المؤلفون: Lyubov V. Rychkova, Marina A. Darenskaya, Natalya V. Semenova, Sergey I. Kolesnikov, Alla G. Petrova, Olga A. Nikitina, Anastasia S. Brichagina, Lyubov I. Kolesnikova

المصدر: International Journal of Biomedicine, Vol 12, Iss 2, Pp 242-246 (2022)

مصطلحات موضوعية: covid-19, oxidative stress index, children, adolescents, polymerase chain reaction, Medicine

الوصف: The aim of our research was to assess the intensity of oxidative stress (OS) in children and adolescents with COVID-19 using the oxidative stress index (OSI). Methods and Results: The study was conducted between May 2020 and March 2021. The main group included 17 children and adolescents [8(47.1%) boys and 9(52.9%) girls; mean age of 12.35±4.01 years] with diagnosed COVID-19 infection (mild to moderate course) selected as a result of the primary diagnostic examination from among those admitted to hospitalization at the Irkutsk Regional Infectious Diseases Clinical Hospital. The control group included 17 healthy children and adolescents (average age of 12.35±4.01 years) matched by copy-pair type. The obtained data indicated statistically significant differences in a number of parameters between children and adolescents with COVID-19 and the control groups. We found statistically significant higher levels of LPO products (CDs, P

وصف الملف: electronic resource

العلاقة: http://www.ijbm.org/articles/i46/ijbm_12Test(2)_oa7.pdf; https://doaj.org/toc/2158-0510Test; https://doaj.org/toc/2158-0529Test

الوصول الحر: https://doaj.org/article/3bd1c9cd9f1e48abbc5ff91a2a9deaa5Test

المؤلفون: Natalya V. Semenova, Anastasia S. Brichagina, Olga A. Nikitina, Irina M. Madaeva, Sergey I. Kolesnikov, Lyubov I. Kolesnikova

المصدر: Ekologiya cheloveka (Human Ecology). 29:415-423

مصطلحات موضوعية: Health (social science), Ecology, Public Health, Environmental and Occupational Health, General Medicine

الوصف: BACKGROUND: Menopause is a risk factor for oxidative stress. Previous study results indicate the lipid peroxidation ethnospecificity, suggesting differences in the metabolism of different ethnic groups of women, associated with the oxidation of not only lipids but proteins and DNA. AIM: To determine advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and DNA oxidative modification levels in the blood of Russian and Buryat peri- and postmenopausal women. MATERIAL AND METHODS: The study involved 86 women of two ethnic groups Russians (n=52) and Buryats (n=34) aged 45 to 60 years with peri- and postmenopausal status, which participated as volunteers. The basis for the exclusion in this study was the use of hormone replacement therapy, antioxidant drugs, diseases of endocrine origin, exacerbation of chronic diseases, premature early menopause, and surgical menopause. The concentration of 8-hydroxy-2'-deoxyguanosine (ng/ml) and AGEs (ng/ml) was determined in blood serum by enzyme immunoassay. The content of AOPP (nmol/l) was determined in blood plasma using the photometric method. RESULTS: An increase of AOPP levels in postmenopause as compared to perimenopause was found in women of both ethnic groups (36.90 [27.09; 42.72] and 19.80 [17.03; 23.78] in the Russian ethnic group (p 0.001) and 31.16 [29.45; 33.99] and 26.30 [23.44; 30.91] in the Buryat ethnic group (p=0.020). Regardless of the menopausal phase, the AGEs levels in Buryat women were higher than the Russian ethnic group: (5015.0 [4584.49; 5486.96] and 3685.87 [3376.11; 4318.0] in perimenopause (p=0.002) and 4970 [4710; 5660] and 4274.59 [3440.67; 4813.05] in postmenopause (p=0.040)) and 8-hydroxy-2'-deoxyguanosine (1.58 [0.66; 4.36] and 0.82 [0.42; 1.09] in perimenopause (p=0.032) and 1.52 [1.06; 4.21] and 0.85 [0.49; 1.34] in postmenopause (p=0.018)). Differences in the AOPP level were revealed only in the perimenopause toward a higher level in Buryat women. CONCLUSION: Protein oxidation depends on the menopausal phase and is more pronounced in postmenopausal women. The carbonyl stress parameters and DNA destruction levels are higher in Buryat women than Russian ethnic group.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b7536f16bb570102555d4f87adf0e854Test
https://doi.org/10.17816/humeco105578Test