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1دورية أكاديمية
المؤلفون: Sugier, PE, Lucotte, EA, Domenighetti, C, Law, MH, Iles, MM, Brown, K, Amos, C, McKay, JD, Hung, RJ, Karimi, M, Bacq-Daian, D, Boland-Auge, A, Olaso, R, Deleuze, JF, Lesueur, F, Ostroumova, E, Kesminiene, A, de Vathaire, F, Guenel, P, Sreelatha, AAK, Schulte, C, Grover, S, May, P, Bobbili, DR, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, AB, Hernandez, DG, Edsall, C, Mellick, GD, Zimprich, A, Pirker, W, Rogaeva, E, Lang, AE, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschlander, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Nakayama, A, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ, Kolber, P, van de Warrenburg, BPC, Bloem, BR, Aasly, J, Toft, M, Pihlstrom, L, Guedes, LC, Ferreira, JJ, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, N, Ran, C, Belin, AC, Puschmann, A, Rodstrom, EY, Clarke, CE, Morrison, KE, Tan, M, Krainc, D, Burbulla, LF, Farrer, MJ, Kruger, R, Gasser, T, Sharma, M, Truong, T, Elbaz, A
المصدر: Movement disorders : official journal of the Movement Disorder Society. 38(4):604-615
مصطلحات موضوعية: Medicin och hälsovetenskap
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2دورية أكاديمية
المؤلفون: Grover, S, Sreelatha, AAK, Pihlstrom, L, Domenighetti, C, Schulte, C, Sugier, PE, Radivojkov-Blagojevic, M, Lichtner, P, Mohamed, O, Portugal, B, Landoulsi, Z, May, P, Bobbili, D, Edsall, C, Bartusch, F, Hanussek, M, Kruger, J, Hernandez, DG, Blauwendraat, C, Mellick, GD, Zimprich, A, Pirker, W, Tan, M, Rogaeva, E, Lang, A, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschlander, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Burbulla, LF, Matsuo, H, Kawamura, Y, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ, Pavelka, L, van de Warrenburg, BPC, Bloem, BR, Singleton, AB, Aasly, J, Toft, M, Guedes, LC, Ferreira, JJ, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, NL, Ran, C, Belin, AC, Puschmann, A, Hellberg, C, Clarke, CE, Morrison, KE, Krainc, D, Farrer, MJ, Kruger, R, Elbaz, A, Gasser, T, Sharma, M
المصدر: Neurology. 99(7):E698-E710
مصطلحات موضوعية: Medicin och hälsovetenskap
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3دورية أكاديمية
المؤلفون: Domenighetti, C, Douillard, V, Sugier, PE, Sreelatha, AAK, Schulte, C, Grover, S, May, P, Bobbili, DR, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, AB, Hernandez, DG, Edsall, C, Gourraud, PA, Mellick, GD, Zimprich, A, Pirker, W, Rogaeva, E, Lang, ANE, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschlander, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Duga, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Nakayama, A, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ, Kolber, P, van de Warrenburg, BPC, Bloem, BR, Aasly, J, Toft, M, Pihlstrom, L, Guedes, LC, Ferreira, JJ, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, NL, Ran, CE, Belin, AC, Puschmann, A, Rodstrom, EY, Clarke, CE, Morrison, KE, Tan, MU, KraincMD, D, Burbulla, LF, Farrer, MJ, Kruger, R, Gasser, T, Sharma, M, Vince, N, Elbaz, A
المصدر: Movement disorders : official journal of the Movement Disorder Society. 37(9):1929-1937
مصطلحات موضوعية: Medicin och hälsovetenskap
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4دورية أكاديمية
المؤلفون: Domenighetti, C, Sugier, PE, Sreelatha, AAK, Schulte, C, Grover, S, Mohamed, O, Portugal, B, May, P, Bobbili, DR, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, AB, Hernandez, DG, Edsall, C, Mellick, GD, Zimprich, A, Pirker, W, Rogaeva, E, Lang, AE, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschlander, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Duga, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Kawamura, Y, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ, Kolber, P, van de Warrenburg, BP, Bloem, BR, Aasly, J, Toft, M, Pihlstrom, L, Guedes, LC, Ferreira, JJ, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, NL, Ran, C, Belin, AC, Puschmann, A, Hellberg, C, Clarke, CE, Morrison, KE, Tan, M, Krainc, D, Burbulla, LF, Farrer, MJ, Kruger, R, Gasser, T, Sharma, M, Elbaz, A
المصدر: Journal of Parkinson's disease. 12(1):267-282
مصطلحات موضوعية: Medicin och hälsovetenskap
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5دورية أكاديمية
المؤلفون: Domenighetti, C, Sugier, PE, Sreelatha, AAK, Schulte, C, Grover, S, Mohamed, O, Portugal, B, May, P, Bobbili, DR, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, AB, Hernandez, DG, Edsall, C, Mellick, GD, Zimprich, A, Pirker, W, Rogaeva, E, Lang, AE, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, JC, Chartier-Harlin, MC, Mutez, E, Brockmann, K, Deutschlander, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Duga, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Kawamura, Y, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ, Kolber, P, van de Warrenburg, BPC, Bloem, BR, Aasly, J, Toft, M, Pihlstrom, L, Guedes, LC, Ferreira, JJ, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, NL, Ran, C, Belin, AC, Puschmann, A, Hellberg, C, Clarke, CE, Morrison, KE, Tan, M, Krainc, D, Burbulla, LF, Farrer, MJ, Kruger, R, Gasser, T, Sharma, M, Elbaz, A
المصدر: Movement disorders : official journal of the Movement Disorder Society. 37(4):857-864
مصطلحات موضوعية: Medicin och hälsovetenskap
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6دورية أكاديمية
المؤلفون: Theuns, J, Verstraeten, A, Sleegers, K, Wauters, E, Gijselinck, I, Smolders, S, Crosiers, D, Corsmit, E, Elinck, E, Sharma, M, Kruger, R, Lesage, S, Brice, A, Chung, SJ, Kim, MJ, Kim, YJ, Ross, OA, Wszolek, ZK, Rogaeva, E, Xi, Z, Lang, AE, Klein, C, Weissbach, A, Mellick, GD, Silburn, PA, Hadjigeorgiou, GM, Dardiotis, E, Hattori, N, Ogaki, K, Tan, EK, Zhao, Y, Aasly, J, Valente, EM, Petrucci, S, Annesi, G, Quattrone, A, Ferrarese, C, Brighina, L, Deutschlander, A, Puschmann, A, Nilsson, C, Garraux, G, LeDoux, MS, Pfeiffer, RF, Boczarska-Jedynak, M, Maraganore, GODM, Engelborghs, S, De Deyn, PP, Cras, P, Cruts, M, Van Broeckhoven, C
المصدر: Neurology. 83(21):1906-1913
مصطلحات موضوعية: Medicin och hälsovetenskap
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7دورية أكاديمية
المؤلفون: Luxenburger, A., Clemmens, H., Hastings, C., Harris, L.D., Ure, E.M., Cameron, S.A., Aasly, J., Bandmann, O., Weymouth-Wilson, A., Furneaux, R.H., Mortiboys, H.
الوصف: Parkinson’s Disease is the most common neurodegenerative movement disorder globally, with prevalence increasing. There is an urgent need for new therapeutics which are disease-modifying rather than symptomatic. Mitochondrial dysfunction is a well-documented mechanism in both sporadic and familial Parkinson’s Disease. Furthermore, ursodeoxycholic acid (UDCA) has been identified as a bile acid which leads to increased mitochondrial function in multiple in vitro and in vivo models of Parkinson’s Disease. Here, we describe the synthesis of novel C-nor-D-homo bile acid derivatives and the 12-hydroxy-methylated derivative of lagocholic acid (7) and their biological evaluation in fibroblasts from patients with either sporadic or LRRK2 mutant Parkinson’s Disease. These compounds boost mitochondrial function to a similar level or above that of UDCA in many assays; notable, however, is their ability to boost mitochondrial function to a higher level and at lower concentrations than UDCA specifically in the fibroblasts from LRRK2 patients. Our study indicates that novel bile acid chemistry could lead to the development of more efficacious bile acids which increase mitochondrial function and ultimately cellular health at lower concentrations proving attractive potential novel therapeutics for Parkinson’s Disease.
وصف الملف: text
العلاقة: https://eprints.whiterose.ac.uk/196513/1/biomolecules-13-00076-v2.pdfTest; Luxenburger, A. orcid.org/0000-0002-7574-8027 , Clemmens, H., Hastings, C. et al. (8 more authors) (2023) 3α,7-dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic acids display neuroprotective properties in common forms of Parkinson’s disease. Biomolecules, 13 (1). 76. ISSN 2218-273X
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8دورية أكاديمية
المؤلفون: Elbaz, A, Ross, OA, Ioannidis, JPA, Soto-Ortolaza, AI, Moisan, F, Aasly, J, Annesi, G, Bozi, M, Brighina, L, Chartier-Harlin, MC, Destee, A, Ferrarese, C, Ferraris, A, Gibson, JM, Gispert, S, Hadjigeorgiou, GM, Jasinska-Myga, B, Klein, C, Kruger, R, Lambert, JC, Lohmann, K, van de Loo, S, Loriot, MA, Lynch, T, Mellick, GD, Mutez, E, Nilsson, C, Opala, G, Puschmann, A, Quattrone, A, Sharma, M, Silburn, PA, Stefanis, L, Uitti, RJ, Valente, EM, Vilarino-Guell, C, Wirdefeldt, K, Wszolek, ZK, Xiromerisiou, G, Maraganore, DM, Farrer, MJ
المصدر: Annals of neurology. 69(5):778-792
مصطلحات موضوعية: Medicin och hälsovetenskap
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9دورية أكاديمية
المؤلفون: Markopoulou, K, Aasly, J, Chung, SJ, Dardiotis, E, Wirdefeldt, K, Premkumar, AP, Schoneburg, B, Kartha, N, Wilk, G, Wei, J, Simon, KC, Tideman, S, Epshteyn, A, Hadsell, B, Garduno, L, Pham, A, Frigerio, R, Maraganore, D
المصدر: Frontiers in neurology. 11:548
مصطلحات موضوعية: Medicin och hälsovetenskap
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10دورية أكاديمية
المؤلفون: Pal, G, Mangone, G, Hill, EJ, Ouyang, B, Liu, Y, Lythe, V, Ehrlich, D, Saunders-Pullman, R, Shanker, V, Bressman, S, Alcalay, RN, Garcia, P, Marder, KS, Aasly, J, Mouradian, MM, Link, S, Rosenbaum, M, Anderson, S, Bernard, B, Wilson, R, Stebbins, G, Nichols, WC, Welter, M-L, Sani, S, Afshari, M, Verhagen, L, de Bie, RMA, Foltynie, T, Hall, D, Corvol, J-C, Goetz, CG
المصدر: Annals of Neurology , 91 (3) pp. 424-435. (2022)
الوصف: OBJECTIVE: To compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and non-carriers with and without subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). METHODS: Clinical and genetic data from 12 datasets were examined. Global cognition was assessed using the Mattis Dementia Rating Scale (MDRS). Subjects were examined for mutations in GBA and categorized as GBA carriers with or without DBS (GBA+DBS+, GBA+DBS-), and non-carriers with or without DBS (GBA-DBS+, GBA-DBS-). GBA mutation carriers were subcategorized according to mutation severity (risk variant, mild, severe). Linear mixed modeling was used to compare rate of change in MDRS scores over time among the groups according to GBA and DBS status and then according to GBA severity and DBS status. RESULTS: Data were available for 367 subjects: 58 GBA+DBS+, 82 GBA+DBS-, 98 GBA-DBS+, and 128 GBA-DBS- subjects who were longitudinal followed (range 36 to 60 months after surgery). Using the MDRS, GBA+DBS+ subjects declined on average 2.02 points/year more than GBA-DBS- subjects (95% CI = -2.35, -1.69), 1.71 points/year more than GBA+DBS- subjects (95% CI = -2.14, -1.28), and 1.49 points/year more than GBA-DBS+ subjects (95% CI = -1.80, -1.18). INTERPRETATION: Although non-randomized, this composite analysis suggests that the combined effects of GBA mutations and STN-DBS negatively impact cognition. We advise that DBS candidates be screened for GBA mutations as part of the pre-surgical decision-making process. We advise that GBA mutation carriers be counseled regarding potential risks associated with STN-DBS and alternative options may be considered. This article is protected by copyright. All rights reserved.
وصف الملف: text
العلاقة: https://discovery.ucl.ac.uk/id/eprint/10141715/3/Foltynie_GBA_DBS_manuscript_v7.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10141715Test/
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