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1دورية أكاديمية
مصطلحات موضوعية: Biophysics, Medicine, Sociology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, real water samples, nanosized graphene oxide, metal ions using, linear dynamic ranges, disposable microfluidic sensor, contact angle measurement, sample flow rate, 29 ± 0, 14 ± 0, 07 ± 0, 04 ± 0, model target species, carbon channel walls, achieve capillary action, 2 +, small ac potential, additional electrodynamic force, driven separation detection, target species, electrodynamic force, flow variables, applied potential, 0 ppb, separation device
الوصف: A disposable microfluidic channel sensor printed on a plastic platform was developed to analyze heavy metal ions (HMIs) as a model target species. Precise separation and detection of multiple targets were established by symmetrically applying a small AC potential on the carbon channel walls to induce an electrodynamic force. The separation device was constructed by covering it with a plastic lid to achieve capillary action in the channel. The sample flow rate was regulated by the hydrophilicity of the lid plastic and electrodynamic convection by the AC field, which was characterized by the contact angle measurement and the additional electrodynamic force. The flow variables and their relevance to the capillary phenomena were demonstrated, and the analytical parameters were optimized. The working electrode was modified with poly(diamino terthiophene) anchored with nanosized graphene oxide (pDATT/GO) to enhance the detection performance. The experimental variables for separating and detecting the target species were optimized according to the AC frequency and amplitude, sample flow rate, electrolytes, pH, temperature, and applied potential for detection. The linear dynamic ranges were between 0.1 and 200.0 ppb, with detection limits of 0.04 ± 0.023, 0.29 ± 0.05, 0.07 ± 0.011, and 0.14 ± 0.06 ppb for Cu 2+ Cd 2+ , Hg 2+ , and Pb 2+ , respectively. Finally, the reliability of the proposed method was evaluated through analysis of HMIs in real water samples. The results were matched to those obtained through parallel analysis using ICP–MS at a 95% confidence level.
الإتاحة: https://doi.org/10.1021/acs.analchem.3c03518.s001Test
https://figshare.com/articles/journal_contribution/Capillary_and_Electrodynamic_Forces-Driven_Separation_Detection_of_Metal_Ions_Using_a_Disposable_Microfluidic_Sensor_with_a_Composite_Electrode/24496648Test -
2دورية أكاديمية
المؤلفون: Margaret Toluwalayo Arowolo, Oluwatosin Qawiyy Orababa, Morufat Oluwatosin Olaitan, Bisola Victoria Osibeluwo, Utibeima Udo Essiet, Olajumoke Hanah Batholomew, Oluwaseyi Gbotoluwa Ogunrinde, Oluwaseyi Aminat Lagoke, Jeffrey Difiye Soriwei, Olanrewaju David Ishola, Onyinye Maryann Ezeani, Aminat Oyeronke Onishile, Elizabeth Olumodeji
مصطلحات موضوعية: Microbiology, Genetics, Molecular Biology, Neuroscience, Biotechnology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Computational Biology,
+sim%22">xlink "> sim, systematically searched following, random effect model, preferred reporting items, african journal online, div >< p, 99 %, 9 %, significantly high multidrug, 04 – 0, 02 – 0, funnel plot analysis, region &# 8217, analysis , 98 %, articles reporting carbapenem, 2 الوصف: Carbapenems are effective drugs against bacterial pathogens and resistance to them is considered a great public health threat, especially in notorious nosocomial pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa . In this study, we aimed to determine the prevalence of carbapenem resistance in A . baumannii and P . aeruginosa infections in Sub-Saharan Africa. Databases (PubMed, Scopus, Web of Science, and African Journal Online) were systematically searched following the Preferred Reporting Items for Systematic review and meta-analysis protocols (PRISMA-P) 2020 statements for articles reporting carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) prevalence between 2012 and 2022. Pooled prevalence was determined with the random effect model and funnel plots were used to determine heterogeneity in R. A total of 47 articles were scanned for eligibility, among which 25 (14 for carbapenem-resistant A . baumannii and 11 for carbapenem-resistant P . aeruginosa ) were included in the study after fulfilling the eligibility criteria. The pooled prevalence of CRPA in the present study was estimated at 8% (95% CI; 0.02–0.17; I 2 = 98%; P <0.01). There was high heterogeneity (Q = 591.71, I 2 = 98.9%; P<0.0001). In addition, this study’s pooled prevalence of CRAB was estimated at 20% (95% CI; 0.04–0.43; I 2 = 99%; P <0.01). There was high heterogeneity (Q = 1452.57, I 2 = 99%; P<0.0001). Also, a funnel plot analysis of the studies showed high degree of heterogeneity. The carbapenemase genes commonly isolated from A . baumannii in this study include bla OXA23, bla OXA48 , bla GES. , bla NDM, bla VIM , bla OXA24 , bla OXA58 , bla OXA51 , bla SIM-1 , bla OXA40 , bla OXA66 , bla OXA69 , bla OXA91 , with bla OXA23 and bla VIM being the most common. On the other hand, bla NDM, bla VIM , bla IMP , bla OXA48 , bla OXA51 , bla SIM-1 , bla OXA181 , bla KPC , bla OXA23 , bla OXA50 were the commonly isolated carbapenemase genes in P . aeruginosa , among ...
الإتاحة: https://doi.org/10.1371/journal.pone.0287762.s002Test
https://figshare.com/articles/journal_contribution/Analysis_summary_for_CRPA_/24651142Test -
3دورية أكاديمية
المؤلفون: Margaret Toluwalayo Arowolo, Oluwatosin Qawiyy Orababa, Morufat Oluwatosin Olaitan, Bisola Victoria Osibeluwo, Utibeima Udo Essiet, Olajumoke Hanah Batholomew, Oluwaseyi Gbotoluwa Ogunrinde, Oluwaseyi Aminat Lagoke, Jeffrey Difiye Soriwei, Olanrewaju David Ishola, Onyinye Maryann Ezeani, Aminat Oyeronke Onishile, Elizabeth Olumodeji
مصطلحات موضوعية: Microbiology, Genetics, Molecular Biology, Neuroscience, Biotechnology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Computational Biology,
+sim%22">xlink "> sim, systematically searched following, random effect model, preferred reporting items, african journal online, div >< p, 99 %, 9 %, significantly high multidrug, 04 – 0, 02 – 0, funnel plot analysis, region &# 8217, analysis , 98 %, articles reporting carbapenem, 2 الوصف: Carbapenems are effective drugs against bacterial pathogens and resistance to them is considered a great public health threat, especially in notorious nosocomial pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa . In this study, we aimed to determine the prevalence of carbapenem resistance in A . baumannii and P . aeruginosa infections in Sub-Saharan Africa. Databases (PubMed, Scopus, Web of Science, and African Journal Online) were systematically searched following the Preferred Reporting Items for Systematic review and meta-analysis protocols (PRISMA-P) 2020 statements for articles reporting carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) prevalence between 2012 and 2022. Pooled prevalence was determined with the random effect model and funnel plots were used to determine heterogeneity in R. A total of 47 articles were scanned for eligibility, among which 25 (14 for carbapenem-resistant A . baumannii and 11 for carbapenem-resistant P . aeruginosa ) were included in the study after fulfilling the eligibility criteria. The pooled prevalence of CRPA in the present study was estimated at 8% (95% CI; 0.02–0.17; I 2 = 98%; P <0.01). There was high heterogeneity (Q = 591.71, I 2 = 98.9%; P<0.0001). In addition, this study’s pooled prevalence of CRAB was estimated at 20% (95% CI; 0.04–0.43; I 2 = 99%; P <0.01). There was high heterogeneity (Q = 1452.57, I 2 = 99%; P<0.0001). Also, a funnel plot analysis of the studies showed high degree of heterogeneity. The carbapenemase genes commonly isolated from A . baumannii in this study include bla OXA23, bla OXA48 , bla GES. , bla NDM, bla VIM , bla OXA24 , bla OXA58 , bla OXA51 , bla SIM-1 , bla OXA40 , bla OXA66 , bla OXA69 , bla OXA91 , with bla OXA23 and bla VIM being the most common. On the other hand, bla NDM, bla VIM , bla IMP , bla OXA48 , bla OXA51 , bla SIM-1 , bla OXA181 , bla KPC , bla OXA23 , bla OXA50 were the commonly isolated carbapenemase genes in P . aeruginosa , among ...
الإتاحة: https://doi.org/10.1371/journal.pone.0287762.s001Test
https://figshare.com/articles/journal_contribution/Analysis_summary_for_CRAB_/24651139Test -
4دورية أكاديمية
المؤلفون: Margaret Toluwalayo Arowolo, Oluwatosin Qawiyy Orababa, Morufat Oluwatosin Olaitan, Bisola Victoria Osibeluwo, Utibeima Udo Essiet, Olajumoke Hanah Batholomew, Oluwaseyi Gbotoluwa Ogunrinde, Oluwaseyi Aminat Lagoke, Jeffrey Difiye Soriwei, Olanrewaju David Ishola, Onyinye Maryann Ezeani, Aminat Oyeronke Onishile, Elizabeth Olumodeji
مصطلحات موضوعية: Microbiology, Genetics, Molecular Biology, Neuroscience, Biotechnology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Computational Biology,
+sim%22">xlink "> sim, systematically searched following, random effect model, preferred reporting items, african journal online, div >< p, 99 %, 9 %, significantly high multidrug, 04 – 0, 02 – 0, funnel plot analysis, region &# 8217, analysis , 98 %, articles reporting carbapenem, 2 الوصف: Carbapenems are effective drugs against bacterial pathogens and resistance to them is considered a great public health threat, especially in notorious nosocomial pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa . In this study, we aimed to determine the prevalence of carbapenem resistance in A . baumannii and P . aeruginosa infections in Sub-Saharan Africa. Databases (PubMed, Scopus, Web of Science, and African Journal Online) were systematically searched following the Preferred Reporting Items for Systematic review and meta-analysis protocols (PRISMA-P) 2020 statements for articles reporting carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) prevalence between 2012 and 2022. Pooled prevalence was determined with the random effect model and funnel plots were used to determine heterogeneity in R. A total of 47 articles were scanned for eligibility, among which 25 (14 for carbapenem-resistant A . baumannii and 11 for carbapenem-resistant P . aeruginosa ) were included in the study after fulfilling the eligibility criteria. The pooled prevalence of CRPA in the present study was estimated at 8% (95% CI; 0.02–0.17; I 2 = 98%; P <0.01). There was high heterogeneity (Q = 591.71, I 2 = 98.9%; P<0.0001). In addition, this study’s pooled prevalence of CRAB was estimated at 20% (95% CI; 0.04–0.43; I 2 = 99%; P <0.01). There was high heterogeneity (Q = 1452.57, I 2 = 99%; P<0.0001). Also, a funnel plot analysis of the studies showed high degree of heterogeneity. The carbapenemase genes commonly isolated from A . baumannii in this study include bla OXA23, bla OXA48 , bla GES. , bla NDM, bla VIM , bla OXA24 , bla OXA58 , bla OXA51 , bla SIM-1 , bla OXA40 , bla OXA66 , bla OXA69 , bla OXA91 , with bla OXA23 and bla VIM being the most common. On the other hand, bla NDM, bla VIM , bla IMP , bla OXA48 , bla OXA51 , bla SIM-1 , bla OXA181 , bla KPC , bla OXA23 , bla OXA50 were the commonly isolated carbapenemase genes in P . aeruginosa , among ...
الإتاحة: https://doi.org/10.1371/journal.pone.0287762.s003Test
https://figshare.com/articles/journal_contribution/S1_File_-/24651145Test -
5دورية أكاديمية
المؤلفون: Xin-Peng Sun, Chen-Sheng Yu, Li-Jing Min, Charles L. Cantrell, Xuewen Hua, Na-Bo Sun, Xing-Hai Liu
مصطلحات موضوعية: Biochemistry, Microbiology, Pharmacology, Biotechnology, Ecology, Plant Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, vitro antifungal activity, scanning electron microscopy, rising pesticide resistance, enhanced biological activity, 94 ± 0, 48 ± 0, 17 ± 0, 06 ± 0, 04 ± 0, 01 ± 0, 77 ± 1, u23 , u22 , u12 , carboxamide (< b, carboxamide derivatives containing, 13 , 71 ± 0, 70 ± 0, 11 ± 0, 50 , 1
الوصف: Developing environmentally friendly fungicides is crucial to tackle the issue of rising pesticide resistance. In this study, a series of novel pyrazole-4-carboxamide derivatives containing N -phenyl substituted amide fragments were designed and synthesized. The structures of target compounds were confirmed by 1 H NMR, 13 C NMR, and HRMS, and the crystal structure of the most active compound N -(1-(4-(4-( tert -butyl)benzamido)phenyl)propan-2-yl)-3-(difluoromethyl)- N -methoxy-1-methyl-1 H -pyrazole-4-carboxamide ( U22 ) was further determined by X-ray single-crystal diffraction. The bioassay results indicated that the 26 target compounds possessed good in vitro antifungal activity against Sclerotinia sclerotiorum with EC 50 values for compounds U12 , U13 , U15 , U16 , U18 , U22 , and U23 being 4.17 ± 0.46, 8.04 ± 0.71, 7.01 ± 0.71, 12.77 ± 1.00, 8.11 ± 0.70, 0.94 ± 0.11, and 9.48 ± 0.83 μg·mL –1 , respectively, which were the similar to controls bixafen (6.70 ± 0.47 μg·mL –1 ), fluxapyroxad (0.71 ± 0.14 μg·mL –1 ), and pydiflumetofen (0.06 ± 0.01 μg·mL –1 ). Furthermore, in vivo antifungal activity results against S. sclerotiorum indicated that compounds U12 (80.6%) and U22 (89.9%) possessed excellent preventative efficacy at 200 μg·mL –1 , which was the same as the control pydiflumetofen (82.4%). Scanning electron microscopy and transmission electron microscopy studies found that the compound U22 could destroy the hyphal morphology and damage mitochondria, cell membranes, and vacuoles. The results of molecular docking of compound U22 and pydiflumetofen with succinate dehydrogenase (SDH) indicated they interact well with the active site of SDH. This study validated our approach and design strategy to produce compounds with an enhanced biological activity as compared to the parent structure.
الإتاحة: https://doi.org/10.1021/acs.jafc.3c04842.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Highly_Efficient_Novel_Antifungal_Lead_Compounds_Targeting_Succinate_Dehydrogenase_Pyrazole-4-carboxamide_Derivatives_with_an_i_N_i_Phenyl_Substituted_Amide_Fragment/24657542Test -
6دورية أكاديمية
المؤلفون: William Whitaker, Igor V. Sazanovich, Yonghwan Kwon, Woojin Jeon, Min Sang Kwon, Andrew J. Orr-Ewing
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Evolutionary Biology, Ecology, Marine Biology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, triplet quantum yields, reverse intersystem crossing, resolved fluorescence spectroscopy, homogeneous organic photocatalysts, 97 ± 0, 83 ± 0, 38 ± 0, 32 ± 0, 18 ± 0, 04 ± 0, induced emission luminogens, example fluorescence lifetimes, 22 ± 1, dicyanobenzene derivative 4dp, 62 ± 0, 0 ± 5, tadf emission enhanced
الوصف: Thermally activated delayed fluorescence (TADF) emitters are molecules of interest as homogeneous organic photocatalysts (OPCs) for photoredox chemistry. Here, three classes of OPC candidates are studied in dichloromethane (DCM) or N,N-dimethylformamide (DMF) solutions, using transient absorption spectroscopy and time-resolved fluorescence spectroscopy. These OPCs are benzophenones with either carbazole (2Cz-BP and 2tCz-BP) or phenoxazine/phenothiazine (2PXZ-BP and 2PTZ-BP) appended groups and the dicyanobenzene derivative 4DP-IPN. Dual lifetimes of the S 1 state populations are observed, consistent with reverse intersystem crossing (RISC) and TADF emission. Example fluorescence lifetimes in DCM are (5.18 ± 0.01) ns and (6.22 ± 1.27) μs for 2Cz-BP, (1.38 ± 0.01) ns and (0.32 ± 0.01) μs for 2PXZ-BP, and (2.97 ± 0.01) ns and (62.0 ± 5.8) μs for 4DP-IPN. From ground state bleach recoveries and time-correlated single photon counting measurements, triplet quantum yields in DCM are estimated to be 0.62 ± 0.16, 0.04 ± 0.01, and 0.83 ± 0.02 for 2Cz-BP, 2PXZ-BP, and 4DP-IPN, respectively. 4DP-IPN displays similar photophysical behavior to the previously studied OPC 4Cz-IPN. Independent of the choice of solvent, 4DP-IPN, 2Cz-BP, and 2tCz-BP are shown to be TADF emitters, whereas emission by 2PXZ-BP and 2PTZ-BP depends on the molecular environment, with TADF emission enhanced in aggregates compared to monomers. Behavior of this type is representative of aggregation-induced emission luminogens (AIEgens).
الإتاحة: https://doi.org/10.1021/acs.jpca.3c04780.s001Test
https://figshare.com/articles/journal_contribution/Characterization_of_the_Reversible_Intersystem_Crossing_Dynamics_of_Organic_Photocatalysts_Using_Transient_Absorption_Spectroscopy_and_Time-Resolved_Fluorescence_Spectroscopy/24811931Test -
7دورية أكاديمية
المؤلفون: Min Seong Kim (2847974), Gil Ju Lee (5006696)
مصطلحات موضوعية: Biophysics, Neuroscience, Biotechnology, Science Policy, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, “ seed ”, unique bit sequences, state light sources, several encryption methods, physically unclonable functions, following three components, external saturated surface, captured raw images, assembled porous polymers, assembled porous polymer, affordable fabrication processes, 04 /∼ 0, optical puf systems, high security levels, connected medicines ), dependent puf system, 5 ), intra, security technologies, optical responses, annealing ), visually hidden, successfully confirmed
الوصف: Owing to the advancement of security technologies, several encryption methods have been proposed. Despite such efforts, forging artifices is financially and somatically becoming a constraint for individuals and society (e.g., imprinting replicas of luxury goods or directly life-connected medicines). Physically unclonable functions (PUFs) are one of the promising solutions to address these personal and social issues. The unreplicability of PUFs is a crucial factor for high security levels. Here, this study proposes a visually hidden and self-assembled porous polymer (VSPP) as a tag for optical PUF systems. The VSPP has virtues in terms of wavelength dependency, lens-free compact PUF system, and simple/affordable fabrication processes (i.e., spin coating and annealing). The VSPP consists of an external saturated surface, which covers the inner structures, and an internally abundant porous layer, which triggers stochastic multiple Mie scattering with wavelength dependency. We theoretically and experimentally validate the unobservability of the VSPP and the uniqueness of optical responses by image sensors. Finally, we establish a wavelength-dependent PUF system by using the following three components: solid-state light sources, a VSPP tag, and an image sensor. The captured raw images by the sensor serve as “seed” for unique bit sequences. The robustness of our system is successfully confirmed in terms of bit uniformity (∼0.5), intra/interdevice Hamming distances (∼0.04/∼0.5), and randomness (using NIST test).
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8دورية أكاديمية
المؤلفون: Eszter Szalai (14419953), Péter Tajti (14419956), Bence Szabó (14071842), Péter Hegyi (353118), László Márk Czumbel (6664193), Saghar Shojazadeh (14419959), Gábor Varga (6664211), Orsolya Németh (12874953), Beata Keremi (14419962)
مصطلحات موضوعية: Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, volatile sulfur compound, randomised controlled trials, organoleptic test scores, last available follow, good supportive therapy, comparator groups used, 14th october 2021, found 325 articles, 6 ], heterogeneity, 41 –- 0, 04 –- 0, 4 %, standardised mean difference, following electronic databases, 0 %, week ols data, 2 , mean difference, vitro <, ten articles, [- 2, 07 ], [- 0
الوصف: The domains and the overall risk of bias were marked using the following traffic light system: red signified high risk, yellow indicated some concerns, and green represented a low risk of bias. (PDF)
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9دورية أكاديمية
المؤلفون: Eszter Szalai (14419953), Péter Tajti (14419956), Bence Szabó (14071842), Péter Hegyi (353118), László Márk Czumbel (6664193), Saghar Shojazadeh (14419959), Gábor Varga (6664211), Orsolya Németh (12874953), Beata Keremi (14419962)
مصطلحات موضوعية: Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, volatile sulfur compound, randomised controlled trials, organoleptic test scores, last available follow, good supportive therapy, comparator groups used, 14th october 2021, found 325 articles, 6 ], heterogeneity, 41 –- 0, 04 –- 0, 4 %, standardised mean difference, following electronic databases, 0 %, week ols data, 2 , mean difference, vitro <, ten articles, [- 2, 07 ], [- 0
الوصف: Note: CI: Confidence interval; SD: Standard deviation. (PDF)
العلاقة: https://figshare.com/articles/journal_contribution/Data_included_in_the_meta-analysis_/21892017Test
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10دورية أكاديمية
المؤلفون: Eszter Szalai (14419953), Péter Tajti (14419956), Bence Szabó (14071842), Péter Hegyi (353118), László Márk Czumbel (6664193), Saghar Shojazadeh (14419959), Gábor Varga (6664211), Orsolya Németh (12874953), Beata Keremi (14419962)
مصطلحات موضوعية: Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, volatile sulfur compound, randomised controlled trials, organoleptic test scores, last available follow, good supportive therapy, comparator groups used, 14th october 2021, found 325 articles, 6 ], heterogeneity, 41 –- 0, 04 –- 0, 4 %, standardised mean difference, following electronic databases, 0 %, week ols data, 2 , mean difference, vitro <, ten articles, [- 2, 07 ], [- 0
الوصف: The domains and the overall risk of bias were marked using the following traffic light system: red signified high risk, yellow indicated some concerns, and green represented a low risk of bias. (PDF)
