المؤلفون: Tran, Tuan A, Williams, Lisa M, Bui, Donna, Anthonisen, Colleen, Poltavskiy, Eduard, Szabo, Robert M

المصدر: The Journal Of Hand Surgery. 43(2)

مصطلحات موضوعية: Allied Health and Rehabilitation Science, Health Sciences, Clinical Research, Neurodegenerative, Neurosciences, Pain Research, Chronic Pain, Peripheral Neuropathy, Carpal Tunnel Syndrome, Female, Humans, Male, Median Nerve, Middle Aged, Pilot Projects, Prospective Studies, Quality of Life, Surveys and Questionnaires, Ultrasonography, Wrist Joint, Carpal tunnel, Neuro-QoL, CTSAQ, ultrasound, Clinical Sciences, Orthopedics, Clinical sciences, Allied health and rehabilitation science

الوصف: PURPOSE:The aims of this study were (1) to assess the utility of the Quality of Life in Neurological Disorder (Neuro-QoL) questionnaire in patients with carpal tunnel syndrome by comparing the validated patient-reported outcome (PRO) measure Neuro-QoL to the validated Carpal Tunnel Syndrome Assessment Questionnaire (CTSAQ) before and following carpal tunnel release, (2) to compare the measurements of the median nerve cross-sectional area (CSA) using high-resolution ultrasound (HRUS) before and after surgery, and (3) to determine a correlation between HRUS and PRO. METHODS:Individuals diagnosed with carpal tunnel syndrome were evaluated using the CTSAQ, Neuro-QoL, and HRUS before surgery and at 3 months after surgery. RESULTS:Twenty patients completed the study. Overwhelmingly, there was an improvement in symptoms and function assessed by patients on both the Neuro-QoL and the CTSAQ at 3 months after surgery. The Neuro-QoL Physical Function and Upper Extremity scores had strong correlation with the CTSAQ activity score but had low to moderate correlation with the CTSAQ symptoms score, before and after surgery. The HRUS measurements of the median nerve at the carpal tunnel inlet demonstrated a decrease in CSA whereas no noticeable changes were observed at mid tunnel and at the outlet (hook of hamate). The correlations between the ultrasound findings and PRO measures ranged from weak to strong. CONCLUSIONS:Patients had resolution of symptoms and higher physical function following carpal tunnel release measured by both the CTSAQ and the Neuro-QoL scores. The Neuro-QoL self-assessment questionnaire, a measurement of quality of life, correlated well with the CTSAQ. Therefore, it could be used as a self-assessment outcomes tool in patients undergoing carpal tunnel release. At 3 months after surgery, HRUS measurements of the median nerve CSA showed a noticeable decrease of CSA only at the inlet of carpal tunnel. This objective improvement correlated with the improvement in CTSAQ and Neuro-QoL scores. TYPE OF STUDY/LEVEL OF EVIDENCE:Diagnosis II.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8z14x5j1Test

المؤلفون: McDonald, Craig M, Marbán, Eduardo, Hendrix, Suzanne, Hogan, Nathaniel, Ruckdeschel Smith, Rachel, Eagle, Michelle, Finkel, Richard S, Tian, Cuixia, Janas, Joanne, Harmelink, Matthew M, Varadhachary, Arun S, Taylor, Michael D, Hor, Kan N, Mayer, Oscar H, Henricson, Erik K, Furlong, Pat, Ascheim, Deborah D, Rogy, Siegfried, Williams, Paula, Marbán, Linda, Butterfield, Russell, Connolly, Anne, Muntoni, Francesco, Joyce, Nanette C., Evans, Maya, Abedi, Mehrdad, Surampudi, Prasanth, Jhawar, Sanjay, Dayan, Jonathan G., Anthonisen, Colleen, Goude, Erica, Nicorici, Alina, Sarwary, Omaid, Prasad, Poonam, Baek, Jayoon, Newton, Andrew, Johnson, Hannah, Kusmik, Kyle, Filar, Lauri, Edmondson, Angie, Rybalsky, Irina, Chouteau, Wendy, Giordano, Anthony F., Rodriguez, Aixa, Anderson, Kristan, Wezel, Germaine, Vega, Melisa, Duke, Julie, Collado, Jorge, Civitello, Matthew

المصدر: The Lancet ; volume 399, issue 10329, page 1049-1058 ; ISSN 0140-6736

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/s0140-6736Test(22)00012-5
https://api.elsevier.com/content/article/PII:S0140673622000125?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0140673622000125?httpAccept=text/plainTest

المؤلفون: Han, Jay J, de Bie, Evan, Nicorici, Alina, Abresch, Richard T, Anthonisen, Colleen, Bajcsy, Ruzena, Kurillo, Gregorij, Mcdonald, Craig M

المصدر: Muscle & Nerve. 53(4)

مصطلحات موضوعية: Orphan Drug, Rare Diseases, Brain Disorders, Intellectual and Developmental Disabilities (IDD), Pediatric, Duchenne/ Becker Muscular Dystrophy, Muscular Dystrophy, Adolescent, Child, Cohort Studies, Humans, Male, Movement, Muscular Dystrophy, Duchenne, Photic Stimulation, Psychomotor Performance, Range of Motion, Articular, Remote Sensing Technology, Upper Extremity, Young Adult, DMD, kinect, PUL, reachable workspace, upper extremity, Medical and Health Sciences, Neurology & Neurosurgery

الوصف: IntroductionThe Kinect-based reachable workspace relative surface area (RSA) is compared with the performance of upper limb (PUL) assessment in Duchenne muscular dystrophy (DMD).Methods29 individuals with DMD (ages: 7-23; Brooke: 1-5) underwent both Kinect-based reachable workspace RSA and PUL assessments. RSAs were also collected from 24 age-matched controls. Total and quadrant RSAs were compared with the PUL total, shoulder-, middle-, and distal-dimension scores.ResultsThe total reachable workspace RSA correlated well with the total PUL score (Spearman ρ = -0.602; P < 0.001), and with each of the PUL dimensional scores: shoulder (ρ = -0.624; P < 0.001), middle (ρ = -0.564; P = 0.001), and distal (ρ = -0.630; P < 0.001). With quadrant RSA, reachability in a particular quadrant was closely associated with respective PUL dimensional-level function (lateral-upper quadrant for shoulder-, lateral-upper/lower quadrants for middle-, and lateral-lower quadrant for distal-level function).ConclusionsThis study demonstrates concurrent validity of the reachable workspace outcome measure (RSA) with the DMD-specific upper extremity outcome measure (PUL).

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/15m9p8dgTest

المؤلفون: Junck, Anthony D, Escobedo, Eva M, Lipa, Bethany M, Cronan, Michael, Anthonisen, Colleen, Poltavskiy, Eduard, Bang, Heejung, Han, Jay J

المصدر: Journal of Ultrasound in Medicine. 34(11)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Clinical Research, Pain Research, Algorithms, Carpal Tunnel Syndrome, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Median Nerve, Middle Aged, Observer Variation, Reproducibility of Results, Sensitivity and Specificity, Ultrasonography, carpal tunnel syndrome, cross-sectional area, median nerve, musculoskeletal ultrasound, reliability, sonography, Nuclear Medicine & Medical Imaging, Clinical sciences

الوصف: Objectives-The aim of this study was to determine the intra- and inter-rater reliability of sonographic measurements of the median nerve cross-sectional area in individuals with carpal tunnel syndrome and healthy control participants.Methods-The median nerve cross-sectional area was evaluated by sonography in 18 participants with carpal tunnel syndrome (18 upper extremities) and 9 control participants (18 upper extremities) at 2 visits 1 week apart. Two examiners, both blinded to the presence or absence of carpal tunnel syndrome, captured independent sonograms of the median nerve at the levels of the carpal tunnel inlet, pronator quadratus, and mid-forearm. The cross-sectional area was later measured by each examiner independently. Each also traced images that were captured by the other examiner.Results-Both the intra- and inter-rater reliability rates were highest for images taken at the carpal tunnel inlet (radiologist, r = 0.86; sonographer, r = 0.87; inter-rater, r = 0.95; all P < .0001), whereas they was lowest for the pronator quadratus (r = 0.49, 0.29, and 0.72, respectively; all P < .0001). At the mid-forearm, the intra-rater reliability was lower for both the radiologist and sonographer, whereas the inter-rater reliability was relatively high (r = 0.54, 0.55, and 0.81; all P < .0001). Tracing of captured images by different examiners showed high concordance for the median cross-sectional area at the carpal tunnel inlet (r = 0.96-0.98; P < .0001).Conclusions-The highest intra- and inter-rater reliability was found at the carpal tunnel inlet. The results also demonstrate that tracing of the median nerve cross-sectional area from captured images by different examiners does not contribute significantly to measurement variability.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2784n6t0Test

المؤلفون: Han, Jay J., de Bie, Evan, Nicorici, Alina, Abresch, Richard T., Anthonisen, Colleen, Bajcsy, Ruzena, Kurillo, Gregorij, Mcdonald, Craig M.

المساهمون: The National Institutes of Health (NIH), NIAMS, U.S. Department of Education (NIDRR), National Science Foundation (NSF), Center for Information Technology Research in the Interest of Society (CITRIS), Parent Project Muscular Dystrophy (PPMD)

المصدر: Muscle & Nerve ; volume 53, issue 4, page 545-554 ; ISSN 0148-639X 1097-4598

الوصف: Introduction : The Kinect‐based reachable workspace relative surface area (RSA) is compared with the performance of upper limb (PUL) assessment in Duchenne muscular dystrophy (DMD). Methods : 29 individuals with DMD (ages: 7–23; Brooke: 1–5) underwent both Kinect‐based reachable workspace RSA and PUL assessments. RSAs were also collected from 24 age‐matched controls. Total and quadrant RSAs were compared with the PUL total, shoulder‐, middle‐, and distal‐dimension scores. Results : The total reachable workspace RSA correlated well with the total PUL score (Spearman ρ = ‐0.602; P < 0.001), and with each of the PUL dimensional scores: shoulder (ρ = ‐0.624; P < 0.001), middle (ρ = ‐0.564; P = 0.001), and distal (ρ = ‐0.630; P < 0.001). With quadrant RSA, reachability in a particular quadrant was closely associated with respective PUL dimensional‐level function (lateral‐upper quadrant for shoulder‐, lateral‐upper/lower quadrants for middle‐, and lateral‐lower quadrant for distal‐level function). Conclusions : This study demonstrates concurrent validity of the reachable workspace outcome measure (RSA) with the DMD‐specific upper extremity outcome measure (PUL). Muscle Nerve 53: 545–554, 2016

الإتاحة: https://doi.org/10.1002/mus.24894Test