المؤلفون: Devineni, Divya, Akbarpour, Meleeka, Gong, Yufan, Wong, Nathan

المصدر: Cardiovascular Drugs and Therapy. 38(2)

مصطلحات موضوعية: Cardiovascular risk, Diabetes, GLP-1 receptor agonists, SGLT2-inhibitors, Adult, Male, Humans, Glycemic Control, Precision Medicine, Cardiovascular Diseases, Sodium-Glucose Transporter 2, Risk Factors, Population Health, Diabetes Mellitus, Heart Disease Risk Factors, Atherosclerosis, Glucagon-Like Peptide 1, Glucose, Diabetes Mellitus, Type 2, Glucagon-Like Peptide-1 Receptor, Hypoglycemic Agents

الوصف: PURPOSE: Data are limited on sodium glucose co-transport 2 inhibitors (SGLT2-is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) among real-world cohorts of underrepresented patients. We examined these therapies and glycemic control in US adults with diabetes mellitus (DM) by atherosclerotic cardiovascular disease (ASCVD) risk and sociodemographic factors. METHODS: In the NIH Precision Medicine Initiative All of Us Research Program, we categorized DM as (1) moderate risk, (2) high risk, and (3) with ASCVD. We examined proportions on DM therapies, including SGLT2-i or GLP-1 RA, and at glycemic control by sociodemographic factors and CVD risk groups. RESULTS: Our 81,332 adults aged ≥ 18 years with DM across 340 US sites included 22.3% non-Hispanic Black, 17.2% Hispanic, and 1.8% Asian participants; 31.1%, 30.3%, and 38.6% were at moderate risk, high risk, or with ASCVD, respectively. Those with DM and ASCVD were most likely on SGLT2-i (8.6%) or GLP-1 RA (11.9%). SGLT2-i use was

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4qr8161gTest

المؤلفون: Akbarpour, Meleeka, Tawk, Karen, Frank, Madelyn, Gomez, Alizah S, Mostaghni, Navid, Abouzari, Mehdi

المصدر: World Journal of Otorhinolaryngology - Head and Neck Surgery. 10(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Research, laryngologist, online rating, patient rating, physician review, website

الوصف: ObjectiveTo assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ratings.MethodsAll the American Laryngological Association (ALA) members were queried across several online platforms. Ratings were normalized for comparison on a five-point Likert scale. Ratings were categorized based on context and for positive/negative aspects.ResultsOf the 331 ALA members, 256 (77%) were rated on at least one online platform. Across all platforms, the average overall rating was 4.39 ± 0.61 (range: 1.00-5.00). Specific positive ratings including "bedside manners," "diagnostic accuracy," "adequate time spent with patient," "appropriate follow-up," and "physician timeliness" had significant positive correlations to overall ratings, by Pearson's correlation (P

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/948781zdTest

المؤلفون: Akbarpour, Meleeka, Devineni, Divya, Gong, Yufan, Wong, Nathan

المصدر: Journal of Clinical Medicine. 13(4)

الوصف: In the original publication [...].

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9zn5s987Test

المؤلفون: Lee, Ariel, Abouzari, Mehdi, Akbarpour, Meleeka, Risbud, Adwight, Lin, Harrison W, Djalilian, Hamid R

المصدر: World Journal of Otorhinolaryngology - Head and Neck Surgery. 09(02)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Chronic Pain, Dental/Oral and Craniofacial Disease, Pain Research, Neurosciences, Migraines, Clinical Research, Headaches, Brain Disorders, Women's Health, Aetiology, 2.1 Biological and endogenous factors, Ear, Neurological, association, cochleovestibular migraine, migraine, otologic migraine, tinnitus

الوصف: ObjectiveTinnitus is defined as the perception of sound in the absence of an external source. We propose the hypothesis that migraine can cause exacerbation of tinnitus in some patients.MethodsEnglish literature from PubMed has been reviewed.ResultsStudies have reported a high prevalence of cochlear symptoms in patients with migraine headaches and up to 45% of tinnitus patients have been shown to concomitantly suffer from migraine. Both conditions are thought to stem from central nervous system disturbances, involving disruption of the auditory and trigeminal nerve pathways. One proposed mechanism of this association is the modulation of sound sensitivity by trigeminal nerve activation of the auditory cortex during migraine attacks, resulting in tinnitus fluctuation in some patients. Increased brain and inner ear vascular permeability resulting from trigeminal nerve inflammation, can also cause observed headache and auditory symptoms. Tinnitus and migraine also share a number of symptom triggers including stress, sleep disturbances, and dietary factors. These shared features may help explain promising results of migraine therapies for the treatment of tinnitus.ConclusionGiven the complex association between tinnitus and migraine, further investigation is needed to identify the underlying mechanisms and determine the optimal treatment strategies for managing migraine-related tinnitus patients.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2rx4s3xhTest
https://escholarship.org/content/qt2rx4s3xh/qt2rx4s3xh.pdfTest

المؤلفون: Akbarpour, Meleeka, Devineni, Divya, Gong, Yufan, Wong, Nathan D

المصدر: Journal of Clinical Medicine. 12(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Atherosclerosis, Cardiovascular, Prevention, Patient Safety, Clinical Research, Diabetes, Heart Disease, Good Health and Well Being, dyslipidemia, diabetes mellitus, LDL-cholesterol, triglycerides, statins, treatment, Biomedical and clinical sciences

الوصف: Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categorized DM as (1) moderate risk (≤1 CVD risk factor), (2) high risk (≥2 CVD risk factors), and (3) DM with atherosclerotic CVD (ASCVD). We examined the use of statin and non-statin therapy as well as LDL-C and triglyceride levels. We studied 81,332 participants with DM, which included 22.3% non-Hispanic Black and 17.2% Hispanic. A total of 31.1% had ≤1 DM risk factor, 30.3% had ≥2 DM risk factors, and 38.6% of participants had DM with ASCVD. Only 18.2% of those with DM and ASCVD were on high-intensity statins. Overall, 5.1% were using ezetimibe and 0.6% PCSK9 inhibitors. Among those with DM and ASCVD, only 21.1% had LDL-C < 70 mg/dL. Overall, 1.9% of participants with triglycerides ≥ 150 mg/dL were on icosapent ethyl. Those with DM and ASCVD were more likely to be on high-intensity statins, ezetimibe, and icosapent ethyl. Guideline-recommended use of high-intensity statins and non-statin therapy among our higher risk DM patients is lacking, with LDL-C inadequately controlled.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8j58f2k3Test

المؤلفون: Akbarpour, Meleeka, Vu, Anderson Nguyen, Duong, Amber, Wang, Jessica, Ahn, Minnah, Patel, Vivek, Ediriwickrema, Lilangi S, Crow, Robert, To, Josiah K, Browne, Andrew

المصدر: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 63(7)

مصطلحات موضوعية: Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry, Ophthalmology and optometry

الوصول الحر: https://escholarship.org/uc/item/4wt6k4rqTest

المؤلفون: Akbarpour, Meleeka, Tawk, Karen, Frank, Madelyn, Gomez, Alizah S., Mostaghni, Navid, Abouzari, Mehdi

المساهمون: National Center for Advancing Translational Sciences, National Center for Research Resources

المصدر: World Journal of Otorhinolaryngology - Head and Neck Surgery ; volume 10, issue 1, page 1-6 ; ISSN 2095-8811 2589-1081

الوصف: Objective To assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ratings. Methods All the American Laryngological Association (ALA) members were queried across several online platforms. Ratings were normalized for comparison on a five‐point Likert scale. Ratings were categorized based on context and for positive/negative aspects. Results Of the 331 ALA members, 256 (77%) were rated on at least one online platform. Across all platforms, the average overall rating was 4.39 ± 0.61 (range: 1.00–5.00). Specific positive ratings including “bedside manners,” “diagnostic accuracy,” “adequate time spent with patient,” “appropriate follow‐up,” and “physician timeliness” had significant positive correlations to overall ratings, by Pearson's correlation ( P < 0.001). Long wait times had significant negative correlations to overall ratings ( P < 0.001). Conclusion Online ratings and comments for laryngologists are significantly influenced by patient perceptions of bedside manner, physician competence, and time spent with the patient.

الإتاحة: https://doi.org/10.1002/wjo2.95Test

المؤلفون: Lee, Ariel, Abouzari, Mehdi, Akbarpour, Meleeka, Risbud, Adwight, Lin, Harrison W., Djalilian, Hamid R.

المساهمون: National Center for Advancing Translational Sciences, National Center for Research Resources

المصدر: World Journal of Otorhinolaryngology - Head and Neck Surgery ; volume 9, issue 2, page 107-114 ; ISSN 2095-8811 2589-1081

الوصف: Objective Tinnitus is defined as the perception of sound in the absence of an external source. We propose the hypothesis that migraine can cause exacerbation of tinnitus in some patients. Methods English literature from PubMed has been reviewed. Results Studies have reported a high prevalence of cochlear symptoms in patients with migraine headaches and up to 45% of tinnitus patients have been shown to concomitantly suffer from migraine. Both conditions are thought to stem from central nervous system disturbances, involving disruption of the auditory and trigeminal nerve pathways. One proposed mechanism of this association is the modulation of sound sensitivity by trigeminal nerve activation of the auditory cortex during migraine attacks, resulting in tinnitus fluctuation in some patients. Increased brain and inner ear vascular permeability resulting from trigeminal nerve inflammation, can also cause observed headache and auditory symptoms. Tinnitus and migraine also share a number of symptom triggers including stress, sleep disturbances, and dietary factors. These shared features may help explain promising results of migraine therapies for the treatment of tinnitus. Conclusion Given the complex association between tinnitus and migraine, further investigation is needed to identify the underlying mechanisms and determine the optimal treatment strategies for managing migraine‐related tinnitus patients.

الإتاحة: https://doi.org/10.1002/wjo2.81Test

المؤلفون: Devineni, Divya, Akbarpour, Meleeka, Gong, Yufan, Wong, Nathan D.

المساهمون: Foundation for the National Institutes of Health

المصدر: Cardiovascular Drugs and Therapy ; ISSN 0920-3206 1573-7241

مصطلحات موضوعية: Pharmacology (medical), Cardiology and Cardiovascular Medicine, Pharmacology, General Medicine

الوصف: Purpose Data are limited on sodium glucose co-transport 2 inhibitors (SGLT2-is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) among real-world cohorts of underrepresented patients. We examined these therapies and glycemic control in US adults with diabetes mellitus (DM) by atherosclerotic cardiovascular disease (ASCVD) risk and sociodemographic factors. Methods In the NIH Precision Medicine Initiative All of Us Research Program, we categorized DM as (1) moderate risk, (2) high risk, and (3) with ASCVD. We examined proportions on DM therapies, including SGLT2-i or GLP-1 RA, and at glycemic control by sociodemographic factors and CVD risk groups. Results Our 81,332 adults aged ≥ 18 years with DM across 340 US sites included 22.3% non-Hispanic Black, 17.2% Hispanic, and 1.8% Asian participants; 31.1%, 30.3%, and 38.6% were at moderate risk, high risk, or with ASCVD, respectively. Those with DM and ASCVD were most likely on SGLT2-i (8.6%) or GLP-1 RA (11.9%). SGLT2-i use was < 10% in those with heart failure or chronic kidney disease. The odds (95% CI) of SGLT2-i use were greater among men (1.35 [1.20, 1.53]) and Asian persons (2.31 [1.78, 2.96]), with GLP-1 RA being less common (0.78 [0.70, 0.86]) in men. GLP-1 RA use was greater among those with health insurance, and both GLP-1 RA and SGLT2-i greater within lower income groups. 72.0% of participants had HbA1c < 7%; Hispanic persons were least likely at glycemic control. Conclusions Treatment with SGLT2-is and GLP-1 RAs remains low, even among higher ASCVD risk persons with DM and use is even lower among underserved groups.

الإتاحة: https://doi.org/10.1007/s10557-022-07403-2Test

المؤلفون: Rao, Sonali, Akbarpour, Meleeka, Tang, Jessica J.

المصدر: Mechanical Ventilation Amid the COVID-19 Pandemic ; page 25-29 ; ISBN 9783030879778 9783030879785

الإتاحة: https://doi.org/10.1007/978-3-030-87978-5_3Test