المؤلفون: Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Persson F, Desai AS, Nicolaides M, Richard A, Xiang Z, Brunel P, Pfeffer MA, Viberti G, Lachin JM, Zinman B, Pedersen TR, Villamil AS, Juncos L, Prager R, Verpooten G, Zanella MT, Leiter L, Pan C, Wang H, Botero R, Cifkova R, Christiansen JS, Groop PH, Marre M, Haller H, Nickenig G, Siamopoulos K, Gero L, Maggioni A, Remuzzi G, Katayama SS, Kim SG, Petrulioniene Z, Lok D, Kooy A, Jorde R, Medina F, Polonia J, Wong KS, Dukat A, Rayner BL, Ruilope L, Weiss L, Wuethrich R, Sheu W, Sritara P, Comlekci A, Bilous R, Toto R, Jamerson K, Carillo E, Orias M, Kuschnir E, Rusculleda M, Garcia S, Farias E, Lema L, Hominal M, Montaña O, Sala J, Diaz M, Piskorz D, Vita N, Litwak L, Sinay I, Marin M, Massari P, Majul C, Aizemberg D, Azize GM, Bartolacci I, Reboredo A, Vico M, Milesi R, Sessa H, Wassermann A, Margulis F, Zangroniz P, Watschinger B, Toplak H, Paulweber B, Drexel H, Francesconi C, Foeger B, Mayer G, Braun RK, Brath H, Gaal LV, Niepen PV, Persu A, Vercammen C, Vriese AD, Coucke F, Mathieu C, Fery F, Treille S, Meeus G, Acker KV, Scheen A, Tits J, Ruige J, Krzesinski JM, Hollanders G, Liénart F, Dendale P, Quinonez M, Arnouts P, Vanuytsel J, Zanella M, Mion D. Jr, Forti A, Almeida F, Cunha R, de Paula RB, Brandao A, Rocha J, Krieger E, Feitosa G, Saraiva J, Martin J, Hissa MN, Schmid H, Felicio J, Sgarbi J, Oigman W, Bowering K, Garceau C, Berlingieri JC, Weisnagel SJ, Hardin P, Powell C, Turcot R, Muirhead N, Aronson R, Barima YT, Steele AW, Pandey S, Woo V, Cha J, Dattani D, Godin C, Gupta M, Saunders K, Tellier G, Ting R, Tobe S, Chouinard G, Schlosser R, Khandwala H, Ekoe JM, Harris SB, Pichette V, Lachance P, Ooi TC, Tildesley H, Barrett B, Cournoyer S, Lu J, Zhang H, Liu X, Yan S, Qi X, Li Q, Li H, Lv X, Yang J, Sun N, Xia W, Wang N, Tong N, Mei C, Gu S, Zhang J, Chen X, Li L, Su B, Wang L, Qiu M, Wu X, Liu Z, Jia W, Xu G, Dong J, Zhu D, Zhang M, Yan J, Liu B, Chen J, Fu J, Yan L, Zhan X, Zhong L, Yang T, Ma J, Xu M, Xu X, Shi B, Ji Q, Zhong H, He R, Yuan Z, Zhou Z, Lin H, Yang W, Ke Y, Hong T, Franco C, Casas L, Triana A, Jaramillo C, Hernandez E, Barrera C, Blanco D, Stipal R, Widimsky P, Dohnalova L, Komroskova M, Kvapil M, Belobradkova J, Tesar V, Vodnansky P, Kocourkova B, Lervang HH, Perrild H, Rossing P, Oestergaard O, Juhl H, Thorsteinsson B, Snorgaard O, Urhammer S, Egstrup K, Tikkanen T, Helin K, Rinne J, Lahtela J, Strand J, Valtonen E, Saari M, Kananen K, Savela K, Blacher J, Aldigier JC, Zaoui P, Fauvel JP, Gouet D, Valensi PE, Charpentier G, Marechaud R, Penfornis A, Ovize M, Kovalchuck AA, Dellanna F, Schoen N, Groeschel W, Eickhoff F, Hanefeld M, Merke J, Rambausek M, Zimmermann U, Stuetz W, Vosskuehler A, Hevendehl G, Schax U, Lehmann G, Haack A, Hilgenberg J, Klausmann G, Adelberger V, Gessner S, Fiesselmann A, Oerter E, Hohenstatt T, Groeschel A, Behnke T, Sisting RT, Schoch D, Bieler T, Schleyer S, Altes U, Klepzig C, Rudofsky G, Mueller G, Burkhardt F, Reschke K, Senftleber I, Wiesweg CK, Herrmann HJ, Brandstetter R, Segner A, Schmitt H, Rippert R, Goebel R, Schreibmueller F, Pencz I, Ott P, Migdalis I, Pappas S, Pagkalos E, Yalouris A, Tsapas A, Maltezos E, Tentolouris N, Papadakis I, Ioannidis G, Goumenos D, Corona V, Gonzalez R, Haase F, Monterroso V, Sánchez V, Turcios E, Wyss F, Arango JL, Bako B, Deak L, Dömötör E, Dudas M, Fulop T, Kiss I, Koranyi L, Lengyel Z, Nyirati G, Oroszlan T, Aniko S, Vörös P, Kapocsi J, Wittmann I, Paragh G, Abraham G, Tandon N, Thomas N, Mohan V, Sahay R, Sethi B, Rao V, Kumar S, Chowdhury S, Dharmalingam M, Seshiah V, Bantwal G, Viswanathan V, Yajnik C, Adhikari P, Krishnan U, Varthakavi P, Hiremath J, Bhattacharyya A, Dani S, Modi KK, Glorioso N, Morosetti M, Perticone F, Dotta F, Quarello F, Sesti G, Aiello A, D'Ospina A, Giordano C, Novo S, Santoro A, Ferri C, Capuano V, Trimarco B, Tonolo G, Villa G, De Pellegrin A, Zanette G, Federici M, Aucello G, Piatti P, Vinciguerra A, Mannarino E, Taddei S, Filetti S, Grandaliano G, Marchionni N, Lambiase C, Locatelli F, Scanferla F, Lembo G, Leotta S, Mos L, Calatola P, Fogari R, David S, Pedrinelli R, Pignone AM, Cozzolino D, Bevilacqua MT, Catena C, Del Prato S, Cerasola G, Frontoni S, Falcone C, Porta A, Bonora E, Cocchi R, Fucili A, Frisinghelli A, Volpe M, Carugo S, Gambardella S, Spagnuolo V, Maglia G, D'Angelo AR, Corsi A, Limone PP, Guarnieri A, Ronchi E, Ravera M, Scioli GA, Sekiguchi M, Aoki S, Ogawa Y, Seino H, Onishi Y, Tojo A, Narimiya M, Iwaita Y, Takeda H, Shimizu H, Yamada T, Kojima S, Zushi S, Kaneko S, Matsumoto A, Kajiyama S, Fujita H, Shikata K, Tone A, Matsubayashi S, Tanaka S, Sekigami T, Tatsukawa Y, Abe N, Kawahara K, Kasahara H, Maeda Y, Suzuki Y, Okamoto H, Tachi K, Yamada K, Uzu T, Itou T, Fukui T, Kim S, Kim Y, Cho W, Kwak I, Chae D, Oh H, Ha S, Shin Y, Cha D, Kang S, Lim C, Song J, Kwon Y, Badariene J, Labutiniene IP, Zabuliene L, Poteliuniene V, Miglinas M, van den Meiracker AH, Gregoor PJ, Luik AJ, van Loon BJ, Feenstra HJ, Kaasjager HA, Viergever PP, Woittiez AJ, van Bemmel T, Lieverse AG, Simsek S, Gaillard CA, van der Zwaan C, Lok DJ, Spiering W, Nierop PR, Baggen MG, Leendert RJ, de Jong A, Leurs PB, Vincent HH, Wins EH, Voors AA, Ronner E, Heeg JE, van Hal JM, Boermans T, Feis WL, Mostard G, Bakker RC, Dunselman PH, Skeie S, Istad H, Skjelvan G, Gronert J, Tomala T, Gudnason S, Torvik DT, Risberg K, Abedini S, Cabrera W, Medina B, Herrada B, Saavedra A, Polonia DJ, Providencia DL, Carvalho D, Vasconcelos MP, da Silva GF, Branco P, Gil DV, da Costa AG, da Silva PM, Arez L, Martins L, Birne R, Dzuponova J, Surovcikova M, Culak J, Filipova S, Andre I, Stevlik J, Uhliar R, Fabryova L, Benacka J, Koleny D, Szentivanyi M, Spisak V, Pella D, Pastrnakova E, Martinka E, Chua T, Lau T, Ng TG, Yeoh LY, Bhana SA, Rayner B, Wellmann H, Amod A, Ranjith N, Ahmed F, Rheeder P, Makan H, Naicker P, Podgorski G, De Teresa E, Olivan J, Fernandez VL, Povedano ST, Terns M, Ricart W, Gonzalez JM, Fernandez P, Parreño Lde T, Redon J, Parra J, Calvo C, Lopez I, Puig JG, Calle A, Garcia JC, Lopez JM, Jimenez ML, Fraile B, Perez JS, Nadal JJ, Guija E, Calviño J, Barrios V, Iglesias JN, Armario P, Garcia M, Aranda P, Brotons C, Gomez P, Catelao AM, Cusachs AR, Sarro M, Martinez V, dell Valle MH, Trias F, Comas A, Salvador N, Martinez F, Hernandez F, Martinez J, Mateos C, Peral JL, Tolosana J, Sobrino J, Isart J, Vizcaino J, Vega FF, Zamorano JL, Bacariza M, Soubriet A, Fernández Cruz A, Querejeta R, Leira VM, Iglesias FE, Ibrik O, Martin D, Nanclares MS, Mediavilla JD, Galceran JM, Lopez A, Muros T, Pascual J, Casalla F, Tornero F, Fernandez G, Pettersson P, Olsen H, Franke F, Stroembom U, Furuland H, Larnefelt H, Allemann Y, Krapf R, Gerber P, Munger R, Hayoz D, Graf HJ, Burnier M, Petrillo A, Batt R, Constam EN, Moccetti T, Bianda T, Rickli H, Bulliard C, Wu KD, Lin SH, Wu CJ, Sheu WH, Su SL, Chen SC, Chou CW, Lee CT, Yang TC, Chen HC, Sukonthasarn A, Sriratanasathavorn C, Eiam Ong S, Supasyndh O, Chanchairujira T, Kitiyakara C, Arici M, Usalan C, Guneri S, Koc M, Kalender B, Ates K, Gurgun C, Araz M, Demirbas B, Biernacki W, Calvert J, Eavis P, Kerrane J, Litchfield J, Middleton A, Roberts J, Simpson H, Charles H, Jardine A, Fisher M, Banerjee D, Gallen I, Gnudi L, Harvey J, O'Hare P, Vora J, Winocour P, Soran H, Browne D, Darko D, Mancebo JG, de Roa ER, Antepara N, Carrillo E, Berrizbeitia M, Guevara L, Pernalete N, Ontiveros C, Zigrang W, Blakney E, Rosenblit P, Weinstein R, Klaff L, Lipetz R, Busick E, Tung P, Cooperman M, Michael S, Sun CH, Hart T, Maddux A, Bowden R, East C, Arakaki R, Villafuerte B, Mamish Z, Mendez R, Connery L, Nour K, Wynne A, Busch R, Zamora B, Sachson R, Prasad J, Lasala G, Smith M, Fitz Patrick D, Ruiz Rivera L, Barranco E, Solomon R, Woolley A, Brown C, Freedman Z, Schmidt S, Pollock J, Ruddy M, Kopyt NP, Bazzi A, Horowitz B, Feng W, Wahl T, Duprez D, Gilbert J, Steigerwalt S, Jacqmein J, Gorton S, Allison J. 3rd, Pino J, Lock J, Leimbach W, Anderson J, Beacom M, Craig W, Gorson D, Kerstein H, Segal S, Downey H, Ledger G, McGill J, Gabriel J, Nolen T, Levinson L, Williams T, Levenson D, Lerman S, Minehart C, Agarwal N, Verma S, Valitutto M, Demetry K, Mersey J, Koeper D, Fanti P, Eng G, Grimm R, Fagan T, Bajaj M, Katz L, Portnay G, Altschuller A, Desai V, Bilazarian S, Ipp E, Rodelas R, Burstein D, Berg J, Velez J, Lund R, Rekhi A, Martin E, Robertson D, Singh N, Narayan P, Moustafa M, Lanier D, Seidner M, Phillips A, Vaughters B, Sprague A, Swartz S, Lopez R, Kumar J, Bressler P, Sadler L, Wise J, Kilbane A., VEGLIO, Franco, GHIGO, Ezio

المساهمون: Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Persson F, Desai AS, Nicolaides M, Richard A, Xiang Z, Brunel P, Pfeffer MA, Viberti G, Lachin JM, Zinman B, Pedersen TR, Villamil AS, Juncos L, Prager R, Verpooten G, Zanella MT, Leiter L, Pan C, Wang H, Botero R, Cifkova R, Christiansen JS, Groop PH, Marre M, Haller H, Nickenig G, Siamopoulos K, Gero L, Maggioni A, Remuzzi G, Katayama SS, Kim SG, Petrulioniene Z, Lok D, Kooy A, Jorde R, Medina F, Polonia J, Wong KS, Dukat A, Rayner BL, Ruilope L, Weiss L, Wuethrich R, Sheu W, Sritara P, Comlekci A, Bilous R, Toto R, Jamerson K, Carillo E, Orias M, Kuschnir E, Rusculleda M, Garcia S, Farias E, Lema L, Hominal M, Montaña O, Sala J, Diaz M, Piskorz D, Vita N, Litwak L, Sinay I, Marin M, Massari P, Majul C, Aizemberg D, Azize GM, Bartolacci I, Reboredo A, Vico M, Milesi R, Sessa H, Wassermann A, Margulis F, Zangroniz P, Watschinger B, Toplak H, Paulweber B, Drexel H, Francesconi C, Foeger B, Mayer G, Braun RK, Brath H, Gaal LV, Niepen PV, Persu A, Vercammen C

مصطلحات موضوعية: aliskiren, hypertension, diabetes

الوصف: BACKGROUND: This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS: In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level. RESULTS: The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P=0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, ≥6 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P<0.001 for both comparisons). CONCLUSIONS: The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23121378; info:eu-repo/semantics/altIdentifier/wos/WOS:000311890600007; volume:367; issue:23; firstpage:2204; lastpage:2213; numberofpages:10; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/2318/129755Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84869492851

الإتاحة: https://doi.org/10.1056/NEJMoa1208799Test
http://hdl.handle.net/2318/129755Test

المؤلفون: Parving, Hh, Brenner, Bm, Mcmurray, Jj, de Zeeuw, D, Haffner, Sm, Solomon, Sd, Chaturvedi, N, Persson, F, Desai, As, Nicolaides, M, Richard, A, Xiang, Z, Brunel, P, Pfeffer, Ma, Viberti, G, Lachin, Jm, Zinman, B, Pedersen, Tr, Villamil, As, Juncos, L, Prager, R, Verpooten, G, Zanella, Mt, Leiter, L, Pan, C, Wang, H, Botero, R, Cifkova, R, Christiansen, Js, Groop, Ph, Marre, M, Haller, H, Nickenig, G, Siamopoulos, K, Gero, L, Maggioni, A, Remuzzi, G, Katayama, Ss, Kim, Sg, Petrulioniene, Z, Lok, D, Kooy, A, Jorde, R, Medina, F, Polonia, J, Wong, Ks, Dukat, A, Rayner, Bl, Ruilope, L, Weiss, L, Wuethrich, R, Sheu, W, Sritara, P, Comlekci, A, Bilous, R, Toto, R, Jamerson, K, Carillo, E, Orias, M, Kuschnir, E, Rusculleda, M, Garcia, S, Farias, E, Lema, L, Hominal, M, Montaña, O, Sala, J, Diaz, M, Piskorz, D, Vita, N, Litwak, L, Sinay, I, Marin, M, Massari, P, Majul, C, Aizemberg, D, Azize, Gm, Bartolacci, I, Reboredo, A, Vico, M, Milesi, R, Sessa, H, Wassermann, A, Margulis, F, Zangroniz, P, Watschinger, B, Toplak, H, Paulweber, B, Drexel, H, Francesconi, C, Foeger, B, Mayer, G, Braun, Rk, Brath, H, Gaal, Lv, Niepen, Pv, Persu, A, Vercammen, C, Vriese, Ad, Coucke, F, Mathieu, C, Fery, F, Treille, S, Meeus, G, Acker, Kv, Scheen, A, Tits, J, Ruige, J, Krzesinski, Jm, Hollanders, G, Liénart, F, Dendale, P, Quinonez, M, Arnouts, P, Vanuytsel, J, Zanella, M, Mion D., Jr, Forti, A, Almeida, F, Cunha, R, de Paula RB, Brandao, A, Rocha, J, Krieger, E, Feitosa, G, Saraiva, J, Martin, J, Hissa, Mn, Schmid, H, Felicio, J, Sgarbi, J, Oigman, W, Bowering, K, Garceau, C, Berlingieri, Jc, Weisnagel, Sj, Hardin, P, Powell, C, Turcot, R, Muirhead, N, Aronson, R, Barima, Yt, Steele, Aw, Pandey, S, Woo, V, Cha, J, Dattani, D, Godin, C, Gupta, M, Saunders, K, Tellier, G, Ting, R, Tobe, S, Chouinard, G, Schlosser, R, Khandwala, H, Ekoe, Jm, Harris, Sb, Pichette, V, Lachance, P, Ooi, Tc, Tildesley, H, Barrett, B, Cournoyer, S, Lu, J, Zhang, H, Liu, X, Yan, S, Qi, X, Li, Q, Li, H, Lv, X, Yang, J, Sun, N, Xia, W, Wang, N, Tong, N, Mei, C, Gu, S, Zhang, J, Chen, X, Li, L, Su, B, Wang, L, Qiu, M, Wu, X, Liu, Z, Jia, W, Xu, G, Dong, J, Zhu, D, Zhang, M, Yan, J, Liu, B, Chen, J, Fu, J, Yan, L, Zhan, X, Zhong, L, Yang, T, Ma, J, Xu, M, Xu, X, Shi, B, Ji, Q, Zhong, H, He, R, Yuan, Z, Zhou, Z, Lin, H, Yang, W, Ke, Y, Hong, T, Franco, C, Casas, L, Triana, A, Jaramillo, C, Hernandez, E, Barrera, C, Blanco, D, Stipal, R, Widimsky, P, Dohnalova, L, Komroskova, M, Kvapil, M, Belobradkova, J, Tesar, V, Vodnansky, P, Kocourkova, B, Lervang, Hh, Perrild, H, Rossing, P, Oestergaard, O, Juhl, H, Thorsteinsson, B, Snorgaard, O, Urhammer, S, Egstrup, K, Tikkanen, T, Helin, K, Rinne, J, Lahtela, J, Strand, J, Valtonen, E, Saari, M, Kananen, K, Savela, K, Blacher, J, Aldigier, Jc, Zaoui, P, Fauvel, Jp, Gouet, D, Valensi, Pe, Charpentier, G, Marechaud, R, Penfornis, A, Ovize, M, Kovalchuck, Aa, Dellanna, F, Schoen, N, Groeschel, W, Eickhoff, F, Hanefeld, M, Merke, J, Rambausek, M, Zimmermann, U, Stuetz, W, Vosskuehler, A, Hevendehl, G, Schax, U, Lehmann, G, Haack, A, Hilgenberg, J, Klausmann, G, Adelberger, V, Gessner, S, Fiesselmann, A, Oerter, E, Hohenstatt, T, Groeschel, A, Behnke, T, Sisting, Rt, Schoch, D, Bieler, T, Schleyer, S, Altes, U, Klepzig, C, Rudofsky, G, Mueller, G, Burkhardt, F, Reschke, K, Senftleber, I, Wiesweg, Ck, Herrmann, Hj, Brandstetter, R, Segner, A, Schmitt, H, Rippert, R, Goebel, R, Schreibmueller, F, Pencz, I, Ott, P, Migdalis, I, Pappas, S, Pagkalos, E, Yalouris, A, Tsapas, A, Maltezos, E, Tentolouris, N, Papadakis, I, Ioannidis, G, Goumenos, D, Corona, V, Gonzalez, R, Haase, F, Monterroso, V, Sánchez, V, Turcios, E, Wyss, F, Arango, Jl, Bako, B, Deak, L, Dömötör, E, Dudas, M, Fulop, T, Kiss, I, Koranyi, L, Lengyel, Z, Nyirati, G, Oroszlan, T, Aniko, S, Vörös, P, Kapocsi, J, Wittmann, I, Paragh, G, Abraham, G, Tandon, N, Thomas, N, Mohan, V, Sahay, R, Sethi, B, Rao, V, Kumar, S, Chowdhury, S, Dharmalingam, M, Seshiah, V, Bantwal, G, Viswanathan, V, Yajnik, C, Adhikari, P, Krishnan, U, Varthakavi, P, Hiremath, J, Bhattacharyya, A, Dani, S, Modi, Kk, Glorioso, N, Morosetti, M, Veglio, Franco, Perticone, F, Dotta, F, Quarello, F, Sesti, G, Aiello, A, D'Ospina, A, Giordano, C, Novo, S, Santoro, A, Ferri, C, Capuano, V, Trimarco, B, Tonolo, G, Villa, G, De Pellegrin, A, Zanette, G, Federici, M, Aucello, G, Piatti, P, Vinciguerra, A, Mannarino, E, Taddei, S, Filetti, S, Grandaliano, G, Marchionni, N, Lambiase, C, Locatelli, F, Scanferla, F, Lembo, G, Leotta, S, Mos, L, Calatola, P, Fogari, R, David, S, Pedrinelli, R, Pignone, Am, Cozzolino, D, Bevilacqua, Mt, Catena, C, Del Prato, S, Cerasola, G, Frontoni, S, Falcone, C, Porta, A, Bonora, E, Cocchi, R, Fucili, A, Frisinghelli, A, Volpe, M, Carugo, S, Gambardella, S, Spagnuolo, V, Maglia, G, D'Angelo, Ar, Corsi, A, Limone, Pp, Guarnieri, A, Ghigo, Ezio, Ronchi, E, Ravera, M, Scioli, Ga, Sekiguchi, M, Aoki, S, Ogawa, Y, Seino, H, Onishi, Y, Tojo, A, Narimiya, M, Iwaita, Y, Takeda, H, Shimizu, H, Yamada, T, Kojima, S, Zushi, S, Kaneko, S, Matsumoto, A, Kajiyama, S, Fujita, H, Shikata, K, Tone, A, Matsubayashi, S, Tanaka, S, Sekigami, T, Tatsukawa, Y, Abe, N, Kawahara, K, Kasahara, H, Maeda, Y, Suzuki, Y, Okamoto, H, Tachi, K, Yamada, K, Uzu, T, Itou, T, Fukui, T, Kim, S, Kim, Y, Cho, W, Kwak, I, Chae, D, Oh, H, Ha, S, Shin, Y, Cha, D, Kang, S, Lim, C, Song, J, Kwon, Y, Badariene, J, Labutiniene, Ip, Zabuliene, L, Poteliuniene, V, Miglinas, M, van den Meiracker AH, Gregoor, Pj, Luik, Aj, van Loon BJ, Feenstra, Hj, Kaasjager, Ha, Viergever, Pp, Woittiez, Aj, van Bemmel, T, Lieverse, Ag, Simsek, S, Gaillard, Ca, van der Zwaan, C, Lok, Dj, Spiering, W, Nierop, Pr, Baggen, Mg, Leendert, Rj, de Jong, A, Leurs, Pb, Vincent, Hh, Wins, Eh, Voors, Aa, Ronner, E, Heeg, Je, van Hal JM, Boermans, T, Feis, Wl, Mostard, G, Bakker, Rc, Dunselman, Ph, Skeie, S, Istad, H, Skjelvan, G, Gronert, J, Tomala, T, Gudnason, S, Torvik, Dt, Risberg, K, Abedini, S, Cabrera, W, Medina, B, Herrada, B, Saavedra, A, Polonia, Dj, Providencia, Dl, Carvalho, D, Vasconcelos, Mp, da Silva GF, Branco, P, Gil, Dv, da Costa AG, da Silva PM, Arez, L, Martins, L, Birne, R, Dzuponova, J, Surovcikova, M, Culak, J, Filipova, S, Andre, I, Stevlik, J, Uhliar, R, Fabryova, L, Benacka, J, Koleny, D, Szentivanyi, M, Spisak, V, Pella, D, Pastrnakova, E, Martinka, E, Chua, T, Lau, T, Ng, Tg, Yeoh, Ly, Bhana, Sa, Rayner, B, Wellmann, H, Amod, A, Ranjith, N, Ahmed, F, Rheeder, P, Makan, H, Naicker, P, Podgorski, G, De Teresa, E, Olivan, J, Fernandez, Vl, Povedano, St, Terns, M, Ricart, W, Gonzalez, Jm, Fernandez, P, Parreño Lde, T, Redon, J, Parra, J, Calvo, C, Lopez, I, Puig, Jg, Calle, A, Garcia, Jc, Lopez, Jm, Jimenez, Ml, Fraile, B, Perez, Js, Nadal, Jj, Guija, E, Calviño, J, Barrios, V, Iglesias, Jn, Armario, P, Garcia, M, Aranda, P, Brotons, C, Gomez, P, Catelao, Am, Cusachs, Ar, Sarro, M, Martinez, V, dell Valle MH, Trias, F, Comas, A, Salvador, N, Martinez, F, Hernandez, F, Martinez, J, Mateos, C, Peral, Jl, Tolosana, J, Sobrino, J, Isart, J, Vizcaino, J, Vega, Ff, Zamorano, Jl, Bacariza, M, Soubriet, A, Fernández Cruz, A, Querejeta, R, Leira, Vm, Iglesias, Fe, Ibrik, O, Martin, D, Nanclares, Ms, Mediavilla, Jd, Galceran, Jm, Lopez, A, Muros, T, Pascual, J, Casalla, F, Tornero, F, Fernandez, G, Pettersson, P, Olsen, H, Franke, F, Stroembom, U, Furuland, H, Larnefelt, H, Allemann, Y, Krapf, R, Gerber, P, Munger, R, Hayoz, D, Graf, Hj, Burnier, M, Petrillo, A, Batt, R, Constam, En, Moccetti, T, Bianda, T, Rickli, H, Bulliard, C, Wu, Kd, Lin, Sh, Wu, Cj, Sheu, Wh, Su, Sl, Chen, Sc, Chou, Cw, Lee, Ct, Yang, Tc, Chen, Hc, Sukonthasarn, A, Sriratanasathavorn, C, Eiam Ong, S, Supasyndh, O, Chanchairujira, T, Kitiyakara, C, Arici, M, Usalan, C, Guneri, S, Koc, M, Kalender, B, Ates, K, Gurgun, C, Araz, M, Demirbas, B, Biernacki, W, Calvert, J, Eavis, P, Kerrane, J, Litchfield, J, Middleton, A, Roberts, J, Simpson, H, Charles, H, Jardine, A, Fisher, M, Banerjee, D, Gallen, I, Gnudi, L, Harvey, J, O'Hare, P, Vora, J, Winocour, P, Soran, H, Browne, D, Darko, D, Mancebo, Jg, de Roa ER, Antepara, N, Carrillo, E, Berrizbeitia, M, Guevara, L, Pernalete, N, Ontiveros, C, Zigrang, W, Blakney, E, Rosenblit, P, Weinstein, R, Klaff, L, Lipetz, R, Busick, E, Tung, P, Cooperman, M, Michael, S, Sun, Ch, Hart, T, Maddux, A, Bowden, R, East, C, Arakaki, R, Villafuerte, B, Mamish, Z, Mendez, R, Connery, L, Nour, K, Wynne, A, Busch, R, Zamora, B, Sachson, R, Prasad, J, Lasala, G, Smith, M, Fitz Patrick, D, Ruiz Rivera, L, Barranco, E, Solomon, R, Woolley, A, Brown, C, Freedman, Z, Schmidt, S, Pollock, J, Ruddy, M, Kopyt, Np, Bazzi, A, Horowitz, B, Feng, W, Wahl, T, Duprez, D, Gilbert, J, Steigerwalt, S, Jacqmein, J, Gorton, S, 3rd, Allison J., Pino, J, Lock, J, Leimbach, W, Anderson, J, Beacom, M, Craig, W, Gorson, D, Kerstein, H, Segal, S, Downey, H, Ledger, G, Mcgill, J, Gabriel, J, Nolen, T, Levinson, L, Williams, T, Levenson, D, Lerman, S, Minehart, C, Agarwal, N, Verma, S, Valitutto, M, Demetry, K, Mersey, J, Koeper, D, Fanti, P, Eng, G, Grimm, R, Fagan, T, Bajaj, M, Katz, L, Portnay, G, Altschuller, A, Desai, V, Bilazarian, S, Ipp, E, Rodelas, R, Burstein, D, Berg, J, Velez, J, Lund, R, Rekhi, A, Martin, E, Robertson, D, Singh, N, Narayan, P, Moustafa, M, Lanier, D, Seidner, M, Phillips, A, Vaughters, B, Sprague, A, Swartz, S, Lopez, R, Kumar, J, Bressler, P, Sadler, L, Wise, J, Kilbane, A.

المساهمون: Groningen Kidney Center (GKC)

المصدر: Parving, Hans-Henrik; Brenner, Barry M.; McMurray, John J.V.; de Zeeuw, Dick; Haffner, Steven M.; Solomon, Scott D.; Chaturvedi, Nish; Persson, Frederik; Desai, Akshay S.; Nicolaides, Maria; Richard, Alexia; Xiang, Zhihua; Brunel, Patrick; Pfeffer, Marc A.; for the ALTITUDE, incl.; Allemann, Yves (2012). Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes. New England journal of medicine NEJM, 367(23), pp. 2204-2213. Waltham, Mass.: Massachusetts Medical Society MMS 10.1056/NEJMoa1208799 <http://dx.doi.org/10.1056/NEJMoa1208799Test>
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
New England Journal of Medicine, 367(23), 2204-2213. MASSACHUSETTS MEDICAL SOC
Parving, H-H, Brenner, B M, McMurray, J J V, de Zeeuw, D, Haffner, S M, Solomon, S D, Chaturvedi, N, Persson, F, Desai, A S, Nicolaides, M, Richard, A, Xiang, Z, Brunel, P, Pfeffer, M A & ALTITUDE Investigators 2012, ' Cardiorenal end points in a trial of aliskiren for type 2 diabetes ', Briefings from the New England Journal of Medicine (Spanish Edition), vol. 367, no. 23, pp. 2204-13 . https://doi.org/10.1056/NEJMoa1208799Test

مصطلحات موضوعية: Male, Hyperkalemia, CARDIOVASCULAR MORTALITY, BLOOD-PRESSURE, Angiotensin-Converting Enzyme Inhibitors, Type 2 diabetes, GLOMERULAR-FILTRATION-RATE, DOUBLE-BLIND, chemistry.chemical_compound, Fumarates, cardiovascular disease, Renin, Treatment Failure, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, 610 Medicine & health, diabetes, Medicine (all), Hazard ratio, aliskiren, diabete, trial clinico, Liter, General Medicine, Middle Aged, hypertension, Cardiovascular Diseases, Combination, HEART-FAILURE, Drug Therapy, Combination, Female, Kidney Diseases, type 2 diabetes, medicine.symptom, Type 2, medicine.medical_specialty, Patient Dropouts, Urology, Hypokalemia, Aliskiren, chronic kidney disease, Placebo, Angiotensin Receptor Antagonists, LEFT-VENTRICULAR DYSFUNCTION, Drug Therapy, Double-Blind Method, Diabetes Mellitus, medicine, Humans, CONVERTING-ENZYME INHIBITORS, Antihypertensive Agents, Aged, Amides, Diabetes Mellitus, Type 2, Follow-Up Studies, business.industry, medicine.disease, Confidence interval, Surgery, Blood pressure, MYOCARDIAL-INFARCTION, chemistry, SYSTOLIC DYSFUNCTION, FOLLOW-UP, business

الوصف: BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level. RESULTS The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P = 0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, = 6 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P CONCLUSIONS The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful. (Funded by Novartis; ALTITUDE ClinicalTrials.gov number, NCT00549757.)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5677047544fe7663fe50b57da467abbcTest

المؤلفون: Le Meur, YL, Leprivey-Lorgeot, V, Mons, S, Matthew Jose, Dantal, J, Lemauff, B, Aldigier, JC, Leroux-Robert, C, Praloran, V

مصطلحات موضوعية: Nephrology and urology, allograft rejection

الوصف: BACKGROUND : Macrophage-colony stimulating factor (M-CSF) is the principal factor for survival of monocytes and macrophages that play an important role in allograft rejection. We studied M-CSF serum levels during successful renal transplantation and acute graft rejection. METHODS : A total of 114 kidney allograft recipients were assessed for M-CSF levels by enzyme-linked immunosorbent assay (ELISA). RESULTS : M-CSF serum levels were elevated in pre-transplant haemodialysis patients (611+/-355 IU/ml vs 168+/-61 in normal controls, P<0.01). Following successful renal transplantation, M-CSF decreased in the first month, stabilizing at 257+/-222 IU/ml (not significantly different from normal controls) in 52 post-transplant stable patients. There was no correlation between M-CSF level and creatinine clearance. M-CSF levels increased significantly (2-5 times) during biopsy-proven acute rejection episodes in 20 of 25 patients. All rejection episodes were successfully treated and serum M-CSF decreased rapidly to pre-rejection levels in 17/20 patients. In contrast, in five patients with cyclosporin toxicity and four patients with other causes of allograft dysfunction, M-CSF serum levels did not change. CONCLUSIONS : M-CSF serum level might be a specific marker of acute rejection. The source of increased production during rejection warrants further investigation, with infiltrating T cells and resident kidney cells being likely candidates.

العلاقة: 102.100.100/577328; https://figshare.com/articles/journal_contribution/Serum_levels_of_macrophage-colony_stimulating_factor_M-CSF_a_marker_of_kidney_allograft_rejection/22909484Test

الإتاحة: https://figshare.com/articles/journal_contribution/Serum_levels_of_macrophage-colony_stimulating_factor_M-CSF_a_marker_of_kidney_allograft_rejection/22909484Test

المؤلفون: Aldigier, JC, Meur, Y Le, Brunel, P

المصدر: Clinical Drug Investigation ; volume 16, issue 6, page 463-472 ; ISSN 1173-2563

مصطلحات موضوعية: Pharmacology (medical), General Medicine

الإتاحة: https://doi.org/10.2165/00044011-199816060-00006Test

المؤلفون: Ruilope LM, Aldigier JC, Ponticelli C, Oddou-Stock P, Botteri F, Mann JF

المصدر: Journal of Hypertension; 2000 Jan, Vol. 18 Issue 1, p89-95, 7p

المؤلفون: Gualde, N., Mexmain, S., Aldigier, Jc., Rigaud, M.

المصدر: Journal of Steroid Biochemistry ; volume 19, page 176 ; ISSN 0022-4731

مصطلحات موضوعية: Endocrinology, Biochemistry

الإتاحة: https://doi.org/10.1016/0022-4731Test(83)92013-7
https://api.elsevier.com/content/article/PII:0022473183920137?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:0022473183920137?httpAccept=text/plainTest