يعرض 1 - 10 نتائج من 66 نتيجة بحث عن '"Alicia A. Tone"', وقت الاستعلام: 0.65s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

    المؤلفون: Delores J. Grant, Ani Manichaikul, Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz‐Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Patricia G. Moorman, Lauren C. Peres, Edward S. Peters, Ann G. Schwartz, Paul D. Terry, Xin‐Qun Wang, Temitope O. Keku, Cathrine Hoyo, Andrew Berchuck, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Digna R. Velez Edwards, Todd L. Edwards, Alicia Beeghly‐Fadiel, Nicolas Wentzensen, Celeste Leigh Pearce, Anna H. Wu, Alice S. Whittemore, Valerie McGuire, Weiva Sieh, Joseph H. Rothstein, Francesmary Modugno, Roberta Ness, Kirsten Moysich, Mary Anne Rossing, Jennifer A. Doherty, Thomas A. Sellers, Jennifer B. Permuth‐Way, Alvaro N. Monteiro, Douglas A. Levine, Veronica Wendy Setiawan, Christopher A. Haiman, Loic LeMarchand, Lynne R. Wilkens, Beth Y. Karlan, Usha Menon, Susan Ramus, Simon Gayther, Aleksandra Gentry‐Maharaj, Kathryn L. Terry, Daniel W. Cramer, Ellen L. Goode, Melissa C. Larson, Scott H. Kaufmann, Rikki Cannioto, Kunle Odunsi, John L. Etter, Ruea‐Yea Huang, Marcus Q. Bernardini, Alicia A. Tone, Taymaa May, Marc T. Goodman, Pamela J. Thompson, Michael E. Carney, Shelley S. Tworoger, Elizabeth M. Poole, Diether Lambrechts, Ignace Vergote, Adriaan Vanderstichele, Els Van Nieuwenhuysen, Hoda Anton‐Culver, Argyrios Ziogas, James D. Brenton, Line Bjorge, Helga B. Salvensen, Lambertus A. Kiemeney, Leon F. A. G. Massuger, Tanja Pejovic, Amanda Bruegl, Melissa Moffitt, Linda Cook, Nhu D. Le, Angela Brooks‐Wilson, Linda E. Kelemen, Paul D.P. Pharoah, Honglin Song, Ian Campbell, Diana Eccles, Anna DeFazio, Catherine J. Kennedy, Joellen M. Schildkraut

    المصدر: Cancer Medicine, Vol 8, Iss 5, Pp 2503-2513 (2019)

    مصطلحات موضوعية: African ancestry risk, genetic association, ovarian cancer, vitamin D pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    الوصف: Abstract An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom‐designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high‐grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2‐1.7, P = 1.2 × 10−6, BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6‐3.4, P = 1.6 × 10−5, BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2‐1.7, P = 2.3 × 10−5, BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC.

    وصف الملف: electronic resource

    العلاقة: https://doaj.org/toc/2045-7634Test

    الوصول الحر: https://doaj.org/article/e1138d0ca72749ca892bbfadf3342940Test

    View record in DOAJ النص الكامل

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  2. 2
    Supplementary Table 1 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 156K, NFκB-regulated and inflammation-related genes used for gene expression analysis.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0956430ab8f31d939fd51522f2ef999bTest
    https://doi.org/10.1158/1078-0432.22445901.v1Test


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  3. 3
    Supplementary Figure 1 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 1402K, Differential expression of RelA and DAB2 proteins in secretory FTE cells.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6034ba3dc2a3ff0b68ab752e1e89cd19Test
    https://doi.org/10.1158/1078-0432.22445913.v1Test


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  4. 4
    Supplementary Data from Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

    المؤلفون: Patricia A. Shaw, Theodore J. Brown, Barry Rosen, Joan Murphy, Monika Sharma, Heather Begley, Alicia A. Tone

    الوصف: Supplementary Data from Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc30f7aa8b13ff926b6e31a93e0a452Test
    https://doi.org/10.1158/1078-0432.22439424Test


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  5. 5
    Supplementary Figure Legend from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 98K.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e6f131b167f316dd9305cc5dbe069Test
    https://doi.org/10.1158/1078-0432.22445904.v1Test


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  6. 6
    Data from Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

    المؤلفون: Patricia A. Shaw, Theodore J. Brown, Barry Rosen, Joan Murphy, Monika Sharma, Heather Begley, Alicia A. Tone

    الوصف: Purpose: To identify molecular alterations potentially involved in predisposition to adnexal serous carcinoma (SerCa) in the nonmalignant fallopian tube epithelium (FTE) of BRCA1/2 mutation carriers, given recent evidence implicating the distal FTE as a common source for SerCa.Experimental Design: We obtained and compared gene expression profiles of laser capture microdissected nonmalignant distal FTE from 12 known BRCA1/2 mutation carriers (FTEb) and 12 control women (FTEn) during the luteal and follicular phase, as well as 13 high-grade tubal and ovarian SerCa.Results: Gene expression profiles of tubal and ovarian SerCa specimens were indistinguishable by unsupervised cluster analysis and significance analysis of microarrays. FTEb samples as a group, and four individual FTEb samples from the luteal phase in particular, clustered closely with SerCa rather than normal control FTE. Differentially expressed genes from these four samples relative to other FTEb samples, as well as differentially expressed genes in all FTEb luteal samples relative to follicular samples, were mapped to the I2D protein-protein interaction database, revealing a complex network affecting signaling pathways previously implicated in tumorigenesis. Two candidates, disabled homolog 2 mitogen-responsive phosphoprotein (DAB2) and Ski-like (SKIL), were further validated by real-time reverse transcription–PCR and tissue arrays. FTEb luteal and SerCa samples expressed higher levels of oncogenic SKIL and decreased levels of tumor suppressor DAB2, relative to FTEb follicular samples.Conclusions: These findings support a common molecular pathway for adnexal SerCa and implicate factors associated with the luteal phase in predisposition to ovarian cancer in BRCA mutation carriers.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bb7319a2cee69a5c41bb6e5b4cd230Test
    https://doi.org/10.1158/1078-0432.c.6516894.v1Test


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  7. 7
    Supplementary Figure 3 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 27K, DAB2 and BRCA1 enhance dexamethasone-induced GR transactivation activity in pancreatic and breast cancer cell lines.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d707caf27afe7e7e9a3ec54dc3dbcd1Test
    https://doi.org/10.1158/1078-0432.22445907Test


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  8. 8
    Supplementary Figure 2 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 25K, Impact of DAB2 and BRCA1 on TNFα-induced BIRC3 expression.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134a9fbb4c2a2ff8d8adc3859e5e490cTest
    https://doi.org/10.1158/1078-0432.22445910Test


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  9. 9
    Supplementary Table 3 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 59K, NFκB-regulated and inflammation-related genes differentially expressed in FTEb(S) samples (n=4) relative to remaining luteal phase FTE samples (n=8).

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79da0dfac486d36a5b0be180a3724c19Test
    https://doi.org/10.1158/1078-0432.22445895Test


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  10. 10
    Supplementary Table 2 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis

    المؤلفون: Theodore J. Brown, Patricia Shaw, Carl Virtanen, Alicia A. Tone

    الوصف: PDF file, 43K, NFκB-regulated and inflammation-related genes differentially expressed in FTEb(S) samples (n=4) relative to remaining FTE samples (n=20).

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b092a9ce6f12a55d7f16c9784223e1eTest
    https://doi.org/10.1158/1078-0432.22445898Test


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