المؤلفون: Yamawaki, Yosuke, Nishida, Misako, Harada, Kana, Akagi, Hiroyuki

المساهمون: JSPS KAKENHI

المصدر: Data in Brief ; volume 18, page 496-500 ; ISSN 2352-3409

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016/j.dib.2018.03.055Test
https://api.elsevier.com/content/article/PII:S2352340918302609?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352340918302609?httpAccept=text/plainTest

المؤلفون: Muroi, Norihiro, Shimada, Masakazu, Murakami, Sawako, Akagi, Hiroyuki, Kanno, Nobuo, Suzuki, Shuji, Harada, Yasuji, Orima, Hiromitsu, Hara, Yasushi

المصدر: Veterinary and Comparative Orthopaedics and Traumatology ; volume 34, issue 06, page 375-385 ; ISSN 0932-0814 2567-6911

الوصف: Objective This study aimed to evaluate implant-induced osteoporosis (IIO) development in toy breed dogs treated using internal fixation with digital radiographs as the index of pixel values. Study Design There were 226 cases (236 limbs) of toy breed dogs with radial–ulnar fractures. Pixel values were measured on radiographs immediately, 2 weeks and 1 to 12 months after surgery. The ratio of pixel values (PVR) represented the bone mineral areal density based on the humeral condyle in the same image. The dogs were grouped based on the fixation methods, age and status of destabilization. Results There was a significant decrease in the PVR at 1 to 12 months postoperatively for all cases. There were not any significant differences in PVR of antebrachial fractures between those repaired with plates using locking head screws, cortex screws or a combination of locking and cortex screws. Implant-induced osteoporosis persisted at 1 to 12 months postoperatively in dogs aged ≧6 months, while the PVR increased after 3 months in dogs aged <6 months. Based on the destabilization method, there was a significant increase in the PVR at 3 months in the plate removal group. Conclusion This study suggests that IIO occurs in small dogs treated with plates and screws. Moreover, patients aged < 6 months showed an early postoperative recovery of bone mineral areal density. Further, screw and plate removal could contribute to the recovery of bone mineral areal density.

الإتاحة: https://doi.org/10.1055/s-0041-1731810Test

المؤلفون: Akagi, Hiroyuki, Patton, David E., Miled, Ricardo

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1989 Oct . 86(20), 8103-8107.

الوصول الحر: https://www.jstor.org/stable/35234Test

المؤلفون: Akagi, Hiroyuki, Miledi, Ricardo

المصدر: Science, 1988 Oct . 242(4876), 270-273.

الوصول الحر: https://www.jstor.org/stable/1702195Test

المؤلفون: Itoi, Shiro, Sato, Tatsunori, Takei, Mitsuki, Yamada, Riko, Ogata, Ryuya, Oyama, Hikaru, Teranishi, Shun, Kishiki, Ayano, Wada, Takenori, Noguchi, Kaede, Abe, Misato, Okabe, Taiki, Akagi, Hiroyuki, Kashitani, Maho, Suo, Rei, Koito, Tomoko, Takatani, Tomohiro, Arakawa, Osamu, Sugita, Haruo

المساهمون: Japan Society for the Promotion of Science

المصدر: Chemosphere ; volume 249, page 126217 ; ISSN 0045-6535

مصطلحات موضوعية: General Medicine, General Chemistry, Environmental Chemistry, Environmental Engineering, Pollution, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health

الإتاحة: https://doi.org/10.1016/j.chemosphere.2020.126217Test
https://api.elsevier.com/content/article/PII:S0045653520304100?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0045653520304100?httpAccept=text/plainTest

المؤلفون: Kodama, Yasushi, Ozaki, Kiyokazu, Sano, Tomoya, Matsuura, Tetsuro, Akagi, Hiroyuki, Narama, Isao

المصدر: Cancer Science ; volume 97, issue 10, page 1023-1030 ; ISSN 1347-9032 1349-7006

الوصف: Male rats of WBN/Kob strain are one of the diabetic model animals and develop long‐lasting diabetic symptoms and some complications from about 40 weeks of age without any treatment. A single intravenous dose of alloxan, a non‐genotoxic diabetogenic chemical, frequently induced proliferative lesions of squamous epithelium in tongue, esophagus and forestomach of male and female WBN/Kob rats, and hastened the onset and acceleration of diabetic conditions. Histopathologically, proliferative changes of squamous cell of forestomach varied with the severity of hyperplasia in alloxan‐treated rats (100% of 31 males and 94.1% of 17 females) and progressed to SCC in approximately 20% of all rats. Metastasis to regional lymph nodes was also observed in two cases. Proliferative changes were most severe in the forestomach and were constantly accompanied with chronic suppurative inflammation of the mucosal epithelium with infection of filamentous fungi and/or bacterial colonies. In contrast, forestomach of the spontaneously diabetic male rats showed only slight hyperplasia of the mucosal epithelium confined to the limiting ridge in approximately 30% of the cases. All non‐diabetic female rats showed neither proliferative changes nor the inflammatory process in the mucosa. Immunohistochemically, COX‐2 and iNOS were positive in these chronic suppurative inflammatory lesions accompanied by proliferative squamous epithelium. From these results, it is suggested that chronic inflammatory processes play an important role in the pathogenesis of alloxan‐induced SCC. An experimental system of alloxan‐induced SCC might serve as a suitable model for the study of the inflammation‐related promotion of carcinogenesis. ( Cancer Sci 2006; 97: 1023–1030)

الإتاحة: https://doi.org/10.1111/j.1349-7006.2006.00279.xTest

المؤلفون: Hosie, Alastair M, Akagi, Hiroyuki, Ishida, Michiko, Shinozaki, Haruhiko

المصدر: British Journal of Pharmacology ; volume 126, issue 5, page 1230-1236 ; ISSN 0007-1188 1476-5381

الوصف: PMBA is a novel antagonist of strychnine‐sensitive glycine receptors in the rat spinal cord, however, its mode of action is unknown. The actions of PMBA on rat glycine receptor α1 and α2 homomers in Xenopus oocytes were studied under two‐electrode voltage‐clamp. Co‐application of PMBA and glycine to both α1 and α2 homomers yielded inward currents which decayed to a steady‐state. Responses rose slowly to the same steady‐state amplitude following a 2 min pre‐incubation in PMBA. Strychnine, but not picrotoxinin, showed similar antagonism to PMBA. The potency of PMBA was independent of membrane potential between −100 and 0 mV. When tested against EC 50 concentrations of glycine, PMBA was almost equally potent on α1 (IC 50 , 406±41 n M : Hill coefficient, 1.5±0.2) and α2 (IC 50 , 539±56 n M ; Hill coefficient, 1.4±0.2) homomers. PMBA (1–10 μ M ) and strychnine (200 n M ) reduced the potency of glycine and the amplitude of the maximal agonist response of α1 and α2 homomers. In 10 μ M PMBA, two distinct classes of glycine response were observed on α2, only a single class of responses were observed on α1. There are similarities in PMBA and strychnine antagonism, although these compounds are structurally distinct. The possibility that PMBA interacts at two binding sites which differ in α1 and α2 subunits is discussed. PMBA may provide a lead structure for novel antagonists with which to investigate structural differences in glycine receptor at α1 and α2 subunits. British Journal of Pharmacology (1999) 126 , 1230–1236; doi: 10.1038/sj.bjp.0702402

الإتاحة: https://doi.org/10.1038/sj.bjp.0702402Test

المؤلفون: Akagi, Hiroyuki, Majima, Takehiko

المصدر: Japanese Journal of Pharmacology ; volume 79, page 132 ; ISSN 0021-5198

مصطلحات موضوعية: Pharmacology

الإتاحة: https://doi.org/10.1016/s0021-5198Test(19)34541-x
https://api.elsevier.com/content/article/PII:S002151981934541X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S002151981934541X?httpAccept=text/plainTest

المؤلفون: Nagahiro, Yukari, Katori, Daichi, Muroi, Norihiro, Akagi, Hiroyuki, Kanno, Nobuo, Harada, Yasuji, Yamaguchi, Shinya, Hayashi, Kei, Hara, Yasushi, Munakata, Shuntaro

المصدر: Veterinary and Comparative Orthopaedics and Traumatology ; volume 31, issue 03, page 159-169 ; ISSN 0932-0814 2567-6911

الوصف: Objective To evaluate the effectiveness of frozen cortical bone allografts (FCBA) in the treatment of severe radial and ulnar atrophic nonunion fractures. Animals Toy breed dogs with nonunion of radial and ulnar fractures (n = 15). Methods Severe atrophic nonunion fractures were treated with FCBA (eight infected and seven non-infected fractures). Radiographs obtained immediately after surgery, and 1, 2, 3, 6 and 12 months later were evaluated and scored for the periosteal reaction at the bone regeneration sites, the healing process in the bone connection areas at both the proximal and distal sites, and the bone remodelling process within the allografts. Results Improvements in the fracture-healing process and weight-bearing function were observed in all cases. Radiographic scores at the bone connection areas and within the allograft improved significantly over time (p < 0.05). There were not any significant differences in radiographic scores between the infected and non-infected groups. Clinical Significance Bone reconstruction with FCBA is effective in the treatment of radial and ulnar nonunion fractures associated with large bone defects, regardless of the infection status of the surgical site.

الإتاحة: https://doi.org/10.1055/s-0038-1631878Test

المؤلفون: Yamawaki, Yosuke, Yoshioka, Norika, Nozaki, Kanako, Ito, Hikaru, Oda, Keisuke, Harada, Kana, Shirawachi, Satomi, Asano, Satoshi, Aizawa, Hidenori, Yamawaki, Shigeto, Kanematsu, Takashi, Akagi, Hiroyuki

المساهمون: JSPS KAKENHI, Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and Development, AMED

المصدر: Brain Research ; volume 1680, page 13-38 ; ISSN 0006-8993

الإتاحة: https://doi.org/10.1016/j.brainres.2017.12.004Test
https://api.elsevier.com/content/article/PII:S0006899317305383?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0006899317305383?httpAccept=text/plainTest