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1دورية أكاديمية
المؤلفون: Li, Z.-Y, Chung, Y.H, Shin, E.-J, Dang, D.-K, Jeong, J.H, Ko, S.K, Nah, S.-Y, Baik, T.G, Jhoo, J.H, Ong, W.-Y, Nabeshima, T, Kim, H.-C
المساهمون: ANATOMY
المصدر: Unpaywall 20201031
مصطلحات موضوعية: 1 alkyl 2 acetylglycerophosphocholine esterase, 1 alkyl 2 acetylglycerophosphocholine esterase 1, amyloid beta protein[1-42], amyloid precursor protein, bilobalide, cyclooxygenase 2, Ginkgo biloba extract, ginkgolide A, ginkgolide B, ginkgolide C, isorhamnetin, kaempferol, meloxicam, presenilin 1, quercetin, reactive oxygen metabolite, terpene, thrombocyte activating factor receptor, unclassified drug, yy 1224, amyloid beta protein, amyloid beta-protein (1-42), lactone, peptide fragment, plant extract, trilactone, animal cell, animal experiment, animal model, animal tissue
الوصف: 10.1186/s12974-017-0866-x ; Journal of Neuroinflammation ; 14 ; 1 ; 94
العلاقة: Li, Z.-Y, Chung, Y.H, Shin, E.-J, Dang, D.-K, Jeong, J.H, Ko, S.K, Nah, S.-Y, Baik, T.G, Jhoo, J.H, Ong, W.-Y, Nabeshima, T, Kim, H.-C (2017). YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2. Journal of Neuroinflammation 14 (1) : 94. ScholarBank@NUS Repository. https://doi.org/10.1186/s12974-017-0866-xTest; https://scholarbank.nus.edu.sg/handle/10635/179510Test
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2دورية أكاديمية
المساهمون: DEPT OF PHYSICS
المصدر: Unpaywall 20201031
مصطلحات موضوعية: 1 alkyl 2 acetylglycerophosphocholine esterase, biological marker, C reactive protein, cholesterol, low density lipoprotein, oxidized low density lipoprotein, triacylglycerol, acute coronary syndrome, adult, blood, female, human, male, metabolism, middle aged, multivariate analysis, risk factor, statistical model, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Biomarkers, C-Reactive Protein, Humans, Lipoproteins, LDL, Logistic Models, Risk Factors, Triglycerides
الوصف: 10.1038/s41598-017-16464-5 ; Scientific Reports ; 7 ; 1 ; 16092
العلاقة: Huang, Y, Wu, Y, Yang, Y, Li, W, Lu, J, Hu, Y (2017). Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China. Scientific Reports 7 (1) : 16092. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-16464-5Test; https://scholarbank.nus.edu.sg/handle/10635/178558Test
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3دورية أكاديمية
المساهمون: MICROBIOLOGY AND IMMUNOLOGY, DEPT OF OTOLARYNGOLOGY
المصدر: Unpaywall 20200831
مصطلحات موضوعية: connective tissue growth factor, CXCL13 chemokine, gelatinase B, Hermes antigen, interleukin 10, interleukin 1beta, interleukin 6, monocyte chemotactic protein 1, monocyte chemotactic protein 2, transforming growth factor beta, tumor necrosis factor, urokinase, vasculotropin A, 1 alkyl 2 acetylglycerophosphocholine esterase, cytokine, PLA2G7 protein, human, Article, carcinoma cell, CCL8 gene, CD44 gene, cell interaction, cell invasion, cell migration, coculture, controlled study, CTGF gene, CXCL13 gene, gene, gene expression
الوصف: 10.18632/oncotarget.10980 ; Oncotarget ; 7 ; 34 ; 55473-55490
العلاقة: Low H.B., Png C.W., Li C., Wang D.Y., Justin Wong S.B., Zhang Y. (2016). Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness. Oncotarget 7 (34) : 55473-55490. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.10980Test; https://scholarbank.nus.edu.sg/handle/10635/175454Test
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4
المصدر: Netherlands Journal of Medicine. 59(3):102-110
مصطلحات موضوعية: endotoxin, clusterin, multiple organ failure, tumor necrosis factor, protein lipid interaction, review, interleukin 6, G protein coupled receptor, chemotactic factor, phosphatidylcholine sterol acyltransferase, interleukin 1, cholesterol esterase, scavenger receptor, sepsis, RANTES, intermediate density lipoprotein, 1 alkyl 2 acetylglycerophosphocholine esterase, cholesterol ester transfer protein, cholesterol transport, hepatic clearance, unindexed drug, human, apolipoprotein A, apoprotein, detoxification, lipopolysaccharide binding protein, lipoprotein metabolism, lipid transport, C reactive protein, nonhuman, lipopolysaccharide, chylomicron, serum amyloid A, CD14 antigen, immunity, mortality, phospholipid transfer protein, glycosylphosphatidylinositol, high density lipoprotein, cholesterol ester, protein protein interaction, tissue factor pathway inhibitor, septic shock, triacylglycerol
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dris___00893::e75574a8d2fc541efe041408a5c9726cTest
https://doi.org/10.1016/s0300-2977Test(01)00144-9 -
5
المؤلفون: Estruch, M, Sanchez-Quesada, JL, Llanos, JO, Benitez, S
المصدر: MEDIATORS OF INFLAMMATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instnameمصطلحات موضوعية: conformation, pathophys, lipid peroxide, alpha tocopherol, ligand, immune response, angiogenesis, endothelial progenitor cell, 1 alkyl 2 acetylglycerophosphocholine esterase, mononuclear cell, T lymphocyte, apolipoprotein B, animal, endothelium cell, phospholipase C, cell regeneration, pathophysiology, lipopolysaccharide, apoptosis, article, unclassified drug, enzyme activity, hydrolysis, priority journal, monocyte, cytotoxicity, lipids (amino acids, peptides, and proteins), monocyte chemotactic protein 1, antiinflammatory agent, leukocyte, glycosylation, Article Subject, antigen antibody complex, review, interleukin 8, chemistry, sphingomyelin phosphodiesterase, sphingomyelin, physical chemistry, human, fibroblast growth factor 2, umbilical vein endothelial cell, proteoglycan, electronegative low density lipoprotein, cell differentiation, inflammation, cytology, phospholipase A2, oxidized low density lipoprotein, pathology, fatty acid, atherosclerosis, low density lipoprotein, oxygen
الوصف: Electronegative low density lipoprotein (LDL(-)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(-) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(-) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(-) suggest that it could have a dual biological effect.
وصف الملف: text/xhtml
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ae636aa62a4b75cd55c102127817287Test
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6دورية أكاديمية
المؤلفون: Tuin, A.W., Mol, M.A.E., Berg, R.M. van den, Fidder, A., Marel, G.A. van der, Overkleeft, H.S., Noort, D.
المصدر: Chemical Research in Toxicology, 4, 22, 683-689
مصطلحات موضوعية: Chemistry, 1 alkyl 2 acetylglycerophosphocholine esterase, Acylamino acid releasing enzyme, Carboxylesterase, Dipeptidyl peptidase, Dipeptidyl peptidase 9, Fatty acid synthase, Methylphosphonofluoridic acid, Organophosphate, Palmitoyl coenzyme A hydrolase, Prolyl endopeptidase, Sarin, Unclassified drug, Animal cell, Biotinylation, Chemical structure, Controlled study, Human, Human cell, Matrix assisted laser desorption ionization time of flight mass spectrometry, Nonhuman, Protein analysis, Quantitative analysis, Sensitivity analysis, Macaca mulatta
الوصف: Elucidation of noncholinesterase protein targets of organophosphates, and nerve agents in particular, may reveal additional mechanisms for their high toxicity as well as clues for novel therapeutic approaches toward intoxications with these agents. Within this framework, we here describe the synthesis of the activity-based probe 3, which contains a phosphonofluoridate moiety, a P-Me moiety, and a biotinylated O-alkyl group, and its use in activity-based protein profiling with two relevant biological samples, that is, rhesus monkey liver and cultured human A549 lung cells. In this way, we have unearthed eight serine hydrolases (fatty acid synthase, acylpeptide hydrolase, dipeptidyl peptidase 9, prolyl oligopeptidase, carboxylesterase, long-chain acyl coenzyme A thioesterase, PAF acetylhydrolase 1b, and esterase D/S-formyl glutathione hydrolase) as targets that are modified by the nerve agent sarin. It is also shown that the newly developed probe 3 might find its way into the development of alternative, less laborious purification protocols for human butyrylcholinesterase, a potent bioscavenger currently under clinical investigation as a prophylactic/therapeutic for nerve agent intoxications. © 2009 American Chemical Society.
العلاقة: uuid:2ad7bce2-36f8-490a-af36-183d6b0dec16; 183522; http://resolver.tudelft.nl/uuid:2ad7bce2-36f8-490a-af36-183d6b0dec16Test
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7
المؤلفون: Wägner A.M., Sánchez-Quesada J.L., Benítez S., Bancells C., Ordóñez-Llanos J., Pérez A.
المصدر: DIABETES RESEARCH AND CLINICAL PRACTICE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instnameمصطلحات موضوعية: Male, crossover procedure, interleukin 8, 1 alkyl 2 acetylglycerophosphocholine esterase, Humans, controlled study, Pyrroles, human, Phospholipases A2, Secretory, Aged, Inflammation, clinical article, C reactive protein, tumor necrosis factor alpha, combination chemotherapy, Cross-Over Studies, drug potentiation, non insulin dependent diabetes mellitus, dyslipidemia, article, Fibric Acids, atorvastatin, Middle Aged, drug efficacy, Phospholipases A2, C-Reactive Protein, Diabetes Mellitus, Type 2, Heptanoic Acids, gemfibrozil, monotherapy, randomized controlled trial, 1-Alkyl-2-acetylglycerophosphocholine Esterase, treatment outcome, secretory phospholipase A2, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, monocyte chemotactic protein 1
الوصف: A randomized, crossover study compared the effects of atorvastatin, gemfibrozil and their combination on inflammatory markers in type 2 diabetes. C-reactive protein (CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), secretory phospholipase A2 (sPLA2), interleukin 8 (IL8), monocyte chemotactic protein 1 (MCP1) and tumor necrosis factor a (TNFa) were measured. Both lipid-lowering drugs had positive, complementary and additive effects on inflammatory markers, which were closely related to baseline inflammatory status. © 2011 Elsevier Ireland Ltd.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::258f8c70a0f679545871d75171a9d0cdTest
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10657Test -
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مصطلحات موضوعية: Unclassified drug, Acylamino acid releasing enzyme, Methylphosphonofluoridic acid, Nonhuman, Fatty acid synthase, Sarin, Macaca mulatta, Dipeptidyl peptidase 9, Carboxylesterase, Chemistry, Organophosphate, Chemical structure, Human cell, 1 alkyl 2 acetylglycerophosphocholine esterase, Dipeptidyl peptidase, Matrix assisted laser desorption ionization time of flight mass spectrometry, Prolyl endopeptidase, Palmitoyl coenzyme A hydrolase, Protein analysis, Biotinylation, Animal cell, Quantitative analysis, Sensitivity analysis, Controlled study, Human
الوصف: Elucidation of noncholinesterase protein targets of organophosphates, and nerve agents in particular, may reveal additional mechanisms for their high toxicity as well as clues for novel therapeutic approaches toward intoxications with these agents. Within this framework, we here describe the synthesis of the activity-based probe 3, which contains a phosphonofluoridate moiety, a P-Me moiety, and a biotinylated O-alkyl group, and its use in activity-based protein profiling with two relevant biological samples, that is, rhesus monkey liver and cultured human A549 lung cells. In this way, we have unearthed eight serine hydrolases (fatty acid synthase, acylpeptide hydrolase, dipeptidyl peptidase 9, prolyl oligopeptidase, carboxylesterase, long-chain acyl coenzyme A thioesterase, PAF acetylhydrolase 1b, and esterase D/S-formyl glutathione hydrolase) as targets that are modified by the nerve agent sarin. It is also shown that the newly developed probe 3 might find its way into the development of alternative, less laborious purification protocols for human butyrylcholinesterase, a potent bioscavenger currently under clinical investigation as a prophylactic/therapeutic for nerve agent intoxications. © 2009 American Chemical Society.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dris___00893::955719a108e99483b4745c34f1167c48Test
http://resolver.tudelft.nl/uuid:2ad7bce2-36f8-490a-af36-183d6b0dec16Test -
9دورية أكاديمية
المؤلفون: van Leeuwen, Henk J., Van Beek, A.P., Dallinga-Thie, G.M., Van Strijp, J.A.G., Verhoef, J., Van Kessel, K.P.M.
المصدر: van Leeuwen , H J , Van Beek , A P , Dallinga-Thie , G M , Van Strijp , J A G , Verhoef , J & Van Kessel , K P M 2001 , ' The role of high density lipoprotein in sepsis ' , Netherlands Journal of Medicine , vol. 59 , no. 3 , pp. 102-110 . https://doi.org/10.1016/S0300-2977Test(01)00144-9
مصطلحات موضوعية: 1 alkyl 2 acetylglycerophosphocholine esterase, apolipoprotein A, apoprotein, C reactive protein, CD14 antigen, chemotactic factor, cholesterol ester, cholesterol ester transfer protein, cholesterol esterase, chylomicron, clusterin, endotoxin, G protein coupled receptor, glycosylphosphatidylinositol, high density lipoprotein, interleukin 1, interleukin 6, intermediate density lipoprotein, lipopolysaccharide, lipopolysaccharide binding protein, phosphatidylcholine sterol acyltransferase, phospholipid transfer protein, RANTES, scavenger receptor, serum amyloid A, tissue factor pathway inhibitor, triacylglycerol, tumor necrosis factor, unindexed drug, cholesterol transport
الإتاحة: https://doi.org/10.1016/S0300-2977Test(01)00144-9
https://hdl.handle.net/11370/34bf0fed-3e75-409c-bda9-b43776e70f20Test
https://research.rug.nl/en/publications/34bf0fed-3e75-409c-bda9-b43776e70f20Test
النص الكامل