المؤلفون: Fabian I. D., Abdallah E., Abdullahi S. U., Abdulqader R. A., Abdulrahaman A. A., Abouelnaga S., Ademola-Popoola D. S., Adio A., Afifi M. A., Afshar A. R., Aggarwal P., Aghaji A. E., Ahmad A., Akib M. N., Akinsete A., Al Harby L., Al Mesfer S., Al Ani M. H., Alarcon Portabella S., Al-Badri S. A., Alcasabas A. P. A., Al-Dahmash S. A., Alejos A., Alemany-Rubio E., Alfa Bio A. I., Alfonso Carreras Y., Al-Haddad C. E., Al-Hussaini H. H., Ali A. M., Alia D. B., Al-Jadiry M. F., Al-Jumaily U., Alkatan H. M., All-Eriksson C., Al-Mafrachi A. A., Almeida A. A., Alsawidi K. M., Al-Shaheen A. A., Al-Shammary E. H., Amankwaa-Frempong D., Amiruddin P. O., Armytasari I., Astbury N. J., Atalay H. T., Ataseven E., Atchaneeyasakul L. -O., Atsiaya R., Autrata R., Balaguer J., Balayeva R., Barranco H., Bartoszek P., Bartuma K., Bascaran C., Bechrakis N. E., Beck Popovic M., Begimkulova A. S., Benmiloud S., Berete R. C., Berry J. L., Bhaduri A., Bhat S., Bhattacharyya A., Biewald E. M., Binkley E., Blum S., Bobrova N., Boldt H. C., Bonanomi M. T. B., Bouda G. C., Bouguila H., Brennan R. C., Brichard B. G., Buaboonnam J., Budiongo A., Burton M. J., Calderon-Sotelo P., Calle Jara D. A., Camuglia J. E., Cano M. R., Capra M., Caspi S., Cassoux N., Castela G., Castillo L., Catala-Mora J., Cavieres I., Chandramohan A., Chantada G. L., Chaudhry S., Chawla B., Chen W., Chiwanga F. S., Chuluunbat T., Cieslik K., Clark A., Cockcroft R. L., Comsa C., Correa Llano M. G., Corson T. W., Couitchere L., Cowan-Lyn K. E., Csoka M., Dangboon W., Das A., Das P., Das S., Davanzo J. M., Davidson A., De Francesco S., De Potter P., Quintero D K., Demirci H., Desjardins L., Diaz Coronado R. Y., Dimaras H., Dodgshun A. J., Donato Macedo C. R., Dragomir M. D., Du Y., Du Bruyn M., Du Plessis J., Dudeja G., Eerme K., Eka Sutyawan I. W., El Kettani A., Elbahi A. M., Elder J. E., Elhaddad A. M., Elhassan M. M., Elzembely M. M., Ericksen C., Essuman V. A., Evina T. G. A., Ezegwui I. R., Fadoo Z., Fandino A. C., Faranoush M., Fasina O., Fernandez D. D., Fernandez-Teijeiro A., Foster A., Frenkel S., Fu L. D., Fuentes-Alabi S. L., Garcia J. L., Garcia Aldana D., Garcia Pacheco H. N., Geel J. A., Ghassemi F., Giron A. V., Goenz M. A., Gold A. S., Goldberg H., Gole G. A., Gomel N., Gonzalez E., Gonzalez Perez G., Gonzalez-Rodriguez L., Gorfine M., Graells J., Gregersen P. A., Grigorovski N. D., Guedenon K. M., Gunasekera D. S., Gunduz A. K., Gupta H., Gupta S., Gupta V., Hadjistilianou T., Hamel P., Hamid S. A., Hamzah N., Hansen E. D., Harbour J. W., Hartnett M. E., Hasanreisoglu M., Muhammad H., Hassan S., Hautz W., Haydar H., Hederova S., Hessissen L., Hongeng S., Hordofa D. F., Hubbard G. B., Hummelen M., Husakova K., Hussein Al-Janabi A. N., Ibanga A., Ida R., Ilic V. R., Islamov Z., Jairaj V., Janjua T., Jeeva I., Ji X., Jo D. H., Jones M. M., Kabesha Amani T. B., Kabore R. L., Kaliki S., Kalinaki A., Kamsang P., Kantar M., Kapelushnik N., Kardava T., Kebudi R., Keomisy J., Kepak T., Ketteler P., Khan Z. J., Khaqan H. A., Khetan V., Khodabande A., Khotenashvili Z., Kim J. W., Kim J. H., Kiratli H., Kivela T. T., Klett A., Koc I., Kosh Komba Palet J. E., Krivaitiene D., Kruger M., Kulvichit K., Kuntorini M. W., Kyara A., Lam G. C., Larson S. A., Latinovic S., Laurenti K. D., Lavy Y., Lavric Groznik A., Leverant A. A., Li C., Li K., Limbu B., Liu C. -H., Quah B., Lopez J. P., Lukamba R. M., Luna-Fineman S., Lutfi D., Lysytsia L., Madgar S., Magrath G. N., Mahajan A., Maitra P., Maka E., Makimbetov E. K., Maktabi A., Maldonado C., Mallipatna A., Manudhane R., Manzhuova L., Martin-Begue N., Masud S., Matende I. O., Mattosinho C. C., Matua M., Mayet I., Mbumba F. B., McKenzie J. D., Mehrvar A., Mengesha A. A., Menon V., Mercado G. J. V., Mets M. B., Midena E., Miller A., Mishra D. K., Mndeme F. G., Mohamedani A. A., Mohammad M. T., Moll A. C., Montero M. M., Moreira C., Mruthyunjaya P., Msina M. S., Msukwa G., Mudaliar S. S., Muma K. I. M., Munier F. L., Murray T. G., Musa K. O., Mushtaq A., Musika A. A., Mustak H., Mustapha T., Muyen O. M., Myezo K. H., Naidu G., Naidu N., Nair A. G., Natarajan S., Naumenko L., Ndoye Roth P. A., Nency Y. M., Neroev V., Ng Y., Nikitovic M., Nkanga E. D., Nkumbe H. E., Numbi M. N., Nummi K., Nuruddin M., Nyaywa M., Nyirenda C., Obono-Obiang G., Oliver S. C., Oporto J., Ortega-Hernandez M., Oscar A. H., Ossandon D., Pagarra H., Paintsil V., Paiva L., Palanivelu M. S., Papyan R., Parrozzani R., Pascual Morales C. R., Paton K. E., Pe'er J., Peralta Calvo J., Peric S., Pham C. T., Philbert R., Plager D. A., Pochop P., Polania R. A., Polyakov V., Ponce J., Qadir A. O., Qayyum S., Qian J., Refaeli D., Rahman A., Rajkarnikar P., Ramanjulu R., Ramasubramanian A., Ramirez-Ortiz M. A., Randhawa J. K., Randrianarisoa H. L., Raobela L., Rashid R., Reddy M. A., Renner L. A., Reynders D., Ribadu D., Ritter-Sovinz P., Rogowska A., Rojanaporn D., Romero L., Roy S. R., Saab R. H., Saakyan S., Sabhan A. H., Sagoo M. S., Said A. M., Saiju R., Salas B., San Roman Pacheco S., Sanchez G. L., Sanchez Orozco A. J., Sayalith P., Scanlan T. A., Schluter S., Schwab C., Sedaghat A., Seth R., Sgroi M., Shah A. S., Shakoor S. A., Sharma M. K., Sherief S. T., Shields C. L., Sia D., Siddiqui S. N., Sidi cheikh S., Silva S., Singh A. D., Singh U., Singha P., Sitorus R. S., Skalet A. H., Soebagjo H. D., Sorochynska T., Ssali G., Stacey A. W., Staffieri S. E., Stahl E. D., Steinberg D. M., Stones D. K., Strahlendorf C., Suarez M. E. C., Sultana S., Sun X., Superstein R., Supriyadi E., Surukrattanaskul S., Suzuki S., Svojgr K., Sylla F., Tamamyan G., Tan D., Tandili A., Tang J., Tarrillo Leiva F. F., Tashvighi M., Tateshi B., Teh K. H., Tehuteru E. S., Teixeira L. F., Tekavcic Pompe M., Thawaba A. D. M., Theophile T., Toledano H., Trang D. L., Traore F., Tripathy D., Tuncer S., Tyau-Tyau H., Umar A. B., Unal E., Uner O. E., Urbak S. F., Ushakova T. L., Usmanov R. H., Valeina S., Valente P., van Hoefen Wijsard M., Vasquez Anchaya J. K., Vaughan L. O., Veleva-Krasteva N. V., Verma N., Victor A. A., Viksnins M., Villacis Chafla E. G., Villegas V. M., Vishnevskia-Dai V., Waddell K., Wali A. H., Wang Y. -Z., Wangtiraumnuay N., Wetter J., Widiarti W., Wilson M. W., Wime A. D., Wiwatwongwana A., Wiwatwongwana D., Wolley Dod C., Wong E. S., Wongwai P., Wu S. -Q., Xiang D., Xiao Y., Xu B., Xue K., Yaghy A., Yam J. C., Yang H., Yanga J. M., Yaqub M. A., Yarovaya V. A., Yarovoy A. A., Ye H., Yee R. I., Yousef Y. A., Yuliawati P., Zapata Lopez A. M., Zein E., Zhang Y., Zhilyaeva K., Zia N., Ziko O. A., Zondervan M., Bowman R.

المساهمون: Fabian, I. D., Abdallah, E., Abdullahi, S. U., Abdulqader, R. A., Abdulrahaman, A. A., Abouelnaga, S., Ademola-Popoola, D. S., Adio, A., Afifi, M. A., Afshar, A. R., Aggarwal, P., Aghaji, A. E., Ahmad, A., Akib, M. N., Akinsete, A., Al Harby, L., Al Mesfer, S., Al Ani, M. H., Alarcon Portabella, S., Al-Badri, S. A., Alcasabas, A. P. A., Al-Dahmash, S. A., Alejos, A., Alemany-Rubio, E., Alfa Bio, A. I., Alfonso Carreras, Y., Al-Haddad, C. E., Al-Hussaini, H. H., Ali, A. M., Alia, D. B., Al-Jadiry, M. F., Al-Jumaily, U., Alkatan, H. M., All-Eriksson, C., Al-Mafrachi, A. A., Almeida, A. A., Alsawidi, K. M., Al-Shaheen, A. A., Al-Shammary, E. H., Amankwaa-Frempong, D., Amiruddin, P. O., Armytasari, I., Astbury, N. J., Atalay, H. T., Ataseven, E., Atchaneeyasakul, L. -O., Atsiaya, R., Autrata, R., Balaguer, J., Balayeva, R., Barranco, H., Bartoszek, P., Bartuma, K., Bascaran, C., Bechrakis, N. E., Beck Popovic, M., Begimkulova, A. S., Benmiloud, S., Berete, R. C., Berry, J. L., Bhaduri, A., Bhat, S., Bhattacharyya, A., Biewald, E. M., Binkley, E., Blum, S., Bobrova, N., Boldt, H. C., Bonanomi, M. T. B., Bouda, G. C., Bouguila, H., Brennan, R. C., Brichard, B. G., Buaboonnam, J., Budiongo, A., Burton, M. J., Calderon-Sotelo, P., Calle Jara, D. A., Camuglia, J. E., Cano, M. R., Capra, M., Caspi, S., Cassoux, N., Castela, G., Castillo, L., Catala-Mora, J., Cavieres, I., Chandramohan, A., Chantada, G. L., Chaudhry, S., Chawla, B., Chen, W., Chiwanga, F. S., Chuluunbat, T., Cieslik, K., Clark, A., Cockcroft, R. L., Comsa, C., Correa Llano, M. G., Corson, T. W.

مصطلحات موضوعية: Child, Eye Enucleation, Human, Infant, Prospective Studie, Treatment Outcome, Retinal Neoplasm, Retinoblastoma

الوصف: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35839812; info:eu-repo/semantics/altIdentifier/wos/WOS:000863614200019; volume:10; issue:8; firstpage:e1128; lastpage:e1140; journal:THE LANCET GLOBAL HEALTH; https://hdl.handle.net/11577/3454248Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133828984

الإتاحة: https://doi.org/10.1016/S2214-109XTest(22)00250-9
https://hdl.handle.net/11577/3454248Test

المؤلفون: Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, Nyaywa, M

الوصف: BACKGROUND: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS: We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS: The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0-36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8-100·0) for children from high-income countries, 91·2% (89·5-93·0) for children from upper-middle-income countries, 80·3% (78·3-82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76-50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44-18·18), and older age at ...

العلاقة: pii: S2214-109X(22)00250-9; Alia, D. B., Tandili, A., Paiva, L., Wime, A. D., Chantada, G. L., Fandino, A. C., Sgroi, M., Papyan, R., Tamamyan, G., Camuglia, J. E., Gole, G. A., Clark, A., Lam, G. C., Elder, J. E., McKenzie, J. D., Staffieri, S. E., Jones, M. M., Manudhane, R., Sia, D. ,. Nyaywa, M. (2022). The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries. LANCET GLOBAL HEALTH, 10 (8), pp.E1128-E1140. https://doi.org/10.1016/S2214-109XTest(22)00250-9.; http://hdl.handle.net/11343/316977Test

الإتاحة: https://doi.org/10.1016/S2214-109XTest(22)00250-9
http://hdl.handle.net/11343/316977Test

المؤلفون: The Global Retinoblastoma Study Group, Fabian, I. D., Abdallah, E., Abdullahi, S. U., Abdulqader, R. A., Abdulrahaman, A. A., Abouelnaga, S., Ademola-Popoola, D. S., Adio, A., Afifi, M. A., Afshar, A. R., Aggarwal, P., Aghaji, A. E., Ahmad, A., Akib, M. N., Akinsete, A., Al Harby, L., Al Mesfer, S., Al Ani, M. H., Alarcón Portabella, S., Al-Badri, S. A., Alcasabas, A. P. A., Al-Dahmash, S. A., Alejos, A., Alemany-Rubio, E., Alfa Bio, A. I., Alfonso Carreras, Y., Al-Haddad, C. E., Al-Hussaini, H. H., Ali, A. M., Alia, D. B., Al-Jadiry, M. F., Al-Jumaily, U., Alkatan, H. M., All-Eriksson, C., Al-Mafrachi, A. A., Almeida, A. A., Alsawidi, K. M., Al-Shaheen, A. A., Al-Shammary, E. H., Amankwaa-Frempong, D., Amiruddin, P. O., Armytasari, I., Astbury, N. J., Atalay, H. T., Ataseven, E., Atchaneeyasakul, L. -O., Atsiaya, R., Autrata, R., Balaguer, J., Balayeva, R., Barranco, H., Bartoszek, P., Bartuma, K., Bascaran, C., Bechrakis, N. E., Beck Popovic, M., Begimkulova, A. S., Benmiloud, S., Berete, R. C., Berry, J. L., Bhaduri, A., Bhat, S., Bhattacharyya, A., Biewald, E. M., Binkley, E., Blum, S., Bobrova, N., Boldt, H. C., Bonanomi, M. T. B., Bouda, G. C., Bouguila, H., Brennan, R. C., Brichard, B. G., Buaboonnam, J., Budiongo, A., Burton, M. J., Calderón-Sotelo, P., Calle Jara, D. A., Camuglia, J. E., Cano, M. R., Capra, M., Caspi, S., Cassoux, N., Castela, G., Castillo, L., Català-Mora, J., Cavieres, I., Chandramohan, A., Chantada, G. L., Chaudhry, S., Chawla, B., Chen, W., Chiwanga, F. S., Chuluunbat, T., Cieslik, K., Clark, A., Cockcroft, R. L., Comsa, C., Correa Llano, M. G., Corson, T. W., Couitchere, L., Cowan-Lyn, K. E., Csóka, M., Dangboon, W., Das, A., Das, P., Das, S., Davanzo, J. M., Davidson, A., De Francesco, S., De Potter, P., Quintero D, K., Demirci, H., Desjardins, L., Díaz Coronado, R. Y., Dimaras, H., Dodgshun, A. J., Donato Macedo, C. R., Dragomir, M. D., Du, Y., Du Bruyn, M., Du Plessis, J., Dudeja, G., Eerme, K., Eka Sutyawan, I. W., El Kettani, A., Elbahi, A. M., Elder, J. E., Elhaddad, A. M., Elhassan, M. M., Elzembely, M. M., Ericksen, C., Essuman, V. A., Evina, T. G. A., Ezegwui, I. R., Fadoo, Z., Fandiño, A. C., Faranoush, M., Fasina, O., Fernández, D. D., Fernández-Teijeiro, A., Foster, A., Frenkel, S., Fu, L. D., Fuentes-Alabi, S. L., Garcia, J. L., García Aldana, D., Garcia Pacheco, H. N., Geel, J. A., Ghassemi, F., Girón, A. V., Goenz, M. A., Gold, A. S., Goldberg, H., Gole, G. A., Gomel, N., Gonzalez, E., Gonzalez Perez, G., González-Rodríguez, L., Gorfine, M., Graells, J., Gregersen, P. A., Grigorovski, N. D., Guedenon, K. M., Gunasekera, D. S., Gündüz, A. K., Gupta, H., Gupta, S., Gupta, V., Hadjistilianou, T., Hamel, P., Hamid, S. A., Hamzah, N., Hansen, E. D., Harbour, J. W., Hartnett, M. E., Hasanreisoglu, M., Muhammad, H., Hassan, S., Hautz, W., Haydar, H., Hederova, S., Hessissen, L., Hongeng, S., Hordofa, D. F., Hubbard, G. B., Hummelen, M., Husakova, K., Hussein Al-Janabi, A. N., Ibanga, A., Ida, R., Ilic, V. R., Islamov, Z., Jairaj, V., Janjua, T., Jeeva, I., Ji, X., Jo, D. H., Jones, M. M., Kabesha Amani, T. B., Kabore, R. L., Kaliki, S., Kalinaki, A., Kamsang, P., Kantar, M., Kapelushnik, N., Kardava, T., Kebudi, R., Keomisy, J., Kepak, T., Ketteler, P., Khan, Z. J., Khaqan, H. A., Khetan, V., Khodabande, A., Khotenashvili, Z., Kim, J. W., Kim, J. H., Kiratli, H., Kivela, T. T., Klett, A., Koç, I., Kosh Komba Palet, J. E., Krivaitiene, D., Kruger, M., Kulvichit, K., Kuntorini, M. W., Kyara, A., Lam, G. C., Larson, S. A., Latinović, S., Laurenti, K. D., Lavy, Y., Lavric Groznik, A., Leverant, A. A., Li, C., Li, K., Limbu, B., Liu, C. -H., Quah, B., López, J. P., Lukamba, R. M., Luna-Fineman, S., Lutfi, D., Lysytsia, L., Madgar, S., Magrath, G. N., Mahajan, A., Maitra, P., Maka, E., Makimbetov, E. K., Maktabi, A., Maldonado, C., Mallipatna, A., Manudhane, R., Manzhuova, L., Martín-Begue, N., Masud, S., Matende, I. O., Mattosinho, C. C., Matua, M., Mayet, I., Mbumba, F. B., McKenzie, J. D., Mehrvar, A., Mengesha, A. A., Menon, V., Mercado, G. J. V., Mets, M. B., Midena, E., Miller, A., Mishra, D. K., Mndeme, F. G., Mohamedani, A. A., Mohammad, M. T., Moll, A. C., Montero, M. M., Moreira, C., Mruthyunjaya, P., Msina, M. S., Msukwa, G., Mudaliar, S. S., Muma, K. I. M., Munier, F. L., Murray, T. G., Musa, K. O., Mushtaq, A., Musika, A. A., Mustak, H., Mustapha, T., Muyen, O. M., Myezo, K. H., Naidu, G., Naidu, N., Nair, A. G., Natarajan, S., Naumenko, L., Ndoye Roth, P. A., Nency, Y. M., Neroev, V., Ng, Y., Nikitovic, M., Nkanga, E. D., Nkumbe, H. E., Numbi, M. N., Nummi, K., Nuruddin, M., Nyaywa, M., Nyirenda, C., Obono-Obiang, G., Oliver, S. C., Oporto, J., Ortega-Hernández, M., Oscar, A. H., Ossandon, D., Pagarra, H., Paintsil, V., Paiva, L., Palanivelu, M. S., Papyan, R., Parrozzani, R., Pascual Morales, C. R., Paton, K. E., Pe'er, J., Peralta Calvo, J., Perić, S., Pham, C. T., Philbert, R., Plager, D. A., Pochop, P., Polania, R. A., Polyakov, V., Ponce, J., Qadir, A. O., Qayyum, S., Qian, J., Refaeli, D., Rahman, A., Rajkarnikar, P., Ramanjulu, R., Ramasubramanian, A., Ramirez-Ortiz, M. A., Randhawa, J. K., Randrianarisoa, H. L., Raobela, L., Rashid, R., Reddy, M. A., Renner, L. A., Reynders, D., Ribadu, D., Ritter-Sovinz, P., Rogowska, A., Rojanaporn, D., Romero, L., Roy, S. R., Saab, R. H., Saakyan, S., Sabhan, A. H., Sagoo, M. S., Said, A. M., Saiju, R., Salas, B., San Román Pacheco, S., Sánchez, G. L., Sanchez Orozco, A. J., Sayalith, P., Scanlan, T. A., Schlüter, S., Schwab, C., Sedaghat, A., Seth, R., Sgroi, M., Shah, A. S., Shakoor, S. A., Sharma, M. K., Sherief, S. T., Shields, C. L., Sia, D., Siddiqui, S. N., Sidi cheikh, S., Silva, S., Singh, A. D., Singh, U., Singha, P., Sitorus, R. S., Skalet, A. H., Soebagjo, H. D., Sorochynska, T., Ssali, G., Stacey, A. W., Staffieri, S. E., Stahl, E. D., Steinberg, D. M., Stones, D. K., Strahlendorf, C., Suarez, M. E. C., Sultana, S., Sun, X., Superstein, R., Supriyadi, E., Surukrattanaskul, S., Suzuki, S., Svojgr, K., Sylla, F., Tamamyan, G., Tan, D., Tandili, A., Tang, J., Tarrillo Leiva, F. F., Tashvighi, M., Tateshi, B., Teh, K. H., Tehuteru, E. S., Teixeira, L. F., Tekavcic Pompe, M., Thawaba, A. D. M., Theophile, T., Toledano, H., Trang, D. L., Traoré, F., Tripathy, D., Tuncer, S., Tyau-Tyau, H., Umar, A. B., Unal, E., Uner, O. E., Urbak, S. F., Ushakova, T. L., Usmanov, R. H., Valeina, S., Valente, P., van Hoefen Wijsard, M., Vasquez Anchaya, J. K., Vaughan, L. O., Veleva-Krasteva, N. V., Verma, N., Victor, A. A., Viksnins, M., Villacís Chafla, E. G., Villegas, V. M., Vishnevskia-Dai, V., Waddell, K., Wali, A. H., Wang, Y. -Z., Wangtiraumnuay, N., Wetter, J., Widiarti, W., Wilson, M. W., Wime, A. D., Wiwatwongwana, A., Wiwatwongwana, D., Wolley Dod, C., Wong, E. S., Wongwai, P., Wu, S. -Q., Xiang, D., Xiao, Y., Xu, B., Xue, K., Yaghy, A., Yam, J. C., Yang, H., Yanga, J. M., Yaqub, M. A., Yarovaya, V. A., Yarovoy, A. A., Ye, H., Yee, R. I., Yousef, Y. A., Yuliawati, P., Zapata López, A. M., Zein, E., Zhang, Y., Zhilyaeva, K., Zia, N., Ziko, O. A., Zondervan, M., Bowman, R.

المساهمون: The Global Retinoblastoma Study, Group, Fabian, I. D., Abdallah, E., Abdullahi, S. U., Abdulqader, R. A., Abdulrahaman, A. A., Abouelnaga, S., Ademola-Popoola, D. S., Adio, A., Afifi, M. A., Afshar, A. R., Aggarwal, P., Aghaji, A. E., Ahmad, A., Akib, M. N., Akinsete, A., Al Harby, L., Al Mesfer, S., Al Ani, M. H., Alarcón Portabella, S., Al-Badri, S. A., Alcasabas, A. P. A., Al-Dahmash, S. A., Alejos, A., Alemany-Rubio, E., Alfa Bio, A. I., Alfonso Carreras, Y., Al-Haddad, C. E., Al-Hussaini, H. H., Ali, A. M., Alia, D. B., Al-Jadiry, M. F., Al-Jumaily, U., Alkatan, H. M., All-Eriksson, C., Al-Mafrachi, A. A., Almeida, A. A., Alsawidi, K. M., Al-Shaheen, A. A., Al-Shammary, E. H., Amankwaa-Frempong, D., Amiruddin, P. O., Armytasari, I., Astbury, N. J., Atalay, H. T., Ataseven, E., Atchaneeyasakul, L. -O., Atsiaya, R., Autrata, R., Balaguer, J., Balayeva, R., Barranco, H., Bartoszek, P., Bartuma, K., Bascaran, C., Bechrakis, N. E., Beck Popovic, M., Begimkulova, A. S., Benmiloud, S., Berete, R. C., Berry, J. L., Bhaduri, A., Bhat, S., Bhattacharyya, A., Biewald, E. M., Binkley, E., Blum, S., Bobrova, N., Boldt, H. C., Bonanomi, M. T. B., Bouda, G. C., Bouguila, H., Brennan, R. C., Brichard, B. G., Buaboonnam, J., Budiongo, A., Burton, M. J., Calderón-Sotelo, P., Calle Jara, D. A., Camuglia, J. E., Cano, M. R., Capra, M., Caspi, S., Cassoux, N., Castela, G., Castillo, L., Català-Mora, J., Cavieres, I., Chandramohan, A., Chantada, G. L., Chaudhry, S., Chawla, B., Chen, W., Chiwanga, F. S., Chuluunbat, T., Cieslik, K., Clark, A., Cockcroft, R. L., Comsa, C., Correa Llano, M. G.

الوصف: Background: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. Methods: We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. Findings: The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1–63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at ...

وصف الملف: ELETTRONICO

العلاقة: volume:10; issue:8; firstpage:e1128; lastpage:e1140; numberofpages:13; journal:THE LANCET GLOBAL HEALTH; http://hdl.handle.net/11365/1216694Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133828984; https://www.sciencedirect.com/science/article/pii/S2214109X22002509Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397647Test/

الإتاحة: https://doi.org/10.1016/S2214-109XTest(22)00250-9
http://hdl.handle.net/11365/1216694Test
https://www.sciencedirect.com/science/article/pii/S2214109X22002509Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397647Test/

المؤلفون: Al-Hazmi, A, Awad, A, Zwaan, J, Al-Mesfer, S A, Al-Jadaan, I, Al-Mohammed, A

مصطلحات موضوعية: Clinical science - Extended reports

الوصف: Aim: To study the correlation between severity of primary congenital glaucoma (PCG) and success of three types of surgery. Methods: This was a retrospective review of all records of patients diagnosed with PCG up to age 1 year who underwent goniotomy, trabeculotomy, or combined trabeculotomy-trabeculectomy with mitomycin C as initial procedure between 1982 and 2002 at the King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. 532 paediatric glaucoma patients below age 1 year (820 eyes) with a minimum 1 year follow up were identified. The main outcome measures used for the surgeries were postoperative intraocular pressure, stability of the corneal diameter, and maintenance of corneal clarity. Surgical success was defined as a postoperative intraocular pressure of ⩽21 mm Hg without additional medical or surgical therapy, and with decreased corneal oedema, stabilised corneal diameter, and no additional optic nerve damage for at least 1 year after surgery. Complications, time of surgical failure, and follow up were recorded. Results: The eyes were grouped into mild (249), moderate (342), and severe (229) PCG, based on intraocular pressure, corneal diameter, and clarity. All three surgical procedures resulted in high success rates of 81–100% for the mild form of PCG. Eyes classified with moderate glaucoma had a 13%, 40%, and 80% success rate respectively for goniotomy, trabeculotomy, and combined trabeculotomy-trabeculectomy with mitomycin C. The success rate for severe PCG was 10% and 70% for trabeculotomy and combined surgery respectively. Goniotomy was never done for eyes with this condition. Conclusion: Clinical classification of PCG is helpful for surgical decision making. The mild form has a high surgical success regardless of the procedure chosen. Combined trabeculotomy-trabeculectomy with mitomycin C gave the best results for moderate and severe cases of PCG.

وصف الملف: text/html

العلاقة: http://bjo.bmj.com/cgi/content/short/89/4/449Test; http://dx.doi.org/10.1136/bjo.2004.047761Test

الإتاحة: https://doi.org/10.1136/bjo.2004.047761Test
http://bjo.bmj.com/cgi/content/short/89/4/449Test

المؤلفون: Asnaghi L, White DT, Key N, Choi J, Mahale A, Alkatan H, Edward DP, Elkhamary SM, Al-Mesfer S, Maktabi A, Hurtado CG, Lee GY, Carcaboso AM, Mumm JS, Safieh LA, Eberhart CG

المصدر: Oncogene
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

مصطلحات موضوعية: eye diseases

الوصف: Retinoblastoma is the most common intraocular cancer in children. While the primary tumor can often be treated by local or systemic chemotherapy, metastatic dissemination is generally resistant to therapy and remains a leading cause of pediatric cancer death in much of the world. In order to identify new therapeutic targets in aggressive tumors, we sequenced RNA transcripts in five snap frozen retinoblastomas which invaded the optic nerve and five which did not. A three-fold increase was noted in mRNA levels of ACVR1C/ALK7, a type I receptor of the TGF-ß family, in invasive retinoblastomas, while downregulation of DACT2 and LEFTY2, negative modulators of the ACVR1C signaling, was observed in most invasive tumors. A two- to three-fold increase in ACVR1C mRNA was also found in invasive WERI Rb1 and Y79 cells as compared to non-invasive cells in vitro. Transcripts of ACVR1C receptor and its ligands (Nodal, Activin A/B, and GDF3) were expressed in six retinoblastoma lines, and evidence of downstream SMAD2 signaling was present in all these lines. Pharmacological inhibition of ACVR1C signaling using SB505124, or genetic downregulation of the receptor using shRNA potently suppressed invasion, growth, survival, and reduced the protein levels of the mesenchymal markers ZEB1 and Snail. The inhibitory effects on invasion, growth, and proliferation were recapitulated by knocking down SMAD2, but not SMAD3. Finally, in an orthotopic zebrafish model of retinoblastoma, a 55% decrease in tumor spread was noted (p = 0.0026) when larvae were treated with 3 µM of SB505124, as compared to DMSO. Similarly, knockdown of ACVR1C in injected tumor cells using shRNA also resulted in a 54% reduction in tumor dissemination in the zebrafish eye as compared to scrambled shRNA control (p = 0.0005). Our data support a role for the ACVR1C/SMAD2 pathway in promoting invasion and growth of retinoblastoma.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5cab500a943292d20a29ddd3a0d6f801Test
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15267Test

المؤلفون: Mullaney, P. B, Karcioglu, Z. A, Huaman, A. M, Al-Mesfer, S.

المصدر: British Journal of Ophthalmology ; volume 82, issue 5, page 517-521 ; ISSN 0007-1161

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Sensory Systems, Ophthalmology

الإتاحة: https://doi.org/10.1136/bjo.82.5.517Test

المؤلفون: Aldahmesh, M. A., Khan, A. O., Mohamed, J. Y., Alkuraya, H., Ahmed, H., Bobis, S., Al-Mesfer, S., Alkuraya, F. S.

المصدر: Journal of Medical Genetics ; volume 48, issue 9, page 597-601 ; ISSN 0022-2593 1468-6244

الإتاحة: https://doi.org/10.1136/jmedgenet-2011-100306Test

المؤلفون: Al-Hazmi, A., Awad, A., Zwaon, I., Al-Mesfer, S. A., Al-Jadoan, I., Al-Mohammed, A.

المصدر: British Journal of Ophthalmology; Apr2005, Vol. 89 Issue 4, p449-453, 5p

مصطلحات موضوعية: OPHTHALMIC surgery, GLAUCOMA, INTRAOCULAR pressure, IMMUNOSUPPRESSIVE agents, CRANIAL nerves, PEDIATRICS

مستخلص: Aim: To study the correlation between severity of primary congenital glaucoma (PCG) and success of three types of surgery. Methods: This was a retrospective review of all records of patients diagnosed with PCG up to age 1 year who underwent goniotomy, trabeculotomy, or combined trabeculotomy-trabeculectomy with mitomycin C as initial procedure between 1982 and 2002 at the King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. 532 paediatric glaucoma patients below age 1 year (820 eyes) with a minimum 1 year follow up were identified. The main outcome measures used for the surgeries were postoperative intraocular pressure, stability of the corneal diameter, and maintenance of corneal clarify. Surgical success was defined as a postoperative intraocular pressure of ⩽ 21 mm Hg without additional medical or surgical therapy, and with decreased corneal oedema, stabilised corned diameter, and no additional optic nerve damage for at least 1 year after surgery. Complications, time of surgical failure, and follow up were recorded. Results: The eyes were grouped into mild (249), moderate (342), and severe (229) PCG, based on intraocular pressure, corned diameter, and clarity. All three surgical procedures resulted in high success rates of 81-100% for the mild form of PCG. Eyes classified with moderate glaucoma had a 13%, 40%, and 80% success rate respectively for goniotomy, trabeculotomy, and combined trabeculotomy-trabeculectomy with mitomycin C. The success rate for severe PCG was 10% and 70% for trabeculotomy and combined surgery respectively. Goniotomy was never done for eyes with this condition. Conclusion: Clinical classification of PCG is helpful for surgical decision making. The mild form has a high surgical success regardless of the procedure chosen. Combined trabeculotomy-trabeculectomy with mitomycin C gave the best results for moderate and severe cases of PCG. [ABSTRACT FROM AUTHOR]

: Copyright of British Journal of Ophthalmology is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Karcioglu, Z. A., Al-Mesfer, S. A., Mullaney, P. B.

المصدر: Ophthalmology; 1998, Vol. 105 Issue: 7 p1311-1316, 6p

المؤلفون: Al-Hazmi, A., Zwaan, J., Awad, A., Al-Mesfer, S., Mullaney, P. B., Wheeler, D. T.

المصدر: Ophthalmology; 1998, Vol. 105 Issue: 10 p1915-1920, 6p