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1دورية أكاديمية
المؤلفون: Parul Chawla Gupta, Bijaya K. Padhi, Hashem Abu Serhan, Arkadiusz Dziedzic, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Abhay M. Gaidhane, Neelima Kukreti, Sarvesh Rustagi, Prakasini Satapathy
المصدر: Ophthalmology and Therapy, Vol 13, Iss 6, Pp 1635-1645 (2024)
مصطلحات موضوعية: COVID-19 vaccine, Corneal transplantation, Meta-analysis, Systematic review, Ophthalmology, RE1-994
الوصف: Abstract Introduction The COVID-19 pandemic has initiated an unparalleled global vaccination campaign, raising concerns about the vaccine's effects on various health conditions, including the risk of corneal transplant rejection. This systematic review aimed to identify the relationship between COVID-19 vaccination and rejection of corneal transplant, filling a significant gap in the existing medical literature. Methods A literature search was performed across multiple databases up to February 12, 2024, to identify studies evaluating the risk of corneal transplant rejection post-COVID-19 vaccination. Eligible studies were original research that reported outcomes of corneal graft rejection following vaccination. Nested Knowledge web software facilitated screening and data extraction. The Newcastle–Ottawa Scale was employed for quality assessment. A meta-analysis was conducted to calculate the aggregated relative risk (RR) utilizing R software version 4.3. Results Six studies were included in the qualitative synthesis, with four meeting the criteria for meta-analysis. These studies varied in geographic location, surgical techniques, and types of vaccines used. The pooled RR for corneal transplant rejection following COVID-19 vaccination was 0.816 (95% CI 0.178–1.453), indicating no significant risk of rejection. No statistical heterogeneity was observed among the studies (I 2 = 0%). Conclusions This review and meta-analysis found no significant evidence that COVID-19 vaccination increases the risk of corneal graft rejection. However, the current evidence is insufficient to conclusively determine the vaccine's safety for corneal transplant recipients. These findings underscore the need for additional research to confirm these preliminary results and investigate the long-term effects of COVID-19 vaccination on corneal transplants, aiming to provide evidence-based guidance to healthcare providers and patients.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Raghad Oday, BDS, Mushriq Abid, PhD, Arkadiusz Dziedzic, PhD
المصدر: Journal of Taibah University Medical Sciences, Vol 19, Iss 2, Pp 379-389 (2024)
مصطلحات موضوعية: Accuracy, Cleft lip and palate, PET-G/EVA, PMMA, Presurgical orthopaedics, Medicine (General), R5-920
الوصف: الملخص: أهداف البحث: تهدف هذه الدراسة المخلوطة والمختبرية إلى تقييم ومقارنة الدقة والاحتفاظ بألواح التشكيل المستخدمة كأجهزة تقويم العظام قبل الجراحة عند الرضع الذين يعانون من الشفة المشقوقة و/أو الحنك المشقوق. طريقة البحث: عشرة ألواح قولبة من كل مادة من ثلاث مواد: بولي ميثيل ميثاكريليت، ومصفف شفاف صلب، ومصفف شفاف صلب وناعم مزدوج الطبقات على نماذج عمل مطبوعة ثلاثية الأبعاد. تم تقييم الدقة عن طريق قياس المسافة الافتراضية بين لوحة التشكيل وبيانات المسح الخاصة بطاقم العمل بعد المسح البصري لكليهما عند 36 نقطة لكل لوحة. قام برنامج إكسوكاد بتسهيل جميع المحاذاة والقياسات الافتراضية. قام مقياس رقمي بقياس قوة الجر، التي تمثل قوة الاحتفاظ، باستخدام قالب مطبوع من الراتنج الناعم. النتائج: أظهرت ألواح المصففات الصلبة والشفافة أفضل ملاءمة مع طاقم العمل، مع تعديلات إجمالية تبلغ 0.146 للمصففات الصلبة الشفافة، و0.250 للمصففات الشفافة الصلبة والناعمة ذات الطبقة المزدوجة، و0.294 للمصففات متعددة الميثيل. بالنسبة إلى عدم التوافق الخاص بالمنطقة، أظهرت لوحات المصففات الصلبة والواضحة دقة فائقة في جميع المناطق، مع متوسط تباين قدره 0.16 مم، 0.15 مم، و0.12 مم في المناطق الأمامية والمتوسطة والخلفية، على التوالي. كان الاحتفاظ ب محاذاة صلبة وواضحة أعلى بكثير مقارنة بالمواد الأخرى، بمتوسط 3.34 ن، مقابل 1.65 ن لميثاكريلات البولي ميثيل و1.27 ن للمصففات الشفافة الصلبة والناعمة ذات الطبقة المزدوجة. الاستنتاجات: أظهرت ألواح التشكيل المصنوعة من مصففات صلبة وشفافة ملاءمة أفضل واحتفاظ أعلى من تلك المصنوعة من مصففات شفافة صلبة وناعمة مزدوجة الطبقات وميثاكريلات البولي ميثيل. يشير هذا إلى أن المصففات الصلبة والشفافة قد تكون المادة المفضلة لبناء أجهزة تقويم العظام قبل الجراحة للشفة المشقوقة و/أو الحنك المشقوق للرضع. Abstract: Objectives: This laboratory-based study aimed to evaluate and compare the accuracy and retention of moulding plates when used as pre-surgical orthopaedic appliances (PSIOs) for infants with cleft lip and/or palate (CL/P). Methods: Ten moulding plates were fabricated from three different materials (total sample size: 30), including polymethyl methacrylate (PMMA), a hard clear aligner (PET-G polymer), and a dual-layered hard and soft clear aligner (mixed PET-G/EVA) on ten three-dimensional (3D) printed working models. Accuracy was evaluated by measuring the virtual gap between the data acquired from the moulding plate and the working model after the optical scanning at each of the designated 36 points for each plate. Exocad software was used to facilitate all virtual alignments and measurements. Retention was measured using a digital gauge that quantified the traction force required to separate the plates from the retention test cast (a soft resin printed cast). Results: PET-G plates exhibited the best fit with the working cast, with overall adaptations of 0.146 ± 0.012 for PET-G, 0.250 ± 0.073 for PET-G/EVA, and 0.294 ± 0.113 for PMMA. For region-specific misfit, PET-G plates exhibited superior accuracy across all regions, with mean discrepancies of 0.16 ± 0.08 mm, 0.15 ± 0.061 mm, and 0.12 ± 0.128 mm in the anterior, middle, and posterior regions, respectively. Retention for PET-G was significantly higher than the other materials, with a mean of 3.34 N ± 0.487, as opposed to 1.65 N ± 0.331for PMMA and 1.27 N ± 0.239 for PET-G/EVA (P
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S1658361224000052Test; https://doaj.org/toc/1658-3612Test
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3دورية أكاديمية
المؤلفون: Tahani Al Rahbeni, Prakasini Satapathy, Ramaiah Itumalla, Roy Rillera Marzo, Khalid A L Mugheed, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Ali A Rabaan, Hayam A Alrasheed, Maha F Al-Subaie, Nawal A Al Kaabil, Mohammed Alissa, Amani Ahmed A L Ibrahim, Hussain Abdulkhaliq Alsaif, Israa Habeeb Naser, Sarvesh Rustagi, Neelima Kukreti, Arkadiusz Dziedzic
المصدر: JMIR Public Health and Surveillance, Vol 10, p e54769 (2024)
مصطلحات موضوعية: Public aspects of medicine, RA1-1270
الوصف: BackgroundThe unprecedented emergence of the COVID-19 pandemic necessitated the development and global distribution of vaccines, making the understanding of global vaccine acceptance and hesitancy crucial to overcoming barriers to vaccination and achieving widespread immunization. ObjectiveThis umbrella review synthesizes findings from systematic reviews and meta-analyses to provide insights into global perceptions on COVID-19 vaccine acceptance and hesitancy across diverse populations and regions. MethodsWe conducted a literature search across major databases to identify systematic reviews and meta-analysis that reported COVID-19 vaccine acceptance and hesitancy. The AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews) criteria were used to assess the methodological quality of included systematic reviews. Meta-analysis was performed using STATA 17 with a random effect model. The data synthesis is presented in a table format and via a narrative. ResultsOur inclusion criteria were met by 78 meta-analyses published between 2021 and 2023. Our analysis revealed a moderate vaccine acceptance rate of 63% (95% CI 0.60%-0.67%) in the general population, with significant heterogeneity (I2 = 97.59%). Higher acceptance rates were observed among health care workers and individuals with chronic diseases, at 64% (95% CI 0.57%-0.71%) and 69% (95% CI 0.61%-0.76%), respectively. However, lower acceptance was noted among pregnant women, at 48% (95% CI 0.42%-0.53%), and parents consenting for their children, at 61.29% (95% CI 0.56%-0.67%). The pooled vaccine hesitancy rate was 32% (95% CI 0.25%-0.39%) in the general population. The quality assessment revealed 19 high-quality, 38 moderate-quality, 15 low-quality, and 6 critically low-quality meta-analyses. ConclusionsThis review revealed the presence of vaccine hesitancy globally, emphasizing the necessity for population-specific, culturally sensitive interventions and clear, credible information dissemination to foster vaccine acceptance. The observed disparities accentuate the need for continuous research to understand evolving vaccine perceptions and to address the unique concerns and needs of diverse populations, thereby aiding in the formulation of effective and inclusive vaccination strategies. Trial RegistrationPROSPERO CRD42023468363; https://tinyurl.com/2p9kv9crTest
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Athar Thair, Mushriq Abid, Arkadiusz Dziedzic
المصدر: Children, Vol 11, Iss 3, p 332 (2024)
مصطلحات موضوعية: caregivers, cleft lip and palate, experience, survey, Pediatrics, RJ1-570
الوصف: Background: This study aimed to assess caregivers’ experiences and perceptions of applying lip taping as presurgical orthopedic therapy (PSO) for infants with a cleft lip and palate. Methods: A retrospective survey was conducted, inviting parents to respond to a series of structured questions between September 2022 and June 2023. The questionnaire focused on evaluating parents’ experience with lip taping, a crucial component of PSO. Descriptive statistics and the Chi-square test were employed to analyze relationships between categorical variables. Results: Of the 157 participants, overall, 122 completed the survey, forming the dataset for analysis. A majority (90.0%) reported sufficient experience in using lip taping and no major difficulties with lip taping application. Caregivers with higher education levels exhibited a significantly positive correlation (p = 0.015). Additionally, 93.4% confirmed the efficacy of lip taping for premaxillary segment retraction, with this outcome being correlated with caregivers’ knowledge and education (p = 0.008). Interestingly, caregivers’ age also demonstrated a substantial association (p = 0.020). Conclusions: While a vast majority expressed positive experiences with lip taping as a presurgical treatment, continuous, tailored education on cleft lip and palate is imperative. This education should be directed towards caregivers and individuals offering direct support to parents of children with CLP, ensuring optimal care and preparation for surgical treatment.
وصف الملف: electronic resource
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5دورية أكاديمية
المؤلفون: Shashi B. Singh, Bijaya K. Padhi, Aravind P. Gandhi, Pallavi Lohani, Nisha Kumari, Geetu Singh, Prakasini Satapathy, Keerti Bhusan Pradhan, Sarvesh Rustagi, Alaa Hamza Hermis, Arkadiusz Dziedzic, Ranjit Sah
المصدر: Travel Medicine and Infectious Disease, Vol 55, Iss , Pp 102633- (2023)
مصطلحات موضوعية: COVID-19 vaccine, Stillbirth, Pregnancy, Complications, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
الوصف: Objective: To estimate the global burden of stillbirths among pregnant women with the COVID-19 vaccination. Data source: In this systematic review and meta-analysis, a literature search was carried out in PubMed, Cochrane and Scopus until February 4, 2023, with language restriction (English). Study selection: Title-abstract screening followed by full text review was done independently by two authors, based on the research question, “What is the prevalence of stillbirths among the pregnant women vaccinated with COVID-19 vaccines?” Data extraction: Two authors independently extracted the relevant data from every study. The third author resolved the conflicts. This study was registered in PROSPERO and followed the PRISMA guidelines. Data analysis: A Random effects model was applied to assess the pooled estimate of stillbirths. The I2 test was used to assess the heterogeneity of the articles included in the study. For checking the publication bias, the Doi plot and the contour-enhanced funnel plot were utilized. Results: The database systematic search yielded 168 articles; 11 of them were determined to be eligible for systematic review and 8 of them ended up being included for meta-analysis. The pooled prevalence of stillbirth in pregnant women vaccinated against COVID-19 infection was 0.00509 (5 per 1000 live births delivered by pregnant women vaccinated against COVID-19 (95% CI: 0.00003–0.01676). Statistically significant heterogeneity was reported across studies (I2 = 98%; p
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S1477893923000935Test; https://doaj.org/toc/1873-0442Test
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6دورية أكاديمية
المؤلفون: Robert Kubina, Kamil Krzykawski, Arkadiusz Sokal, Marcel Madej, Arkadiusz Dziedzic, Monika Kadela-Tomanek
المصدر: Cells, Vol 12, Iss 18, p 2288 (2023)
مصطلحات موضوعية: flavonol, anticancer, flow cytometry, apoptosis, head and neck cancer, cyclin, Cytology, QH573-671
الوصف: Head and neck cancer (HNC) therapy is limited; therefore, new solutions are increasingly being sought among flavonoids, which exhibit numerous biological properties, including potential anticancer activity. However, because they are mostly insoluble in water, are unstable and have low bioavailability, they are subjected to chemical modification to obtain new derivatives with better properties. This study aimed to synthesize and analyze new propargyloxy derivatives of galangin, kaempferol and fisetin, and to evaluate their anticancer activity against selected HNC cell lines. The obtained derivatives were assessed by spectroscopic analysis; next, their anticancer activity was evaluated using a flow cytometer and real-time cell analysis. The results showed that only the fisetin derivative was suitable for further analysis, due to the lack of crystal formation of the compound. The fisetin derivative statistically significantly increases the number of cells in the G2/M phase (p < 0.05) and increases cyclin B1 levels. A statistically significant increase in the number of apoptotic cells after being exposed to the tested compound was also observed (p < 0.05). The data indicate that the obtained fisetin derivative exhibits anticancer activity by affecting the cell cycle and increasing apoptosis in selected HNC lines, which suggests its potential use as a new medicinal agent in the future.
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Mohammad Amin Amiri, Nima Farshidfar, Richard J. Miron, Arkadiusz Dziedzic, Shahram Hamedani, Sajad Daneshi, Lobat Tayebi
المصدر: International Journal of Biomaterials, Vol 2023 (2023)
مصطلحات موضوعية: Biotechnology, TP248.13-248.65
الوصف: Osteoporosis is a chronic multifactorial condition that affects the skeletal system, leading to the deterioration of bone microstructure and an increased risk of bone fracture. Platelet-derived biomaterials (PDBs), so-called platelet concentrates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have shown potential for improving bone healing by addressing microstructural impairment. While the administration of platelet concentrates has yielded positive results in bone regeneration, the optimal method for its administration in the clinical setting is still debatable. This comprehensive review aims to explore the systemic and local use of PRP/PRF for treating various bone defects and acute fractures in patients with osteoporosis. Furthermore, combining PRP/PRF with stem cells or osteoinductive and osteoconductive biomaterials has shown promise in restoring bone microstructural properties, treating bony defects, and improving implant osseointegration in osteoporotic animal models. Here, reviewing the results of in vitro and in vivo studies, this comprehensive evaluation provides a detailed mechanism for how platelet concentrates may support the healing process of osteoporotic bone fractures.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/1687-8795Test
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8دورية أكاديمية
المصدر: Medycyna Pracy, Vol 72, Iss 6, Pp 685-692 (2021)
مصطلحات موضوعية: sars-cov-2, covid-19, oral lesions, oral manifestations, oral cavity, salivary glands, Public aspects of medicine, RA1-1270
الوصف: Virus-induced oral abnormalities, occurring especially in severe COVID-19 cases of hospitalized patients, have various characteristics and clinical features being, either directly or indirectly, related to SARS-CoV-2 infection. Deregulation of the immune system as a result of SARS-CoV-2 infection may lead to the impairment of the normal defense pathway in the SARS-CoV-2 positive patients. This scoping mini-review is aimed to critically appraise the existing evidence concerning the potential link between COVID-19 condition and abnormal manifestations within oral cavity, affecting oral mucosa, salivary glands and sensory elements. COVID-induced oral mucosa manifestations, with various clinical aspects, are likely to occur as coinfections and secondary symptoms, as immune system imbalance is per se a causative factor of secondary manifestations. Oral mucosal lesions related to SARS-CoV-2 infection do not seem to demonstrate gender predilection, with the average reported age around 50 years of age. They include mainly white and erythematous plaques, ulcers, blisters, petechiae. The affected intraoral areas were mainly: tongue, palate, lips, gingiva, and buccal mucosa. The “aggressive” therapies utilized to treat COVID-19, including drug interactions may aggravate or initiate OMLs pathologies. Neglected oral hygiene or partial or complete abandonment of oral hygiene during intensive hospitalization constitutes an independent factor promoting a wide range of oral pathologies. In addition, stress factor indirectly impairs functioning of the immune system. Oral mucosa lesions occurring in COVID-19 cases present with a wide variation of non-characteristic features. These intraoral, soft tissues abnormalities seem to be reversible and transient. A potential impact of severe oral pathologies to systemic health resulting from SARS-CoV-2 infection, along with associated poor oral hygiene should not be ignored, predominantly in seriously ill patients hospitalized in intensive care units. Med Pr. 2021;72(6):685–92
وصف الملف: electronic resource
العلاقة: http://medpr.imp.lodz.pl/The-spectrum-of-non-characteristic-oral-manifestations-in-COVID-19-a-scoping-brief,139473,0,2.htmlTest; https://doaj.org/toc/0465-5893Test; https://doaj.org/toc/2353-1339Test
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9دورية أكاديمية
المؤلفون: Alvaro Cavalheiro Soares, Fabio Ramoa Pires, Nara Regina de Oliveira Quintanilha, Lilian Rocha Santos, Thaylla Nunez Amin Dick, Arkadiusz Dziedzic, Bruna Lavinas Sayed Picciani
المصدر: Biomedicines, Vol 11, Iss 7, p 1882 (2023)
مصطلحات موضوعية: Behçet’s syndrome, Behçet’s disease, oral lesions, ulcers, vasculitis, inflammation, Biology (General), QH301-705.5
الوصف: Background: Behçet’s disease (BD) is a rare chronic auto-inflammatory systemic disease with non-specific oral manifestations, categorised as generalised variable vessel vasculitis that requires an interdisciplinary approach to diagnose due to its phenotypic heterogeneity. Whilst the oral lesions that reoccur in BD underpin the complex diagnostic process, the crucial role of dental professionals is highlighted in a case report summarised herein. We present a case of a 47-year-old male referred to the Oral Medicine Department by a rheumatologist after previous hospitalization for thrombosis of the iliac vein and inferior vena cava. He had elevated inflammatory C-reactive protein biomarker and an increased erythrocyte sedimentation rate. Recurrent episodes of folliculitis, oral and genital ulcers were reported. Clinical examination revealed multiple ulcerations in the oral mucosa. The complementary, histopathological analysis performed to rule out other disorders, based on excisional biopsy, showed non-keratinised stratified squamous epithelium with areas of exocytosis and ulceration. The connective tissue presented an intense mixed inflammatory infiltrate, congested blood vessels, haemorrhage, vasculitis, and HLA-B genotyping identified the expression of HLA-B15, further supporting the BD diagnosis. Treatment was initiated with colchicine, prednisolone, and weekly subcutaneous administration of methotrexate and resulted in the complete remission of oral lesions and no recurrence of other manifestations. Conclusions: This BD case report emphasizes the importance of a multidisciplinary approach in diagnosing BD, including the use of histopathological assessment and genetic profiling. It highlights the significance of thorough intraoral assessment and referral to a multidisciplinary team for diagnosis. The oral manifestations of BD as the primary symptoms often indicate underlying major systemic pathologies. The authors stress the need for a structured diagnostic algorithm to facilitate timely and effective management of BD.
وصف الملف: electronic resource
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10دورية أكاديمية
المؤلفون: Robert Kubina, Kamil Krzykawski, Arkadiusz Dziedzic, Agata Kabała-Dzik
المصدر: Cells, Vol 12, Iss 12, p 1568 (2023)
مصطلحات موضوعية: fisetin, kaempferol, apoptosis, head and neck cancer, cell cycle, caspase-3, Cytology, QH573-671
الوصف: Despite the relative effectiveness of standard cancer treatment strategies, head and neck cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While selected bioactive compounds of plant origin reveal a pro-apoptotic effect, kaempferol and fisetin flavonols have been reported as potential anti-cancer agents against malignant neoplasms. To date, their exact role in signaling pathways of head and neck cancer cells is largely unknown. Based on the various methods of cytotoxicity testing, we elucidated that kaempferol and fisetin inhibit proliferation, reduce the capacity of cell migration, and induce apoptosis in SCC-9, SCC-25, and A-253 HNC cells in a dose-dependent manner in vitro (p < 0.05, fisetin IC50 values of 38.85 µM, 62.34 µM, and 49.21 µM, and 45.03 µM, 49.90 µM, and 47.49 µM for kaempferol–SCC-9, SCC-25, and A-253, respectively). The obtained results showed that exposure to kaempferol and fisetin reduces Bcl-2 protein expression, simultaneously leading to the arrest in the G2/M and S phases of the cell cycle. Kaempferol and fisetin inhibit cell proliferation by interfering with the cell cycle, which is strongly associated with the induction of G2/M arrest, and induce apoptosis by activating caspase-3 and releasing cytochrome c in human HNC cells. In addition, investigating flavonols, by inhibiting anti-apoptotic proteins from the Bcl-2 family and damaging the mitochondrial transmembrane potential, increased the level of cytochrome c. While flavonols selectively induce apoptosis of head and neck cancer cells, they may support oncological therapy as promising agents. The discovery of new derivatives may be a breakthrough in the search for effective chemotherapeutic agents with less toxicity and thus fewer side effects.
وصف الملف: electronic resource
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