المؤلفون: Martini, Daniela, Domínguez-Perles, Raúl, Rosi, Alice, Tassotti, Michele, Angelino, Donato, Medina, Sonia, Ricci, Cristian, Guy, Alexandre, Oger, Camille, Gigliotti, Letizia, Durand, Thierry, Marino, Mirko, Gottfried-Genieser, Hans, Porrini, Marisa, Antonini, Monica, Dei Cas, Alessandra, Bonadonna, Riccardo C., Ferreres, Federico, Scazzina, Francesca, Brighenti, Furio, Riso, Patrizia, Del Bo’, Cristian, Mena, Pedro, Gil-Izquierdo, Angel, Del Rio, Daniele

مصطلحات موضوعية: coffee, DNA damage, comet assay, lipid peroxidation, oxidative stress, randomized controlled trial, info:eu-repo/classification/ddc/610, ddc:610

الوصف: The effect of coffee and cocoa on oxidative damage to macromolecules has been investigated in several studies, often with controversial results. This study aimed to investigate the effect of one-month consumption of different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy volunteers. Twenty-one volunteers were randomly assigned into a three-arm, crossover, randomized trial. Subjects were assigned to consume one of the three following treatments: one cup of espresso coffee/day (1C), three cups of espresso coffee/day (3C), and one cup of espresso coffee plus two cocoa-based products containing coffee (PC) twice per day for 1 month. At the end of each treatment, blood samples were collected for the analysis of endogenous and H2O2-induced DNA damage and DNA oxidation catabolites, while urines were used for the analysis of oxylipins. On the whole, four DNA catabolites (cyclic guanosine monophosphate (cGMP), 8-OH-2′-deoxy-guanosine, 8-OH-guanine, and 8-NO2-cGMP) were detected in plasma samples following the one-month intervention. No significant modulation of DNA and lipid damage markers was documented among groups, apart from an effect of time for DNA strand breaks and some markers of lipid peroxidation. In conclusion, the consumption of coffee and cocoa-based confectionery containing coffee was apparently not able to affect oxidative stress markers. More studies are encouraged to better explain the findings obtained and to understand the impact of different dosages of these products on specific target groups.

العلاقة: 2399

الإتاحة: https://ul.qucosa.de/id/qucosa%3A85315Test
https://ul.qucosa.de/api/qucosa%3A85315/attachment/ATT-0Test/

المؤلفون: Fadini, Gian Paolo, Longato, Enrico, Morieri, Mario Luca, Del Prato, Stefano, Avogaro, Angelo, Solini, Anna, Baldassarre, Mariella, Consoli, Agostino, Morganet, Sara, Zugaro, Antonella, Baroni, Marco Giorgio, Andreozzi, Francesco, Gatti, Adriano, De Riu, Stefano, Del Buono, Andrea, Aldigeri, Raffaella, Bonadonna, Riccardo, Cas, Alessandra Dei, Vazzana, Angela, Antonini, Monica, Moretti, Valentina, Volsi, Patrizia Li, Cesare, Miranda, Zanette, Giorgio, Carletti, Silvia, D'Angelo, Paola, Leto, Gaetano, Leonetti, Frida, D'Onofrio, Luca, Maddaloni, Ernesto, Buzzetti, Raffaella, Frontoni, Simona, Cavallo, Giselle, Morano, Susanna, Filardi, Tiziana, Capece, Umberto, Giaccari, Andrea, Bossi, Antonio C., Meregalli, Giancarla, Querci, Fabrizio, Gaglio, Alessia, Resi, Veronica, Orsi, Emanuela, Fazion, Stefano, Franzetti, Ivano G., Berra, Cesare, Manfrini, Silvia, Garrapa, Gabriella, Lucarelli, Giulio

المصدر: The Lancet Regional Health - Europe ; volume 38, page 100847 ; ISSN 2666-7762

مصطلحات موضوعية: Health Policy, Oncology, Internal Medicine

الإتاحة: https://doi.org/10.1016/j.lanepe.2024.100847Test
https://api.elsevier.com/content/article/PII:S2666776224000139?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666776224000139?httpAccept=text/plainTest

المؤلفون: Vanhatalo, Saara, Dall'Asta, Margherita, Cossu, Marta, Chiavaroli, Laura, Francinelli, Veronica, Pede, Giuseppe Di, Dodi, Rossella, Närväinen, Johanna, Antonini, Monica, Goldoni, Matteo, Holopainen-Mantila, Ulla, Cas, Alessandra Dei, Bonadonna, Riccardo, Brighenti, Furio, Poutanen, Kaisa, Scazzina, Francesca

المصدر: Vanhatalo , S , Dall'Asta , M , Cossu , M , Chiavaroli , L , Francinelli , V , Pede , G D , Dodi , R , Närväinen , J , Antonini , M , Goldoni , M , Holopainen-Mantila , U , Cas , A D , Bonadonna , R , Brighenti , F , Poutanen , K & Scazzina , F 2022 , ' Pasta Structure Affects Mastication, Bolus Properties, and Postprandial Glucose and Insulin Metabolism in Healthy Adults ' , Journal of Nutrition , vol. 152 , no. 4 , pp. 994-1005 . https://doi.org/10.1093/jn/nxab361Test

مصطلحات موضوعية: Adult, Blood Glucose/metabolism, Bread, Glucose/metabolism, Humans, Insulin, Insulins, Mastication, Starch/metabolism, Triticum/chemistry, insulin response, structure, glycemic response, C-peptide response

الوصف: BACKGROUND: Structure and protein-starch interactions in pasta products can be responsible for lower postprandial glycemic responses compared with other cereal foods. OBJECTIVES: We tested the effect on postprandial glucose metabolism induced by 2 pasta products, couscous, and bread, through their structural changes during mastication and simulated gastric digestion. METHODS: Two randomized controlled trials (n = 30/trial) in healthy, normal-weight adults (mean BMI of 23.9 kg/m2 (study 1) and 23.0 kg/m2 (study 2)) evaluated postprandial glucose metabolism modulation to portions of durum wheat semolina spaghetti, penne, couscous, and bread each containing 50 g available carbohydrate. A mastication trial involving 26 normal-weight adults was conducted to investigate mastication processes and changes in particle size distribution and microstructure (light microscopy) of boluses after mastication and in vitro gastric digestion. RESULTS: Both pasta products resulted in lower areas under the 2-h curve for blood glucose (-40% for spaghetti and -22% for penne compared with couscous; -41% for spaghetti and -30% for penne compared with bread), compared with the other grain products (P < 0.05). Pasta products required more chews (spaghetti: 34 ± 18; penne: 38 ± 20; bread: 27 ± 13; couscous: 24 ± 17) and longer oral processing (spaghetti: 21 ± 13 s; penne: 23 ± 14 s; bread: 18 ± 9 s; couscous: 14 ± 10 s) compared with bread or couscous (P < 0.01). Pastas contained more large particles (46-67% of total particle area) compared with bread (0-30%) and couscous (1%) after mastication and in vitro gastric digestion. After in vitro gastric digestion, pasta samples still contained large areas of nonhydrolyzed starch embedded within the protein network; the protein in bread and couscous was almost entirely digested, and the starch was hydrolyzed. CONCLUSIONS: Preservation of the pasta structure during mastication and gastric digestion explains slower starch hydrolysis and, consequently, lower postprandial glycemia compared ...

العلاقة: https://cris.vtt.fi/en/publications/9cb3f09e-58f7-4f00-99e2-7c02d7043f06Test

الإتاحة: https://doi.org/10.1093/jn/nxab361Test
https://cris.vtt.fi/en/publications/9cb3f09e-58f7-4f00-99e2-7c02d7043f06Test
http://www.scopus.com/inward/record.url?scp=85128160822&partnerID=8YFLogxKTest

المؤلفون: Mena, Pedro, Bresciani, Letizia, Tassotti, Michele, Rosi, Alice, Martini, Daniela, Antonini, Monica, Cas, Alessandra Dei, Bonadonna, Riccardo, Brighenti, Furio, Del Rio, Daniele

المصدر: The American Journal of Clinical Nutrition ; volume 114, issue 6, page 2107-2118 ; ISSN 0002-9165

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1093/ajcn/nqab299Test
https://api.elsevier.com/content/article/PII:S000291652200541X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S000291652200541X?httpAccept=text/plainTest
https://academic.oup.com/ajcn/article-pdf/114/6/2107/41395070/nqab299.pdfTest

المؤلفون: Angelino, Donato, Martina, Alessia, Rosi, Alice, Veronesi, Licia, Antonini, Monica, Mennella, Ilario, Vitaglione, Paola, Grioni, Sara, Brighenti, Furio, Zavaroni, Ivana, Fares, Clara, Torriani, Sandra, Pellegrini, Nicoletta

المساهمون: Angelino, Donato, Martina, Alessia, Rosi, Alice, Veronesi, Licia, Antonini, Monica, Mennella, Ilario, Vitaglione, Paola, Grioni, Sara, Brighenti, Furio, Zavaroni, Ivana, Fares, Clara, Torriani, Sandra, Pellegrini, Nicoletta

مصطلحات موضوعية: Bacillus coagulan, gastrointestinal tract, inflammation, obesity, randomized controlled trial, resistin, whole grain, β-glucan, γ-glutamyltransferase

الوصف: BACKGROUND: Synbiotic foods, which combine the action of prebiotics and probiotics along the gastrointestinal tract, can affect inflammatory and glucose-related markers. OBJECTIVE: The aim of this study was to investigate the effects on inflammatory and glycemia-related markers of a whole-grain pasta containing barley β-glucans and Bacillus coagulans BC30, 6086 in healthy overweight or obese volunteers. METHODS: A single-blind, parallel, randomized, placebo-controlled dietary intervention study was carried out. Forty-one healthy sedentary overweight (body mass index [BMI] 25-29.9 kg/m2) and obese (BMI ≥30) volunteers, aged 30-65 y and low consumers of fruit and vegetables, ate 1 serving/d of whole-grain control (CTR) or innovative (INN) pasta for 12 wk and maintained their habitual diets. Biological samples were collected at baseline and every 4 wk for primary (plasma high-sensitivity C-reactive protein [hs-CRP] and fasting plasma lipid profile) and secondary outcomes (glycemia-related markers, blood pressure, fecal microbiota composition, and body weight). Between (CTR compared with INN) and within (among weeks) group differences were tested for the whole population and for subgroups stratified by baseline values of BMI (≥30) and glycemia (≥100 mg/dL). RESULTS: INN or CTR pasta consumption had no effect on primary and secondary outcomes over time, except for a significant increase in plasma γ-glutamyltransferase (GGT) after 12 wk of CTR pasta consumption. Comparisons between intervention groups revealed differences only at 12 wk: plasma GGT was higher in the CTR group; plasma hs-CRP, plasma LDL/HDL cholesterol ratio, and Bifidobacterium spp. were lower in the INN subgroup of obese volunteers; plasma resistin was lower and Faecalibacterium prausnitzii abundance was higher in the INN subgroup of hyperglycemic volunteers. CONCLUSIONS: A daily serving of a synbiotic whole-grain pasta had limited effects on primary and secondary outcomes in the entire group of volunteers but affected glycemia- and lipid-related ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31162597; info:eu-repo/semantics/altIdentifier/wos/WOS:000488558200005; firstpage:1714; lastpage:1723; numberofpages:10; journal:JOURNAL OF NUTRITION; http://hdl.handle.net/11562/1013436Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072746926

الإتاحة: https://doi.org/10.1093/jn/nxz071Test
http://hdl.handle.net/11562/1013436Test

المؤلفون: Martini, Daniela, Rosi, Alice, Tassotti, Michele, Antonini, Monica, Dall'Asta, Margherita, Bresciani, Letizia, Fantuzzi, Federica, Spigoni, Valentina, Domínguez-Perles, Raúl, Angelino, Donato, Ricci, Cristian, Del Pozo-Luengo, Soledad, Tornel, Pedro Luis, Scazzina, Francesca, Gil-Izquierdo, Angel, Dei Cas, Alessandra, Brighenti, Furio, Bonadonna, Riccardo R.C., Del Rio, Daniele, Mena, Pedro

المصدر: European journal of nutrition

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Cardiometabolic health, Coffee, Dietary pattern, Randomized-controlled trial, Real-life setting

الوصف: Coffee is an important source of bioactive compounds, including caffeine, trigonelline, and phenolic compounds. Several studies have highlighted the preventive effects of coffee consumption on major cardiometabolic (CM) diseases, but the impact of different coffee dosages on markers of CM risk in a real-life setting has not been fully understood. This study aimed to investigate the effect of coffee and cocoa-based confectionery containing coffee consumption on several CM risk factors in healthy subjects. ; info:eu-repo/semantics/published

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.1007/s00394-020-02347-5; uri/info:pii/10.1007/s00394-020-02347-5; uri/info:pmid/32728879; https://dipot.ulb.ac.be/dspace/bitstream/2013/317772/1/doi_301416.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/317772Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/317772Test

المؤلفون: Mena, Pedro, Tassotti, Michele, Rosi, Alice, Martini, Daniela, Righetti, Laura, Antonini, Monica, Dall'Asta, Margherita, Bresciani, Letizia, Fantuzzi, Federica, Spigoni, Valentina, Gil-Izquierdo, Angel, Domínguez-Perles, Raúl, Tornel, Pedro Luis, Del Pozo-Luengo, Soledad, Angelino, Donato, Del Bo', Cristian, Dall'Asta, Chiara, Riso, Patrizia, Cas, Alessandra Dei, Bonadonna, Riccardo, Brighenti, Furio, Del Rio, Daniele

المصدر: Proceedings of the Nutrition Society ; volume 79, issue OCE2 ; ISSN 0029-6651 1475-2719

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous)

الوصف: Coffee is an important source of bioactive compounds, including caffeine, trigonelline, and phenolic compounds. Several studies have highlighted the preventive effects of coffee consumption on major cardiometabolic diseases, but the impact of coffee dosage on markers of cardiometabolic risk is not well understood. Moreover, the pool of coffee-derived circulating metabolites in real-life settings is unknown. This study evaluated the bioavailability and effects on recognised cardiometabolic markers of coffee bioactives, considering different levels of consumption. An innovative experimental design, including both a chronic and an acute sub-study, and a comprehensive analytical approach were used. A 3-arm, randomised, crossover trial was conducted in 21 healthy volunteers (age, 23 ± 2 y; BMI, 22.3 ± 2.5 kg/m 2 ) (Mena et al., Trials 2017, 18, 527). Volunteers were assigned to consume 3 treatments for 4 weeks, including 1 cup of espresso coffee/day, 3 cups of espresso coffee/day, and 1 cup of espresso coffee plus 2 cocoa-based confectionary products containing-coffee twice per day. The last day of each treatment, blood and urine samples were collected at specific time points for 24 hours. Dietary intake, body weight, BMI, waist circumference, blood pressure, fasting glucose, insulin, LDL- and HDL-cholesterol, triglycerides, nitric oxide, inflammatory markers (IL-8, TNFα, VEGF), trimethylamine- N -oxide (TMAO), DNA damage, DNA catabolites, and eicosanoids were assessed. The pool of coffee-derived circulating metabolites was also assessed in acute conditions. Untargeted metabolomics was performed. Energy intake did not change among treatments after 4 weeks, while significant differences were observed in the intake of saturated fatty acids and carbohydrates. The effect of different coffee dosages on the set of cardiometabolic markers assessed was negligible. Plasma and urinary pharmacokinetic profiles were evaluated for 6 caffeine metabolites, 3 trigonelline derivatives, and up to 40 phenolic metabolites. ...

الإتاحة: https://doi.org/10.1017/s0029665120000713Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0029665120000713Test

المؤلفون: Lezo, A, Diamanti, A., Capriati, T., Gandullia, P., Lacitignola, L., Spagnuolo, M. I., Cecchi, N., Verlato, G., Borodani, S., Forchielli, L., Panceri, R., Brunori, E., Pastore, M., Amarri, S., Abate, Rosaria, Accorsi, Paola, Aidala, Enrico, Amarri, Sergio, Ancora, Gina, Angelotti, Luisella, Annibali, Roberta, Antonini Monica, Antonietta, Banzato, Claudia, Barbaglia, Michelangelo, Bardasi, Giulia, Barrani, Monica, Basso, Tiziano, Brach del Prever, Adalberto, Belli, Fina, Bellomo Anna, Rita, Besenzon, Luigi, Biagioni, Martina, Bonaudo, Roberto, Bruni, Giulia, Brunori, Elena, Cagnoli, Giacomo, Campanozzi, Angelo, Casaccia, Germana, Castello, Mario, Chiaro, Andrea, Cimadore, Nicoletta, Cioni, Maddalena, Cortinovis, Francesca, De Cosmi, Valentina, De Giacomo, Costantino, Del Vecchio, Sergio, Diamanti, Antonella, Di Leo, Grazia, Di Scala, Carmen, Famiani, Annalisa, Felici, Enrico, Ferraris, Silvio, Fomasi, Martina, Fontanella, Giovanna, Frimaire, Alessia, Fusco, Patrizia, Galvagno, Graziana, Gandullia, Paolo, Gasparrini, Enrico, Guerra, Azzurra, Lanari, Marcello, Lacitignola, Laura, Lezo, Antonella, Lizzoli, Francesca, Maggiore, Giuseppe, Magistà Anna, Maria, Malaventura, Cristina, Marmetucci, Luigi, Mazzocchi, Alessandra, Mazzoni, Elisa, Melli, Paola, Memmini, Graziano, Meneghini, Anna, Miglietti, Nunzia, Migliore, Giuseppina, Mistura, Laura, Monaci, Alessandro, Morganti, Alessia, Nesi, Francesca, Opinto, Vittoria, Pace, Mariella, Palamone, Gianluigi, Panceri, Roberto, Parisi, Giuseppe, Pastore, Maria, Penagini, Francesca, Perrone, Michela, Petitti, Patrizia, Pettinari, Chiara, Peverelli, Paola, Pinon, Michele, Russo, Carla, Sala, Alessandra, Salata, Michele, Salmaso, Mara, Sangerardi, Maria, Santangelo, Barbara, Savino, Francesco, Scatã , Donata, Siani, Paolo, Spagnuolo, Maria Immacolata, Sparano, Paola, Stamati Filomena, Andreina, Tulli, Monica, Uga, Elena, Urbano, Flavia, Verlato, Giovanna, Zoppo, Marisa, Zuin, Giovanna, FIORE, Francesco Paolo, GATTI, STEFANO, GUANA, RICCARDO

المساهمون: Lezo, A, Diamanti, A., Capriati, T., Gandullia, P., Fiore, Francesco Paolo, Lacitignola, L., Gatti, Stefano, Spagnuolo, M. I., Cecchi, N., Verlato, G., Borodani, S., Forchielli, L., Panceri, R., Brunori, E., Pastore, M., Amarri, S., Abate, Rosaria, Accorsi, Paola, Aidala, Enrico, Amarri, Sergio, Ancora, Gina, Angelotti, Luisella, Annibali, Roberta, Antonini Monica, Antonietta, Banzato, Claudia, Barbaglia, Michelangelo, Bardasi, Giulia, Barrani, Monica, Basso, Tiziano, Brach del Prever, Adalberto, Belli, Fina, Bellomo Anna, Rita, Besenzon, Luigi, Biagioni, Martina, Bonaudo, Roberto, Bruni, Giulia, Brunori, Elena, Cagnoli, Giacomo, Campanozzi, Angelo, Casaccia, Germana, Castello, Mario, Chiaro, Andrea, Cimadore, Nicoletta, Cioni, Maddalena, Cortinovis, Francesca, De Cosmi, Valentina, De Giacomo, Costantino, Del Vecchio, Sergio, Diamanti, Antonella, Di Leo, Grazia, Di Scala, Carmen, Famiani, Annalisa, Felici, Enrico, Ferraris, Silvio, Fomasi, Martina, Fontanella, Giovanna, Frimaire, Alessia, Fusco, Patrizia, Galvagno, Graziana, Gandullia, Paolo, Gasparrini, Enrico, Guana, Riccardo, Guerra, Azzurra, Lanari, Marcello, Lacitignola, Laura, Lezo, Antonella, Lizzoli, Francesca, Maggiore, Giuseppe, Magistà Anna, Maria, Malaventura, Cristina, Marmetucci, Luigi, Mazzocchi, Alessandra, Mazzoni, Elisa, Melli, Paola, Memmini, Graziano, Meneghini, Anna, Miglietti, Nunzia, Migliore, Giuseppina, Mistura, Laura, Monaci, Alessandro, Morganti, Alessia, Nesi, Francesca, Opinto, Vittoria, Pace, Mariella, Palamone, Gianluigi, Panceri, Roberto, Parisi, Giuseppe, Pastore, Maria, Penagini, Francesca, Perrone, Michela, Petitti, Patrizia, Pettinari, Chiara, Peverelli, Paola, Pinon, Michele, Russo, Carla, Sala, Alessandra, Salata, Michele, Salmaso, Mara, Sangerardi, Maria, Santangelo, Barbara

مصطلحات موضوعية: Malnutrition, Nutritional support, Pediatric, Stunting, Wasting, Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000446656200010; volume:21; firstpage:72; lastpage:78; numberofpages:7; journal:CLINICAL NUTRITION ESPEN; http://hdl.handle.net/11583/2678641Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85020251568; http://www.journals.elsevier.com/clinical-nutrition-espenTest

الإتاحة: https://doi.org/10.1016/j.clnesp.2017.05.002Test
http://hdl.handle.net/11583/2678641Test
http://www.journals.elsevier.com/clinical-nutrition-espenTest

المؤلفون: Spigoni, Valentina, Aldigeri, Raffaella, Antonini, Monica, Micheli, Maria Maddalena, Fantuzzi, Federica, Fratter, Andrea, Pellizzato, Marzia, Derlindati, Eleonora, Zavaroni, Ivana, Bonadonna, Riccardo R.C., Dei Cas, Alessandra

المصدر: International journal of molecular sciences, 18 (7

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Adult, Aged, Berberine -- therapeutic use, Biological Products -- therapeutic use, Chitosan -- therapeutic use, Cholesterol -- blood, Drug Compounding, Dyslipidemias -- blood -- drug therapy, Female, Humans, Male, Middle Aged, Proprotein Convertase 9 -- metabolism, PCSK9, non-HDL cholesterol, nutraceuticals, randomized clinical trial

الوصف: Increased non high-density lipoprotein (HDL)/low-density lipoprotein (LDL) cholesterol levels are independent risk factors for cardiovascular (CV) mortality with no documented threshold. A new combination of nutraceuticals (berberine 200 mg, monacolin K 3 mg, chitosan 10 mg and coenzyme Q 10 mg) with additive lipid-lowering properties has become available. The aim of the study is to test the efficacy of the nutraceutical formulation (one daily) in lowering non-HDL cholesterol vs. placebo at 12 weeks in individuals with non-HDL-cholesterol levels ≥160 mg/dL. 39 subjects (age 52 ± 11 years; 54% females; body mass index 27 ± 4 kg/m²) were randomized (3:1) in a double blind phase II placebo-controlled study. At baseline, 4 and 12 weeks main clinical/biohumoral parameters, pro-inflammatory cytokines, (gut)-hormones, proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and endothelial progenitor cell (EPC) number were assessed. Baseline characteristics were comparable in the two groups. The intervention significantly decreased non-HDL cholesterol (-30 ± 20 mg/dL; p = 0.012), LDL cholesterol (-31 ± 18 mg/dL, p = 0.011) and apolipoprotein (Apo) B (-14 ± 12 mg/dL, p = 0.030) levels compared to the placebo. Pro-inflammatory, hormonal, PCSK9 and EPC levels remained stable throughout the study in both groups. The intervention was well tolerated. Three adverse events occurred: Epstein Barr virus infection, duodenitis and asymptomatic but significant increase in creatine phosphokinase (following intense physical exercise) which required hospitalization. The tested nutraceutical formulation may represent a possible therapeutic strategy in dyslipidemic individuals in primary prevention. ; info:eu-repo/semantics/published

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.3390/ijms18071498; uri/info:pii/ijms18071498; uri/info:pmid/28704936; uri/info:pmcid/PMC5535988; https://dipot.ulb.ac.be/dspace/bitstream/2013/317775/1/doi_301419.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/317775Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/317775Test

المؤلفون: Favari, Claudia, Righetti, Laura, Tassotti, Michele, Gethings, Lee A, Martini, Daniela, Rosi, Alice, Antonini, Monica, Rubert, Josep, Manach, Claudine, Cas, Alessandra Dei, Bonadonna, Riccardo, Brighenti, Furio, Dall'Asta, Chiara, Mena, Pedro, Rio, Daniele Del

المساهمون: Favari, Claudia, Righetti, Laura, Tassotti, Michele, Gethings, Lee A, Martini, Daniela, Rosi, Alice, Antonini, Monica, Rubert, Josep, Manach, Claudine, Cas, Alessandra Dei, Bonadonna, Riccardo, Brighenti, Furio, Dall'Asta, Chiara, Mena, Pedro, Rio, Daniele Del

مصطلحات موضوعية: biomarker, cocoa, coffee, metabolomic, xenobiotics

الوصف: SCOPE: Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aimed at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, one cup of espresso coffee/day and two cocoa-based products containing coffee two times per day) might impact endogenous molecular pathways.METHODS AND RESULTS: A three-arm, randomized, cross-over trial was performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples were collected to perform untargeted metabolomics based on UHPLC-IMS-HRMS. A total of 153 discriminant metabolites were identified. Several molecular features were associated with coffee consumption, while others were linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis and arginine biosynthesis and metabolism.CONCLUSION: This information has provided new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health. This article is protected by copyright. All rights reserved.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000602658200001; volume:65; issue:3; firstpage:2000875; journal:MOLECULAR NUTRITION & FOOD RESEARCH; http://hdl.handle.net/11381/2885912Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85098169554

الإتاحة: https://doi.org/10.1002/mnfr.202000875Test
http://hdl.handle.net/11381/2885912Test