المؤلفون: Ma, Renqiang^1,2 (AUTHOR) 15196643789@163.com, Li, Sijia² (AUTHOR) shijianyu@126.com, Mo, Qingmei^1,2 (AUTHOR) 19850858730@163.com, Chen, Xiaojuan^1,2 (AUTHOR) 15907650622@163.com, Liang, Yan² (AUTHOR) hb_nj@163.com, Hu, Tao² (AUTHOR), Hu, Hui² (AUTHOR), He, Bao² (AUTHOR), Li, Renshi¹ (AUTHOR) junpingkou@cpu.edu.cn, Kou, Junping¹ (AUTHOR), Yu, Boyang¹ (AUTHOR) li-renshi@cpu.edu.cn

المصدر: Pharmaceuticals (14248247). Apr2024, Vol. 17 Issue 4, p496. 21p.

مصطلحات موضوعية: *HEART failure, *ABDOMINAL aorta, *HEART, *RATS, *CORONARY arteries, *EDIBLE plants, *FUNCTIONAL status

مستخلص: Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats induced by various etiologies. It further compares the efficacy differences between preventative and treatment administration, varying dosages, and treatment durations, to provide improved guidance for medication in heart failure rats and determine which categories of chronic heart failure rats might benefit most from crocetin. Chronic heart failure models induced by abdominal aorta constriction, renal hypertension, and coronary artery ligation were constructed. By examining cardiac function, blood biochemistry, and histopathology, the study assessed the preventive and therapeutic effects of crocetin on load-induced and myocardial ischemia-induced heart failure. The results showed that in all three models, both treatment and preventative administration of crocetin significantly improved chronic heart failure in rats, especially in preventative administration. The results indicate crocetin may be beneficial for improving symptoms and functional capacity in rats with heart failure. Furthermore, long-term administration was more effective than short-term administration across all three rat models, with therapeutic onset observed over 6 weeks. [ABSTRACT FROM AUTHOR]

المؤلفون: Steiner, Kristoffer¹ (AUTHOR), Sjöberg, Gunnar¹ (AUTHOR), Karsenty, Clément² (AUTHOR), Bianco, Lisa^3,4 (AUTHOR), Bautista‐Rodriguez, Carles^3,4 (AUTHOR), Fraisse, Alain^3,4 (AUTHOR) a.fraisse@rbht.nhs.uk

المصدر: Acta Paediatrica. Apr2024, Vol. 113 Issue 4, p812-817. 6p.

مصطلحات موضوعية: *PATENT ductus arteriosus, *AORTA

مستخلص: Aim: To describe our initial experience with the indications and results of the 5/7 Occlutech® duct Occluder (ODO, Occlutech International AB, Helsingborg, Sweden). A small incremental increase in occluder sizes is of utmost importance for successful outcomes, especially in smaller patients in whom protrusion of the distal disk towards the aorta should be minimised. Methods: Retrospective study of all patients undergoing PDA closure with the 5/7 ODO in three institutions since 2018. Results: The 5/7 ODO was used in 18 patients with median age and weight at the time of the procedure of 17.5 months (interquartile range 25th to 75th percentile 8 months– 4.4 years) and 13.6 kg (interquartile range 25th to 75th percentile 6.4–22.5 kg) respectively. All cases were successful. There were no cases of device embolisation, haemolysis, or flow disturbance of the LPA or the aorta. Conclusions: This small retrospective study demonstrated an excellent outcome of transcatheter PDA closure with the 5/7 ODO. The device is a beneficial complement to the existing sizes of PDA devices, filling the gap between the 4/6 and 6/8 ODO and avoiding protrusion of a larger disk in the aortic isthmus. [ABSTRACT FROM AUTHOR]

المؤلفون: Bera, Anjan¹, Maji, Avik², Chakrabarti, Debasmita³ dmdebojyoti22@gmail.com, Adhikary, Shilpi⁴, Manna, Debojyoti⁴, Gangopadhyay, Soham³, Mandal, Srikrishna⁵

المصدر: Asian Journal of Medical Sciences. Apr2024, Vol. 15 Issue 4, p8-12. 5p.

مصطلحات موضوعية: *ABDOMINAL aorta, *RADIOTHERAPY treatment planning, *ILIAC artery, *INTERVENTIONAL radiology, *MAGNETIC resonance imaging, *AORTIC dissection, *ANATOMY

مستخلص: Background: The course, the origin of the branch, and the division of the aorta may vary and the aortic bifurcation level and branching can be determined by arteriogram, magnetic resonance imaging, computed tomography (CT) scan, and cadaveric dissection. Aims and Objectives: This study aimed to find the variation in aortic bifurcation levels in cervical malignancy patients who underwent radiotherapy. Materials and Methods: Between January 2018 and December 2022 previously untreated, histologically proven squamous cell carcinoma of the cervix patients who received radiotherapy in our department were selected for this retrospective analysis. A planning contrast-enhanced CT scan with a 3 mm slice thickness was done in a CT simulator to delineate the target volume and aorta, common iliac vessels in all patients. Results: 407 cervical carcinoma patients who received radiotherapy in Linear Accelerator (LINAC) were included in this analysis. The aortic bifurcation is most commonly situated at the level of the L3-L4 intervertebral disc in 290 (71.25%) cases with a range between the upper L3 body and the lower L5 body. The common iliac bifurcation was situated at the level of L5-S1 in 338 cases (83.04%) and S1 vertebral body in 63 cases (15.47%). The average length of the left common iliac artery was 4.58 cm and the right common iliac artery was 4.44 cm. The diameter of the aorta at the level of just before the bifurcation is 1.39 cm. The average diameter of the left common iliac artery and right common iliac artery were 1.21 cm and 1.13 cm, respectively. The right and left take-off angles (αR, αL) are 25.58° and 23.78°, respectively. Conclusion: The knowledge regarding the anatomic variation of branching and bifurcation of the aorta of utmost importance for surgical procedures, interventional radiology procedures, and proper radiotherapy treatment planning. Acknowledging these anatomic variations may also reduce complications. [ABSTRACT FROM AUTHOR]

المؤلفون: Ayu Ishida¹, Mitsuru Ida¹ nwnh0131@yahoo.co.jp, Yuki Kinugasa^1,2, Hitomi Nakatani^1,3, Kayo Uyama⁴, Masahiko Kawaguchi⁵

المصدر: Annals of Cardiac Anaesthesia. Apr-Jun2024, Vol. 27 Issue 2, p144-149. 6p.

مصطلحات موضوعية: *ELECTIVE surgery, *AORTA, *CRONBACH'S alpha, *ADULTS

مستخلص: Background: Patient-centered outcome measures should be evaluated postoperatively as the recovery after surgery varies between patients. We aimed to evaluate the feasibility, reliability, and trajectory of the quality of recovery-15 (QoR-15) in patients undergoing cardiothoracic and aortic surgeries. Materials and Methods: This retrospective study included adult patients who underwent elective cardiothoracic and aortic surgeries. The primary outcome was the QoR-15, with a minimal clinically important difference of 6.8, assessed on postoperative days (POD) 2, 4, and 7. The final analysis included patients with at least one valid outcome. Feasibility and reliability were assessed by the successful completion rate on each POD and using Cronbach's alpha of the QoR-15 on POD 4. A linear mixed model was used to evaluate the trajectory of the postoperative QoR-15 scores. Results: Of the 36 eligible patients, 30 with a mean age of 70 years were included in the final analysis. The successful completion rates on POD 2, 4, and 7 were 72.7%, 87.8%, and 87.8%, respectively. The mean QoR-15 scores on POD 2, 4, and 7 were 89.9, 98.0, and 108.3, respectively. The QoR-15 scores on POD 2 and 4 were not statistically different (P = 0.06) but were clinically significant. The QoR-15 score on POD 7 was statically (P < 0.001) and clinically higher than the QoR-15 score on POD 2. Cronbach's alpha for the QoR-15 score measured on POD 4 was 0.85. Conclusion: The QoR-15 is a feasible and valid measurement after elective cardiothoracic surgery, which increases significantly over time after surgery. [ABSTRACT FROM AUTHOR]

المؤلفون: Shi, Caiyun¹ (AUTHOR) caiyunshi@gzhmu.edu.cn, Liang, Dong^2,3 (AUTHOR), Wang, Haifeng² (AUTHOR), Zhu, Yanjie^1,2 (AUTHOR) yj.zhu@siat.ac.cn

المصدر: Magnetic Resonance Imaging (0730725X). Apr2024, Vol. 107, p80-87. 8p.

مصطلحات موضوعية: *IMAGE reconstruction, *THORACIC aorta, *MAGNETIC resonance imaging

مستخلص: To improve the scan efficiency of thoracic aorta vessel wall imaging using a self-gating (SG)-based motion correction scheme. A slab-selective variable-flip-angle 3D turbo spin-echo (SPACE) sequence was modified to acquire SG signals and imaging data. Cartesian sampling with a tiny golden-step spiral profile ordering was used to obtain the imaging data during the systolic period, and then the image data were subsequently corrected based on the SG signals and binned to different respiratory cycles. Finally, respiratory artifacts were estimated from image-based registration of 3D undersampled respiratory bins that were reconstructed with L1 iterative self-consistent parallel imaging reconstruction (SPIRiT). This method was evaluated in 11 healthy volunteers and compared against conventional diaphragmatic navigator-gated acquisition to assess the feasibility of the proposed framework. Results showed that the proposed method achieved image quality comparable to that of conventional diaphragmatic navigator-gated acquisition with an average scan time of 4 min. The sharpness of the vessel wall and the definition of the liver boundary were in good agreement with the navigator-gated acquisition, which took approximately above 8.5 min depend on the respiratory rate. Further valuation of this technique in patients will be conducted to determine its clinical use. [ABSTRACT FROM AUTHOR]

المؤلفون: Homma, Satoki^1,2 satoki.homma@nifty.com, Kato, Kiyoe³

المصدر: Angiology. Apr2024, Vol. 75 Issue 4, p349-358. 10p.

مصطلحات موضوعية: *CORONARY arterial radiography, *AORTA radiography, *BIOMARKERS, *DISEASE progression, *LOW density lipoproteins, *RISK assessment, *ARTERIAL diseases, *ARTERIOSCLEROSIS, *DESCRIPTIVE statistics, *COMPUTED tomography, *DATA analysis software, *CARDIOVASCULAR disease diagnosis

مستخلص: The significance of atherosclerotic calcified lesions observed on low-dose computed tomography (LDCT) performed during general checkups was investigated. The coronary arteries (CA), ascending aorta and aortic arch (AAAA), descending thoracic aorta (DTA), and abdominal aorta (AA) were examined. Semiquantitative calcified index analysis of the DTA and AA in terms of atherosclerosis risk factors and cardio-ankle vascular index (CAVI) measurements was also performed. We included 1594 participants (mean age: 59.2 years; range: 31–91 years). The prevalence of calcified lesions was 71.0%, 66.6%, 57.2%, and 37.9% in the AA, CA, AAAA, and DTA, respectively. Age-related advances in calcification among participants with no major risk factors, revealed that calcification appeared earliest in the AA, followed by the CA, AAAA, and DTA. Participants with calcified lesions in all arteries had a significantly greater CAVI than those without calcification. The CAVI was negatively correlated with low-density lipoprotein cholesterol levels, particularly in participants without calcified lesions in the DTA. Calcified lesions on LDCT could indicate the end stage of atherosclerotic lesions. The CAVI can be used to assess atherosclerotic changes at all stages of disease progression. A combination of LDCT and CAVI could be used as a routine non-invasive assessment of atherosclerosis. [ABSTRACT FROM AUTHOR]

المؤلفون: Wei, Shixiong^1,2 (AUTHOR), Zhang, Yiyuan^1,2 (AUTHOR), Luo, Feixiang¹ (AUTHOR), Duan, Kexing¹ (AUTHOR), Li, Mingqian¹ (AUTHOR), Lv, Guoyue¹ (AUTHOR) prof_lvgy@163.com

المصدر: European Journal of Cardio-Thoracic Surgery. Apr2024, Vol. 65 Issue 4, p1-9. 9p.

مصطلحات موضوعية: *HOMOGRAFTS, *AORTA, *IN situ hybridization, *NEOVASCULARIZATION, *REGENERATION (Biology), *BREAST implants, *THORACIC surgery

مستخلص: OBJECTIVES Tracheal reconstruction post-extensive resection remains an unresolved challenge in thoracic surgery. This study evaluates the use of aortic allografts (AAs) for tracheal replacement and reconstruction in a rat model, aiming to elucidate the underlying mechanisms of tracheal regeneration. METHODS AAs from female rats were employed for tracheal reconstruction in 36 male rats, with the replacement exceeding half of the tracheal length. To avert collapse, silicone stents were inserted into the AA lumens. No immunosuppressive therapy was administered. The rats were euthanized biweekly, and the AAs were examined for neovascularization, cartilage formation, respiratory epithelial ingrowth, submucosal gland regeneration and the presence of the Sex-determining region of Y-chromosome (SRY) gene. RESULTS All procedures were successfully completed without severe complications. The AA segments were effectively integrated into the tracheal framework, with seamless distinction at suture lines. Histological analysis indicated an initial inflammatory response, followed by the development of squamous and mucociliary epithelia, new cartilage ring formation and gland regeneration. In situ hybridization identified the presence of the SRY gene in newly formed cartilage rings, confirming that regeneration was driven by recipient cells. CONCLUSIONS This study demonstrates the feasibility of AAs transforming into functional tracheal conduits, replicating the main structural and functional characteristics of the native trachea. The findings indicate that this approach offers a novel pathway for tissue regeneration and holds potential for treating extensive tracheal injuries. [ABSTRACT FROM AUTHOR]

المؤلفون: P., Padmaja¹, T., Prashanti¹, Gooty, Uma Maheswari², Somasekher, Rupanagudi¹ anatomyfaculty.kmc@gmail.com

المصدر: European Journal of Cardiovascular Medicine. 2024, Vol. 14 Issue 2, p1113-1117. 5p.

مصطلحات موضوعية: *THORACIC aorta, *SUBCLAVIAN artery, *VERTEBRAL artery, *CAROTID artery, *BRACHIOCEPHALIC trunk

مستخلص: Background: Knowledge concerning the various anomalies of aortic arch derivatives is important to the clinician, radiologist and surgeon. This knowledge aids in evaluating the finding in cases in which symptoms may result from the vascular anomalies. Aim: to study the branching pattern of aortic arch and its clinical importance Materials and Methods: A total of 50 dead foetuses (Male-30; Females-20) collected from the Department of Obstetrics and Gynaecology and 10 adult cadavers (Male-7; Female-3) from the Department of Anatomy, Kurnool was utilized for the present study. The mediastinum was opened, and the branching pattern of the arch of aorta was observed Results: The present study is carried out on 60 specimens of 50 dead fetuses (Male-33; Female-17) and 10 cadavers (Male-7; Female-3). The normal branching pattern (Type-I) of Arch of Aorta was observed in 47 (78.3%) and the most common variation of a common stem for the brachiocephalic trunk and left common carotid artery (Type-II) observed in 8 (13.3%) specimens. The left vertebral artery arose directly from the Arch of the Aorta (Type-III) with an incidence of 4 (6.6%) and one specimen (1.7%) has a common stem (Type-IX) for the left common carotid and left subclavian artery was noted in the present study. Conclusion: The present study could be of valuable information to radiologists and surgeons. Further studies on the Aortic Arch and its branches in live individuals will enable us to design stents. [ABSTRACT FROM AUTHOR]

المؤلفون: Egbe, Alexander C.¹ (AUTHOR) egbe.alexander@mayo.edu, Miranda, William R.¹ (AUTHOR), Abozied, Omar¹ (AUTHOR), Jain, C. Charles¹ (AUTHOR), Burchill, Luke J.¹ (AUTHOR), Karnakoti, Snigdha¹ (AUTHOR), Ahmed, Marwan H.¹ (AUTHOR), Francois, Christopher J.² (AUTHOR), Connolly, Heidi M.¹ (AUTHOR)

المصدر: Journal of the American College of Cardiology (JACC). Mar2024, Vol. 83 Issue 12, p1136-1146. 11p.

مصطلحات موضوعية: *ASCENDING aorta aneurysms, *AORTIC coarctation, *AORTIC valve, *TRICUSPID valve, *THORACIC aneurysms

مستخلص: Aortic aneurysm is common in patients with coarctation of aorta (COA), but it is unclear whether the risk of aortic aneurysms is due to COA or related to the presence of other risk factors such as bicuspid aortic valve (BAV) and hypertension. The purpose of this study was to assess the relationship among COA, BAV, and thoracic aortic aneurysms. A total of 867 patients with COA (COA group) were matched 1:1:1 to 867 patients with isolated BAV (BAV group) and 867 patients without structural heart disease (SHD) (no-SHD group). The COA group was further subdivided into a COA+BAV subgroup (n = 304 [35%]), and COA with tricuspid aortic valve (TAV) (COA+TAV subgroup [n = 563 (65%)]). Aortic dimensions were assessed at baseline and at 3, 5, and 7 years. Compared with the no-SHD group, the COA+BAV subgroup had larger aortic root diameter (37 mm [Q1-Q3: 30-43 mm] vs 32 mm [Q1-Q3: 27-35 mm]; P < 0.001) and mid ascending aorta dimeter (34 mm [Q1-Q3: 29-40 mm] vs 28 mm [Q1-Q3: 24-31 mm]; P = 0.008). Similarly, the BAV group had larger aortic root diameter (37 mm [Q1-Q3: 30-42 mm] vs 32 mm [Q1-Q3: 27-35 mm]; P < 0.001), and mid ascending aorta dimeter (35 mm [Q1-Q3: 30-40 mm] vs 28 mm [Q1-Q3: 24-31 mm]; P < 0.001). Compared with the COA+TAV subgroup, the COA+BAV subgroup and BAV group were associated with larger aortic root and mid ascending aorta diameter at baseline and follow-up. The risk of acute aortic complications was low in all groups. These findings suggest that BAV (and not COA) was associated with ascending thoracic aorta dimensions, and that patients with COA+TAV were not at a greater risk of developing ascending aortic aneurysms as compared with patients without SHD. [Display omitted] [ABSTRACT FROM AUTHOR]

المؤلفون: Goto, Hidenori¹ (AUTHOR) goto.hidenori.sv@mail.hosp.go.jp, Nakanishi, Kozo¹ (AUTHOR)

المصدر: Journal of Cardiothoracic Surgery. 3/19/2024, Vol. 19 Issue 1, p1-5. 5p.

مصطلحات موضوعية: *VIDEO-assisted thoracic surgery, *THORACIC aorta, *LUNG surgery, *LUNG cancer, *RECURRENT laryngeal nerve

مستخلص: Background: A right-sided aortic arch is a rare congenital vascular structure variation. Right lobectomy is not commonly performed on patients with such a condition. Further, there are no reports on lobectomy under uniportal video-assisted thoracoscopic surgery (VATS) in this patient group. Case presentation: A 67-year-old man with a right-sided aortic arch and Kommerell diverticulum underwent right upper lobectomy with mediastinal lymph node dissection under uniportal VATS for primary lung cancer. Due to the right descending aorta, which narrows the space of the dorsal hilum, handling of the stapler for stapling the right upper lobe bronchus from the uniport in the 6th intercostal space at the medial axillary line can be challenging. This issue was resolved by manipulating the staple over the azygos vein toward the inferior margin of the aortic arch. Via mediastinal lymphadenectomy, we found that the right recurrent laryngeal nerve branched from the right vagus nerve and hooked around the right-sided aortic arch. Conclusions: Right lobectomy with mediastinal lymph node dissection under uniportal VATS can be performed for lung cancer in patients with a right-sided aortic arch. [ABSTRACT FROM AUTHOR]