المؤلفون: Aas‐Eng, M. K., Young, V. S., Dormagen, J. B., Pripp, A. H., Hudelist, G., Lieng, M.

المصدر: Ultrasound in Obstetrics & Gynecology ; volume 61, issue 2, page 243-250 ; ISSN 0960-7692 1469-0705

الوصف: Objectives To compare transvaginal sonography (TVS) and magnetic resonance imaging (MRI) with intraoperative measurement (IOM) using a rectal probe in the estimation of the location of rectosigmoid endometriotic lesions, i.e. lesion‐to‐anal‐verge distance (LAVD), and to compare two different MRI techniques for measuring LAVD. Methods This was a prospective single‐center observational study that included women undergoing surgery for symptomatic rectosigmoid endometriosis by discoid (DR) or segmental (SR) resection from December 2018 to December 2019. TVS and MRI were performed presurgically for each participant to evaluate LAVD, and the measurements on imaging were compared with IOM using a rectal probe. Clinically acceptable difference and limits of agreement (LoA) between TVS and MRI compared with IOM were set at ± 20 mm. Two different measuring methods for MRI, MRI Center and MRI Direct , were proposed and evaluated, as there is currently no guideline to describe deep endometriosis on MRI. Bland–Altman plots and LoA were used to assess agreement of TVS and both MRI methods with IOM. Systematic and proportional biases were assessed using paired t ‐test and Bland–Altman plots. Results Seventy‐five women were eligible for inclusion. Twenty‐eight women were excluded, leaving 47 women for the analysis. Twenty‐three DR and 26 SR procedures were performed, with both procedures performed in two women. The Bland–Altman plots showed that there were no systematic differences between TVS or MRI Center when compared with IOM for all included participants. MRI Direct systematically underestimated LAVD for lesions located further from the anal verge. TVS, MRI Center and MRI Direct had LoA outside the preset clinically acceptable difference when compared with IOM. LAVD was within the clinically acceptable difference from IOM of ± 20 mm in 70% (33/47) of women on TVS, 72% (34/47) of women on MRI Center and 47% (22/47) of women on MRI Direct . Conclusions TVS should be the preferred method to estimate the location of a ...

الإتاحة: https://doi.org/10.1002/uog.26083Test

المؤلفون: Pascoal, E, Wessels, J M, Aas-Eng, M K, Abrao, M S, Condous, G, Jurkovic, D, Espada, M, Exacoustos, C, Ferrero, S, Guerriero, S, Hudelist, G, Malzoni, M, Reid, S, Tang, S, Tomassetti, C, Singh, S S, Van den Bosch, T, Leonardi, M

المساهمون: Pascoal, E, Wessels, J M, Aas-Eng, M K, Abrao, M S, Condous, G, Jurkovic, D, Espada, M, Exacoustos, C, Ferrero, S, Guerriero, S, Hudelist, G, Malzoni, M, Reid, S, Tang, S, Tomassetti, C, Singh, S S, Van den Bosch, T, Leonardi, M

الوصف: Endometriosis is a chronic systemic disease that can cause pain, infertility and reduced quality of life. Diagnosing endometriosis remains challenging, which yields diagnostic delays for patients. Research on diagnostic test accuracy in endometriosis can be difficult due to verification bias, as not all patients with endometriosis undergo definitive diagnostic testing. The purpose of this State-of-the-Art Review is to provide a comprehensive update on the strengths and limitations of the diagnostic modalities used in endometriosis and discuss the relevance of diagnostic test accuracy research pertaining to each. We performed a comprehensive literature review of the following methods: clinical assessment including history and physical examination, biomarkers, diagnostic imaging, surgical diagnosis and histopathology. Our review suggests that, although non-invasive diagnostic methods, such as clinical assessment, ultrasound and magnetic resonance imaging, do not yet qualify formally as replacement tests for surgery in diagnosing all subtypes of endometriosis, they are likely to be appropriate for advanced stages of endometriosis. We also demonstrate in our review that all methods have strengths and limitations, leading to our conclusion that there should not be a single gold-standard diagnostic method for endometriosis, but rather, multiple accepted diagnostic methods appropriate for different circumstances. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35229963; info:eu-repo/semantics/altIdentifier/wos/WOS:000849851700004; volume:60; issue:3; firstpage:309; lastpage:327; numberofpages:19; journal:ULTRASOUND IN OBSTETRICS & GYNECOLOGY; https://hdl.handle.net/11584/350020Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85134671511

الإتاحة: https://doi.org/10.1002/uog.24892Test
https://hdl.handle.net/11584/350020Test

المؤلفون: Reynolds, A., Aas, A. M., Axelsen, Mette, 1965, Churuangsuk, C., Hermansen, K., Kendall, C. W. C., Kahleova, H., Khan, T., Lean, M. E. J., Mann, J. I., Pedersen, E., Pfeiffer, A., Rahelic, D., Reynolds, A. N., Riserus, U., Rivellese, A. A., Salas-Salvado, J., Schwab, U., Sievenpiper, J. L., Thanopoulou, A., Uusitupa, M.

المصدر: Diabetologia. 66(6):965-985

مصطلحات موضوعية: Endocrinology and Diabetes, Endokrinologi och diabetes, Diabetes management, Dietary guidance, Eating advice, Nutrition, recommendations, Type 2 diabetes prevention, Type 2 diabetes remission

الوصف: Diabetes management relies on effective evidence-based advice that informs and empowers individuals to manage their health. Alongside other cornerstones of diabetes management, dietary advice has the potential to improve glycaemic levels, reduce risk of diabetes complications and improve health-related quality of life. We have updated the 2004 recommendations for the nutritional management of diabetes to provide health professionals with evidence-based guidelines to inform discussions with patients on diabetes management, including type 2 diabetes prevention and remission. To provide this update we commissioned new systematic reviews and meta-analyses on key topics, and drew on the broader evidence available. We have strengthened and expanded on the previous recommendations to include advice relating to dietary patterns, environmental sustainability, food processing, patient support and remission of type 2 diabetes. We have used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach to determine the certainty of evidence for each recommendation based on findings from the commissioned and identified systematic reviews. Our findings indicate that a range of foods and dietary patterns are suitable for diabetes management, with key recommendations for people with diabetes being largely similar for those for the general population. Important messages are to consume minimally processed plant foods, such as whole grains, vegetables, whole fruit, legumes, nuts, seeds and non-hydrogenated non-tropical vegetable oils, while minimising the consumption of red and processed meats, sodium, sugar-sweetened beverages and refined grains. The updated recommendations reflect the current evidence base and, if adhered to, will improve patient outcomes.

الوصول الحر: https://gup.ub.gu.se/publication/326825Test

المؤلفون: Augustin L. S. A., Aas A. -M., Astrup A., Atkinson F. S., Baer-Sinnott S., Barclay A. W., Brand-Miller J. C., Brighenti F., Bullo M., Buyken A. E., Ceriello A., Ellis P. R., Ha M. -A., Henry J. C., Kendall C. W. C., Vecchia C. L., Liu S., Livesey G., Poli A., Salas-Salvado J., Riccardi G., Riserus U., Rizkalla S. W., Sievenpiper J. L., Trichopoulou A., Usic K., Wolever T. M. S., Willett W. C., Jenkins D. J. A.

المساهمون: Augustin, L. S. A., Aas, A. -M., Astrup, A., Atkinson, F. S., Baer-Sinnott, S., Barclay, A. W., Brand-Miller, J. C., Brighenti, F., Bullo, M., Buyken, A. E., Ceriello, A., Ellis, P. R., Ha, M. -A., Henry, J. C., Kendall, C. W. C., Vecchia, C. L., Liu, S., Livesey, G., Poli, A., Salas-Salvado, J., Riccardi, G., Riserus, U., Rizkalla, S. W., Sievenpiper, J. L., Trichopoulou, A., Usic, K., Wolever, T. M. S., Willett, W. C., Jenkins, D. J. A.

مصطلحات موضوعية: Carbohydrate quality, Consensu, Dietary fibre, ICQC, Labelling

الوصف: Dietary fibre is a generic term describing non-absorbed plant carbohydrates and small amounts of associated non-carbohydrate components. The main contributors of fibre to the diet are the cell walls of plant tissues, which are supramolecular polymer networks containing variable proportions of cellulose, hemicelluloses, pectic substances, and non-carbohydrate components, such as lignin. Other contributors of fibre are the intracellular storage oligosaccharides, such as fructans. A distinction needs to be made between intrinsic sources of dietary fibre and purified forms of fibre, given that the three-dimensional matrix of the plant cell wall confers benefits beyond fibre isolates. Movement through the digestive tract modifies the cell wall structure and may affect the interactions with the colonic microbes (e.g., small intestinally non-absorbed carbohydrates are broken down by bacteria to short-chain fatty acids, absorbed by colonocytes). These aspects, combined with the fibre associated components (e.g., micronutrients, polyphenols, phytosterols, and phytoestrogens), may contribute to the health outcomes seen with the consumption of dietary fibre. Therefore, where possible, processing should minimise the degradation of the plant cell wall structures to preserve some of its benefits. Food labelling should include dietary fibre values and distinguish between intrinsic and added fibre. Labelling may also help achieve the recommended intake of 14 g/1000 kcal/day.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000580081900001; volume:12; issue:9; firstpage:1; lastpage:11; numberofpages:11; journal:NUTRIENTS; http://hdl.handle.net/11381/2882729Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85089985419

الإتاحة: https://doi.org/10.3390/nu12092553Test
http://hdl.handle.net/11381/2882729Test

المؤلفون: Rognli, Eline B., Aas, Erlend M., Drake, Robert E., Marsden, John, Anders, Paul, Bond, Gary R., Lystad, June U., Reme, Silje E., Arnevik, Espen A.

الوصف: Background Employment is associated with better outcomes of substance use treatment and protects against relapse after treatment completion. Unemployment rates are high for people with substance use disorders (SUD) who undergo treatment, with Norwegian estimates ranging from 81 to 91%. Evidence-based vocational models are lacking for patients in SUD treatment but exist for patients with psychosis in terms of Individual Placement and Support (IPS). The aim of the IPS for substance use disorders (IPS-SUD) trial is to investigate the effect of IPS in a SUD population. Methods/design The IPS-SUD trial is a randomized controlled trial (RCT) comparing IPS to an enhanced control intervention. The study is a seven-site, two-arm, pragmatic, parallel-group, superiority RCT. Participants are randomly assigned (1:1) to receive either IPS plus treatment as usual (TAU) or to receive a self-help guide book and 12-h workshop plus 1-h individual vocational guidance plus TAU. Aiming to recruit 200 participants, we will be able to detect a 20% difference in the main outcome of employment with 90% power. We will make assessments at inclusion and at 6- and 12-month follow-ups and obtain outcome data on employment from national mandatory registries. The primary outcome will be at least 1 day of competitive employment during the 18-month follow-up period. Secondary employment outcomes will capture the pattern and extent of employment in terms of total time worked (days/hours), time to first employment, number of different jobs, duration of the longest employment, and sustained employment. Secondary non-employment outcomes will be substance use, mental distress, and quality of life measured by validated instruments at 6, 12, and 18 months follow-up assessments. To be eligible, participants must be between 18 and 65 years, currently unemployed and in treatment for SUD. Discussion The IPS-SUD trial will provide evidence for the use of IPS in a SUD population. Findings from the study will have implications for service delivery. Trial ...

العلاقة: http://urn.nb.no/URN:NBN:no-91587Test; Trials. 2021 Oct 15;22(1):705; http://hdl.handle.net/10852/88974Test; https://doi.org/10.1186/s13063-021-05673-zTest; URN:NBN:no-91587; Fulltext https://www.duo.uio.no/bitstream/handle/10852/88974/1/13063_2021_Article_5673.pdfTest

الإتاحة: https://doi.org/10.1186/s13063-021-05673-zTest
http://hdl.handle.net/10852/88974Test
http://urn.nb.no/URN:NBN:no-91587Test

المؤلفون: Aas‐Eng, M. K., Lieng, M., Dauser, B., Diep, L. M., Leonardi, M., Condous, G., Hudelist, G.

المصدر: Ultrasound in Obstetrics & Gynecology ; volume 58, issue 6, page 933-939 ; ISSN 0960-7692 1469-0705

الوصف: Objective To investigate the agreement of measurements of the three diameters of rectosigmoid deep endometriosis (DE) lesions between presurgical evaluation using transvaginal sonography (TVS) and postsurgical specimen measurement (PSM). Methods This was a prospective observational multicenter study including symptomatic women undergoing surgical treatment for DE involving the rectosigmoid, by either discoid or segmental resection, from April 2017 to December 2019. TVS was performed presurgically to evaluate lesion size (craniocaudal–midsagittal length, anteroposterior thickness and transverse diameter), in accordance with the International Deep Endometriosis Analysis (IDEA) group consensus statement, and was compared with PSM. The agreement of lesion dimensions between the two methods was assessed by Bland–Altman plots and limits of agreement and additionally by the intraclass correlation coefficient (ICC) and Pearson's correlation coefficient. Systematic and proportional bias was assessed using the paired t ‐test. Results A total of 207 consecutive women were eligible for inclusion. Forty‐one women were excluded, leaving 166 women for final analysis. A total of 123 segmental resections and 46 discoid resections were performed (both procedures were performed in three women). The mean difference between TVS and PSM was 0.90 (95% CI, 0.85–0.95) mm for lesion length measurements, 1.03 (95% CI, 0.98–1.09) mm for lesion thickness measurements and 0.84 (95% CI, 0.79–0.89) mm for transverse diameter measurements. Bland–Altman analysis demonstrated good agreement between the two methods for measurements of lesion length. Furthermore, there was good reliability and correlation between TVS and PSM for lesion length measurements, as demonstrated by an ICC of 0.82 (95% CI, 0.75–0.87) and Pearson's correlation coefficient of 0.72 (95% CI, 0.62–0.80), moderate‐to‐good reliability and correlation for lesion thickness measurements, with an ICC of 0.76 (95% CI, 0.67–0.82) and Pearson's correlation coefficient of 0.61 ...

الإتاحة: https://doi.org/10.1002/uog.23728Test

المؤلفون: Aas‐Eng, M. K., Salama, M., Sevelda, U., Ruesch, C., Nemeth, Z., Hudelist, G.

المصدر: Ultrasound in Obstetrics & Gynecology ; volume 55, issue 2, page 264-268 ; ISSN 0960-7692 1469-0705

الوصف: Objective To investigate how many examinations it takes to be able to identify the pelvic parts of the ureters on transvaginal sonography (TVS). Methods This was a prospective study including consecutive women attending a gynecological outpatient clinic in a tertiary referral setting. Prior to commencement of the study, three trainees, with a focus on gynecological surgery and TVS but with no experience in identifying ureters, each observed an expert examiner performing 10 routine TVS examinations, including identification of both ureters. All were standardized gynecological TVS examinations, with visualization of the pelvic part of both ureters. Consecutive women were then examined, first by the expert, unobserved by the trainees, and then by one of the three trainees, in the presence of the expert. To ensure that identification of the pelvic parts of the ureters could be incorporated feasibly into routine gynecological TVS in a tertiary referral setting, a time limit of 150 s was set for successful identification of each ureter. A successful examination was defined by identifying both ureters within the time limit. The number of women examined by each trainee was determined by how quickly they achieved proficiency, which was evaluated using the learning curve cumulative summation (LC‐CUSUM) score. Results Between January 2017 and June 2017, a total of 140 women were recruited for the study, with 135 patients being included in the final analysis. The three trainees were able to identify the right ureter after a maximum of 48 (range, 34–48) TVS examinations, and the left ureter after a maximum of 47 (range, 27–47) TVS examinations. Conclusions Sonographers and/or gynecologists who are familiar with gynecological TVS should be able to become proficient in identifying both ureters after 40–50 TVS examinations. Detection of the ureters is a feasible part of the TVS workup of patients attending a clinic in a tertiary referral center. © 2019 the Authors. Ultrasound in Obstetrics & Gynecology published by ...

الإتاحة: https://doi.org/10.1002/uog.20379Test

المؤلفون: Aas‐Eng, M. K., Dauser, B., Lieng, M., Diep, L. M., Leonardi, M., Condous, G., Hudelist, G.

المصدر: Ultrasound in Obstetrics & Gynecology ; volume 56, issue 5, page 766-772 ; ISSN 0960-7692 1469-0705

الوصف: Objectives First, to investigate the accuracy of transvaginal sonography (TVS) for presurgical evaluation of the distance between the most caudal part of the endometriotic lesion and the anal verge (lesion‐to‐anal‐verge distance (LAVD)) in women with rectosigmoid deep endometriosis (DE), compared with intraoperative measurement (IOM). Second, to assess the agreement between anastomosis height and LAVD measured using TVS. Methods This was a prospective observational multicenter study of symptomatic women who were scheduled for surgical treatment of rectosigmoid DE, by either discoid or segmental resection, between April 2017 and September 2019. Presurgical TVS was performed to evaluate the LAVD in two ways, depending on the level of the lesion. Method 1: for lesions at the level of the rectovaginal septum (RVS), the caudal part of the lesion was identified on TVS and an index finger was placed on the TVS probe at the level of the anal verge. The probe was withdrawn and the distance from the tip of the TVS probe down to the index finger was measured using a ruler, representing the LAVD. Method 2: for lesions above the RVS, the distance between the caudal part of the lesion and the lower lip of the posterior cervix was measured in a frozen image (LAVD‐1), and the distance between the lower lip of the posterior cervix and the anal verge (LAVD‐2) was measured using Method 1. These two measurements (LAVD‐1 and LAVD‐2) were added together and the result represented the total LAVD. During surgery, a rectal probe was used to perform IOM of LAVD, which was considered as the gold standard test. Agreement between LAVD measured using TVS and the IOM was assessed using Bland–Altman analysis. The intraclass correlation coefficient (ICC) for absolute agreement and Spearman's correlation coefficient were also calculated. Systematic and proportional bias were tested for significance using the paired t ‐test. Similar analysis was performed to assess agreement between LAVD measured using TVS and anastomosis height. Results ...

الإتاحة: https://doi.org/10.1002/uog.21995Test

المؤلفون: Pascoal, E., Wessels, J. M., Aas‐Eng, M. K., Abrao, M. S., Condous, G., Jurkovic, D., Espada, M., Exacoustos, C., Ferrero, S., Guerriero, S., Hudelist, G., Malzoni, M., Reid, S., Tang, S., Tomassetti, C., Singh, S. S., Van den Bosch, T., Leonardi, M., Aas-Eng, M K

المصدر: Ultrasound in Obstetrics & Gynecology; Sep2022, Vol. 60 Issue 3, p309-327, 19p

مصطلحات موضوعية: ENDOMETRIOSIS, DIAGNOSIS methods, PELVIC pain, DELAYED diagnosis, MAGNETIC resonance imaging, SURGICAL diagnosis, DIAGNOSTIC imaging, ULTRASONIC imaging, ROUTINE diagnostic tests, FERRANS & Powers Quality of Life Index, QUALITY of life

مستخلص: Endometriosis is a chronic systemic disease that can cause pain, infertility and reduced quality of life. Diagnosing endometriosis remains challenging, which yields diagnostic delays for patients. Research on diagnostic test accuracy in endometriosis can be difficult due to verification bias, as not all patients with endometriosis undergo definitive diagnostic testing. The purpose of this State-of-the-Art Review is to provide a comprehensive update on the strengths and limitations of the diagnostic modalities used in endometriosis and discuss the relevance of diagnostic test accuracy research pertaining to each. We performed a comprehensive literature review of the following methods: clinical assessment including history and physical examination, biomarkers, diagnostic imaging, surgical diagnosis and histopathology. Our review suggests that, although non-invasive diagnostic methods, such as clinical assessment, ultrasound and magnetic resonance imaging, do not yet qualify formally as replacement tests for surgery in diagnosing all subtypes of endometriosis, they are likely to be appropriate for advanced stages of endometriosis. We also demonstrate in our review that all methods have strengths and limitations, leading to our conclusion that there should not be a single gold-standard diagnostic method for endometriosis, but rather, multiple accepted diagnostic methods appropriate for different circumstances. © 2022 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

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المؤلفون: Wolf, Markus, Aas, Bianca M., Klüfers, Peter

المصدر: European Journal of Inorganic Chemistry ; volume 2017, issue 17, page 2302-2302 ; ISSN 1434-1948 1099-0682

الوصف: Invited for the cover of this issue is the group of Peter Klüfers from Ludwig‐Maximilians‐Universität München, Germany. The cover image shows a laboratory‐scale bubble column, which was used for the nitrosation of a dissolved ferrous edta complex to obtain the nitrosyl complex shown at the top left.

الإتاحة: https://doi.org/10.1002/ejic.201700383Test