نتائج البحث - "ACh, acetylcholine"

المصدر: Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 3, Iss 1, Pp 1-13 (2019)

مصطلحات موضوعية: Ach, acetylcholine, IVUS, intravascular ultrasound, medicine.medical_specialty, CAD, coronary artery disease, ECFC, endothelial colony-forming cell, EPC-CFU, EPC–colony-forming unit, Vasodilation, Disease, Review, 030204 cardiovascular system & hematology, CVD, cardiovascular disease, Endothelial progenitor cell, HF, heart failure, Coronary artery disease, 03 medical and health sciences, EDHF, endothelium-derived hyperpolarizing factor, 0302 clinical medicine, ROS, reactive oxygen species, EPC, endothelial progenitor cell, Internal medicine, LVEF, left ventricular ejection fraction, medicine, 030212 general & internal medicine, Endothelial dysfunction, Progenitor cell, NOS, NO synthase, lcsh:R5-920, NO, nitric oxide, Ejection fraction, HFpEF, HF with preserved ejection fraction, PAT, peripheral arterial tonometry, business.industry, eNOS, endothelial nitric oxide synthase, QCA, quantitative coronary angiography, medicine.disease, HFrEF, HF with reduced ejection fraction, 3. Good health, FMD, flow-mediated vasodilation, Heart failure, H2O2, hydrogen peroxide, Cardiology, cGMP, cyclic guanosine monophosphate, business, lcsh:Medicine (General)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8572ff89842d2aa25c73c583ed34b02Test
https://pubmed.ncbi.nlm.nih.gov/30899903Test

35

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

المؤلفون: Celine Valant, Patrick M. Sexton, Elham Khajehali, Peter J. Scammells, Manuela Jörg, Craig W. Lindsley, Arthur Christopoulos, Andrew B. Tobin, P. Jeffrey Conn

المصدر: Biochemical Pharmacology

مصطلحات موضوعية: WT, wild type, 0301 basic medicine, PF-06767832, N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-(4-(thiazol-4-yl)benzyl)pyridine-2-carboxamide, Cooperativity, Biochemistry, Muscarinic acetylcholine receptor, Cricetinae, TM, transmembrane domain, BQCA, benzylquinolone carboxylic acid, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Allosteric modulation, MIPS1780, 3-(2-hydroxycyclohexyl)-6-(2-((4-(1-methyl-1H-pyrazol-4-yl)- benzyl)oxy)phenyl)pyrimidin-4(3H)-one, ANOVA, analysis of variance, Drug discovery, Chemistry, PBZ, phenoxybenzamine, 3. Good health, PAM, positive allosteric modulator, BQZ-12, 3-((1S,2S)-2-hydroxycyclohexyl)-6-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)benzo [h]-quinazolin-4(3H)-one, medicine.symptom, Allosteric Site, Allosteric modulator, DMEM, Dulbecco modified eagle medium, Allosteric regulation, PBS, phosphate-buffered saline, BQCA, CHO Cells, ECL, extracellular loop, Cholinergic Agonists, Muscarinic Agonists, AD, Alzheimer’s disease, CHO, Chinese hamster ovary, Article, NMS, N-methylscopolamine, 03 medical and health sciences, Cricetulus, FBS, fetal bovine serum, Allosteric Regulation, medicine, Animals, Humans, mAChR, muscarinic acetylcholine receptor, Binding site, GPCR, G protein-coupled receptor, ComputingMethodologies_COMPUTERGRAPHICS, NAM, negative allosteric modulator, Pharmacology, IP1, inositol monophosphate, Binding Sites, Dose-Response Relationship, Drug, ACh, acetylcholine, Receptor, Muscarinic M1, VU6004256 (4, 6-difluoro-N-(1S,2S)-2-hydroxycyclohexyl-1-((6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-yl)methyl)-1H-indole-3-carboxamide, Rational design, Acetylcholine, 030104 developmental biology, Mechanism of action, Mutagenesis, HBSS, Hanks’ balanced salt solution, Biophysics, BSA, bovine serum albumin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825fb21ad2045775ecf4d26ab83b0c2Test
https://eprints.gla.ac.uk/163141/1/163141.pdfTest

36

Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity

المؤلفون: Charlotte Buckley, Calum Wilson, Matthew D. Lee, Helen R. Heathcote, Nasser M Alorfi, Margaret MacDonald, Xun Zhang, Sharon Dolan, John G. McCarron

المصدر: Metabolism

مصطلحات موضوعية: Male, 0301 basic medicine, HFD, high-fat diet, Endothelial cells, Endocrinology, Diabetes and Metabolism, Cell, Vasodilation, 4-DAMP, 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide, 030204 cardiovascular system & hematology, 0302 clinical medicine, Endocrinology, Basic Science, MEP, myoendothelial projection, Endothelial dysfunction, ANOVA, analysis of variance, Calcium signaling, RuR, ruthenium red, L-NAME, L-NG-Nitro arginine methyl ester, 0303 health sciences, education.field_of_study, 3. Good health, Endothelial stem cell, medicine.anatomical_structure, Cardiovascular Diseases, SNP, sodium nitroprusside, IP3, inositol triphosphate, Blood vessel, medicine.medical_specialty, Endothelium, SD, standard diet, Population, 030209 endocrinology & metabolism, IEL, internal elastic lamina, Nitric Oxide, RS, Prediabetic State, 03 medical and health sciences, 2-APB, 2-aminoethoxydiphenyl borate, Internal medicine, Diabetes mellitus, medicine, Animals, Calcium Signaling, Obesity, Rats, Wistar, education, 030304 developmental biology, NO, nitric oxide, ACh, acetylcholine, business.industry, Vascular disease, medicine.disease, Rats, 030104 developmental biology, Endothelium, Vascular, Heterogeneity, Networks, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7335dbb86f3e5a503faa5a51dc672aTest
https://doi.org/10.1016/j.metabol.2020.154340Test

37

Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors

المؤلفون: Kenton M. Sanders, Hikaru Hashitani, Yoshihiko Kito, Masaaki Kurahashi, Masayasu Hara, Hiromitsu Takeyama

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 658-671.e1 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Sympathetic Nervous System, Receptor, Platelet-Derived Growth Factor alpha, Endogeny, PDGFRα+ Cells, CM, circular muscle, chemistry.chemical_compound, AUC, area under the curve, Norepinephrine, 0302 clinical medicine, TPM, transcripts per kilobase million, SPCs, spontaneous phasic contractions, Original Research, Aged, 80 and over, Purinergic receptor, Gastroenterology, ICC, interstitial cells of Cajal, Middle Aged, Cell biology, symbols, 030211 gastroenterology & hepatology, SMC, smooth muscle cells, Female, Epi, epinephrine, Intracellular, SIP Syncytium, EFS, electrical field stimulation, medicine.drug, Muscle Contraction, Ach, acetylcholine, Adult, Colon, FBD, functional bowel disorders, Myocytes, Smooth Muscle, ARs, adrenoceptors, Apamin, L-NNA, N-nitro-L-arginine methyl ester hydrochloride, SK channel, 03 medical and health sciences, symbols.namesake, PDGFRα+ cells, platelet-derived growth factor receptor α+ cells, Growth factor receptor, Receptors, Adrenergic, alpha-1, medicine, Humans, lcsh:RC799-869, TTX, tetrodotoxin, Gastrointestinal Transit, Phenylephrine, Aged, Hepatology, PE, phenylephrine, SK channels, small conductance Ca2+-activated K+ channels, ADP, adenosine diphosphate, Interstitial cell of Cajal, Colonic Motility, 030104 developmental biology, α1 Adrenoceptor, chemistry, Adrenergic alpha-1 Receptor Antagonists, lcsh:Diseases of the digestive system. Gastroenterology, Adrenergic alpha-1 Receptor Agonists, NE, norepinephrine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0385dfcc050c2f853e4874371a16636aTest
http://europepmc.org/articles/PMC7474159Test

38

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis

المؤلفون: Verónica Miguel, Susana Vallejo, Pablo Cannata, Eva Maria Blanco, Concepción Peiró, Elena Sandoval, Francisco Sánchez, Carlos F. Sánchez-Ferrer, Santiago Lamas, Cristina Espinosa-Diez

المساهمون: UAM. Departamento de Anatomía Patológica, UAM. Departamento de Farmacología, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ), Centro de Biología Molecular Severo Ochoa (CBM), Enogas, Fundación Ramón Areces, European Cooperation in Science and Technology, Comunidad de Madrid, Instituto de Salud Carlos III, European Commission, Fundación Renal Íñigo Álvarez de Toledo

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
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Redox Biology
Redox Biology, Vol 14, Iss, Pp 88-99 (2018)
Digital.CSIC. Repositorio Institucional del CSIC

مصطلحات موضوعية: 0301 basic medicine, Male, Clinical Biochemistry, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, NAC, N-acetylcysteine, Haploinsufficiency, Kidney, Biochemistry, KHS, Krebs-Henseleit solution, chemistry.chemical_compound, Mice, EDRF, Endothelium-derived relaxing factor, Enos, Fibrosis, Kidney Fibrosis, GCL, glutamate cysteine ligase, Endothelial dysfunction, SDS, sodium dodecyl sulphate, lcsh:QH301-705.5, Cells, Cultured, chemistry.chemical_classification, NA, noradrenaline, Mice, Knockout, lcsh:R5-920, biology, Chemistry, GCLM, UUO, Unilateral ureteral obstruction, eNOS, Endothelial nitric-oxide synthase, ROS, Biología y Biomedicina / Biología, Farmacia, Glutathione, Mesenteric Arteries, GCLC, SNP, sodium nitroprusside, Female, Kidney Diseases, lcsh:Medicine (General), Research Paper, Ach, acetylcholine, medicine.medical_specialty, Nitric Oxide Synthase Type III, BH4, Tetrahydrobiopterin, Glutamate-Cysteine Ligase, Biopterin, ARE, antioxidant response element, Glutamate-cysteine ligase, 03 medical and health sciences, DMNQ, 2,3-Dimethoxy-1,4-naphthoquinone, Internal medicine, medicine, Animals, Reactive oxygen species, Organic Chemistry, Endothelial Cells, Fibroblasts, biology.organism_classification, medicine.disease, MLEC, mouse lung endothelial cells, Disease Models, Animal, 030104 developmental biology, Endocrinology, lcsh:Biology (General), GS, glutathione synthetase, Reactive Oxygen Species