المؤلفون: Chen, J., Spracklen, C.N., Marenne, G., Varshney, A., Corbin, L.J., Luan, J., Willems, S.M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T.S., Mägi, R., Waage, J., Li-Gao, R., Chan, KHK, Yao, J., Anasanti, M.D., Chu, A.Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J.J., Huo, S., Kaakinen, M.A., Louie, T., März, W., Moreno-Macias, H., Ndungu, A., Nelson, S.C., Nolte, I.M., North, K.E., Raulerson, C.K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I.D., Wang, C.A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T.S., Appel, EVR, Bielak, L.F., Brody, J.A., Burtt, N.P., Cabrera, C.P., Cade, B.E., Chai, J.F., Chai, X., Chang, L.C., Chen, C.H., Chen, B.H., Chitrala, K.N., Chiu, Y.F., de Haan, H.G., Delgado, G.E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S.A., Gayán, J., Giulianini, F., Gong, J.H., Gustafsson, S., Hai, Y., Hartwig, F.P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M.Y., Jensen, R.A., Kawaguchi, T., Kentistou, K.A., Kim, Y.J., Kleber, M.E., Kooner, I.K., Lai, S., Lange, L.A., Langefeld, C.D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M.E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L.J., Rich, S.S., Robertson, N.R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K.E., Sennblad, B., Setoh, K., Smith, A.V., Sparsø, T., Strawbridge, R.J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P.J., Verweij, N., Vogel, M., Wang, H., Wang, C., Wang, N., Warren, H.R., Wen, W., Wilsgaard, T., Wong, A., Wood, A.R., Xie, T., Zafarmand, M.H., Zhao, J.H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, SJL, Baldassarre, D., Beekman, M., Bergman, R.N., Bertoni, A., Blüher, M., Bonnycastle, L.L., Bornstein, S.R., Bowden, D.W., Cai, Q., Campbell, A., Campbell, H., Chang, Y.C., de Geus, EJC, Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A.E., Frånberg, M., Fuchsberger, C., Gao, Y., Gjesing, A.P., Goel, A., Han, S., Hartman, C.A., Herder, C., Hicks, A.A., Hsieh, C.H., Hsueh, W.A., Ichihara, S., Igase, M., Ikram, M.A., Johnson, W.C., Jørgensen, M.E., Joshi, P.K., Kalyani, R.R., Kandeel, F.R., Katsuya, T., Khor, C.C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Läll, K., Lam, K., Lawlor, D.A., Lee, N.R., Lemaitre, R.N., Li, H., Lin, S.Y., Lindström, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, G., Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G.N., Nadler, J.L., Nelis, M., Neville, M.J., Norris, J.M., Ohyagi, Y., Peters, A., Peyser, P.A., Polasek, O., Qi, Q., Raven, D., Reilly, D.F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schürmann, A., Shi, J., Stringham, H.M., Taylor, K.D., Teslovich, T.M., Thuesen, B., Timmers, PRHJ, Tremoli, E., Tsai, M.Y., Uitterlinden, A., van Dam, R.M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J.V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G.R., Adair, L.S., Aguilar-Salinas, C.A., Alarcón-Riquelme, M.E., An, P., Aviles-Santa, L., Becker, D.M., Beilin, L.J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Böhm, B.O., Bønnelykke, K., Boomsma, D.I., Bottinger, E.P., Buchanan, T.A., Canouil, M., Caulfield, M.J., Chambers, J.C., Chasman, D.I., Chen, Y.I., Cheng, C.Y., Collins, F.S., Correa, A., Cucca, F., de Silva, H.J., Dedoussis, G., Elmståhl, S., Evans, M.K., Ferrannini, E., Ferrucci, L., Florez, J.C., Franks, P.W., Frayling, T.M., Froguel, P., Gigante, B., Goodarzi, M.O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S.R., Horta, B.L., Huang, W., Ingelsson, E., James, P.S., Jarvelin, M.R., Jonas, J.B., Jukema, J.W., Kaleebu, P., Kaplan, R., Kardia, SLR, Kato, N., Keinanen-Kiukaanniemi, S.M., Kim, B.J., Kivimaki, M., Koistinen, H.A., Kooner, J.S., Körner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T.A., Launer, L.J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, RJF, Magnusson, PKE, Mahajan, A., Metspalu, A., Mook-Kanamori, D.O., Mori, T.A., Munroe, P.B., Njølstad, I., O'Connell, J.R., Oldehinkel, A.J., Ong, K.K., Padmanabhan, S., Palmer, CNA, Palmer, N.D., Pedersen, O., Pennell, C.E., Porteous, D.J., Pramstaller, P.P., Province, M.A., Psaty, B.M., Qi, L., Raffel, L.J., Rauramaa, R., Redline, S., Ridker, P.M., Rosendaal, F.R., Saaristo, T.E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L.J., Selvin, E., Sever, P., Shu, X.O., Slagboom, P.E., Small, K.S., Smith, B.H., Snieder, H., Sofer, T., Sørensen, TIA, Spector, T.D., Stanton, A., Steves, C.J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E.S., Timpson, N.J., Tönjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, TGM, Wagenknecht, L.E., Walker, M., Wang, Y.X., Wareham, N.J., Watanabe, R.M., Watkins, H., Wei, W.B., Wickremasinghe, A.R., Willemsen, G., Wilson, J.F., Wong, T.Y., Wu, J.Y., Xiang, A.H., Yanek, L.R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A.B., Rotter, J.I., Gloyn, A.L., McCarthy, M.I., Dupuis, J., Meigs, J.B., Scott, R.A., Prokopenko, I., Leong, A., Liu, C.T., Parker, SCJ, Mohlke, K.L., Langenberg, C., Wheeler, E., Morris, A.P., Barroso, I.

المساهمون: Lifelines Cohort Study, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), de Haan, H.G., van den Akker, E., van der Most, P.J., de Geus, EJC, van Dam, R.M., van Heemst, D., van Hylckama Vlieg, A., van Willems van Dijk, K., de Silva, H.J., van der Harst, P., van Duijn, C.

المصدر: Nature genetics, vol. 53, no. 6, pp. 840-860

مصطلحات موضوعية: Alleles, Blood Glucose/genetics, Epigenesis, Genetic, European Continental Ancestry Group/genetics, Gene Expression Profiling, Genome, Human, Genome-Wide Association Study, Glycated Hemoglobin A/metabolism, Humans, Multifactorial Inheritance/genetics, Physical Chromosome Mapping, Quantitative Trait Loci/genetics, Quantitative Trait, Heritable

الوصف: Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10 -8 ), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34059833; info:eu-repo/semantics/altIdentifier/eissn/1546-1718; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_53C688CA509F9; https://serval.unil.ch/notice/serval:BIB_53C688CA509FTest; urn:issn:1061-4036; https://serval.unil.ch/resource/serval:BIB_53C688CA509F.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_53C688CA509F9Test

الإتاحة: https://doi.org/10.1038/s41588-021-00852-9Test
https://serval.unil.ch/notice/serval:BIB_53C688CA509FTest
https://serval.unil.ch/resource/serval:BIB_53C688CA509F.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_53C688CA509F9Test

المؤلفون: Chen, J., Spracklen, C.N., Marenne, G., Varshney, A., Corbin, L.J., Luan, J.A., Willems, S.M., Wu, Y., Zhang, X.S., Horikoshi, M., Boutin, T.S., Magi, R., Waage, J., Li-Gao, R.F., Chan, K.H.K., Yao, J., Anasanti, M.D., Chu, A.Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J.J., Huo, S.F., Kaakinen, M.A., Louie, T., Marz, W., Moreno-Macias, H., Ndungu, A., Nelson, S.C., Nolte, I.M., North, K.E., Raulerson, C.K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X.L., Southam, L., Stewart, I.D., Wang, C.A., Wang, Y.J., Wu, P.T., Zhang, W.H., Ahluwalia, T.S., Appel, E.V.R., Bielak, L.F., Brody, J.A., Burtt, N.P., Cabrera, C.P., Cade, B.E., Chai, J.F., Chai, X.R., Chang, L.C., Chen, C.H., Chen, B.H., Chitrala, K.N., Chiu, Y.F., Haan, H.G. de, Delgado, G.E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S.A., Gayan, J., Giulianini, F., Gong, J.H., Gustafsson, S., Hai, Y., Hartwig, F.P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M.Y., Jensen, R.A., Kawaguchi, T., Kentistou, K.A., Kim, Y.J., Kleber, M.E., Kooner, I.K., Lai, S.Q., Lange, L.A., Langefeld, C.D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J.R., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M.E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L.J., Rich, S.S., Robertson, N.R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K.E., Sennblad, B., Setoh, K., Smith, A.V., Sparso, T., Strawbridge, R.J., Takeuchi, F., Tan, J.Y., Trompet, S., Akker, E. van den, Most, P.J. van der, Verweij, N., Vogel, M., Wang, H.M., Wang, C.L., Wang, N., Warren, H.R., Wen, W.Q., Wilsgaard, T., Wong, A., Wood, A.R., Xie, T., Zafarmand, M.H., Zhao, J.H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, S.J.L., Baldassarre, D., Beekman, M., Bergman, R.N., Bertoni, A., Bluher, M., Bonnycastle, L.L., Bornstein, S.R., Bowden, D.W., Cai, Q.Y., Campbell, A., Campbell, H., Chang, Y.C., Geus, E.J.C. de, Dehghan, A., S.F. du, Eiriksdottir, G., Farmaki, A.E., Franberg, M., Fuchsberger, C., Gao, Y.T., Gjesing, A.P., Goel, A., Han, S., Hartman, C.A., Herder, C., Hicks, A.A., Hsieh, C.H., Hsueh, W.A., Ichihara, S., Igase, M., Ikram, M.A., Johnson, W.C., Jorgensen, M.E., Joshi, P.K., Kalyani, R.R., Kandeel, F.R., Katsuya, T., Khor, C.C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Lall, K., Lam, K., Lawlor, D.A., Lee, N.R., Lemaitre, R.N., Li, H.L., Lin, S.Y., Lindstrom, J., Linneberg, A., Liu, J.J., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, G., Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G.N., Nadler, J.L., Nelis, M., Neville, M.J., Norris, J.M., Ohyagi, Y., Peters, A., Peyser, P.A., Polasek, O., Qi, Q.B., Raven, D., Reilly, D.F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schurmann, A., Shi, J.X., Stringham, H.M., Taylor, K.D., Teslovich, T.M., Thuesen, B., Timmers, P.R.H.J., Tremoli, E., Tsai, M.Y., Uitterlinden, A., Dam, R.M. van, Heemst, D. van, Vlieg, A.V., Vliet-Ostaptchouk, J.V. van, Vangipurapu, J., Vestergaard, H., Wang, T., Dijk, K.W. van, Zemunik, T., Abecasis, G.R., Adair, L.S., Aguilar-Salinas, C.A., Alarcon-Riquelme, M.E., An, P., Aviles-Santa, L., Becker, D.M., Beilin, L.J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Bohm, B.O., Bonnelykke, K., Boomsma, D.I., Bottinger, E.P., Buchanan, T.A., Canouil, M., Caulfield, M.J., Chambers, J.C., Chasman, D.I., Chen, Y.D.I., Cheng, C.Y., Collins, F.S., Correa, A., Cucca, F., Silva, H.J. de, Dedoussis, G., Elmstahl, S., Evans, M.K., Ferrannini, E., Ferrucci, L., Florez, J.C., Franks, P.W., Frayling, T.M., Froguel, P., Gigante, B., Goodarzi, M.O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X.Q., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S.R., Horta, B.L., Huang, W., Ingelsson, E., James, P.S., Jarvelin, M.R., Jonas, J.B., Jukema, J.W., Kaleebu, P., Ka

المصدر: Nature Genetics

الوصف: Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets. ; Diabetes mellitus: pathophysiological changes and therapy

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/ws/files/59072891/Trans_ancestry_MAGIC_1000G_Main_Text_Feb2021v3_Final_AAM.pdfTest; lumc-id: 116436823; https://hdl.handle.net/1887/3204099Test

الإتاحة: https://doi.org/10.1038/s41588-021-00852-9Test
https://hdl.handle.net/1887/3204099Test
https://discovery.dundee.ac.uk/ws/files/59072891/Trans_ancestry_MAGIC_1000G_Main_Text_Feb2021v3_Final_AAM.pdfTest

المؤلفون: Chen, J., Spracklen, C.N., Marenne, G., Varshney, A., Corbin, L.J., Luan, J., Willems, S.M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T.S., Mägi, R., Waage, J., Li-Gao, R., Chan, KHK, Yao, J., Anasanti, M.D., Chu, A.Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J.J., Huo, S., Kaakinen, M.A., Louie, T., März, W., Moreno-Macias, H., Ndungu, A., Nelson, S.C., Nolte, I.M., North, K.E., Raulerson, C.K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I.D., Wang, C.A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T.S., Appel, EVR, Bielak, L.F., Brody, J.A., Burtt, N.P., Cabrera, C.P., Cade, B.E., Chai, J.F., Chai, X., Chang, L.C., Chen, C.H., Chen, B.H., Chitrala, K.N., Chiu, Y.F., de Haan, H.G., Delgado, G.E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S.A., Gayán, J., Giulianini, F., Gong, J.H., Gustafsson, S., Hai, Y., Hartwig, F.P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M.Y., Jensen, R.A., Kawaguchi, T., Kentistou, K.A., Kim, Y.J., Kleber, M.E., Kooner, I.K., Lai, S., Lange, L.A., Langefeld, C.D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M.E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L.J., Rich, S.S., Robertson, N.R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K.E., Sennblad, B., Setoh, K., Smith, A.V., Sparsø, T., Strawbridge, R.J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P.J., Verweij, N., Vogel, M., Wang, H., Wang, C., Wang, N., Warren, H.R., Wen, W., Wilsgaard, T., Wong, A., Wood, A.R., Xie, T., Zafarmand, M.H., Zhao, J.H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, SJL, Baldassarre, D., Beekman, M., Bergman, R.N., Bertoni, A., Blüher, M., Bonnycastle, L.L., Bornstein, S.R., Bowden, D.W., Cai, Q., Campbell, A., Campbell, H., Chang, Y.C., de Geus, EJC, Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A.E., Frånberg, M., Fuchsberger, C., Gao, Y., Gjesing, A.P., Goel, A., Han, S., Hartman, C.A., Herder, C., Hicks, A.A., Hsieh, C.H., Hsueh, W.A., Ichihara, S., Igase, M., Ikram, M.A., Johnson, W.C., Jørgensen, M.E., Joshi, P.K., Kalyani, R.R., Kandeel, F.R., Katsuya, T., Khor, C.C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Läll, K., Lam, K., Lawlor, D.A., Lee, N.R., Lemaitre, R.N., Li, H., Lin, S.Y., Lindström, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, G., Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G.N., Nadler, J.L., Nelis, M., Neville, M.J., Norris, J.M., Ohyagi, Y., Peters, A., Peyser, P.A., Polasek, O., Qi, Q., Raven, D., Reilly, D.F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schürmann, A., Shi, J., Stringham, H.M., Taylor, K.D., Teslovich, T.M., Thuesen, B., Timmers, PRHJ, Tremoli, E., Tsai, M.Y., Uitterlinden, A., van Dam, R.M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J.V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G.R., Adair, L.S., Aguilar-Salinas, C.A., Alarcón-Riquelme, M.E., An, P., Aviles-Santa, L., Becker, D.M., Beilin, L.J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Böhm, B.O., Bønnelykke, K., Boomsma, D.I., Bottinger, E.P., Buchanan, T.A., Canouil, M., Caulfield, M.J., Chambers, J.C., Chasman, D.I., Chen, Y.I., Cheng, C.Y., Collins, F.S., Correa, A., Cucca, F., de Silva, H.J., Dedoussis, G., Elmståhl, S., Evans, M.K., Ferrannini, E., Ferrucci, L., Florez, J.C., Franks, P.W., Frayling, T.M., Froguel, P., Gigante, B., Goodarzi, M.O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S.R., Horta, B.L., Huang, W., Ingelsson, E., James, P.S., Jarvelin, M.R., Jonas, J.B., Jukema, J.W., Kaleebu, P., Kaplan, R., Kardia, SLR, Kato, N., Keinanen-Kiukaanniemi, S.M., Kim, B.J., Kivimaki, M., Koistinen, H.A., Kooner, J.S., Körner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T.A., Launer, L.J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, RJF, Magnusson, PKE, Mahajan, A., Metspalu, A., Mook-Kanamori, D.O., Mori, T.A., Munroe, P.B., Njølstad, I., O'Connell, J.R., Oldehinkel, A.J., Ong, K.K., Padmanabhan, S., Palmer, CNA, Palmer, N.D., Pedersen, O., Pennell, C.E., Porteous, D.J., Pramstaller, P.P., Province, M.A., Psaty, B.M., Qi, L., Raffel, L.J., Rauramaa, R., Redline, S., Ridker, P.M., Rosendaal, F.R., Saaristo, T.E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L.J., Selvin, E., Sever, P., Shu, X.O., Slagboom, P.E., Small, K.S., Smith, B.H., Snieder, H., Sofer, T., Sørensen, TIA, Spector, T.D., Stanton, A., Steves, C.J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E.S., Timpson, N.J., Tönjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, TGM, Wagenknecht, L.E., Walker, M., Wang, Y.X., Wareham, N.J., Watanabe, R.M., Watkins, H., Wei, W.B., Wickremasinghe, A.R., Willemsen, G., Wilson, J.F., Wong, T.Y., Wu, J.Y., Xiang, A.H., Yanek, L.R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A.B., Rotter, J.I., Gloyn, A.L., McCarthy, M.I., Dupuis, J., Meigs, J.B., Scott, R.A., Prokopenko, I., Leong, A., Liu, C.T., Parker, SCJ, Mohlke, K.L., Langenberg, C., Wheeler, E., Morris, A.P., Barroso, I.

المساهمون: Lifelines Cohort Study, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), de Haan, H.G., van den Akker, E., van der Most, P.J., de Geus, EJC, van Dam, R.M., van Heemst, D., van Hylckama Vlieg, A., van Willems van Dijk, K., de Silva, H.J., van der Harst, P., van Duijn, C.

المصدر: Nature genetics, vol. 53, no. 6, pp. 840-860

مصطلحات موضوعية: Alleles, Blood Glucose/genetics, Epigenesis, Genetic, European Continental Ancestry Group/genetics, Gene Expression Profiling, Genome, Human, Genome-Wide Association Study, Glycated Hemoglobin A/metabolism, Humans, Multifactorial Inheritance/genetics, Physical Chromosome Mapping, Quantitative Trait Loci/genetics, Quantitative Trait, Heritable, envir, psy

الوصف: Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10 -8 ), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

العلاقة: https://serval.unil.ch/resource/serval:BIB_53C688CA509F.P001/REF.pdfTest; https://serval.unil.ch/notice/serval:BIB_53C688CA509FTest

الإتاحة: https://serval.unil.ch/resource/serval:BIB_53C688CA509F.P001/REF.pdfTest
https://serval.unil.ch/notice/serval:BIB_53C688CA509FTest

المؤلفون: Chen, J., Spracklen, C.N., Marenne, G., Varshney, A., Corbin, L.J., Luan, J., Willems, S.M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T.S., Mägi, R., Waage, J., Li-Gao, R., Chan, KHK, Yao, J., Anasanti, M.D., Chu, A.Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J.J., Huo, S., Kaakinen, M.A., Louie, T., März, W., Moreno-Macias, H., Ndungu, A., Nelson, S.C., Nolte, I.M., North, K.E., Raulerson, C.K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I.D., Wang, C.A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T.S., Appel, EVR, Bielak, L.F., Brody, J.A., Burtt, N.P., Cabrera, C.P., Cade, B.E., Chai, J.F., Chai, X., Chang, L.C., Chen, C.H., Chen, B.H., Chitrala, K.N., Chiu, Y.F., de Haan, H.G., Delgado, G.E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S.A., Gayán, J., Giulianini, F., Gong, J.H., Gustafsson, S., Hai, Y., Hartwig, F.P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M.Y., Jensen, R.A., Kawaguchi, T., Kentistou, K.A., Kim, Y.J., Kleber, M.E., Kooner, I.K., Lai, S., Lange, L.A., Langefeld, C.D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M.E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L.J., Rich, S.S., Robertson, N.R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K.E., Sennblad, B., Setoh, K., Smith, A.V., Sparsø, T., Strawbridge, R.J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P.J., Verweij, N., Vogel, M., Wang, H., Wang, C., Wang, N., Warren, H.R., Wen, W., Wilsgaard, T., Wong, A., Wood, A.R., Xie, T., Zafarmand, M.H., Zhao, J.H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, SJL, Baldassarre, D., Beekman, M., Bergman, R.N., Bertoni, A., Blüher, M., Bonnycastle, L.L., Bornstein, S.R., Bowden, D.W., Cai, Q., Campbell, A., Campbell, H., Chang, Y.C., de Geus, EJC, Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A.E., Frånberg, M., Fuchsberger, C., Gao, Y., Gjesing, A.P., Goel, A., Han, S., Hartman, C.A., Herder, C., Hicks, A.A., Hsieh, C.H., Hsueh, W.A., Ichihara, S., Igase, M., Ikram, M.A., Johnson, W.C., Jørgensen, M.E., Joshi, P.K., Kalyani, R.R., Kandeel, F.R., Katsuya, T., Khor, C.C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Läll, K., Lam, K., Lawlor, D.A., Lee, N.R., Lemaitre, R.N., Li, H., Lin, S.Y., Lindström, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, G., Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G.N., Nadler, J.L., Nelis, M., Neville, M.J., Norris, J.M., Ohyagi, Y., Peters, A., Peyser, P.A., Polasek, O., Qi, Q., Raven, D., Reilly, D.F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schürmann, A., Shi, J., Stringham, H.M., Taylor, K.D., Teslovich, T.M., Thuesen, B., Timmers, PRHJ, Tremoli, E., Tsai, M.Y., Uitterlinden, A., van Dam, R.M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J.V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G.R., Adair, L.S., Aguilar-Salinas, C.A., Alarcón-Riquelme, M.E., An, P., Aviles-Santa, L., Becker, D.M., Beilin, L.J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Böhm, B.O., Bønnelykke, K., Boomsma, D.I., Bottinger, E.P., Buchanan, T.A., Canouil, M., Caulfield, M.J., Chambers, J.C., Chasman, D.I., Chen, Y.I., Cheng, C.Y., Collins, F.S., Correa, A., Cucca, F., de Silva, H.J., Dedoussis, G., Elmståhl, S., Evans, M.K., Ferrannini, E., Ferrucci, L., Florez, J.C., Franks, P.W., Frayling, T.M., Froguel, P., Gigante, B., Goodarzi, M.O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S.R., Horta, B.L., Huang, W., Ingelsson, E., James, P.S., Jarvelin, M.R., Jonas, J.B., Jukema, J.W., Kaleebu, P., Kaplan, R., Kardia, SLR, Kato, N., Keinanen-Kiukaanniemi, S.M., Kim, B.J., Kivimaki, M., Koistinen, H.A., Kooner, J.S., Körner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T.A., Launer, L.J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, RJF, Magnusson, PKE, Mahajan, A., Metspalu, A., Mook-Kanamori, D.O., Mori, T.A., Munroe, P.B., Njølstad, I., O'Connell, J.R., Oldehinkel, A.J., Ong, K.K., Padmanabhan, S., Palmer, CNA, Palmer, N.D., Pedersen, O., Pennell, C.E., Porteous, D.J., Pramstaller, P.P., Province, M.A., Psaty, B.M., Qi, L., Raffel, L.J., Rauramaa, R., Redline, S., Ridker, P.M., Rosendaal, F.R., Saaristo, T.E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L.J., Selvin, E., Sever, P., Shu, X.O., Slagboom, P.E., Small, K.S., Smith, B.H., Snieder, H., Sofer, T., Sørensen, TIA, Spector, T.D., Stanton, A., Steves, C.J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E.S., Timpson, N.J., Tönjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, TGM, Wagenknecht, L.E., Walker, M., Wang, Y.X., Wareham, N.J., Watanabe, R.M., Watkins, H., Wei, W.B., Wickremasinghe, A.R., Willemsen, G., Wilson, J.F., Wong, T.Y., Wu, J.Y., Xiang, A.H., Yanek, L.R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A.B., Rotter, J.I., Gloyn, A.L., McCarthy, M.I., Dupuis, J., Meigs, J.B., Scott, R.A., Prokopenko, I., Leong, A., Liu, C.T., Parker, SCJ, Mohlke, K.L., Langenberg, C., Wheeler, E., Morris, A.P., Barroso, I.

المساهمون: Lifelines Cohort Study, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), de Haan, H.G., van den Akker, E., van der Most, P.J., de Geus, EJC, van Dam, R.M., van Heemst, D., van Hylckama Vlieg, A., van Willems van Dijk, K., de Silva, H.J., van der Harst, P., van Duijn, C.

المصدر: Serveur académique Lausannois ; Nature genetics, vol. 53, no. 6, pp. 840-860

مصطلحات موضوعية: envir, psy

الوصف: Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P -8 ), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

العلاقة: urn:issn:1061-4036; 10670/1.3knu5o; https://serval.unil.ch/resource/serval:BIB_53C688CA509F.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_53C688CA509F9Test

الإتاحة: https://doi.org/10.1038/s41588-021-00852-9Test
https://serval.unil.ch/resource/serval:BIB_53C688CA509F.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_53C688CA509F9Test