المؤلفون: Ferreira, M. L., De Luca, K., Haile, L. M., Steinmetz, J. D., Culbreth, G. T., Cross, M., Kopec, J. A., Ferreira, P. H., Blyth, F. M., Buchbinder, R., Hartvigsen, J., Wu, A. -M., Safiri, S., Woolf, A. D., Collins, G. S., Ong, K. L., Vollset, S. E., Smith, A. E., Cruz, J. A., Fukutaki, K. G., Abate, S. M., Abbasifard, M., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abdelalim, A., Abedi, A., Abidi, H., Adnani, Q. E. S., Ahmadi, A., Akinyemi, R. O., Alamer, A. T., Alem, A. Z., Alimohamadi, Y., Alshehri, M. A., Alshehri, M. M., Alzahrani, H., Amini, S., Amiri, S., Amu, H., Andrei, C. L., Andrei, T., Antony, B., Arabloo, J., Arulappan, J., Arumugam, A., Ashraf, T., Athari, S. S., Awoke, N., Azadnajafabad, S., Renzaho, Andre M. N. (R17978)

مصطلحات موضوعية: XXXXXX - Unknown

الوصف: Background: Low back pain is highly prevalent and the main cause of years lived with disability (YLDs). We present the most up-to-date global, regional, and national data on prevalence and YLDs for low back pain from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Methods: Population-based studies from 1980 to 2019 identified in a systematic review, international surveys, US medical claims data, and dataset contributions by collaborators were used to estimate the prevalence and YLDs for low back pain from 1990 to 2020, for 204 countries and territories. Low back pain was defined as pain between the 12th ribs and the gluteal folds that lasted a day or more; input data using alternative definitions were adjusted in a network meta-regression analysis. Nested Bayesian meta-regression models were used to estimate prevalence and YLDs by age, sex, year, and location. Prevalence was projected to 2050 by running a regression on prevalence rates using Socio-demographic Index as a predictor, then multiplying them by projected population estimates. Findings: In 2020, low back pain affected 619 million (95% uncertainty interval 554–694) people globally, with a projection of 843 million (759–933) prevalent cases by 2050. In 2020, the global age-standardised rate of YLDs was 832 per 100 000 (578–1070). Between 1990 and 2020, age-standardised rates of prevalence and YLDs decreased by 10·4% (10·9–10·0) and 10·5% (11·1–10·0), respectively. A total of 38·8% (28·7–47·0) of YLDs were attributed to occupational factors, smoking, and high BMI. Interpretation: Low back pain remains the leading cause of YLDs globally, and in 2020, there were more than half a billion prevalent cases of low back pain worldwide. While age-standardised rates have decreased modestly over the past three decades, it is projected that globally in 2050, more than 800 million people will have low back pain. Challenges persist in obtaining primary country-level data on low back pain, and there is an urgent need for more high-quality, primary, ...

وصف الملف: print

العلاقة: The Lancet Rheumatology--2665-9913 Vol. 5 Issue. 6 pp: e316-e329

الإتاحة: https://doi.org/10.1016/S2665-9913Test(23)00098-X
https://hdl.handle.net/1959.7/uws:74305Test

المؤلفون: Alvarez E. M., Force L. M., Xu R., Compton K., Lu D., Henrikson H. J., Kocarnik J. M., Harvey J. D., Pennini A., Dean F. E., Fu W., Vargas M. T., Keegan T. H. M., Ariffin H., Barr R. D., Erdomaeva Y. A., Gunasekera D. S., John-Akinola Y. O., Ketterl T. G., Kutluk T., Malogolowkin M. H., Mathur P., Radhakrishnan V., Ries L. A. G., Rodriguez-Galindo C., Sagoyan G. B., Sultan I., Abbasi B., Abbasi-Kangevari M., Abbasi-Kangevari Z., Abbastabar H., Abdelmasseh M., Abd-Elsalam S., Abdoli A., Abebe H., Abedi A., Abidi H., Abolhassani H., Abubaker Ali H., Abu-Gharbieh E., Achappa B., Acuna J. M., Adedeji I. A., Adegboye O. A., Adnani Q. E. S., Advani S. M., Afzal M. S., Aghaie Meybodi M., Ahadinezhad B., Ahinkorah B. O., Ahmad S., Ahmadi S., Ahmed M. B., Ahmed Rashid T., Ahmed Salih Y., Aiman W., Akalu G. T., Al Hamad H., Alahdab F., AlAmodi A. A., Alanezi F. M., Alanzi T. M., Alem A. Z., Alem D. T., Alemayehu Y., Alhalaiqa F. N., Alhassan R. K., Ali S., Alicandro G., Alipour V., Aljunid S. M., Alkhayyat M., Alluri S., Almasri N. A., Al-Maweri S. A., Almustanyir S., Al-Raddadi R. M., Alvis-Guzman N., Ameyaw E. K., Amini S., Amu H., Ancuceanu R., Andrei C. L., Andrei T., Ansari F., Ansari-Moghaddam A., Anvari D., Anyasodor A. E., Arabloo J., Arab-Zozani M., Argaw A. M., Arshad M., Arulappan J., Aryannejad A., Asemi Z., Asghari Jafarabadi M., Atashzar M. R., Atorkey P., Atreya A., Attia S., Aujayeb A., Ausloos M., Avila-Burgos L., Awedew A. F., Ayala Quintanilla B. P., Ayele A. D., Ayen S. S., Azab M. A., Azadnajafabad S., Azami H., Azangou-Khyavy M., Azari Jafari A., Azarian G., Azzam A. Y., Bahadory S., Bai J., Baig A. A., Baker J. L., Banach M., Barnighausen T. W., Barone-Adesi F., Barra F., Barrow A., Basaleem H., Batiha A. -M. M., Behzadifar M., Bekele N. C., Belete R., Belgaumi U. I., Bell A. W., Berhie A. Y., Bhagat D. S., Bhagavathula A. S., Bhardwaj N., Bhardwaj P., Bhaskar S., Bhattacharyya K., Bhojaraja V. S., Bibi S., Bijani A., Biondi A., Birara S., Bjorge T., Bolarinwa O. A., Bolla S. R., Boloor A., Braithwaite D., Brenner H., Bulamu N. B., Burkart K., Bustamante-Teixeira M. T., Butt N. S., Butt Z. A., Caetano dos Santos F. L., Cao C., Cao Y., Carreras G., Catala-Lopez F., Cembranel F., Cerin E., Chakinala R. C., Chakraborty P. A., Chattu V. K., Chaturvedi P., Chaurasia A., Chavan P. P., Chimed-Ochir O., Choi J. -Y. J., Christopher D. J., Chu D. -T., Chung M. T., Conde J., Costa V. M., Da'ar O. B., Dadras O., Dahlawi S. M. A., Dai X., Damiani G., D'Amico E., Dandona L., Dandona R., Daneshpajouhnejad P., Darwish A. H., Daryani A., De la Hoz F. P., Debela S. A., Demie T. G. G., Demissie G. D., Demissie Z. G., Denova-Gutierrez E., Derbew Molla M., Desai R., Desta A. A., Dhamnetiya D., Dharmaratne S. D., Dhimal M. L., Dhimal M., Dianatinasab M., Didehdar M., Diress M., Djalalinia S., Do H. P., Doaei S., Dorostkar F., dos Santos W. M., Drake T. M., Ekholuenetale M., El Sayed I., El Sayed Zaki M., El Tantawi M., El-Abid H., Elbahnasawy M. A., Elbarazi I., Elhabashy H. R., Elhadi M., El-Jaafary S. I., Enyew D. B., Erkhembayar R., Eshrati B., Eskandarieh S., Faisaluddin M., Fares J., Farooque U., Fasanmi A. O., Fatima W., Ferreira de Oliveira J. M. P., Ferrero S., Ferro Desideri L., Fetensa G., Filip I., Fischer F., Fisher J. L., Foroutan M., Fukumoto T., Gaal P. A., Gad M. M., Gaewkhiew P., Gallus S., Garg T., Gebremeskel T. G., Gemeda B. N. B., Getachew T., Ghafourifard M., Ghamari S. -H., Ghashghaee A., Ghassemi F., Ghith N., Gholami A., Gholizadeh Navashenaq J., Gilani S. A., Ginindza T. G., Gizaw A. T., Glasbey J. C., Goel A., Golechha M., Goleij P., Golinelli D., Gopalani S. V., Gorini G., Goudarzi H., Goulart B. N. G., Grada A., Gubari M. I. M., Guerra M. R., Guha A., Gupta B., Gupta S., Gupta V. B., Gupta V. K., Haddadi R., Hafezi-Nejad N., Hailu A., Haj-Mirzaian A., Halwani R., Hamadeh R. R., Hambisa M. T., Hameed S., Hamidi S., Haque S., Hariri S., Haro J. M., Hasaballah A. I., Hasan S. M. M., Hashemi S. M., Hassan T. S., Hassanipour S., Hay S. I., Hayat K., Hebo S. H., Heidari G., Heidari M., Herrera-Serna B. Y., Herteliu C., Heyi D. Z., Hezam K., Hole M. K., Holla R., Horita N., Hossain M. M., Hossain M. B., Hosseini M. -S., Hosseini M., Hosseinzadeh A., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Hsairi M., Huang J., Hussein N. R., Hwang B. -F., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Innos K., Irham L. M., Islam R. M., Islam S. M. S., Ismail N. E., Isola G., Iwagami M., Jacob L., Jadidi-Niaragh F., Jain V., Jakovljevic M., Janghorban R., Javadi Mamaghani A., Jayaram S., Jayawardena R., Jazayeri S. B., Jebai R., Jha R. P., Joo T., Joseph N., Joukar F., Jurisson M., Kaambwa B., Kabir A., Kalankesh L. R., Kaliyadan F., Kamal Z., Kamath A., Kandel H., Kar S. S., Karaye I. M., Karimi A., Kassa B. G., Kauppila J. H., Kemp Bohan P. M., Kengne A. P., Kerbo A. A., Keykhaei M., Khader Y. S., Khajuria H., Khalili N., Khan E. A., Khan G., Khan M., Khan M. N., Khan M. A., Khanali J., Khayamzadeh M., Khosravizadeh O., Khubchandani J., Khundkar R., Kim M. S., Kim Y. J., Kisa A., Kisa S., Kissimova-Skarbek K., Kolahi A. -A., Kopec J. A., Koteeswaran R., Koulmane Laxminarayana S. L., Koyanagi A., Kugbey N., Kumar G. A., Kumar N., Kwarteng A., La Vecchia C., Lan Q., Landires I., Lasrado S., Lauriola P., Ledda C., Lee S. -W., Lee W. -C., Lee Y. Y., Lee Y. H., Leigh J., Leong E., Li B., Li J., Li M. -C., Lim S. S., Liu X., Lobo S. W., Loureiro J. A., Lugo A., Lunevicius R., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahmoudi M., Majeed A., Makki A., Male S., Malekpour M. -R., Malekzadeh R., Malik A. A., Mamun M. A., Manafi N., Mansour-Ghanaei F., Mansouri B., Mansournia M. A., Martini S., Masoumi S. Z., Matei C. N., Mathur M. R., McAlinden C., Mehrotra R., Mendoza W., Menezes R. G., Mentis A. -F. A., Meretoja T. J., Mersha A. G., Mesregah M. K., Mestrovic T., Miao Jonasson J., Miazgowski B., Michalek I. M., Miller T. R., Mingude A. B., Mirmoeeni S., Mirzaei H., Misra S., Mithra P., Mohammad K. A., Mohammadi M., Mohammadi S. M., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed A., Mohammed S., Mohammed T. A., Moka N., Mokdad A. H., Molokhia M., Momtazmanesh S., Monasta L., Moni M. A., Moradi G., Moradi Y., Moradzadeh M., Moradzadeh R., Moraga P., Morrison S. D., Mostafavi E., Mousavi Khaneghah A., Mpundu-Kaambwa C., Mubarik S., Mwanri L., Nabhan A. F., Nagaraju S. P., Nagata C., Naghavi M., Naimzada M. D., Naldi L., Nangia V., Naqvi A. A., Narasimha Swamy S., Narayana A. I., Nayak B. P., Nayak V. C., Nazari J., Nduaguba S. O., Negoi I., Negru S. M., Nejadghaderi S. A., Nepal S., Neupane Kandel S., Nggada H. A., Nguyen C. T., Nnaji C. A., Nosrati H., Nouraei H., Nowroozi A., Nunez-Samudio V., Nwatah V. E., Nzoputam C. I., Oancea B., Odukoya O. O., Oguntade A. S., Oh I. -H., Olagunju A. T., Olagunju T. O., Olakunde B. O., Oluwasanu M. M., Omar E., Omar Bali A., Ong S., Onwujekwe O. E., Ortega-Altamirano D. V., Otstavnov N., Otstavnov S. S., Oumer B., Owolabi M. O., P A M., Padron-Monedero A., Padubidri J. R., Pakshir K., Pana A., Pandey A., Pardhan S., Pashazadeh Kan F., Pasovic M., Patel J. R., Pati S., Pattanshetty S. M., Paudel U., Pereira R. B., Peres M. F. P., Perianayagam A., Postma M. J., Pourjafar H., Pourshams A., Prashant A., Pulakunta T., Qadir M. M. F. F., Rabiee M., Rabiee N., Radfar A., Radhakrishnan R. A., Rafiee A., Rafiei A., Rafiei S., Rahim F., Rahimzadeh S., Rahman M., Rahman M. A., Rahmani A. M., Rajesh A., Ramezani-Doroh V., Ranabhat K., Ranasinghe P., Rao C. R., Rao S. J., Rashedi S., Rashidi M., Rashidi M. -M., Rath G. K., Rawaf D. L., Rawaf S., Rawal L., Rawassizadeh R., Razeghinia M. S., Regasa M. T., Renzaho A. M. N., Rezaei M., Rezaei N., Rezaeian M., Rezapour A., Rezazadeh-Khadem S., Riad A., Rios Lopez L. E., Rodriguez J. A. B., Ronfani L., Roshandel G., Rwegerera G. M., Saber-Ayad M. M., Sabour S., Saddik B., Sadeghi E., Sadeghian S., Saeed U., Sahebkar A., Saif-Ur-Rahman K. M., Sajadi S. M., Salahi S., Salehi S., Salem M. R., Salimzadeh H., Samy A. M., Sanabria J., Sanmarchi F., Sarveazad A., Sathian B., Sawhney M., Sawyer S. M., Saylan M., Schneider I. J. C., Seidu A. -A., Sekerija M., Sendo E. G., Sepanlou S. G., Seylani A., Seyoum K., Sha F., Shafaat O., Shaikh M. A., Shamsoddin E., Shannawaz M., Sharma R., Sheikhbahaei S., Shetty A., Shetty B. S. K., Shetty P. H., Shin J. I., Shirkoohi R., Shivakumar K. M., Shobeiri P., Siabani S., Sibhat M. M., Siddappa Malleshappa S. K., Sidemo N. B., Silva D. A. S., Silva Julian G., Singh A. D., Singh J. A., Singh J. K., Singh S., Sinke A. H., Sintayehu Y., Skryabin V. Y., Skryabina A. A., Smith L., Sofi-Mahmudi A., Soltani-Zangbar M. S., Song S., Spurlock E. E., Steiropoulos P., Straif K., Subedi R., Sufiyan M. B., Suliankatchi Abdulkader R., Sultana S., Szerencses V., Szocska M., Tabaeian S. P., Tabares-Seisdedos R., Tabary M., Tabuchi T., Tadbiri H., Taheri M., Taherkhani A., Takahashi K., Tampa M., Tan K. -K., Tat V. Y., Tavakoli A., Tbakhi A., Tehrani-Banihashemi A., Temsah M. -H., Tesfay F. H., Tesfaye B., Thakur J. S., Thapar R., Thavamani A., Thiyagarajan A., Thomas N., Tobe-Gai R., Togtmol M., Tohidast S. A., Tohidinik H. R., Tolani M. A., Tollosa D. N., Touvier M., Tovani-Palone M. R., Traini E., Tran B. X., Tran M. T. N., Tripathy J. P., Tusa B. S., Ukke G. G., Ullah I., Ullah S., Umapathi K. K., Unnikrishnan B., Upadhyay E., Ushula T. W., Vacante M., Valadan Tahbaz S., Varthya S. B., Veroux M., Villeneuve P. J., Violante F. S., Vlassov V., Vu G. T., Waheed Y., Wang N., Ward P., Weldesenbet A. B., Wen Y. F., Westerman R., Winkler A. S., Wubishet B. L., Xu S., Yahyazadeh Jabbari S. H., Yang L., Yaya S., Yazdi-Feyzabadi V., Yazie T. S., Yehualashet S. S., Yeshaneh A., Yeshaw Y., Yirdaw B. W., Yonemoto N., Younis M. Z., Yousefi Z., Yu C., Yunusa I., Zadnik V., Zahir M., Zahirian Moghadam T., Zamani M., Zamanian M., Zandian H., Zare F., Zastrozhin M. S., Zastrozhina A., Zhang J., Zhang Z. -J., Ziapour A., Zoladl M., Murray C. J. L., Fitzmaurice C., Bleyer A., Bhakta N.

المساهمون: Alvarez E.M., Force L.M., Xu R., Compton K., Lu D., Henrikson H.J., Kocarnik J.M., Harvey J.D., Pennini A., Dean F.E., Fu W., Vargas M.T., Keegan T.H.M., Ariffin H., Barr R.D., Erdomaeva Y.A., Gunasekera D.S., John-Akinola Y.O., Ketterl T.G., Kutluk T., Malogolowkin M.H., Mathur P., Radhakrishnan V., Ries L.A.G., Rodriguez-Galindo C., Sagoyan G.B., Sultan I., Abbasi B., Abbasi-Kangevari M., Abbasi-Kangevari Z., Abbastabar H., Abdelmasseh M., Abd-Elsalam S., Abdoli A., Abebe H., Abedi A., Abidi H., Abolhassani H., Abubaker Ali H., Abu-Gharbieh E., Achappa B., Acuna J.M., Adedeji I.A., Adegboye O.A., Adnani Q.E.S., Advani S.M., Afzal M.S., Aghaie Meybodi M., Ahadinezhad B., Ahinkorah B.O., Ahmad S., Ahmadi S., Ahmed M.B., Ahmed Rashid T., Ahmed Salih Y., Aiman W., Akalu G.T., Al Hamad H., Alahdab F., AlAmodi A.A., Alanezi F.M., Alanzi T.M., Alem A.Z., Alem D.T., Alemayehu Y., Alhalaiqa F.N., Alhassan R.K., Ali S., Alicandro G., Alipour V., Aljunid S.M., Alkhayyat M., Alluri S., Almasri N.A., Al-Maweri S.A., Almustanyir S., Al-Raddadi R.M., Alvis-Guzman N., Ameyaw E.K., Amini S., Amu H., Ancuceanu R., Andrei C.L., Andrei T., Ansari F., Ansari-Moghaddam A., Anvari D., Anyasodor A.E., Arabloo J., Arab-Zozani M., Argaw A.M., Arshad M., Arulappan J., Aryannejad A., Asemi Z., Asghari Jafarabadi M., Atashzar M.R., Atorkey P., Atreya A., Attia S.

مصطلحات موضوعية: Adolescent, Adult, Cause of Death, Disability-Adjusted Life Year, Female, Global Burden of Disease, Human, Incidence, Life Expectancy, Male, Mortality, Neoplasm, Prevalence, Risk Factor, Socioeconomic Factor, Young Adult, Global Health

الوصف: Background: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15–39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15–39 years to define adolescents and young adults. Findings: There were 1·19 million (95% UI 1·11–1·28) incident cancer cases and 396 000 (370 000–425 000) deaths due to cancer among people aged 15–39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5–65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8–57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9–15·6] per 100 000 person-years) and ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34871551; info:eu-repo/semantics/altIdentifier/wos/WOS:000821937900038; volume:23; issue:1; firstpage:27; lastpage:52; numberofpages:26; journal:THE LANCET ONCOLOGY; https://hdl.handle.net/11585/869044Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85122091989; https://www.sciencedirect.com/science/article/pii/S1470204521005817?via=ihubTest

الإتاحة: https://doi.org/10.1016/S1470-2045Test(21)00581-7
https://hdl.handle.net/11585/869044Test
https://www.sciencedirect.com/science/article/pii/S1470204521005817?via=ihubTest

المؤلفون: Sheena, B. S., Hiebert, L., Han, H., Ippolito, H., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abbastabar, H., Abdoli, A., Ali, H. A., Adane, M. M., Adegboye, O. A., Adnani, Q. E. S., Advani, S. M., Afzal, M. S., Afzal, S., Meybodi, M. A., Ahadinezhad, B., Ahinkorah, B. O., Ahmad, S., Ahmad, T., Ahmadi, S., Ahmed, H., Ahmed, M. B., Rashid, T. A., Akalu, G. T., Aklilu, A., Akram, T., Al Hamad, H., Alahdab, F., Alem, A. Z., Alem, D. T., Alhalaiqa, F. A. N., Alhassan, R. K., Ali, L., Ali, M. A., Alimohamadi, Y., Alipour, V., Alkhayyat, M., Almustanyir, S., Al-Raddadi, R. M., Altawalah, H., Amini, S., Amu, H., Ancuceanu, R., Andrei, C. L., Andrei, T., Anoushiravani, A., Ansar, A., Anyasodor, A. E., Arabloo, J., Arab-Zozani, M., Argaw, A. M., Argaw, Z. G., Arshad, M., Artamonov, A. A., Ashraf, T., Atlaw, D., Ausloos, F., Ausloos, M., Azadnajafabad, S., Azangou-Khyavy, M., Jafari, A. A., Azarian, G., Bagheri, S., Bahadory, S., Baig, A. A., Banach, M., Barati, N., Barrow, A., Batiha, A. M. M., Ramirez, D. F. B., Belgaumi, U. I., Berhie, A. Y., Bhagat, D. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhojaraja, V. S., Bijani, A., Biondi, A., Bodicha, B. B. A., Bojia, H. A., Boloor, A., Bosetti, C., Braithwaite, D., Briko, N. I., Butt, Z. A., Camera, L. A., Chakinala, R. C., Chakraborty, P. A., Charan, J., Chen, S., Choi, J. Y. J., Choudhari, S. G., Chowdhury, F. R., Chu, D. T., Chung, S. C., Cortesi, P. A., Cowie, B. C., Culbreth, G. T., Dadras, O., Dai, X., Dandona, L., Dandona, R., De la Hoz, F. P., Debela, S. A., Dedefo, M. G., Demeke, F. M., Demie, T. G. G., Demissie, G. D., Molla, M. D., Desta, A. A., Dhamnetiya, D., Dhimal, M. L., Dhimal, M., Didehdar, M., Doan, L. P., Dorostkar, F., Drake, T. M., Eghbalian, F., Ekholuenetale, M., El Sayed, I., Zaki, M. E., Elhadi, M., Elmonem, M. A., Elsharkawy, A., Enany, S., Enyew, D. B., Erkhembayar, R., Eskandarieh, S., Esmaeilzadeh, F., Ezzikouri, S., Farrokhpour, H., Fetensa, G., Fischer, F., Foroutan, M., Gad, M. M., Gaidhane, A. M., Gaidhane, S., Galles, N. C., Gallus, S., Gebremeskel, T. G., Gebreyohannes, E. A., Ghadiri, K., Ghaffari, K., Ghafourifard, M., Ghamari, S. H., Ghashghaee, A., Gholami, A., Gholizadeh, A., Gilani, A., Goel, A., Golechha, M., Goleij, P., Golinelli, D., Gorini, G., Goshu, Y. A., Griswold, M. G., Gubari, M. I. M., Gupta, B., Gupta, S., Gupta, V. B., Gupta, V. K., Haddadi, R., Halwani, R., Hamid, S. S., Hamidi, S., Hanif, A., Haque, S., Harapan, H., Hargono, A., Hariri, S., Hasaballah, A. I., Hasan, S. M. M., Hassanipour, S., Hassankhani, H., Hay, S. I., Hayat, K., Heidari, G., Herteliu, C., Heyi, D. Z., Hezam, K., Holla, R., Hosseini, M. S., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Househ, M., Huang, J., Hussein, N. R., Iavicoli, I., Ibitoye, S. E., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Irham, L. M., Islam, J. Y., Ismail, N. 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المصدر: Lancet Gastroenterology & Hepatology. 7(9):796-829

مصطلحات موضوعية: Gastroenterology and Hepatology, Gastroenterologi, antiviral therapy, viral-hepatitis, liver-cancer, hepatocellular-carcinoma, disability weights, c viruses, follow-up, vaccination, infection, transmission, Gastroenterology & Hepatology

الوصف: Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-ofsample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4 center dot 1% (95% uncertainty interval [UI] 3 center dot 7 to 4 center dot 5), corresponding to 316 million (284 to 351) infected people. There was a 31 center dot 3% (29 center dot 0 to 33 center dot 9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76 center dot 8% (76 center dot 2 to 77 center dot 5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5 center dot 9% [-5 center dot 6 to 19 center dot 2]) and between 2015 and 2019 (by 2 center dot 9% [-5 center dot 9 to 11 center dot 3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination.

الوصول الحر: https://gup.ub.gu.se/publication/325144Test