المؤلفون: Amankwah, Ernest K., Taylor, Bradley

المصدر: Journal of Clinical and Translational Science ; volume 8, issue s1, page 24-25 ; ISSN 2059-8661

الوصف: OBJECTIVES/GOALS: To describe an Honest Broker (HB) tool and workflow integrated with the Institutional Review Board (IRB) to automate requests, approvals and delivery of both de-identified and identified data extractions from a clinical research data warehouse (CRDW). METHODS/STUDY POPULATION: The HB tool has predefined domain tables and is closely integrated IRB for quick and easy review and approval. Investigators can access patient data using query tools, barcodes from biospecimens or build a query in TriNetX and provide the patient list as an input for the HB tool. For de-identified data extraction, the required data domain tables and date ranges can be selected and submitted in the HB tool. For identified data extractions, investigators with an approved IRB protocol can enter the protocol number and the approved date range in the HB tool. This request is automatically forwarded to the IRB for review. RESULTS/ANTICIPATED RESULTS: For de-identified data extraction, an email alert is automatically sent to the investigator once the data extract is completed. For identified data extraction, if IRB approves the request, an HB is immediately notified to release the data. Data release triggers two emails to the investigator: (1) a link to an encrypted zipped file with the requested data, and (2) a password to unlock the encrypted file. If the request is denied, the IRB sends an email to the investigator with the reason for denial and options for remediation. The entire HB workflow is accomplished in a secure environment with an audit trail from the initial data request to data download by the investigator. Since the launch of the HB tool, the time from data request to delivery is approximately an hour for deidentified data and 24 hrs for identified data. DISCUSSION/SIGNIFICANCE: The HB tool has increased successful data delivery in support of publications, grant submissions, and clinical trial recruitment. Optimization of data extraction from the CRDW through automation and integration with the IRB can minimize ...

الإتاحة: https://doi.org/10.1017/cts.2024.90Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S2059866124000906Test

المؤلفون: Adabor, Opoku, Mintah, Kwabena, Amankwah, Ernest

المصدر: Social Science Quarterly ; volume 104, issue 4, page 742-760 ; ISSN 0038-4941 1540-6237

الوصف: Background Ghana has witnessed rapid urban population growth over the past decades, which has led to vast environmental, settlement, human, and ecological issues. It is therefore extremely important to examine the factors that influence urban population growth in Ghana to provide policy directions for policymakers. Objectives The article examines the impact of financial inclusion on urban population growth using three different measures of financial inclusion. Methods We applied the autoregressive distributed lag model (ARDL) to historical time‐series data covering the period of 1960 to 2020. Results The estimates from the ARDL model show that financial inclusion exerts a positive effect on urban population growth. Specifically, the findings confirm that financial knowledge, usage, and availability of financial services contribute significantly to urban population growth over time. Conclusion The findings in this study suggest that government and financial institutions should utilize various channels to increase financial knowledge, usage and availability of financial services among individuals living in deprived areas where there are a limited number of financial institutions.

الإتاحة: https://doi.org/10.1111/ssqu.13267Test

المؤلفون: Chellapandian, Deepak, Vaughn, Gretchen, Duff, Carla, Ribickas, Albert, Mosha, Maua, Amankwah, Ernest, Walter, Jolan, Leiding, Jennifer W., Oshrine, Benjamin

المصدر: Transplantation and Cellular Therapy ; volume 29, issue 2, page S300 ; ISSN 2666-6367

مصطلحات موضوعية: Transplantation, Cell Biology, Hematology, Molecular Medicine, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/s2666-6367Test(23)00465-7
https://api.elsevier.com/content/article/PII:S2666636723004657?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666636723004657?httpAccept=text/plainTest

المؤلفون: McNerney, Kevin O., Lim, Stephanie Si, Miller, Alexandra, Amankwah, Ernest, Dreyzin, Alexandra, Vatsayan, Anant, Hermiston, Michelle, Baggott, Christina, Prabhu, Snehit, Pacenta, Holly L, Phillips, Christine L, Fabrizio, Vanessa A, Rossoff, Jenna, Bonifant, Challice, Stefanski, Heather E., Talano, Julie, Moskop, Amy, Verneris, Michael R., Myers, Doug, Karras, Nicole, Qayed, Muna, Satwani, Prakash, Krupski, M. Christa, Keating, Amy K., Baumeister, Susanne H.C., Chinnabhandar, Vasant, Egeler, Emily, Mavroukakis, Sharon, Curran, Kevin J., Mackall, Crystal, Laetsch, Theodore W, Schultz, Liora Michal

المصدر: Transplantation and Cellular Therapy ; volume 29, issue 2, page S202-S203 ; ISSN 2666-6367

مصطلحات موضوعية: Transplantation, Cell Biology, Hematology, Molecular Medicine, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/s2666-6367Test(23)00331-7
https://api.elsevier.com/content/article/PII:S2666636723003317?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666636723003317?httpAccept=text/plainTest

المؤلفون: Jaffray, Julie, Mosha, Maua, Branchford, Brian, Goldenberg, Neil A., Silvey, Michael, Croteau, Stacy E., Fargo, John H., Cooper, James D., Bakeer, Nihal, Stillings, Amy, Krava, Emily, Young, Guy, Amankwah, Ernest K.

المساهمون: National Center for Advancing Translational Sciences, National Institutes of Health, Children's Hospital of Philadelphia, Children's Hospital Los Angeles, Takeda Pharmaceuticals U.S.A., Takeda Pharmaceutical Company, National Heart, Lung, and Blood Institute, Hemostasis and Thrombosis Research Society, Children's Hospital Los Angeles Saban Research Institute

المصدر: Journal of Thrombosis and Haemostasis ; volume 21, issue 9, page 2441-2450 ; ISSN 1538-7836

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1016/j.jtha.2023.03.045Test
https://api.elsevier.com/content/article/PII:S1538783623003367?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1538783623003367?httpAccept=text/plainTest

المؤلفون: Whitworth, Hilary, Amankwah, Ernest K., Betensky, Marisol, Castellucci, Lana A., Cuker, Adam, Goldenberg, Neil A., Male, Christoph, Rinzler, Elliot, Zia, Ayesha, Raffini, Leslie

المصدر: Journal of Thrombosis and Haemostasis ; volume 21, issue 6, page 1666-1673 ; ISSN 1538-7836

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1016/j.jtha.2023.03.004Test
https://api.elsevier.com/content/article/PII:S1538783623002301?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1538783623002301?httpAccept=text/plainTest

المؤلفون: Patel, Krupesh, Moshe, Maua, Amankwah, Ernest, Holloway, Leah, Stapleton, Stacie

المصدر: Neuro-Oncology ; volume 25, issue Supplement_1, page i48-i48 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الوصف: To this point there is no standard imaging schedule across all institutions in the surveillance of pediatric low-grade gliomas (pLGG) and pediatric high-grade gliomas (pHGG) after therapy completion. We at our institution use the Children’s Oncology Group (COG) protocols ACNS1831/ACNS1833 to guide our surveillance of pLGG. The MRI schedule is every 3 months for year 1 (after therapy), every 6 months for years 2 and 3, and annually for years 4 and 5. For pHGG we do MRI imaging every 3 months for year 1, every 4 months for year 2, every 6 months for years 3-5, and annually for years 6-10. It is uncertain if this imaging schedule is optimal in terms of tracking tumor evolution post-treatment. pLGG are a diverse group of tumors but generally tend have a slower progression rate when compared to pHGG. Studies have shown a 5-year progression-free survival (PFS) of 45% to 65% for residual tumor of any size for pLGG. 3-year PFS for pHGG at best is 18%. When possible, spacing imaging, decreasing sedations, and decreasing gadolinium-based contrast agents that can deposit in the body are key drivers in imaging schedules. Through retrospective analysis we are establishing if imaging schedules should be adjusted based on disease progression or recurrence.

الإتاحة: https://doi.org/10.1093/neuonc/noad073.186Test
https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_1/i48/50575132/noad073.186.pdfTest

المؤلفون: Alvis, Courtney E., Mosha, Maua, Amankwah, Ernest K., Hernandez, Raquel G., Morrison, John M.

المصدر: Clinical Pediatrics; Jun2024, Vol. 63 Issue 5, p650-658, 9p

مصطلحات موضوعية: CROSS-sectional method, HEALTH services accessibility, HEALTH attitudes, SOCIAL determinants of health, RESEARCH funding, FOOD security, CHILDREN'S hospitals, ATTITUDES of medical personnel, MEDICAL screening, SHAME, CAREGIVER attitudes, PATIENTS' attitudes, DISCLOSURE

مستخلص: Food insecurity is a public health concern associated with poor health. Evidence guiding how to best implement screening for food insecurity across a pediatric health care system is lacking. We performed a single-center, multi-department, cross-sectional study of caregivers and health care providers in outpatient and inpatient settings to describe the beliefs, barriers, preferences, and preferred food insecurity screening location. Most providers and caregivers underestimated the pervasiveness of food insecurity while acknowledging the benefit of screening. Caregivers are overall receptive to food insecurity screening and disagree with feelings of discomfort or shame when disclosing food insecurity status. Providers acknowledged perceived caregiver discomfort, lack of community food resources, and lack of a validated screening tool as barriers to screening. Both caregivers and providers identified the primary care setting as the preferred screening setting. [ABSTRACT FROM AUTHOR]

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المؤلفون: Sochet, Anthony A., Jaffray, Julie, Branchford, Brian R., Havlicek, Elizabeth E., Mosha, Maua, Amankwah, Ernest K., Ignjatovic, Vera, Faustino, E. Vincent S., Goldenberg, Neil A.

المصدر: Pediatric Critical Care Medicine; Feb2024, Vol. 25 Issue 2, pe82-e90, 9p

المؤلفون: Stephens, Elizabeth T., Nguyen, Anh Thy H., Jaffray, Julie, Branchford, Brian, Amankwah, Ernest K., Goldenberg, Neil A., Faustino, E. Vincent S., Zakai, Neil A., Stillings, Amy, Krava, Emily, Young, Guy, Fargo, John H.

المساهمون: National Center for Advancing Translational Sciences

المصدر: Research and Practice in Thrombosis and Haemostasis ; volume 6, issue 7, page e12810 ; ISSN 2475-0379

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1002/rth2.12810Test
https://api.elsevier.com/content/article/PII:S2475037922024487?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2475037922024487?httpAccept=text/plainTest