المؤلفون: Anna-Sophie Grimm, Charlotte Schubert, Alexander Grimm, Jan-Hendrik Stahl, Hanna Küpper, Veronka Horber, Josua Kegele, Sophia Willikens, Julia Wittlinger, Lina Serna-Higuita, Natalie Winter, Samuel Groeschel

المصدر: Frontiers in Neurology, Vol 11 (2020)

مصطلحات موضوعية: nerve ultrasound, children neuropathy, reference values, lysosomal storage diseases, nerve imaging, Neurology. Diseases of the nervous system, RC346-429

الوصف: Backgrounds: We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies.Methods: High-resolution ultrasounds of the nerves were performed in 117 healthy children and adolescents at 20 predefined landmarks in the neck and the extremities of both sides. Mean values, side-to-side differences and intraneural ratios, as well as upper limits have been calculated. In a second step, a comparison between 25 children and adolescents of the same age range with proven hereditary and acquired neuropathies and lysosomal storage diseases has been carried out.Results: Nerve growth correlates significantly with age and reaches adult values at the age of around 15 years. The influence of body mass index and gender is negligible at most segments. By the use of age-specific upper limits, nerve enlargement could be seen in distinct types of neuropathies, particularly in demyelinating hereditary and inflammatory types, which is comparable to findings in adults, but also in rare lysosomal storage diseases.Conclusion: Nerve size correlates with age during childhood and reaches a climax in younger adults. Age-matched reference data are inevitable to differ between hypertrophic and non-hypertrophic nerve damage, e.g., in neuropathies.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fneur.2020.00303/fullTest; https://doaj.org/toc/1664-2295Test

الوصول الحر: https://doaj.org/article/4520057ad8c04a0ba36b3c8de04b8fd0Test

المؤلفون: Anna-Sophie, Grimm, Charlotte, Schubert, Alexander, Grimm, Jan-Hendrik, Stahl, Hanna, Küpper, Veronka, Horber, Josua, Kegele, Sophia, Willikens, Julia, Wittlinger, Lina, Serna-Higuita, Natalie, Winter, Samuel, Groeschel

المصدر: Frontiers in Neurology

مصطلحات موضوعية: children neuropathy, Neurology, nerve ultrasound, nerve imaging, reference values, lysosomal storage diseases, Original Research

الوصف: Backgrounds: We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies. Methods: High-resolution ultrasounds of the nerves were performed in 117 healthy children and adolescents at 20 predefined landmarks in the neck and the extremities of both sides. Mean values, side-to-side differences and intraneural ratios, as well as upper limits have been calculated. In a second step, a comparison between 25 children and adolescents of the same age range with proven hereditary and acquired neuropathies and lysosomal storage diseases has been carried out. Results: Nerve growth correlates significantly with age and reaches adult values at the age of around 15 years. The influence of body mass index and gender is negligible at most segments. By the use of age-specific upper limits, nerve enlargement could be seen in distinct types of neuropathies, particularly in demyelinating hereditary and inflammatory types, which is comparable to findings in adults, but also in rare lysosomal storage diseases. Conclusion: Nerve size correlates with age during childhood and reaches a climax in younger adults. Age-matched reference data are inevitable to differ between hypertrophic and non-hypertrophic nerve damage, e.g., in neuropathies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::fd2d6d71aaf095e43ba6b2b538214065Test
https://pubmed.ncbi.nlm.nih.gov/32411079Test

المؤلفون: Charlotte Schubert, Lina María Serna-Higuita, Josua Kegele, Natalie Winter, Alexander Grimm, Samuel Groeschel, Jan-Hendrik Stahl, Hanna Küpper, Anna-Sophie Grimm, Julia Wittlinger

المصدر: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 131(4)

مصطلحات موضوعية: Male, Nerve ultrasound, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Physiology (medical), Medicine, Humans, 0501 psychology and cognitive sciences, Cervical spinal nerve 5, Peripheral Nerves, Tibial nerve, Child, Ultrasonography, business.industry, 05 social sciences, Sensory Systems, Peripheral, medicine.anatomical_structure, Spinal Nerves, Neurology, Reference values, Healthy individuals, Child, Preschool, Female, Neurology (clinical), business, Nuclear medicine, Body mass index, 030217 neurology & neurosurgery, Echo intensity

الوصف: Objective We examined selected peripheral and spinal nerves of children aged between two and seven years. Method High resolution ultrasound was performed in 116 children (2–7 years of age) at 19 predefined landmarks of median, ulnar, tibial, fibular, sural and radial nerves, the vagus as well as cervical spinal nerve 5 and 6. Further, side-to-side measuring and grey-scale analysis was done at selected nerve sites. Results Nerves of children were on average smaller than those of adults. Nerve growth correlates significantly with age in all nerves, the mean values were similar in the age of two to four years and five to seven years. Body mass index (BMI) and gender showed moderate effect at some nerve sites, however not uniformly in all. A side-to-side difference of up to 30% in median, and up to 20% in tibial nerve can occur in healthy individuals. Grey-scale analysis for echointensity has been performed in median, ulnar and tibial nerves. Conclusion Nerve size increases with age, BMI and gender have moderate effect. A side-to-side-difference of up to 30% can exist. Significance Reference values of nerve cross-sectional area, side-to-side-difference and echo intensity are necessary to detect nerve pathology in children as well as in adults.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7914fb8b391a0ac340f4035948e25798Test
https://pubmed.ncbi.nlm.nih.gov/32066105Test