المؤلفون: Qiu, Zhen, Minegishi, Takunori, Aoki, Daichi, Abe, Kouki, Baba, Kentarou, Inagaki, Naoyuki

المصدر: Frontiers in Molecular Neuroscience ; volume 17 ; ISSN 1662-5099

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Molecular Biology

الوصف: The growth cone, a motile structure located at the tip of growing axons, senses extracellular guidance cues and translates them into directional forces that drive axon outgrowth and guidance. Axon guidance directed by chemical cues on the extracellular adhesive substrate is termed haptotaxis. Recent studies reported that netrin-1 on the substrate functions as a haptotactic axon guidance cue. However, the mechanism mediating netrin-1–induced axonal haptotaxis remains unclear. Here, we demonstrate that substrate-bound netrin-1 induces axonal haptotaxis by facilitating physical interactions between the netrin-1 receptor, DCC, and the adhesive substrates. DCC serves as an adhesion receptor for netrin-1. The clutch-linker molecule shootin1a interacted with DCC, linking it to actin filament retrograde flow at the growth cone. Speckle imaging analyses showed that DCC underwent either grip (stop) or retrograde slip on the adhesive substrate. The grip state was more prevalent on netrin-1–coated substrate compared to the control substrate polylysine, thereby transmitting larger traction force on the netrin-1–coated substrate. Furthermore, disruption of the linkage between actin filament retrograde flow and DCC by shootin1 knockout impaired netrin-1–induced axonal haptotaxis. These results suggest that the directional force for netrin-1–induced haptotaxis is exerted on the substrates through the adhesion-clutch between DCC and netrin-1 which occurs asymmetrically within the growth cone.

الإتاحة: https://doi.org/10.3389/fnmol.2024.1307755Test

المؤلفون: Mutaguchi, Yukiko, Kumabe, Yohei, Fukui, Tomoaki, Sawauchi, Kenichi, Tsuji, Yoriko, Aoki, Daichi, Kuroda, Ryosuke, Oe, Keisuke

المصدر: JOS Case Reports ; ISSN 2772-9648

الإتاحة: https://doi.org/10.1016/j.joscr.2024.03.001Test
https://api.elsevier.com/content/article/PII:S2772964824000145?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2772964824000145?httpAccept=text/plainTest

المؤلفون: Imajuku, Wataru, Aoki, Daichi, Yamaga, Yuki, Yamamoto, Kensuke, Takahashi, Shunsuke

المساهمون: ICT priority technology R&D promotion of innovative optical transmission technologies for supporting green society, Ministry of Internal Affairs and Communications Japan

المصدر: Journal of Lightwave Technology ; volume 42, issue 6, page 1853-1860 ; ISSN 0733-8724 1558-2213

مصطلحات موضوعية: Atomic and Molecular Physics, and Optics

الإتاحة: https://doi.org/10.1109/jlt.2023.3332912Test
http://xplorestaging.ieee.org/ielx7/50/10463647/10319062.pdf?arnumber=10319062Test

المؤلفون: Kurata, Atsushi, Aoki, Daichi, Fukuta, Yoshihumi, Kamimura, Taichi, Onishi, Taiki, Kishimoto, Noriaki, Uegaki, Koichi

المساهمون: the Japan Society for the Promotion of Science, the Food Science Institute Foundation

المصدر: Biotechnology & Biotechnological Equipment ; volume 35, issue 1, page 445-452 ; ISSN 1310-2818 1314-3530

الإتاحة: https://doi.org/10.1080/13102818.2021.1885995Test

المؤلفون: Fujita, Kazuki, Tanaka, Susumu, Iizumi, Kyoichi, Akiyama, Shuri, Uchida, Kaoru, Ogata, Makoto, Aoki, Daichi, Hosomi, Osamu, Kubohara, Yuzuru

المساهمون: Japan Society for the Promotion of Science, KAKENHI

المصدر: Biochemistry and Biophysics Reports ; volume 19, page 100658 ; ISSN 2405-5808

مصطلحات موضوعية: Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrep.2019.100658Test
https://api.elsevier.com/content/article/PII:S240558081930024X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S240558081930024X?httpAccept=text/plainTest

المؤلفون: Aoki, Daichi, Minematsu, Kazuhiko, Okamura, Toshihiko, Takagi, Tsuyoshi

المصدر: 2022 IEEE 29th Symposium on Computer Arithmetic (ARITH)

الإتاحة: https://doi.org/10.1109/arith54963.2022.00026Test
http://xplorestaging.ieee.org/ielx7/9973813/9974162/09974215.pdf?arnumber=9974215Test

المؤلفون: Azami, Hidekazu, Miyashita, Masaki, Aoki, Daichi, Andou, Hidemi, Matsumura, Atsuki, Iwasaki, Masakazu

المصدر: Chemistry Letters ; volume 46, issue 9, page 1285-1287 ; ISSN 0366-7022 1348-0715

مصطلحات موضوعية: General Chemistry

الإتاحة: https://doi.org/10.1246/cl.170497Test

المؤلفون: Ogata, Makoto, Aoki, Daichi, Suzuki, Moeka, Tanaka, Daisuke, Wakamatsu, Takashi

المساهمون: Ministry of Education, Culture, Sports, Science and Technology

المصدر: Japanese Journal of Applied Physics ; volume 58, issue 11, page 110903 ; ISSN 0021-4922 1347-4065

الإتاحة: https://doi.org/10.7567/1347-4065/ab496cTest

المؤلفون: Ono, Akiko, Suzuki, Tomohiro, Gotoh, Saki, Kono, Haruka, Matsui, Megumi, Aoki, Daichi, Matsuda, Masaru, Kawagishi, Hirokazu, Ogata, Makoto

المساهمون: Ministry of Education, Culture, Sports, Science and Technology

المصدر: Carbohydrate Research ; volume 475, page 27-33 ; ISSN 0008-6215

مصطلحات موضوعية: Organic Chemistry, Biochemistry, General Medicine, Analytical Chemistry

الإتاحة: https://doi.org/10.1016/j.carres.2019.02.001Test
https://api.elsevier.com/content/article/PII:S0008621518307109?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0008621518307109?httpAccept=text/plainTest

المؤلفون: Kureha, Takuma, Aoki, Daichi, Hiroshige, Seina, Iijima, Keisuke, Aoki, Daisuke, Takata, Toshikazu, Suzuki, Daisuke

المساهمون: Grants-in-Aid for Scientific Research on Innovative Areas, a fellowship from the Japan Society for the Promotion of Science

المصدر: Angewandte Chemie International Edition ; volume 56, issue 48, page 15393-15396 ; ISSN 1433-7851 1521-3773

الوصف: Rotaxane cross‐linked (RC) microgels that exhibit a decoupled thermo‐ and pH‐responsive volume transition were developed. The pH‐induced changes of the aggregation/disaggregation states of cyclodextrin in the RC networks were used to control the swelling capacity of the entire microgels. Different from conventional thermo‐ and pH‐responsive microgels, which are usually obtained from copolymerizations involving charged monomers, the RC microgels respond to temperature as intended, even in the presence of charged functional molecules such as dyes in the microgel dispersion. The results of this study should lead to new applications, including drug delivery systems that require a retention of their smart functions even in environments that may contain foreign ions, for example, in in vivo experiments.

الإتاحة: https://doi.org/10.1002/anie.201709633Test