المؤلفون: Lehto, Mika, Haukka, Jari, Aro, Aapo, Halminen, Olli, Putaala, Jukka, Linna, Miika, Mustonen, Pirjo, Kinnunen, Janne, Kouki, Elis, Niiranen, Jussi, Luojus, Alex, Tiili, Paula, Itäinen-Strömberg, Saga, Hartikainen, Juha, Airaksinen, Juhani K. E.

المساهمون: Clinicum, University of Helsinki, HUS Heart and Lung Center, Department of Public Health, Jari Haukka / Principal Investigator, HUS Neurocenter, Department of Neurosciences, Neurologian yksikkö, Kardiologian yksikkö

مصطلحات موضوعية: Atrial Fibrillation, Epidemiology, Health Care Economics and Organizations, 3121 General medicine, internal medicine and other clinical medicine

الوصف: Peer reviewed

وصف الملف: application/pdf

العلاقة: Lehto , M , Haukka , J , Aro , A , Halminen , O , Putaala , J , Linna , M , Mustonen , P , Kinnunen , J , Kouki , E , Niiranen , J , Luojus , A , Tiili , P , Itäinen-Strömberg , S , Hartikainen , J & Airaksinen , J K E 2022 , ' Comprehensive nationwide incidence and prevalence trends of atrial fibrillation in Finland ' , Open Heart , vol. 9 , no. 2 , e002140 . https://doi.org/10.1136/openhrt-2022-002140Test; ORCID: /0000-0001-7030-6740/work/125976996; ORCID: /0000-0003-1450-6208/work/125978375; e2e0852e-0afa-4ef0-9c1c-bbd1ae9c28c4; http://hdl.handle.net/10138/352446Test; 000890806100001

الإتاحة: http://hdl.handle.net/10138/352446Test

المؤلفون: Lehto, Mika, Haukka, Jari, Aro, Aapo, Halminen, Olli, Putaala, Jukka, Linna, Miika, Mustonen, Pirjo, Kinnunen, Janne, Kouki, Elis, Niiranen, Jussi, Luojus, Alex, Tiili, Paula, Itäinen-Strömberg, Saga, Hartikainen, Juha, Airaksinen, Juhani K E

المساهمون: Aarne Koskelon Säätiö, Sydäntutkimussäätiö, Helsinki and Uusimaa Hospital District research fund, Yrjö Jahnssonin Säätiö, Sigrid Jusélius Foundation

المصدر: Open Heart ; volume 9, issue 2, page e002140 ; ISSN 2053-3624

الوصف: Objective Atrial fibrillation (AF) is a worldwide healthcare challenge owing to population ageing. In this study, we assessed the current trends in the incidence and prevalence of AF for the first time in an unselected, nationwide population. Methods In the Finnish Anticoagulation in Atrial Fibrillation study, we gathered comprehensive data including all primary, secondary and tertiary healthcare visits and drug reimbursement from national healthcare registers to identify all patients with incident AF between 2004 and 2018 in Finland. Incident AF was defined as new-onset AF occurring after 2007. Time trends for the incidence and prevalence of AF were calculated and stratified by sex and age. Results A total of 411 387 patients with AF diagnosis were documented in Finland during 2004–2018. In 2018, the incidence and prevalence of AF in the total Finnish population were 469/100 000 and 4.1%, respectively. The incidence of new-onset AF in the adult population (≥20 years) increased from 471/100 000 in 2007 to 604/100 000 in 2018, but the age-adjusted incidence remained stable. The prevalence of AF increased in the adult population from 2.5% to 5.2%, and was higher in men than in women (5.9% vs 4.6%, p<0.001). The incidence and prevalence of AF increased with age and were 3194/100 000 and 23.4% in patients older than 75 years. Conclusions Based on comprehensive nationwide data including primary care, we observed an increasing incidence and prevalence of AF over time. This increase was strongly age-dependent with the age-standardised incidence remaining stable during 2007–2018. Trial registration number NCT04645537 .

الإتاحة: https://doi.org/10.1136/openhrt-2022-002140Test

المؤلفون: Putaala, Jukka, Teppo, Konsta, Halminen, Olli, Haukka, Jari, Tiili, Paula, Jaakkola, Jussi, Karlsson, Elin, Linna, Miika, Mustonen, Pirjo, Kinnunen, Janne, Kiviniemi, Tuomas, Aro, Aapo, Hartikainen, Juha, Airaksinen, Juhani K. E., Lehto, Mika

المصدر: Stroke (00392499); Jan2024, Vol. 55 Issue 1, p122-130, 9p

المؤلفون: Relander, Arto, Hellman, Tapio, Vasankari, Tuija, Nuotio, Ilpo, Airaksinen, Juhani K. E., Kiviniemi, Tuomas

المساهمون: Finnish Medical Foundation, Finnish Foundation for Cardiovascular Research, State Clinical Research Fund of Turku University Hospital, Finnish Cardiac Society, Emil Aaltonen Foundation, Maud Kuistila Foundation

المصدر: Annals of Medicine ; volume 53, issue 1, page 722-729 ; ISSN 0785-3890 1365-2060

الإتاحة: https://doi.org/10.1080/07853890.2021.1930139Test

المؤلفون: Nissinen, Maunu, Lehto, Joonas, Biancari, Fausto, Nieminen, Tuomo, Malmberg, Markus, Yannopoulos, Fredrik, Salmi, Samuli, Airaksinen, Juhani K. E., Kiviniemi, Tuomas, Hartikainen, Juha E. K.

المساهمون: Department of Medicine, HUS Heart and Lung Center, South Carelia Social and Health care District Eksote, HYKS erva, Päijät-Häme Welfare Consortium, HUS Internal Medicine and Rehabilitation, Clinicum, Helsinki University Hospital Area

مصطلحات موضوعية: 3121 General medicine, internal medicine and other clinical medicine, aortic valve replacement, bioprosthesis, mortality, paroxysmal atrial fibrillation, stroke, SURVIVAL, METAANALYSIS, STENOSIS, RISK STRATIFICATION, OUTCOMES, THROMBOEMBOLISM

الوصف: Background Preoperative permanent atrial fibrillation (AF) is associated with impaired outcome after surgical aortic valve replacement (SAVR). The impact of preoperative paroxysmal AF, however, has remained elusive. Purpose We assessed the impact of preoperative paroxysmal AF on outcome in patients undergoing SAVR with bioprosthesis. Methods A total of 666 patients undergoing isolated AVR with a bioprosthesis were included. Survival data was obtained from the national registry Statistics Finland. Patients were divided into three groups according to the preoperative rhythm: sinus rhythm (n = 502), paroxysmal AF (n = 90), and permanent AF (n = 74). Results Patients in the sinus rhythm and paroxysmal AF groups did not differ with respect to age (P = .484), gender (P = .402) or CHA(2)DS(2)-VASc score (P = .333). At 12-month follow-up, AF was present in 6.2% of sinus rhythm patients and in 42.4% of paroxysmal AF patients (P <.001). During follow-up, incidence of fatal strokes in the paroxysmal AF group was higher compared to sinus rhythm group (1.9 vs 0.4 per 100 patient-years, HR 4.4 95% Cl 1.8-11.0, P = .001). Cardiovascular mortality was higher in the paroxysmal AF group than in the sinus rhythm group (5.0 vs 3.0 per 100 patient-years, HR 1.70 95% CI 1.05-2.76, P = .03) and equal to patients in the permanent AF (5.0 per 100 patient-years). Conclusion Patients undergoing SAVR with bioprosthesis and history of paroxysmal AF had higher risk of developing permanent AF, cardiovascular mortality and incidence of fatal strokes compared to patients with preoperative sinus rhythm. Life-long anticoagulation should be considered in patients with a history of preoperative paroxysmal AF. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Nissinen , M , Lehto , J , Biancari , F , Nieminen , T , Malmberg , M , Yannopoulos , F , Salmi , S , Airaksinen , J K E , Kiviniemi , T & Hartikainen , J E K 2020 , ' Preoperative paroxysmal atrial fibrillation predicts high cardiovascular mortality in patients undergoing surgical aortic valve replacement with a bioprosthesis: CAREAVR study ' , Clinical Cardiology (Hoboken) , vol. 43 , no. 4 , pp. 401-409 . https://doi.org/10.1002/clc.23329Test; RIS: urn:7E8B8C6BDF4BC2DAB5FCE1EBE096BCC2; ORCID: /0000-0003-1755-1688/work/76334411; 52b94b23-6965-4fc1-a4cf-430bb79dee1a; http://hdl.handle.net/10138/316705Test; 000511020700001

الإتاحة: http://hdl.handle.net/10138/316705Test

المؤلفون: Bouisset, Frederic, Sia, Jussi, Mizukami, Takuya, Karjalainen, Pasi P., Tonino, Pim A. L., Pijls, Nico H. J., Van der Heyden, Jan, Romppanen, Hannu, Kervinen, Kari, Airaksinen, Juhani K. E., Lalmand, Jacques, Frambach, Peter, Roza da Costa, Bruno, Collet, Carlos, De Bruyne, Bernard

المصدر: JAMA Cardiology ; volume 8, issue 7, page 703 ; ISSN 2380-6583

الوصف: Importance Titanium-nitride-oxide (TiNO)–coated stents show faster strut coverage compared with drug-eluting stents without excessive intimal-hyperplasia observed in bare metal stents. It is important to study long-term clinical outcomes after treatment of patients with an acute coronary syndrome (ACS) by TiNO-coated stents, which are neither drug-eluting stents nor bare metal stents. Objective To compare the rate of main composite outcome of cardiac death, myocardial infarction (MI), or ischemia-driven target lesion revascularization at 5 years in patients with ACS randomized to receive either a TiNO-coated stent or a third-generation everolimus-eluting stent (EES). Design, Setting, and Participants This multicenter, randomized, controlled, open-label trial was conducted in 12 clinical sites in 5 European countries and enrolled patients from January 2014 to August 2016. Patients presenting with ACS (ST-segment elevation MI, non–ST-segment elevation MI, and unstable angina) with at least 1 de novo lesion were randomized to receive either a TiNO-coated stent or an EES. The present report analyzes the long-term follow-up for the main composite outcome and its individual components. Analysis took place between November 2022 to March 2023. Main outcome The primary end point was a composite of cardiac death, MI, or target lesion revascularization at 12-month follow-up. Results A total of 1491 patients with ACS were randomly assigned to receive either TiNO-coated stents (989 [66.3%]) or EES (502 [33.7%]). The mean (SD) age was 62.7 (10.8) years, and 363 (24.3%) were female. At 5 years, the main composite outcome events occurred in 111 patients (11.2%) in the TiNO group vs 60 patients (12%) in the EES group (hazard ratio [HR], 0.94; 95% CI, 0.69-1.28; P = .69). The rate of cardiac death was 0.9% (9 of 989) vs 3.0% (15 of 502) (HR, 0.30; 95% CI, 0.13-0.69; P = .005), the rate of MI was 4.6% (45 of 989) vs 7.0% (35 of 502) (HR, 0.64; 95% CI, 0.41-0.99; P = .049), the rate of stent thrombosis was 1.2% (12 of 989) vs 2.8% ...

الإتاحة: https://doi.org/10.1001/jamacardio.2023.1373Test
https://jamanetwork.com/journals/jamacardiology/articlepdf/2805071/jamacardiology_bouisset_2023_br_230008_1688580105.37218.pdfTest

المؤلفون: Karjalainen, Pasi P., Niemela, Matti, Laine, Mika, Airaksinen, Juhani K. E., Ylitalo, Antti, Nammas, Wail

المساهمون: Kardiologian yksikkö, Clinicum, Department of Medicine, HUS Heart and Lung Center

مصطلحات موضوعية: OPTICAL COHERENCE TOMOGRAPHY, ELUTING STENT IMPLANTATION, ADJUNCTIVE BALLOON POSTDILATATION, INTRAVASCULAR ULTRASOUND ANALYSIS, COATED BIOACTIVE STENTS, TERM-FOLLOW-UP, DEPLOYMENT, THROMBOSIS, MALAPPOSITION, UNDEREXPANSION, General medicine, internal medicine and other clinical medicine

الوصف: Stent underexpansion is associated with worse outcome after stent implantation. Whether post-dilation (PD) improves outcome in patients with acute coronary syndrome (ACS) remains unclear. We performed post hoc analysis of outcome in patients from the BASE ACS (A prospective randomized comparison of titanium-nitride-oxide-coated bioactive stents with everolimus-eluting stents in acute coronary syndrome) trial who underwent PD versus those who did not. The BASE ACS trial randomized 827 patients (1:1) with ACS to receive either titanium-nitride-oxide coated bioactive stents or everolimus-eluting stents. The primary end point was major adverse cardiac events (MACE): a composite of cardiac death, nonfatal myocardial infarction (MI), or ischemia-driven target lesion revascularization. Follow-up was planned at 12 months and yearly thereafter for up to 7 years. Of 827 patients enrolled in the BASE ACS trial, 357 (43.2%) underwent PD. Median follow-up duration was 5 years. Patients who, underwent PD had less frequent nonfatal MI events at long-term follow-up, compared with those who did not (4.5% vs 8.5%, respectively, p = 0.02). The rates of MACE (15.7% vs 15.1%, respectively, p = 0.81), and the other endpoints, were not significantly different (p >0.5 for all). The results were consistent in propensity score matched analysis (270 pairs). In patients treated with bioactive stents, those who underwent PD had a trend for a fewer nonfatal MI events (p = 0.076). Comparably, in patients treated with everofimus-eluting stents, MACE and all the individual end points were comparable (p >0.5 for all). In conclusion, patients treated with early percutaneous coronary intervention for ACS who underwent PD had less frequent nonfatal MI events at long-term follow-up, compared with those who did not; MACE rates were not significantly different. (C) 2016 Elsevier Inc. All rights reserved. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Karjalainen , P P , Niemela , M , Laine , M , Airaksinen , J K E , Ylitalo , A & Nammas , W 2017 , ' Usefulness of Post-coronary Dilation to Prevent Recurrent Myocardial Infarction in Patients Treated With Percutaneous Coronary Intervention for Acute Coronary Syndrome (from the BASE ACS Trial) ' , American Journal of Cardiology , vol. 119 , no. 3 , pp. 345-350 . https://doi.org/10.1016/j.amjcard.2016.09.057Test; http://hdl.handle.net/10138/233341Test; f314ee60-cf48-4223-b29c-0a62080752a9; 85007021754; 000393533200001

الإتاحة: http://hdl.handle.net/10138/233341Test

المؤلفون: Biancari, Fausto, Anttila, Vesa, Dell’Aquila, Angelo M., Airaksinen, Juhani K. E., Brascia, Debora

المصدر: Journal of Cardiothoracic Surgery ; volume 13, issue 1 ; ISSN 1749-8090

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, General Medicine, Surgery, Pulmonary and Respiratory Medicine

الإتاحة: https://doi.org/10.1186/s13019-018-0710-0Test

المؤلفون: Itäinen, Saga, Lehto, Mika, Vasankari, Tuija, Mustonen, Pirjo, Kotamäki, Mervi, Numminen, Anna, Lahtela, Heli, Bah, Aissa, Hartikainen, Juha, Hekkala, Anna-Mari, Airaksinen, Juhani K E

المصدر: EP Europace ; volume 20, issue 4, page 565-568 ; ISSN 1099-5129 1532-2092

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1093/europace/eux116Test
http://academic.oup.com/europace/article-pdf/20/4/565/24524754/eux116.pdfTest

المؤلفون: Tauriainen, Tuomas, Kinnunen, Eeva-Maija, Laitinen, Idamaria, Anttila, Vesa, Kiviniemi, Tuomas, Airaksinen, Juhani K E, Biancari, Fausto

المصدر: Interactive CardioVascular and Thoracic Surgery ; volume 26, issue 2, page 325-327 ; ISSN 1569-9293 1569-9285

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1093/icvts/ivx320Test
http://academic.oup.com/icvts/article-pdf/26/2/325/23575328/ivx320.pdfTest