المؤلفون: Goetz, Matthew, Cicin, Irfan, Testa, Laura, Tolaney, Sara, Huober, Jens, Guarneri, Valentina, Johnston, Stephen, Martin, Miguel, Rastogi, Priya, Harbeck, Nadia, Shahir, Ashwin, Wei, Ran, André, Valérie, Rugo, Hope, OShaughnessy, Joyce

المصدر: npj Breast Cancer. 10(1)

الوصف: In monarchE, adjuvant abemaciclib significantly improved invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS), with sustained benefit beyond the 2-year treatment period. Abemaciclib dose reductions were allowed to proactively manage adverse events. Exploratory analyses to investigate the impact of dose reductions on efficacy were conducted. Across the three patient subgroups as defined by relative dose intensity (≤66%, 66-93%, ≥93%), the estimated 4-year IDFS rates were generally consistent (87.1%, 86.4%, and 83.7%, respectively). In the time-dependent Cox proportional hazard model, the effect of abemaciclib was consistent at the full dose compared to being reduced to a lower dose (IDFS hazard ratio: 0.905; 95% confidence interval: 0.727, 1.125; DRFS hazard ratio: 0.942; 95% confidence interval: 0.742, 1.195). These analyses showed that the efficacy of adjuvant abemaciclib was not compromised by protocol mandated dose reductions for patients with node positive, hormone receptor positive, human epidermal growth factor 2-negative, high-risk early breast cancer.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3rv856b9Test
https://escholarship.org/content/qt3rv856b9/qt3rv856b9.pdfTest

المؤلفون: Rastogi, Priya, OShaughnessy, Joyce, Martin, Miguel, Boyle, Frances, Cortes, Javier, Goetz, Matthew, Hamilton, Erika, Huang, Chiun-Sheng, Senkus, Elzbieta, Tryakin, Alexey, Cicin, Irfan, Testa, Laura, Neven, Patrick, Huober, Jens, Shao, Zhimin, Wei, Ran, André, Valérie, Munoz, Maria, San Antonio, Belen, Shahir, Ashwin, Harbeck, Nadia, Johnston, Stephen, Rugo, Hope

المصدر: Journal of Clinical Oncology. 42(9)

مصطلحات موضوعية: Humans, Female, Breast Neoplasms, Neoplasm Recurrence, Local, Adjuvants, Immunologic, Receptor, ErbB-2, Antineoplastic Combined Chemotherapy Protocols, Aminopyridines, Benzimidazoles

الوصف: Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.Two years of adjuvant abemaciclib combined with endocrine therapy (ET) resulted in a significant improvement in invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) that persisted beyond the 2-year treatment period in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative, node-positive, high-risk early breast cancer (EBC). Here, we report 5-year efficacy results from a prespecified overall survival (OS) interim analysis. In the intent-to-treat population, with a median follow-up of 54 months, the benefit of abemaciclib was sustained with hazard ratios of 0.680 (95% CI, 0.599 to 0.772) for IDFS and 0.675 (95% CI, 0.588 to 0.774) for DRFS. This persistence of abemaciclib benefit translated to continuous separation of the curves with a deepening in 5-year absolute improvement in IDFS and DRFS rates of 7.6% and 6.7%, respectively, compared with rates of 6% and 5.3% at 4 years and 4.8% and 4.1% at 3 years. With fewer deaths in the abemaciclib plus ET arm compared with the ET-alone arm (208 v 234), statistical significance was not reached for OS. No new safety signals were observed. In conclusion, abemaciclib plus ET continued to reduce the risk of developing invasive and distant disease recurrence beyond the completion of treatment. The increasing absolute improvement at 5 years is consistent with a carryover effect and further supports the use of abemaciclib in patients with high-risk EBC.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8zj689v4Test

المؤلفون: Acke, Daniel, Bernard, Bruno, André, Valérie, Brix, Michel, Cerman, Ivo, Chaouche, Sabine, Colson, Bruno, Cornaz, Marie, Couvreur, Manuel, Guri, Shipé, de Harlez de Deulin, Nathalie, Loir, Christophe, Mouriau de Meulenacker, Pierre, Speeckaert, Jean-Charles, Preyat, Fabrice

المساهمون: André, Valérie, Couvreur, Manuel

مصطلحات موضوعية: history, literature, Belgium, thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism

الوقت: eighteenth century

الوصف: Feld-maréchal, septième prince du nom, Charles-Joseph de Ligne (1735-1814) exerça une véritable fascination sur ses contemporains. Ce volume, auquel ont contribué des spécialistes issus de plusieurs disciplines, entend rompre avec la représentation figée d'un homme et d’une œuvre trop longtemps méconnus.

وصف الملف: application/pdf

العلاقة: Études sur le XVIIIe siècle

الوصول الحر: http://library.oapen.org/handle/20.500.12657/22258Test

المؤلفون: André, Valérie, Beaurepaire, Pierre-Yves

مصطلحات موضوعية: Sciences humaines, Histoire de la littérature, Histoire culturelle

الوصف: info:eu-repo/semantics/published

وصف الملف: No full-text files

العلاقة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/369011Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/369011Test

المؤلفون: André, Valérie

مصطلحات موضوعية: Sciences humaines, Histoire de la littérature, Histoire culturelle

الوصف: info:eu-repo/semantics/inPress

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: https://dipot.ulb.ac.be/dspace/bitstream/2013/368183/3/Monselet_volume_Plagnol.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/368183Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/368183Test
https://dipot.ulb.ac.be/dspace/bitstream/2013/368183/3/Monselet_volume_Plagnol.pdfTest

المؤلفون: André, Valérie, Trousson, Raymond

المصدر: Les Dix-Huitièmes Siècles

مصطلحات موضوعية: Sciences humaines, Histoire de la littérature, Histoire culturelle

الوصف: info:eu-repo/semantics/inPress

وصف الملف: 1 v. (612 p.); No full-text files

العلاقة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/355489Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/355489Test

المؤلفون: André, Valérie, Aron, Paul, Wagneur, Jean-Didier, Cestor, Françoise

مصطلحات موضوعية: Sciences humaines, Histoire de la littérature, Histoire culturelle

الوصف: info:eu-repo/semantics/inPress

وصف الملف: 1 v. (355 p.); 1 full-text file(s): application/pdf

العلاقة: https://dipot.ulb.ac.be/dspace/bitstream/2013/368170/3/Monselet_premieres_epreuves.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/368170Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/368170Test
https://dipot.ulb.ac.be/dspace/bitstream/2013/368170/3/Monselet_premieres_epreuves.pdfTest

المؤلفون: Colin-Pierre, Charlie, El Baraka, Oussama, Danoux, Louis, Bardey, Vincent, André, Valérie, Ramont, Laurent, Brézillon, Stéphane

المساهمون: Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), BASF Beauty Care Solutions, BASF SE

المصدر: ISSN: 2057-3995 ; NPJ Regenerative medicine ; https://hal.univ-reims.fr/hal-03946375Test ; NPJ Regenerative medicine, 2022, 7 (1), pp.77. ⟨10.1038/s41536-022-00267-y⟩.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience ; Abstract Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives.

العلاقة: hal-03946375; https://hal.univ-reims.fr/hal-03946375Test; https://hal.univ-reims.fr/hal-03946375/documentTest; https://hal.univ-reims.fr/hal-03946375/file/NPJ%2041536_2022_Article_267.pdfTest

الإتاحة: https://doi.org/10.1038/s41536-022-00267-yTest
https://hal.univ-reims.fr/hal-03946375Test
https://hal.univ-reims.fr/hal-03946375/documentTest
https://hal.univ-reims.fr/hal-03946375/file/NPJ%2041536_2022_Article_267.pdfTest

المؤلفون: Afiouni, Nada, André, Valérie, Ball, Susan, Berthillot, Emilie, Carswell, Richard, Cary-Pernon, Niaz, Davis, Richard, Mansour, Claire, Molinari, Véronique, Parra, Mona, Sharp, Alan, Yakoubi, Myriam

العلاقة: info:eu-repo/semantics/reference/issn/0248-9015; info:eu-repo/semantics/reference/issn/2429-4373; http://journals.openedition.org/rfcb/8492Test

الإتاحة: http://journals.openedition.org/rfcb/8492Test

المؤلفون: André, Valérie

الوصف: Les cinquante dernières années ont présidé à un certain effacement de la relation bilatérale franco-britannique ; cette perte de visibilité s’explique à la fois par sa dilution dans l’espace politique et économique de l’Union européenne mais aussi par la concurrence d’un jeu d’alliances formelles et informelles qui a vu le Royaume-Uni lier son destin à celui des États-Unis et la France jouer la carte du couple franco-allemand à la suite de la ratification du Traité de l’Elysée. Les relations .

العلاقة: info:eu-repo/semantics/reference/issn/0248-9015; info:eu-repo/semantics/reference/issn/2429-4373; http://journals.openedition.org/rfcb/8494Test

الإتاحة: http://journals.openedition.org/rfcb/8494Test