المؤلفون: David Achaintre, Pekka Keski-Rahkonen, Matty P. Weijenberg, Verena Katzke, Nikos Papadimitriou, Ellen Kampman, Augustin Scalbert, Audrey Gicquiau, Sandra Colorado-Yohar, Neil Murphy, Per Magne Ueland, Ruth C. Travis, Jennifer Ose, Anne J.M.R. Geijsen, Elisabete Weiderpass, María José Sánchez, Andrea Gsur, Andreas Baierl, Marc J. Gunter, Cornelia M. Ulrich, Biljana Gigic, Eva Ardanaz, Vittorio Krogh, Bas Bueno-de-Mesquita, Stefanie Brezina, Eline H. van Roekel, Tanja Gumpenberger, Nina Habermann, Rudolf Kaaks, Matthias B. Schulze

المساهمون: RS: GROW - R1 - Prevention, Epidemiologie

المصدر: International Journal of Cancer, 149(9), 1659-1669
Int J Cancer
International Journal of Cancer 149 (2021) 9
International Journal of Cancer, 149(9), 1659-1669. Wiley

مصطلحات موضوعية: Male, Cancer Research, Nutrition and Disease, Colorectal cancer, Gastroenterology, DISEASE, COLORECTAL-CANCER, IDO, chemistry.chemical_compound, MARKERS, Risk Factors, ADIPONECTIN, Voeding en Ziekte, Epidemiology, Prospective Studies, Prospective cohort study, Aged, 80 and over, Middle Aged, INSULIN, European Prospective Investigation into Cancer and Nutrition, serotonin, Oncology, colon cancer, Colonic Neoplasms, Female, Adult, medicine.medical_specialty, Article, INFLAMMATION, Internal medicine, medicine, Humans, tryptophan, plasma, Aged, VLAG, business.industry, Cancer, PLASMA SEROTONIN, Odds ratio, medicine.disease, kynurenine, Logistic Models, WHOLE-GRAIN INTAKE, chemistry, Case-Control Studies, Serotonin, business, Kynurenine

الوصف: Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis, however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited. We studied associations of plasma tryptophan, serotonin, and kynurenine with colon cancer risk in two studies with cancer patients and controls, and in one prospective cohort: ColoCare Study (110 patients/153 controls), the Colorectal Cancer Study of Austria (CORSA; 46 patients/390 controls), and the European Prospective Investigation into Cancer and Nutrition (EPIC; 456 matched case-control pairs). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for colon cancer risk. Tryptophan was inversely associated with colon cancer risk in ColoCare [OR per 1-standard deviation (SD) = 0.44; 95% CI, 0.31-0.64] and EPIC (OR per 1-SD = 0.86; 95% CI, 0.74-0.99). Comparing detectable versus non-detectable levels, serotonin was positively associated with colon cancer in CORSA (OR = 6.39; 95% CI, 3.61-11.3) and EPIC (OR = 2.03; 95% CI, 1.20-3.40). Kynurenine was inversely associated with colon cancer in ColoCare (OR per 1-SD = 0.74; 95% CI, 0.55-0.98), positively associated in CORSA (OR per 1-SD = 1.79; 95% CI, 1.27-2.52), while no association was observed in EPIC. The kynurenine-to-tryptophan ratio was positively associated with colon cancer in ColoCare (OR per 1-SD = 1.38; 95% CI, 1.03-1.84) and CORSA (OR per 1-SD = 1.44; 95% CI, 1.06-1.96), but not in EPIC. These results suggest that higher plasma tryptophan may be associated with lower colon cancer risk, while increased serotonin may be associated with a higher risk of colon cancer. The kynurenine-to-tryptophan ratio may also reflect altered tryptophan catabolism during colon cancer development. This article is protected by copyright. All rights reserved.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f537f6449b174e7d2b7100171c198abTest
https://doi.org/10.1002/ijc.33725Test

المؤلفون: Evertine Wesselink, Hendriek C. Boshuizen, Johannes H. W. de Wilt, Maryska L.G. Janssen-Heijnen, Ernst Jan Spillenaar Bilgen, Fränzel J.B. van Duijnhoven, Marlou Floor Kenkhuis, Henk K. van Halteren, Eric T.P. Keulen, Dieuwertje E. Kok, Martijn J.L. Bours, Moniek van Zutphen, Stephanie O. Breukink, Renate M. Winkels, Ellen Kampman, Anne J.M.R. Geijsen, Matty P. Weijenberg

المساهمون: RS: GROW - R1 - Prevention, Epidemiologie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health

المصدر: The American Journal of Clinical Nutrition
The American journal of clinical nutrition 113 (2021) 6
The American journal of clinical nutrition, 113(6), 1447-1457
American Journal of Clinical Nutrition, 113(6), 1447-1457. Oxford University Press
The American Journal of Clinical Nutrition, 113, 1447-1457
The American Journal of Clinical Nutrition, 113, 6, pp. 1447-1457

مصطلحات موضوعية: medicine.medical_specialty, lifestyle, recurrence, Nutrition and Disease, Colorectal cancer, Concordance, Medicine (miscellaneous), physical activity, body mass index, colorectal cancer, GUIDELINES, survival, AcademicSubjects/MED00160, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, AcademicSubjects/MED00060, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, COLON, Internal medicine, Voeding en Ziekte, medicine, 030212 general & internal medicine, VALIDITY, Prospective cohort study, SQUASH, VLAG, Nutrition and Dietetics, Cancer prevention, business.industry, Proportional hazards model, alcohol, Cancer, medicine.disease, PREVENTION, Original Research Communications, PHYSICAL-ACTIVITY, Biometris, 030220 oncology & carcinogenesis, SHORT QUESTIONNAIRE, Population study, HEALTH, business, diet, Body mass index

الوصف: Background An unhealthy lifestyle is associated with the risk of colorectal cancer (CRC), but it is unclear whether overall lifestyle after a CRC diagnosis is associated with risks of recurrence and mortality. Objectives To examine associations between postdiagnosis lifestyle and changes in lifestyle after a CRC diagnosis with risks of CRC recurrence and all-cause mortality. Methods The study population included 1425 newly diagnosed, stage I–III CRC patients from 2 prospective cohort studies enrolled between 2010 and 2016. Lifestyle, including BMI, physical activity, diet, and alcohol intake, was assessed at diagnosis and at 6 months postdiagnosis. We assigned lifestyle scores based on concordance with 2 sets of cancer prevention guidelines—from the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and the American Cancer Society (ACS)—and national disease prevention guidelines. Higher scores indicate healthier lifestyles. We computed adjusted HRs and 95% CIs using Cox regression. Results We observed 164 recurrences during a 2.8-year median follow-up and 171 deaths during a 4.4-year median follow-up. No associations were observed for CRC recurrence. A lifestyle more consistent with the ACS recommendations was associated with a lower all-cause mortality risk (HR per +1 SD, 0.85; 95% CI: 0.73–0.995). The same tendency was observed for higher WCRF/AICR (HR, 0.92; 95% CI: 0.78–1.08) and national (HR, 0.90; 95% CI: 0.77–1.05) lifestyle scores, although these associations were statistically nonsignificant. Generally, no statistically significant associations were observed for BMI, physical activity, diet, or alcohol. Improving one's lifestyle after diagnosis (+1 SD) was associated with a lower all-cause mortality risk for the ACS (HR, 0.80; 95% CI: 0.67–0.96) and national (HR, 0.84; 95% CI: 0.70–0.999) scores, yet was statistically nonsignificant for the WCRF/AICR score (HR, 0.94; 95% CI: 0.78–1.13). Conclusions A healthy lifestyle after CRC diagnosis and improvements therein were not associated with the risk of CRC recurrence, but were associated with a decreased all-cause mortality risk.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835c5ce2b3b04fce4a977001e7d68d2bTest
https://doi.org/10.1093/ajcn/nqaa394Test

المؤلفون: Dieuwertje E. Kok, Flip M. Kruyt, Augustin Scalbert, Pekka Keski-Rahkonen, Matty P. Weijenberg, Evertine Wesselink, Cornelia M. Ulrich, Moniek van Zutphen, Ellen Kampman, Fränzel J.B. Van Duijnhoven, Anne J.M.R. Geijsen, Johannes H. W. de Wilt, Audrey Gicquiau, Andrea Gsur, David Achaintre

المساهمون: RS: GROW - R1 - Prevention, Epidemiologie

المصدر: European Journal of Nutrition, 60, 6, pp. 3171-3184
European Journal of Nutrition, 60, 3171-3184
European Journal of Nutrition 60 (2021)
European Journal of Nutrition, 60(6), 3171-3184. Springer
European Journal of Nutrition

مصطلحات موضوعية: Male, Nutrition and Disease, Colorectal cancer, Metabolite, Medicine (miscellaneous), Physiology, Stage ii, Body Mass Index, chemistry.chemical_compound, Colorectal cancer patients, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Voeding en Ziekte, Metabolites, Humans, Medicine, Metabolomics, Dietary patterns, Aged, VLAG, Nutrition and Dietetics, business.industry, Cancer, Original Contribution, Dietary pattern, medicine.disease, Diet, Diet quality, chemistry, Diet quality indices, Smoking status, Diet, Healthy, Colorectal Neoplasms, business, Body mass index

الوصف: Purpose Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Methods Concentrations of 134 metabolites of the Biocrates AbsoluteIDQ p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate. Results Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations. Conclusion In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum. Clinical trial registry ClinicalTrials.gov Identifier: NCT03191110.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8871af80236cce774ae24164b5327aTest
https://doi.org/10.1007/s00394-021-02488-1Test

المؤلفون: Tengda Lin, Evertine Wesselink, Henk K. van Halteren, Ellen Kampman, Petra Schrotz-King, Dieuwertje E. Kok, Kathy Vickers, Jennifer Ose, Cornelia M. Ulrich, Andreas Baierl, Stephanie O. Breukink, Stefanie Brezina, Hermann Brenner, Anita R. Peoples, Rama Kiblawi, Andreana N. Holowatyj, Martin Schneider, Øivind Midttun, Biljana Gigic, Alexis Ulrich, Andrea Gsur, Eline H. van Roekel, Peter van Duijvendijk, Per Magne Ueland, Tanja Gumpenberger, Christopher I. Li, Michael Hoffmeister, Flip M. Kruyt, Matty P. Weijenberg, Janna L. Koole, Eric T.P. Keulen, Nina Habermann, Anne J.M.R. Geijsen, Maryska L.G. Janssen-Heijnen, Fränzel J.B. van Duijnhoven, Arve Ulvik, Johannes H. W. de Wilt, Jenny Chang-Claude, Martijn J.L. Bours, Jürgen Böhm

المساهمون: Epidemiologie, RS: GROW - R1 - Prevention, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health

المصدر: The American journal of clinical nutrition, 113(6), 1468-1481
The American Journal of Clinical Nutrition, 113, 1468-1481
Am J Clin Nutr
The American Journal of Clinical Nutrition, 113, 6, pp. 1468-1481
The American journal of clinical nutrition 113 (2021) 6
American Journal of Clinical Nutrition, 113(6), 1468-1481. Oxford University Press

مصطلحات موضوعية: Oncology, Male, Nutrition and Disease, Colorectal cancer, pyridoxal 5′-phosphate, Medicine (miscellaneous), Riboflavin, HOMOCYSTEINE, FOLIC-ACID, vitamin B6, Cohort Studies, chemistry.chemical_compound, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Quality of life, Voeding en Ziekte, 030212 general & internal medicine, POPULATION, ASSOCIATIONS, education.field_of_study, Nutrition and Dietetics, PLASMA, Middle Aged, Europe, health-related quality of life, Original Research Communications, 030220 oncology & carcinogenesis, Vitamin B Complex, Biomarker (medicine), Female, Colorectal Neoplasms, medicine.medical_specialty, B vitamins, Population, colorectal cancer, METABOLISM, Cobalamin, functioning, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, INFLAMMATION, Internal medicine, medicine, Humans, education, dietary supplement use, Aged, VLAG, business.industry, Cancer, biomarkers, pyridoxal 5 '-phosphate, medicine.disease, folates, chemistry, Dietary Supplements, Multivariate Analysis, RISK-FACTORS, Quality of Life, fatigue, business, FOLATE

الوصف: Background B vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear. Objectives To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circulating concentrations of B vitamins and related biomarkers 6 months postdiagnosis; 2) changes in these concentrations between diagnosis and 6 months postdiagnosis; 3) B-vitamin supplement use 6 months postdiagnosis; and 4) changes in B-vitamin supplement use between diagnosis and 6 months postdiagnosis. Methods We included 1676 newly diagnosed stage I-III CRC patients from 3 prospective European cohorts. Circulating concentrations of 9 biomarkers related to the B vitamins folate, riboflavin, vitamin B6, and cobalamin were measured at diagnosis and 6 months postdiagnosis. Information on dietary supplement use was collected at both time points. Health-related quality of life (global quality of life, functioning scales, and fatigue) was assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire 6 months postdiagnosis. Confounder-adjusted linear regression analyses were performed, adjusted for multiple testing. Results Higher pyridoxal 5'-phosphate (PLP) was cross-sectionally associated with better physical, role, and social functioning, as well as reduced fatigue, 6 months postdiagnosis. Associations were observed for a doubling in the hydroxykynurenine ratio [3-hydroxykynurenine: (kynurenic acid + xanthurenic acid + 3-hydroxyanthranilic acid + anthranilic acid); an inverse marker of vitamin B6] and both reduced global quality of life (β = -3.62; 95% CI: -5.88, -1.36) and worse physical functioning (β = -5.01; 95% CI: -7.09, -2.94). Dose-response relations were observed for PLP and quality of life. No associations were observed for changes in biomarker concentrations between diagnosis and 6 months. Participants who stopped using B-vitamin supplements after diagnosis reported higher fatigue than nonusers. Conclusions Higher vitamin B6 status was associated with better quality of life, yet limited associations were observed for the use of B-vitamin supplements. Vitamin B6 needs further study to clarify its role in relation to quality of life.

وصف الملف: application/octet-stream; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84addda8b4092945ba9a1ea92ca5058Test
https://doi.org/10.1093/ajcn/nqaa422Test

المؤلفون: Martijn J.L. Bours, Tengda Lin, Mary C. Playdon, Jennifer Ose, Cornelia M. Ulrich, Caroline Himbert, Anne J.M.R. Geijsen, Eline H. van Roekel, Andreana N. Holowatyj, Tanja Gumpenberger, Per Magne Ueland, Alexis Ulrich, Christy A. Warby, Petra Schrotz-King, Andrea Gsur, Dieuwertje E. Kok, Rama Kiblawi, Janna L. Koole, Arve Ulvik, Nina Habermann, Sheetal Hardikar, Fränzel J.B. van Duijnhoven, Jürgen Böhm, Stefanie Brezina, Matty P. Weijenberg, Biljana Gigic, Martin Schneider

المساهمون: Epidemiologie, RS: GROW - R1 - Prevention

المصدر: Br J Nutr
British Journal of Nutrition, 123(10), 1187-1200
British Journal of Nutrition, 123(10):0007114520000422, 1187-1200. Cambridge University Press
British Journal of Nutrition 123 (2020) 10

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Folate, Nutrition and Disease, Colorectal cancer, Angiogenesis, Medicine (miscellaneous), Systemic inflammation, chemistry.chemical_compound, 0302 clinical medicine, Glutamates, Voeding en Ziekte, FOLIC-ACID SUPPLEMENTATION, Prospective Studies, PYRIDOXAL 5'-PHOSPHATE, OXIDATIVE STRESS, Vitamin B, Tetrahydrofolates, Aged, 80 and over, THIAMINE-DEFICIENCY, RISK, Nutrition and Dietetics, biology, Neovascularization, Pathologic, CRPangiogenesis, Middle Aged, One-carbon metabolism, C-REACTIVE PROTEIN, Vascular endothelial growth factor, Intestines, CATABOLISM, 030220 oncology & carcinogenesis, Vitamin B Complex, Female, medicine.symptom, Inflammation Mediators, Colorectal Neoplasms, Adult, medicine.medical_specialty, Amyloid, Adolescent, B vitamins, colorectal cancer, Inflammation, folate, Article, Statistics, Nonparametric, folic acid, 03 medical and health sciences, Young Adult, B-vitamins, Folic Acid, Internal medicine, medicine, Biomarkers, Tumor, Humans, Serum amyloid A, Aged, business.industry, Interleukin-6, Tumor Necrosis Factor-alpha, C-reactive protein, Interleukin-8, medicine.disease, Carbon, Phosphoric Monoester Hydrolases, ASPIRIN, 030104 developmental biology, Cross-Sectional Studies, chemistry, inflammation, PLASMA HOMOCYSTEINE, biology.protein, Linear Models, Vitamin B-6, business

الوصف: B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients (n 238) in the prospective ColoCare Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5’-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) (r –0·33, Plinear < 0·0001), serum amyloid A (SAA) (r –0·23, Plinear = 0·003), IL-6 (r –0·39, Plinear < 0·0001), IL-8 (r –0·20, Plinear = 0·02) and TNFα (r –0·12, Plinear = 0·045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r –0·14), SAA (r –0·14) and TNFα (r –0·15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 (r 0·27, Plinear < 0·0001), and pABG was positively correlated with IL-8 (r 0·21, Plinear < 0·0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for CRC patients.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0852b029804b1393233e31037405500cTest
https://doi.org/10.1017/s0007114520000422Test

المؤلفون: Nivonirina Robinot, Andreana N. Holowatyj, Alexis Ulrich, Audrey Gicquiau, Annaleen Koole, Arve Ulvik, Augustin Scalbert, Tengda Lin, Jennifer Ose, Pekka Keski-Rahkonen, Per-Magne Ueland, Martin Schneider, Biljana Gigic, Matty P. Weijenberg, David Achaintre, Eline van van Roekel, Cornelia M. Ulrich, Anne J.M.R. Geijsen, Tanja Gumpenberger, Fränzel J.B. Van Duijnhoven, Andreas Baierl, Andrea Gsur, Dieuwertje E. Kok, Petra Schrotz-King, Stefanie Brezina, Nina Habermann

المساهمون: RS: GROW - R1 - Prevention, Epidemiologie

المصدر: Metabolites, 11(3), 1-16
Metabolites
Volume 11
Issue 3
Metabolites, Vol 11, Iss 129, p 129 (2021)
Metabolites, 11(3):129. Multidisciplinary Digital Publishing Institute (MDPI)
Metabolites 11 (2021) 3

مصطلحات موضوعية: 0301 basic medicine, False discovery rate, Oncology, medicine.medical_specialty, recurrence, Nutrition and Disease, Colorectal cancer, Endocrinology, Diabetes and Metabolism, lcsh:QR1-502, colorectal cancer, Stage ii, Biochemistry, lcsh:Microbiology, Article, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, Recurrence, Internal medicine, Voeding en Ziekte, COLON, medicine, targeted metabolomics, Prospective cohort study, Molecular Biology, business.industry, Targeted metabolomics, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Cohort, Multiple comparisons problem, SURVIVAL, LIFE-STYLE, business, Body mass index

الوصف: The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort
false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15%) had a recurrence after a median follow-up time of 20 months. We identified 13 metabolites that were nominally associated with a reduced risk of recurrence. None of the associations were statistically significant after controlling for multiple testing. Pathway topology analyses did not reveal statistically significant associations between recurrence and alterations in metabolic pathways (e.g., sphingolipid metabolism p = 0.04
pFDR = 1.00). To conclude, we did not observe statistically significant associations between metabolites and CRC recurrence using a well-established metabolomics assay. The observed results require follow-up in larger studies.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266cbb2950fe62f463fc7041040fa817Test
https://cris.maastrichtuniversity.nl/en/publications/98db5a2b-27a1-4429-b6b3-a8a5b33f391eTest

المؤلفون: Paul C. van de Meeberg, Johannes H. W. de Wilt, Fränzel J.B. van Duijnhoven, Renate M. Winkels, Ellen Kampman, Merel Snellen, Moniek van Zutphen, Anne J.M.R. Geijsen, Ewout A. Kouwenhoven, Anouk Geelen, Henk K. van Halteren, Dieuwertje E. Kok, Ernst Jan Spillenaar Bilgen, Evertine Wesselink, Hendriek C. Boshuizen

المصدر: Supportive Care in Cancer, 27, 4, pp. 1541-1549
Supportive Care in Cancer, 27, 1541-1549
Supportive Care in Cancer
Supportive Care in Cancer 27 (2019) 4
Supportive Care in Cancer, 27(4), 1541-1549

مصطلحات موضوعية: Male, medicine.medical_specialty, Nutrition and Disease, Colorectal cancer, medicine.medical_treatment, Disease, Gastroenterology, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Weight loss, Voeding en Ziekte, Internal medicine, Weight Loss, medicine, Humans, Chemotherapy, 030212 general & internal medicine, Prospective cohort study, Weight gain, Aged, Netherlands, VLAG, Human Nutrition & Health, business.industry, Body Weight, Weight change, Humane Voeding & Gezondheid, Middle Aged, medicine.disease, Biometris, Oncology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Disease Progression, Body-Weight Trajectory, Female, Original Article, Observational study, medicine.symptom, Colorectal Neoplasms, business

الوصف: Purpose: Previous studies have shown that > 50% of colorectal cancer (CRC) patients treated with adjuvant chemotherapy gain weight after diagnosis. This may affect long-term health. Therefore, prevention of weight gain has been incorporated in oncological guidelines for CRC with a focus on patients that undergo adjuvant chemotherapy treatment. It is, however, unknown how changes in weight after diagnosis relate to weight before diagnosis and whether weight changes from pre-to-post diagnosis are restricted to chemotherapy treatment. We therefore examined pre-to-post diagnosis weight trajectories and compared them between those treated with and without adjuvant chemotherapy. Methods: We included 1184 patients diagnosed with stages I–III CRC between 2010 and 2015 from an ongoing observational prospective study. At diagnosis, patients reported current weight and usual weight 2 years before diagnosis. In the 2 years following diagnosis, weight was self-reported repeatedly. We used linear mixed models to analyse weight trajectories. Results: Mean pre-to-post diagnosis weight change was −0.8 (95% CI −1.1, −0.4) kg. Post-diagnosis weight gain was + 3.5 (95% CI 2.7, 4.3) kg in patients who had lost ≥ 5% weight before diagnosis, while on average clinically relevant weight gain after diagnosis was absent in the groups without pre-diagnosis weight loss. Pre-to-post diagnosis weight change was similar in patients treated with (−0.1 kg (95%CI −0.8, 0.6)) and without adjuvant chemotherapy (−0.9 kg (95%CI −1.4, −0.5)). Conclusions: Overall, hardly any pre-to-post diagnosis weight change was observed among CRC patients, because post-diagnosis weight gain was mainly observed in patients who lost weight before diagnosis. This was observed independent of treatment with adjuvant chemotherapy.

وصف الملف: application/pdf; application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2628fe1e3b555b0533e9f3629d1b94Test
https://doi.org/10.1007/s00520-018-4560-zTest

المؤلفون: Ernst Jan Spillenaar Bilgen, Johannes H. W. de Wilt, Evertine Wesselink, Ellen Kampman, Fränzel J.B. van Duijnhoven, Ewout A. Kouwenhoven, Anne J.M.R. Geijsen, Flip M. Kruyt, Renzo P. Veenstra, Moniek van Zutphen, Laura E. Staritsky, Dieuwertje E. Kok

المصدر: Clinical Nutrition, 40(6), 4436-4443
Clinical Nutrition 40 (2021) 6
Clinical Nutrition, 40, 6, pp. 4436-4443
Clinical Nutrition, 40, 4436-4443

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, medicine.medical_specialty, Nutrition and Disease, Colorectal cancer, Inflammatory markers, 030209 endocrinology & metabolism, Inflammation, Critical Care and Intensive Care Medicine, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Interquartile range, Recurrence, Internal medicine, Voeding en Ziekte, medicine, Humans, Mortality, Inflammatory potential of the diet, Prospective cohort study, Aged, VLAG, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Middle Aged, medicine.disease, All-cause mortality, Cancer registry, Diet, Clinical trial, Interleukin 10, C-Reactive Protein, Human and Animal Physiology, Fysiologie van Mens en Dier, Cytokines, Observational study, Female, medicine.symptom, Neoplasm Recurrence, Local, business, Colorectal Neoplasms

الوصف: Background & aims: The inflammatory potential of the diet has been linked to colorectal cancer (CRC) development and mortality. However, it is unknown whether it is also associated with CRC recurrence. Therefore, the aim of this study was to investigate the associations between the inflammatory potential of the diet and plasma inflammation markers as well as recurrence and all-cause mortality in CRC patients. Methods: Data of the Colorectal cancer, Observational, LONgitudinal (COLON) study, a prospective cohort study, was used. Dietary intake, assessed using a semi-quantitative food frequency questionnaire, was available for 1478 patients at diagnosis and for 1334 patients six months after diagnosis. Dietary intake data were used to calculate the adapted dietary inflammatory index (ADII). Data about cancer recurrence and all-cause mortality, were assessed through linkage with the Netherlands Cancer Registry and the Municipal Personal Records Database, respectively. The association between the ADII (continuous) and inflammation markers (Interleukin (IL)6, IL8, IL10, Tumor Necrosis Factor (TNF)α, high sensitivity C-reactive protein (hsCRP) and a summary inflammatory z-score), measured with a multiplex assay using electrochemiluminiscence detection, was assessed using quantile regression analyses. Restricted cubic splines (RCS) analyses and multivariable Cox proportional hazard models were used to explore the relationship between the ADII and CRC outcomes. Results: During a median follow-up time of 3.2 years (Interquartile range (IQR) 2.0–4.1) for recurrence and 4.8 years (IQR 3.5–5.9) for all-cause mortality, 228 recurrences and 279 deaths occurred. A more pro-inflammatory diet at diagnosis as well as six months after diagnosis was associated with higher levels of TNFα, hsCRP and the summary inflammatory z-score. Results of RCS showed no relationship between the ADII and CRC outcomes at both time points. Also results of the Cox proportional hazard models showed no associations between the ADII at both time points and recurrence (HR (95%CI) 0.98 (0.94–1.04) & 0.96 (0.91–1.02) or all-cause mortality (HR (95%CI) 1.03 (0.98–1.07) & 1.00 (0.95–1.05)). Conclusion: Our study did not show an association between the ADII and recurrence and all-cause mortality in CRC patients. Further research should also take into account molecular tumor subtypes, as the effect of the inflammatory potential of the diet on cancer recurrence and mortality is more likely to be present in tumors with an inflammatory signature. Clinical Trial Registry numbers and website: The colon study: NCT03191110; clinical trials.gov.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462059e9706529fe90616f0bf7c015aeTest
https://research.wur.nl/en/publications/the-association-between-the-adapted-dietary-inflammatory-index-anTest

المؤلفون: Matty P. Weijenberg, Per Magne Ueland, Jolanta Jedrzkiewicz, Stephanie O. Breukink, Jennifer Ose, Petra Schrotz-King, Jenny Chang-Claude, F. Jeroen Vogelaar, Anne J.M.R. Geijsen, Torsten Kölsch, Alexis Ulrich, Peter Schirmacher, Fränzel J.B. van Duijnhoven, Janna L. Koole, Tengda Lin, Biljana Gigic, Johannes H. W. de Wilt, Courtney L. Scaife, Eric T.P. Keulen, Flip M. Kruyt, Eline H. van Roekel, William M. Grady, Dieuwertje E. Kok, Ellen Kampman, Martijn J.L. Bours, Henk K. van Halteren, Tanja Gumpenberger, Martin Schneider, Michael Hoffmeister, Cornelia M. Ulrich, Mary P. Bronner, Andreas Baierl, Katharina Kosma, Nina Habermann, Rama Kiblawi, Eric R. Swanson, Gry Kvalheim, Moniek van Zutphen, Andrea Gsur, Marie C Singer, Arve Ulvik, Evertine Wesselink, Hermann Brenner, Ewout A. Kouwenhoven, T Bartley Pickron, Peter van Duijvendijk, Jürgen Böhm, Andreana N. Holowatyj, Kathy Vickers, Stefanie Brezina, Esther Herpel, Christopher I. Li, Thomas Grünberger, Lyen C. Huang, Michael Bergmann

المساهمون: Epidemiologie, RS: GROW - R1 - Prevention, Surgery, MUMC+: MA Heelkunde (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy

المصدر: JNCI Cancer Spectrum, 4
JNCI Cancer Spectrum, 4, 5
JNCI Cancer Spectrum, 4(5)
JNCI Cancer Spectrum, 4(5):051. Oxford University Press
JNCI Cancer Spectrum
JNCI Cancer Spectrum 4 (2020) 5

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Nutrition and Disease, Colorectal cancer, BIOMARKERS, VITAMINS, METABOLISM, medicine.disease_cause, Gastroenterology, Article, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Dual role, Voeding en Ziekte, Internal medicine, medicine, Life Science, TANDEM MASS-SPECTROMETRY, Stage (cooking), VLAG, 030304 developmental biology, 0303 health sciences, PLASMA, business.industry, Hazard ratio, medicine.disease, Confidence interval, Oncology, Folic acid, 030220 oncology & carcinogenesis, CATABOLITES, NUTRITION, DIHYDROFOLATE-REDUCTASE, AcademicSubjects/MED00010, HUMAN SERUM, Carcinogenesis, business, Cohort study

الوصف: Background Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating concentrations of folate and folic acid, measured around time of diagnosis, are associated with recurrence and survival in colorectal cancer patients is largely unknown. Methods Circulating concentrations of folate, folic acid, and folate catabolites p-aminobenzoylglutamate and p-acetamidobenzoylglutamate were measured by liquid chromatography-tandem mass spectrometry at diagnosis in 2024 stage I-III colorectal cancer patients from European and US patient cohort studies. Multivariable-adjusted Cox proportional hazard models were used to assess associations between folate, folic acid, and folate catabolites concentrations with recurrence, overall survival, and disease-free survival. Results No statistically significant associations were observed between folate, p-aminobenzoylglutamate, and p-acetamidobenzoylglutamate concentrations and recurrence, overall survival, and disease-free survival, with hazard ratios ranging from 0.92 to 1.16. The detection of folic acid in the circulation (yes or no) was not associated with any outcome. However, among patients with detectable folic acid concentrations (n = 296), a higher risk of recurrence was observed for each twofold increase in folic acid (hazard ratio = 1.31, 95% confidence interval = 1.02 to 1.58). No statistically significant associations were found between folic acid concentrations and overall and disease-free survival. Conclusions Circulating folate and folate catabolite concentrations at colorectal cancer diagnosis were not associated with recurrence and survival. However, caution is warranted for high blood concentrations of folic acid because they may increase the risk of colorectal cancer recurrence.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb749cdfe9b73207d94bfe60e4db29cTest
https://doi.org/10.1093/jncics/pkaa051Test

المؤلفون: Johannes H. W. de Wilt, Moniek van Zutphen, Dieuwertje E. Kok, Ellen Kampman, Jody van den Ouweland, Anne J.M.R. Geijsen, Michiel G.J. Balvers, Henk K. van Halteren, Martijn J.L. Bours, Harm van Baar, Fränzel J.B. van Duijnhoven, Eric T.P. Keulen, Ewout A. Kouwenhoven, Evertine Wesselink, Renger F. Witkamp, Matty P. Weijenberg

المساهمون: Epidemiologie, RS: GROW - R1 - Prevention

المصدر: Therapeutic Advances in Gastroenterology, 13
Therapeutic Advances in Gastroenterology, Vol 13 (2020)
Therapeutic Advances in Gastroenterology, 13:1756284820923922, 1-15. SAGE Publications Inc.
Therapeutic Advances in Gastroenterology 13 (2020)
Therapeutic Advances in Gastroenterology

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Calcitriol, Nutrition and Disease, Colorectal cancer, NF-KAPPA-B, MODELS, interleukin 6, PROGRESSION, colorectal cancer, IMMUNITY, 25(OH)D3, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Voeding en Ziekte, medicine, Vitamin D and neurology, 25(OH)D-3, SERUM INTERLEUKIN-6 LEVELS, lcsh:RC799-869, Interleukin 6, HNRU&LB, Original Research, VLAG, Human Nutrition & Health, biology, 25(OH)D, business.industry, Humane Voeding & Gezondheid, Gastroenterology, Advances and Future Perspectives in Colorectal Cancer, QUANTIFICATION, medicine.disease, inflammatory markers, PREVENTION, Nutritional Biology, cytokines, LIFE, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, HEALTH, business, medicine.drug

الوصف: Background: Calcitriol, the active form of vitamin D, may inhibit colorectal cancer (CRC) progression, which has been mechanistically linked to an attenuation of a pro-inflammatory state. The present study investigated the associations between circulating 25 hydroxy vitamin D3 (25(OH)D3) levels and inflammatory markers (IL10, IL8, IL6, TNFα and hsCRP) in the 2 years following CRC diagnosis. Methods: Circulating 25(OH)D3 levels and inflammatory markers were assessed at diagnosis, after 6, 12 and 24 months from 798 patients with sporadic CRC participating in two prospective cohort studies. Associations between 25(OH)D3 levels and individual inflammatory markers as well as a summary inflammatory z-score were assessed at each time point by multiple linear regression analyses. To assess the association between 25(OH)D3 and inflammatory markers over the course of 2 years, linear mixed model regression analyses were conducted. Results: Higher 25(OH)D3 levels were associated with lower IL6 levels at diagnosis, at 6 months after diagnosis and over the course of 2 years (β −0.06, 95% CI −0.08 to −0.04). In addition, 25(OH)D3 levels were inversely associated with the summary inflammatory z-score at diagnosis and over the course of 2 years (β −0.17, 95% CI −0.25 to −0.08). In addition, a significant inverse association between 25(OH)D3 levels and IL10 was found over the course of 2 years. Intra-individual analyses showed an inverse association between 25(OH)D3 and IL10, IL6 and TNFα. No statistically significant associations between 25(OH)D3 and IL8 and hsCRP levels were observed. Conclusions: Serum 25(OH)D3 levels were inversely associated with the summary inflammatory z-score and in particular with IL6 in the years following CRC diagnosis. This is of potential clinical relevance as IL6 has an important role in chronic inflammation and is also suggested to stimulate cancer progression. Further observational studies should investigate whether a possible 25(OH)D3-associated reduction of inflammatory mediators influences treatment efficacy and CRC recurrence.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b235a1918a565e7805e46aabe5d8246Test
https://research.wur.nl/en/publications/the-association-between-circulating-levels-of-vitamin-d-and-inflaTest