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1دورية أكاديمية
المؤلفون: Jensen, ASH, Winther-Sorensen, M, Burisch, J, Bergquist, A, Ytting, H, Gluud, LL, Albrechtsen, NJW
المصدر: Liver international : official journal of the International Association for the Study of the Liver. 43(11):2479-2491
مصطلحات موضوعية: Medicin och hälsovetenskap
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2دورية أكاديمية
المؤلفون: Batista, TM, Jayavelu, AK, Albrechtsen, NJW, Iovino, S, Lebastchi, J, Pan, H, Dreyfuss, JM, Krook, A, Zierath, JR, Mann, M, Kahn, CR
المصدر: Cell metabolism. 32(5):844
مصطلحات موضوعية: Medicin och hälsovetenskap
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3دورية أكاديمية
المؤلفون: Alexiadou, K, Cuenco, J, Howard, J, Albrechtsen, NJW, Ilesanmi, I, Kamocka, A, Tharakan, G, Behary, P, Bech, PR, Ahmed, AR, Purkayastha, S, Wheller, R, Fleuret, M, Holst, JJ, Bloom, SR, Khoo, B, Tan, TM-M
المساهمون: National Institute for Health Research
المصدر: 10 ; 1
مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, glucagon, glucagon-like peptide-1 (GLP-1), obesity, bariatric surgery, Y GASTRIC BYPASS, BETA-CELL FUNCTION, GLUCAGON-LIKE PEPTIDE-1, WEIGHT-LOSS, RECEPTOR ANTAGONIST, GLUCOSE-TOLERANCE, OXYNTOMODULIN, GLICENTIN, HORMONES, GLP-1, 1103 Clinical Sciences
الوصف: Introduction Hyperglucagonemia is a key pathophysiological driver of type 2 diabetes. Although Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for diabetes, it is presently unclear how surgery alters glucagon physiology. The aim of this study was to characterize the behavior of proglucagon-derived peptide (glucagon, glucagon-like peptide-1 (GLP-1), oxyntomodulin, glicentin) secretion after RYGB surgery. Research design and methods Prospective study of 19 patients with obesity and pre-diabetes/diabetes undergoing RYGB. We assessed the glucose, insulin, GLP-1, glucose-dependent insulinotropic peptide (GIP), oxyntomodulin, glicentin and glucagon responses to a mixed-meal test (MMT) before and 1, 3 and 12 months after surgery. Glucagon was measured using a Mercodia glucagon ELISA using the ‘Alternative’ improved specificity protocol, which was validated against a reference liquid chromatography combined with mass spectrometry method. Results After RYGB, there were early improvements in fasting glucose and glucose tolerance and the insulin response to MMT was accelerated and amplified, in parallel to significant increases in postprandial GLP-1, oxyntomodulin and glicentin secretion. There was a significant decrease in fasting glucagon levels at the later time points of 3 and 12 months after surgery. Glucagon was secreted in response to the MMT preoperatively and postoperatively in all patients and there was no significant change in this postprandial secretion. There was no significant change in GIP secretion. Conclusions There is a clear difference in the dynamics of secretion of proglucagon peptides after RYGB. The reduction in fasting glucagon secretion may be one of the mechanisms driving later improvements in glycemia after RYGB.
العلاقة: BMJ Open Diabetes Research and Care; http://hdl.handle.net/10044/1/82366Test; EME/13/121/07
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4دورية أكاديمية
المؤلفون: Tan, T, Behary, P, Tharakan, G, Minnion, J, Al-Najim, W, Albrechtsen, NJW, Holst, JJ, Bloom, SR
المساهمون: Medical Research Council (MRC), Imperial College Healthcare NHS Trust, National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, Imperial Health Charity, Imperial College Healthcare NHS Trust - CLRN Funding
المصدر: 2372 ; 2364
مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, GLUCAGON-LIKE PEPTIDE-1, GASTRIC BYPASS-SURGERY, PLACEBO-CONTROLLED TRIAL, FOOD-INTAKE, BARIATRIC SURGERY, WEIGHT MANAGEMENT, EATING BEHAVIOR, OXYNTOMODULIN, APPETITE, HUMANS, Adult, Analysis of Variance, Area Under Curve, Body Mass Index, Cross-Over Studies, Energy Metabolism, Female, Follow-Up Studies, Gastric Bypass, Glucagon-Like Peptide 1, Infusions, Subcutaneous, Male, Middle Aged, Obesity, Morbid, Pain Measurement
الوصف: Background: Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment of obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY), and Oxyntomodulin (OXM) are elevated postprandially after RYGB, which has been postulated to contribute to its metabolic benefits. Objective: We hypothesized that infusion of the three gut hormones to achieve levels similar to those encountered postprandially in RYGB patients might be effective in suppressing appetite. The aim of this study was to investigate the effect of a continuous infusion of GLP-1, OXM, and PYY (GOP) on energy intake and expenditure in obese volunteers. Methods: Obese volunteers were randomized to receive an infusion of GOP or placebo in a single-blinded, randomized, placebo-controlled crossover study for 10.5 hours a day. This was delivered subcutaneously using a pump device, allowing volunteers to remain ambulatory. Ad libitum food intake studies were performed during the infusion, and energy expenditure was measured using a ventilated hood calorimeter. Results: Postprandial levels of GLP-1, OXM, and PYY seen post RYGB were successfully matched using 4 pmol/kg/min, 4 pmol/kg/min, and 0.4 pmol/kg/min, respectively. This dose led to a mean reduction of 32% in food intake. No significant effects on resting energy expenditure were observed. Conclusion: This is, to our knowledge, the first time that an acute continuous subcutaneous
العلاقة: Journal of Clinical Endocrinology and Metabolism; http://hdl.handle.net/10044/1/82896Test; MR/K02115X/1; RDC06 79560; RDA11 79560; P31576; 7006/R50U; G0802390; G1000474; MR/J010731/1
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5دورية أكاديمية
المؤلفون: Kuhre, RE, Albrechtsen, NJW, Larsen, O, Jepsen, SL, Balk-Moller, E, Andersen, DB, Deacon, CF, Schoonjans, K, Reimann, F, Gribble, FM, Albrechtsen, R, Hartmann, B, Rosenkilde, MM, Holst, JJ
العلاقة: http://infoscience.epfl.ch/record/258415Test; isi:000439548700007
الإتاحة: https://doi.org/10.1016/j.molmet.2018.03.007Test
http://infoscience.epfl.ch/record/258415Test
النص الكامل