المؤلفون: Patrizia Natale, Sharon Chen, Clara K. Chow, Ngai Wah Cheung, David Martinez‐Martin, Corinne Caillaud, Nicole Scholes‐Robertson, Ayano Kelly, Jonathan C. Craig, Giovanni Strippoli, Allison Jaure

المصدر: Journal of Diabetes, Vol 15, Iss 12, Pp 1048-1069 (2023)

مصطلحات موضوعية: 连续血糖监测, 胰岛素泵治疗, 患者体验, 1型糖尿病, 2型糖尿病, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Aims Blood glucose control is central to the management of diabetes, and continuous glucose monitoring (CGM) improves glycemic control. We aimed to describe the perspectives of people with diabetes using CGM. Materials and methods We performed a systematic review of qualitative studies. Results Fifty‐four studies involving 1845 participants were included. Six themes were identified: gaining control and convenience (reducing pain and time, safeguarding against complications, achieving stricter glucose levels, and sharing responsibility with family); motivating self‐management (fostering ownership, and increasing awareness of glycemic control); providing reassurance and freedom (attaining peace of mind, and restoring social participation); developing confidence (encouraged by the endorsement of others, gaining operational skills, customizing settings for ease of use, and trust in the device); burdened with device complexities (bewildered by unfamiliar technology, reluctant to rely on algorithms, overwhelmed by data, frustrated with malfunctioning and inaccuracy, distressed by alerts, and bulkiness of machines interfering with lifestyle); and excluded by barriers to access (constrained by cost, lack of suppliers). Conclusions CGM can improve self‐management and confidence in patients managing diabetes. However, the technical issues, uncertainty in readings, and cost may limit the uptake. Education and training from the health professionals may help to reduce the practical and psychological burden for better patient outcomes.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test

الوصول الحر: https://doaj.org/article/944ef3370fae45ebafc7db5ed8b7a73bTest

المؤلفون: Dicle Canoruc Emet, Hande Nur Karavar, Onur Gozmen, Arife Aslan Agyar, Yağmur Ünsal, Merve Canturk, Pınar Cengiz, Dogus Vuralli, Z. Alev Ozon, E. Nazlı Gonc

المصدر: Journal of Diabetes, Vol 15, Iss 12, Pp 1011-1019 (2023)

مصطلحات موضوعية: BMI, 缓解, 1型糖尿病, 体重变化, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Background Residual beta‐cell function and improvement in insulin sensitivity by reversal of glucose toxicity are two phenomena thought to be related to partial remission (PR). Body fat mass is the major determinant of insulin sensitivity. The aim of this study is to investigate the relationship between the rate of body weight gain after diagnosis of type 1 diabetes mellitus (T1DM) and other clinical factors for the development and duration of PR. Methods Children (2–16 years) with new‐onset T1DM (n = 99) were grouped into remitters and non‐remitters by using insulin dose‐adjusted glycosylated hemoglobin (HbA1c) values. Laboratory and clinical data as well as daily insulin requirement per kilogram of body weight at diagnosis and each visit were recorded, and the duration of PR was determined. Changes in body mass index standard deviation score (BMI‐SDS) were calculated by the auxological data collected every 6 months. Results There were 47 remitters (47.5%) and 52 (52.5%) non‐remitters. The mean increase in BMI‐SDS at the first 6 months of diagnosis was higher in the non‐remitters than in the remitters (p = 0.04). Duration of PR was negatively correlated with the change in BMI‐SDS between 6 and 12 months after diagnosis. Male sex, younger age, prepubertal status, and lower HbA1c were predictors of remission, among which male sex had the highest chance by multivariate regression. Conclusions Early rapid weight gain after diagnosis of T1DM may play a role in the lack of remission and shorter duration of PR. Interventions to prevent early rapid weight gain can maintain the development and prolongation of remission.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test

الوصول الحر: https://doaj.org/article/f326db3fcaf045ceb43025058221198dTest

المؤلفون: LUO Xinchun (罗新春), YE Haidan (叶海丹), CHEN Huilin (陈慧琳)

المصدر: 中西医结合护理, Vol 9, Iss 10, Pp 227-230 (2023)

مصطلحات موضوعية: kidney transplantation, islet transplantation, type 1 diabetic mellitus, renal failure, 肾移植, 胰岛移植, 围手术期护理, 1型糖尿病, 肾功能衰竭, Nursing, RT1-120

الوصف: To review the clinical data and perioperative nursing of a child undergoing islet transplantation followed by kidney transplantation for diabetic mellitus complicated with renal failure. Based on the comprehensive analysis of psychological characteristics and disease condition of the child, preoperative preparation and medication care were carried out. Key issues of postoperative nursing were prevention of portal thrombosis, blood glucose monitoring, prevention of transplant rejection and infection. (本文回顾1例儿童糖尿病合并肾功能衰竭肾移植术后行胰岛移植的临床资料, 总结围手术期护理措施。针对儿童心理特点和病情特点, 术前做好相关准备、用药的护理, 术后做好预防门静脉血栓形成的护理、严密的血糖监测、预防术后排斥反应、感染的护理, 保证患儿术后早期康复。)

وصف الملف: electronic resource

العلاقة: http://www.zxyjhhl.hk/thesisDetails#10.55111/j.issn2709-1961.202304009Test; https://doaj.org/toc/2709-1961Test

الوصول الحر: https://doaj.org/article/a4f87faa6a5447ec8a2312c5bdcc3728Test

المؤلفون: Alfonso Lendínez‐Jurado, Ana Gómez‐Perea, Ana B. Ariza‐Jiménez, Leopoldo Tapia‐Ceballos, Icía Becerra‐Paz, María F. Martos‐Lirio, Fernando Moreno‐Jabato, Isabel Leiva‐Gea

المصدر: Journal of Diabetes, Vol 15, Iss 8, Pp 699-708 (2023)

مصطلحات موضوعية: 儿童1型糖尿病, 高级混合闭环, 目标范围内时间, 高血糖时间, MiniMedTM 780G, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Background In recent years, technological advances in the field of diabetes have revolutionized the management, prognosis, and quality of life of diabetes patients and their environment. The aim of our study was to evaluate the impact of implementing the MiniMed 780G closed‐loop system in a pediatric and adolescent population previously treated with a continuous subcutaneous insulin infusion pump and intermittent glucose monitoring. Methods Data were collected from 28 patients with type 1 diabetes aged 6 to 17 years, with a follow‐up of 6 months. We included both glucometric and quality of life variables, as well as quality of life in primary caregivers. Metabolic control variables were assessed at baseline (before system change) and at different cutoff points after initiation of the closed‐loop system (48 hours, 7 days, 14 days, 21 days, 1 month, 3 months, 6 months). Results Time in range 70–180 mg/dL increased from 59.44% at baseline to 74.29% in the first 48 hours after automation of the new system, and this improvement was maintained at the other cutoff points, as was time in hyperglycemia 180–250 mg/dL (24.44% at baseline to 18.96% at 48 hours) and >250 mg/dL (11.71% at baseline to 3.82% at 48 hours). Conclusions Our study showed an improvement in time in range and in all time spent in hyperglycemia from the first 48 hours after the automation of the system, which was maintained at 6 months.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test

الوصول الحر: https://doaj.org/article/014cf4f980ba486da0c24b1c8aaef0adTest

المؤلفون: Jessie J. Wong, Ananta Addala, Sarah J. Hanes, Sara Krugman, Diana Naranjo, Sierra Nelmes, Kyle Jacques Rose, Molly L. Tanenbaum, Korey K. Hood

المصدر: Journal of Diabetes, Vol 15, Iss 7, Pp 597-606 (2023)

مصطلحات موضوعية: 动态血糖监测, 糖尿病困扰, 胰岛素, 胰岛素泵, 1型糖尿病, 2型糖尿病, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Background DiabetesWise is an unbranded, data‐driven online resource that tailors device recommendations based on preferences and priorities of people with insulin‐requiring diabetes. The objective of this study is to examine whether DiabetesWise increases uptake of diabetes devices, which are empirically supported to improve glycemic and psychosocial outcomes. Methods The sample included 458 participants (Mage = 37.1, SD = 9.73; 66% female; 81% type 1 diabetes) with insulin‐requiring diabetes and minimal diabetes device use at enrollment. Participants used DiabetesWise and completed online surveys. Chi‐square and t tests evaluated requests for a device prescription, receiving a prescription, and starting a new device at 1 and 3 months post use. Baseline predictors of these variables and past use of continuous glucose monitors (CGMs) and changes in diabetes distress post use were also examined. Results Within the first month of interacting with DiabetesWise 19% of participants asked for a prescription for a diabetes device. This rate rose to 31% in the first 3 months. These requests resulted in 16% of the sample starting a new device within the first 3 months. Whereas several factors were associated with prior CGM use, receiving a prescription, and starting a new device, more diabetes distress (t(343) = −3.13, p = .002) was the only factor associated with asking for a prescription. Diabetes distress decreased after interacting with DiabetesWise within 1 month (t(193) = 3.51, p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test

الوصول الحر: https://doaj.org/article/5e6f113e151a4f6ea0cffc4cfd55a714Test

المؤلفون: Neihenuo Chuzho, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gunja Mishra, Akanksha Sharma, Narinder K. Mehra, Neeraj Kumar

المصدر: Journal of Diabetes, Vol 15, Iss 7, Pp 607-621 (2023)

مصطلحات موضوعية: CD4 T细胞, 细胞因子, GAD65, HLA, 1型糖尿病, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Aim We planned this study to identify diabetogenic glutamic acid decarboxylase (GAD65) peptides possibly responsible for human leucocyte antigen (HLA)‐DR3/DQ2‐mediated activation of GAD65‐specific CD4 T cells in type 1 diabetes (T1D). Methods Top 30 GAD65 peptides, found to strongly bind in silico with HLA‐DR3/DQ2 molecules, were selected and grouped into four pools. The peptides were used to stimulate CD4 T cells of study subjects in 16‐h peripheral blood mononuclear cell culture. CD4 T cells' stimulation in terms of interferon‐gamma (IFN‐γ), interleukin (IL)‐17, tumor necrosis factor‐alpha (TNF‐α), and IL‐10 expression was analyzed using flow cytometry. Results Although all four GAD65 peptide pools (PP1‐4) resulted in significantly higher expression of IFN‐γ by CD4 T cells (p = .003, p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test

الوصول الحر: https://doaj.org/article/29ef37f916e442c4abfe137d2e417e0cTest

المؤلفون: Yongwen Zhou, Mao Zheng, Hongrong Deng, Xueying Zheng, Sihui Luo, Daizhi Yang, Xiaodong Mai, Wen Xu, Jinhua Yan, Jianping Weng

المصدر: Journal of Diabetes, Vol 15, Iss 6, Pp 465-473 (2023)

مصطلحات موضوعية: 基础高血糖, 餐后血糖, HbA1C, 1型糖尿病, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract Aim Evidence for contribution of basal and postprandial glucose increment, and glycemic variability to glycated hemoglobin (HbA1c) among adults with type 1 diabetes (T1D) is limited. This study aimed to capture glycemic fluctuation patterns and quantify contributions of these factors to HbA1c levels among adults with T1D. Methods HbA1c, continuous glucose monitoring (CGM), and diet diaries were collected and pooled from two clinical trials. Available data sets were divided into HbA1c quartiles: group 1 (≤6.7%), group 2 (6.7%–7.3%), group 3 (7.3%–7.8%), and group 4 (≥7.8%). Area under curve above 110 mg/dL (AUC>110mg/dL) in 24‐h profile was defined as overall hyperglycemia and stratified with postprandial hyperglycemia (PHG, AUC>110mg/dL in 3‐h period after meals) and basal hyperglycemia (BHG, AUC>110mg/dL in remaining period). Linear regression analysis was used to estimate the proportion of variance in HbA1c explained by BHG, preprandial glucose, PHG, glycemic variability, and non‐glycemic factors (age, body mass index, hemoglobin, and duration). Results A total of 169 550 glucose data in 2409 meals recorded from 102 patients (male/female, 34/68) were included. Age and duration were 35.2 ± 12.6 and 8.9 (2.9, 13.0) years, with 51.0% using pumps. Overall, BHG was four times higher than PHG (p all .05). Factors included in analysis explained a total of 74% of the variance in HbA1c, in which BHG accounted for 32.1% of variance whereas PHG accounted for 24.4%. In group with HbA1c >7.3%, BHG accounted for a higher percentage with 33.8% of the variance in HbA1c. Conclusions In our study, basal hyperglycemia better predicts overall glycemic control than postprandial hyperglycemia among adults with T1D. The relative contribution of basal hyperglycemia increased gradually with HbA1c increasing and predominant strategy for insulin titration among T1D is different among different levels of glycemic control.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test

الوصول الحر: https://doaj.org/article/39a39a127dd44b2497e70df2a731f168Test

المؤلفون: Hiroshi Ikegami, 池上 博司

المصدر: 糖尿病 / Journal of the Japan Diabetes Society. 2024, 67(1):1

المؤلفون: 1型糖尿病における新病態の探索的検討委員会, Akihisa Imagawa, Akira Shimada, Daisuke Chujo, Eiji Kawasaki, Haruhiko Osawa, Hiroshi Ikegami, Hiroshi Kajio, Junji Ozawa, Junnosuke Miura, Kazuki Yasuda, Kazuma Takahashi, Norio Abiru, Shinsuke Noso, Takuya Awata, The Committee of Type 1 Diabetes, Japan Diabetes Society, Tomoyasu Fukui, Yasufumi Yasuda, Yoichi Oikawa, 三浦 順之助, 中條 大輔, 今川 彰久, 及川 洋一, 大澤 春彦, 安田 和基, 安田 尚史, 小澤 純二, 島田 朗, 川﨑 英二, 梶尾 裕, 池上 博司, 福井 智康, 粟田 卓也, 能宗 伸輔, 阿比留 教生, 高橋 和眞

المصدر: 糖尿病 / Journal of the Japan Diabetes Society. 2023, 66(12):807

المؤلفون: Hiroshi Nakao, Junki Abe, Keizo Ohnaka, Ryuichi Sakamoto, Saori Yamasita, Toshihiko Nagao, Yasuko Oryoji, Yayoi Matsuda, Yoshihiro Ogawa, Yumika Hino, 中尾 裕, 坂本 竜一, 大中 佳三, 小川 佳宏, 山下 彩織, 押領司 虞子, 日野 有美香, 松田 やよい, 長尾 敏彦, 阿部 隼希

المصدر: 糖尿病 / Journal of the Japan Diabetes Society. 2023, 66(12):850