المؤلفون: Pandey, J P, Montes-Cano, M A, Aguilar-Reina, J, Gonzalez-Escribano, M F

المصدر: Clinical and Experimental Immunology ; volume 150, issue 3, page 518-522 ; ISSN 0009-9104 1365-2249

مصطلحات موضوعية: Immunology, Immunology and Allergy

الوصف: Summary Particular alleles of human leucocyte antigen (HLA) and immunoglobulin gamma (GM) and immunoglobulin kappa (KM) allotypes (polymorphic determinants of IgG heavy chains and κ-type light chains, respectively) are associated with the outcome of several infections. To examine their role in the outcome of hepatitis C virus (HCV) infection, we genotyped 50 individuals with resolved and 117 with persistent HCV infection. None of the GM, KM or HLA-C genotypes by themselves were associated with the resolution or persistence of HCV infection. However, particular combinations of HLA and GM genotypes were associated significantly with the outcome of HCV infection. Subjects with the HLA C1C1 genotype, in the absence of GM ff, were more than seven times [odds ratio (OR) 7·15] as likely to have persistent infection as the subjects who lacked both these genotypes. The presence of GM ff, in the absence of HLA C1C2, was associated with the resolution of infection (OR 0·27). The absence of GM fz, in the presence of HLA C2C2, was also associated with the resolution of infection (OR 0·27). Compared to the subjects who lacked both these genotypes, subjects with GM fz, in the absence of HLA C1C2, were almost four times as likely to have persistent infection (OR 3·91); similarly, subjects with HLA C1C2, in the absence of GM fz, were almost three times as likely to have persistent infection (OR 2·80). These results show, for the first time, interactive effects of GM and HLA genotypes in the outcome of HCV infection.

الإتاحة: https://doi.org/10.1111Test/j.1365-2249.2007.03519.x
https://academic.oup.com/cei/article-pdf/150/3/518/42037718Test/j.1365-2249.2007.03519.x.pdf

المؤلفون: Roque Cuéllar, M. C., García‐Lozano, J. R., Sánchez, B., Praena‐Fernández, J. M., Martínez Sierra, C., Núñez‐Roldán, A., Aguilar‐Reina, J.

المساهمون: Instituto de Salud Carlos III

المصدر: Journal of Viral Hepatitis ; volume 23, issue 8, page 606-613 ; ISSN 1352-0504 1365-2893

الوصف: Summary The expression of activation‐induced cytidine deaminase, B‐aggressive lymphoma, cyclin D1 and serine/threonine kinase 15 genes, among others, is increased in B cells from patients with chronic hepatitis C virus ( HCV ) infection. It is unknown whether the level of expression of these genes in B cells is increased in patients with hepatitis C who have achieved a sustained virological response ( SVR ) but who have persistent, detectable HCV RNA , so‐called occult infection. Eighty‐three patients who achieved and SVR , 27 with detectable HCV and 56 without detectable HCV RNA , 28 chronic hepatitis C patients and 32 healthy controls were studied. RNA was extracted from B cells, and gene expression levels were measured by RT ‐ PCR . Patients with chronic HCV and those who achieved an SVR (with and without persistent low‐level HCV RNA ) showed a statistically significant higher expression compared to healthy controls, of activation‐induced cytidine deaminase ( P = 0.004, P < 0.001 and P = 0.002, respectively), B‐aggressive lymphoma ( P < 0.001, P = 0.001 and P = 0.006) and cyclin D1 ( P = 0.026, P = 0.001; P = 0.038). For activation‐induced cytidine deaminase patients with an SVR and ‘occult infection’ had a statistically significantly higher expression level than patients with and SVR without ‘occult infection’ ( P = 0.014). The higher expression levels found for activation‐induced cytidine deaminase, together with other genes indicates that these B lymphomagenesis‐related genes are upregulated following HCV therapy and this is more marked when HCV can be detected in PBMC s.

الإتاحة: https://doi.org/10.1111/jvh.12526Test

المؤلفون: Aguilar Reina, J.

المصدر: Medicine - Programa de Formación Médica Continuada Acreditado ; volume 11, issue 11, page 660-662 ; ISSN 0304-5412

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/s0304-5412Test(12)70363-3
https://api.elsevier.com/content/article/PII:S0304541212703633?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0304541212703633?httpAccept=text/plainTest

المؤلفون: Aguilar Reina, J.

المصدر: Medicine - Programa de Formación Médica Continuada Acreditado ; volume 11, issue 11, page 652-659 ; ISSN 0304-5412

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/s0304-5412Test(12)70362-1
https://api.elsevier.com/content/article/PII:S0304541212703621?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0304541212703621?httpAccept=text/plainTest

المؤلفون: Roque-Cuéllar, M. C., Sánchez, B., García-Lozano, J. R., Praena-Fernández, J. M., Núñez-Roldán, A., Aguilar-Reina, J.

المصدر: Journal of Viral Hepatitis ; volume 18, issue 10, page e541-e549 ; ISSN 1352-0504

الإتاحة: https://doi.org/10.1111Test/j.1365-2893.2011.01464.x

المؤلفون: Romero-Gómez, M., Montes-Cano, M.A., García-Lozano, J.R., Abad-Molina, C., Barroso, N., Maraver, M., Aguilar-Reina, J., Núñnez-Roldán, A., González-Escribano, M.F.

المصدر: Journal of Hepatology ; volume 52, page S454 ; ISSN 0168-8278

مصطلحات موضوعية: Hepatology

الإتاحة: https://doi.org/10.1016/s0168-8278Test(10)61176-2
https://api.elsevier.com/content/article/PII:S0168827810611762?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168827810611762?httpAccept=text/plainTest

المؤلفون: Aguilar Reina,J.

المصدر: Revista Española de Enfermedades Digestivas v.101 n.10 2009

وصف الملف: text/html

الإتاحة: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009001000001Test

المؤلفون: Montes-Cano, M.A., García-Lozano, J.R., Aguilar-Reina, J., Romero-Gómez, M., Barroso, N., Nuñez-Roldán, A., Martín, J., González-Escribano, M.F.

المصدر: Viral Immunology ; volume 21, issue 4, page 491-494 ; ISSN 0882-8245 1557-8976

مصطلحات موضوعية: Virology, Molecular Medicine, Immunology

الإتاحة: https://doi.org/10.1089/vim.2008.0040Test

المؤلفون: Aguilar-Reina, J., Roque-Cuellar, M.C., Alvarez-Marquez, M.A., Garcia-Lozano, R., Nunez, A., Gonzalez-Escribano, M.F., Sanchez, B.

المصدر: Journal of Hepatology ; volume 48, page S268-S269 ; ISSN 0168-8278

مصطلحات موضوعية: Hepatology

الإتاحة: https://doi.org/10.1016/s0168-8278Test(08)60721-7
https://api.elsevier.com/content/article/PII:S0168827808607217?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168827808607217?httpAccept=text/plainTest

المؤلفون: Aguilar Reina, J

مصطلحات موضوعية: Hepatitis

وصف الملف: 76 p. + 12 p. de lám. : il.; 21 cm

العلاقة: Medicina; 19; http://bibliotecavirtual.ranm.es/ranm/es/consulta/registro.do?id=16901Test

الإتاحة: http://bibliotecavirtual.ranm.es/ranm/es/consulta/registro.do?id=16901Test