microRNA, Biomarkers, Tumor, Humans, Medicine, Epigenetics, Lung cancer, education, Aged, miRNA, education.field_of_study, business.industry, Mesothelioma, Malignant, Cancer, Asbestos, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Carcinogens, Cancer research, Biomarker (medicine), Female, business, Carcinogenesis

الوصف: Background: Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs able to distinguish asbestos-induced cancer from cancer with different etiology can be useful for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-induced malignancies. Methods: Four groups of patients were included in the study, including patients with asbestos-related (NSCLCAsb) and asbestos-unrelated non–small cell lung cancer (NSCLC) or with malignant pleural mesothelioma (MPM), and disease-free subjects (CTRL). The selected miRNAs were evaluated in asbestos-exposed population. Results: Four serum miRNAs, that is miR-126, miR-205, miR-222, and miR-520g, were found to be implicated in asbestos-related malignant diseases. Notably, increased expression of miR-126 and miR-222 were found in asbestos-exposed subjects, and both miRNAs are involved in major pathways linked to cancer development. Epigenetic changes and cancer-stroma cross-talk could induce repression of miR-126 to facilitate tumor formation, angiogenesis, and invasion. Conclusions: This study indicates that miRNAs are potentially involved in asbestos-related malignancies, and their expression outlines mechanism(s) whereby miRNAs may be involved in an asbestos-induced pathogenesis. Impact: The discovery of a miRNA panel for asbestos-related malignancies would impact on occupational compensation and may be utilized for screening asbestos-exposed populations.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc6a9adda140c58d797d23046bee02cTest
https://hdl.handle.net/11368/2929668Test

المؤلفون: Luca Bertolaccini, Fabio Davoli, Alessandro Pardolesi, Jury Brandolini, Desideria Argnani, Alessandro Bertani, Andrea Droghetti, Alessandro Gonfiotti, Duilio Divisi, Roberto Crisci, Piergiorgio Solli, Mario Nosotti, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano di Rienzo, Camillo Lopez, Angelo Morelli, Francesco Londero, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Giuseppe Cardillo, Francesco Carleo, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco, Pio Maniscalco, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Claudio Andretti, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera

المساهمون: Bertolaccini, Luca, Davoli, Fabio, Pardolesi, Alessandro, Brandolini, Jury, Argnani, Desideria, Bertani, Alessandro, Droghetti, Andrea, Gonfiotti, Alessandro, Divisi, Duilio, Crisci, Roberto, Solli, Piergiorgio, Nosotti, Mario, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco, Bertolaccini L., Davoli F., Pardolesi A., Brandolini J., Argnani D., Bertani A., Droghetti A., Gonfiotti A., Divisi D., Crisci R., Solli P., Nosotti M., Curcio C., Amore D., Marulli G., Nicotra S., De Negri A., Maineri P., di Rienzo G., Lopez C., Morelli A., Londero F., Spaggiari L., Gasparri R., Baietto G., Casadio C., Infante M., Benato C., Alloisio M., Bottoni E., Cardillo G., Carleo F., Stella F., Dolci G., Puma F., Vinci D., Cavallesco G., Maniscalco P., Ampollini L., Carbognani P., Terzi A., Viti A., Negri G., Bandiera A., Perkmann R., Zaraca F., Andretti C., Poggi C., Mucilli F., Camplese P., Luzzi L., Ghisalberti M., Imperatori A., Rotolo N., Bortolotti L., Rizzardi G., Torre M., Rinaldo A., Sabbatini A., Refai M., Benvenuti M.R., Benetti D., Stefani A., Natali P., Lausi P., Guerrera F.

مصطلحات موضوعية: Registrie, Male, Complications, Lung Neoplasms, medicine.medical_treatment, Iatrogenic Disease, 030204 cardiovascular system & hematology, 0302 clinical medicine, Retrospective Studie, Risk Factors, Thoracotomy, Registries, Pneumonectomy, Video-assisted thoracic surgery lobectomy, Univariate analysis, Thoracic Surgery, Video-Assisted, Thoracic Surgery, General Medicine, Treatment Outcome, Oncology, Italy, Cardiothoracic surgery, Female, Lung cancer, Human, medicine.medical_specialty, Complications, Conversion, Lung cancer, Lymph nodes dissection, Vascular injury, Video-assisted thoracic surgery lobectomy, VATS lobectomy, Video-Assisted, Vascular injury, NO, 03 medical and health sciences, medicine, Conversion, Lymph nodes dissection, Aged, Humans, Retrospective Studies, Vascular System Injuries, business.industry, Risk Factor, nutritional and metabolic diseases, Retrospective cohort study, medicine.disease, Surgery, Lung Neoplasm, 030228 respiratory system, business, Complication

الوصف: Objectives Vascular injuries are among the most severe causes of unplanned conversion during VATS lobectomies. The study aimed to analyse the incidence of vascular injuries and their risk factors during VATS lobectomy. Methods The Italian VATS lobectomy Registry was used to collect data from 66 Thoracic Surgery Units. From 2013 to October 2016 (out of more than 3,700 patients enrolled) only information from Units with an enrollment >100 VATS lobectomies were retrospectively analysed. Logistic regression analysis was performed on selected variables of the univariate analysis. Results Ten institutions contributed a total of 1,679 patients. Vascular injuries leading to conversion occurred in 44 (2.6%) patients. Years of experiences were inversely related to the risk of vascular injuries. Univariate analysis showed age, gender, surgical activity, Charlson Index Score and number of resected lymph nodes like significantly associated variables. Multivariate analysis revealed that number of resected lymph nodes, VATS experience ratio (number of VATS lobectomies/total lobectomies performed in the same year at same centre), and surgical activity of the centre were significantly associated with the risk of conversion. Unplanned thoracotomy was correlated with postoperative morbidity. Conclusion Vascular injuries in VATS lobectomies represented a rare complication which could directly affect the postoperative outcomes. The predictive factors for conversion were multifactorial and depended on characteristics of centres and surgeons’ seniority. Minimally invasive VATS lobectomy approaches did not influence the risk of vascular damages.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561bd5bb0f953e9bdd6361ee0bcaea7fTest
http://hdl.handle.net/2318/1719895Test