المؤلفون: Hinault, Thomas, D’argembeau, Arnaud, Bowler, Dermot, La Corte, Valentina, Desaunay, Pierre, Provasi, Joelle, Platel, Hervé, Tran The, Jessica, Charretier, Laura, Giersch, Anne, Droit-Volet, Sylvie

المساهمون: Neuropsychologie et imagerie de la mémoire humaine (NIMH), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Liège, University of London London, Laboratoire Mémoire, Cerveau et Cognition (LMC2 (URP_7536)), Université Paris Cité (UPCité), Institut universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Cognitions Humaine et ARTificielle (CHART), Université Paris 8 Vincennes-Saint-Denis (UP8)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Paris Nanterre (UPN)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-CY Cergy Paris Université (CY), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS)-Les Hôpitaux Universitaires de Strasbourg (HUS), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)

المصدر: ISSN: 0149-7634.

مصطلحات موضوعية: Neurology, Neuropsychology, Psychiatry, Time perception, Timing, MESH: Humans, MESH: Time Perception, MESH: Mental Disorders, MESH: Cognition, MESH: Judgment, MESH: Auditory Perception, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health

الوصف: International audience ; A central question in understanding cognition and pathology-related cognitive changes is how we process time. However, time processing difficulties across several neurological and psychiatric conditions remain seldom investigated. The aim of this review is to develop a unifying taxonomy of time processing, and a neuropsychological perspective on temporal difficulties. Four main temporal judgments are discussed: duration processing, simultaneity and synchrony, passage of time, and mental time travel. We present an integrated theoretical framework of timing difficulties across psychiatric and neurological conditions based on selected patient populations. This framework provides new mechanistic insights on both (a) the processes involved in each temporal judgement, and (b) temporal difficulties across pathologies. By identifying underlying transdiagnostic time-processing mechanisms, this framework opens fruitful avenues for future research.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37871780; hal-04308980; https://hal.science/hal-04308980Test; https://hal.science/hal-04308980/documentTest; https://hal.science/hal-04308980/file/1-s2.0-S0149763423003998-main.pdfTest; PUBMED: 37871780

الإتاحة: https://doi.org/10.1016/j.neubiorev.2023.105430Test
https://hal.science/hal-04308980Test
https://hal.science/hal-04308980/documentTest
https://hal.science/hal-04308980/file/1-s2.0-S0149763423003998-main.pdfTest

المؤلفون: Ihme, H., Courtet, Philippe, Risch, Nathan, Dubois, Jonathan, Belzeaux, R., Olié, Émilie

المساهمون: Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Lapeyronie Montpellier (CHU), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), ANR-17-EURE-0029,nEURo*AMU,Marseille NeuroSchool, une formation d'excellence(2017), ANR-23-CE06-0020,CANOLA,Gels d'Huiles Alimentaires avec des Amide Gras Endogènes(2023)

المصدر: ISSN: 0924-9338.

مصطلحات موضوعية: Suicidal ideation, attachment, childhood trauma, depression, psychological pain, social pain, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health

الوصف: International audience ; Introduction: Childhood trauma (CT), depression and psychological pain are known predictors of suicidal ideation. Recent literature additionally highlights the importance of the attachment system.Methods: We aimed to predict suicidal ideation through CT, attachment, and psychological and social pain by using mediation models aiming to predict suicidal ideation through CT (predictor) and attachment (mediator). In the same models, we introduced psychological or social pain as moderator of the relationship between attachment, CT, and suicidal ideation. We included 161 depressed patients and assessed depression, attachment, CT, suicidal ideation, psychological pain, and social pain.Results: We found I) a complete mediating effect of anxious attachment (a2b2 = 0.0035, CI95% = [0.0010; 0.0069]) on the relationship between CT on suicidal ideation, and II) a significant complete conditional mediating effect of anxious attachment and psychological pain (Index of moderated mediation VAS: 0.0014; CI95% = [0.0002; 0.0032]) but not social pain on the relationship between CT and suicidal ideation. Both models were controlled for history of suicidal attempt, depression severity, and sex.Conclusion: Our results suggest a developmental profile of suicidal ideation in mood disorder that is characterized by the presence of CT and insecure attachment, especially anxious attachment, that is sensitive to experiences of psychological pain. Nevertheless, we cannot conclude that avoidantly attached individuals do not present the same mechanism, as they may not disclose those ideas.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37737057; hal-04220283; https://hal.science/hal-04220283Test; https://hal.science/hal-04220283/documentTest; https://hal.science/hal-04220283/file/Ihme%20et%20al%202023.pdfTest; PUBMED: 37737057; PUBMEDCENTRAL: PMC10594339

الإتاحة: https://doi.org/10.1192/j.eurpsy.2023.2452Test
https://hal.science/hal-04220283Test
https://hal.science/hal-04220283/documentTest
https://hal.science/hal-04220283/file/Ihme%20et%20al%202023.pdfTest

المؤلفون: Lucarini, Valeria, Alouit, Anaëlle, Yeh, Delphine, Le Coq, Jeanne, Savatte, Romane, Charre, Mylène, Louveau, Cécile, Houamri, Meryem Benlaifa, Penaud, Sylvain, Gaston-Bellegarde, Alexandre, Rio, Stéphane, Drouet, Laurent, Elbaz, Maxime, Becchio, Jean, Pourchet, Sylvain, Pruvost-Robieux, Estelle, Marchi, Angela, Moyal, Mylène, Lefebvre, Aline, Chaumette, Boris, Grice, Martine, Lindberg, Påvel, G, Dupin, Lucile, Piolino, Pascale, Lemogne, Cédric, Léger, Damien, Gavaret, Martine, Krebs, Marie-Odile, Iftimovici, Anton

المساهمون: Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), GHU Paris Psychiatrie et Neurosciences, Laboratoire Mémoire, Cerveau et Cognition (LMC2 (URP_7536)), Université Paris Cité (UPCité), Centre du Sommeil et de la Vigilance Paris, Hôpital Hôtel-Dieu Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Epileptologie et de Rythmologie Cérébrale Hôpital de la Timone, AP-HM, Aix Marseille Université (AMU)-Hôpital de la Timone CHU - APHM (TIMONE), Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle (UNIACT), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Neurosciences intégratives et Cognition / Integrative Neuroscience and Cognition Center (INCC - UMR 8002), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM (URP_7330)), Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA)-Université Paris Cité (UPCité)

المصدر: ISSN: 1471-244X ; BMC Psychiatry ; https://hal.science/hal-04314404Test ; BMC Psychiatry, 2023, 23 (1), pp.860. ⟨10.1186/s12888-023-05347-x⟩.

مصطلحات موضوعية: Neurophysiology, EEG microstates, Sleep, Sensorimotor integration, Speech, Virtual reality, Psychosis, Autism, Depression, Sense of self, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Background: Quantitative electroencephalography (EEG) analysis offers the opportunity to study high-level cognitive processes across psychiatric disorders. In particular, EEG microstates translate the temporal dynamics of neuronal networks throughout the brain. Their alteration may reflect transdiagnostic anomalies in neurophysiological functions that are impaired in mood, psychosis, and autism spectrum disorders, such as sensorimotor integration, speech, sleep, and sense of self. The main questions this study aims to answer are as follows: 1) Are EEG microstate anomalies associated with clinical and functional prognosis, both in resting conditions and during sleep, across psychiatric disorders? 2) Are EEG microstate anomalies associated with differences in sensorimotor integration, speech, sense of self, and sleep? 3) Can the dynamic of EEG microstates be modulated by a non-drug intervention such as light hypnosis?Methods: This prospective cohort will include a population of adolescents and young adults, aged 15 to 30 years old, with ultra-high-risk of psychosis (UHR), first-episode psychosis (FEP), schizophrenia (SCZ), autism spectrum disorder (ASD), and major depressive disorder (MDD), as well as healthy controls (CTRL) (N = 21 × 6), who will be assessed at baseline and after one year of follow-up. Participants will undergo deep phenotyping based on psychopathology, neuropsychological assessments, 64-channel EEG recordings, and biological sampling at the two timepoints. At baseline, the EEG recording will also be coupled to a sensorimotor task and a recording of the characteristics of their speech (prosody and turn-taking), a one-night polysomnography, a self-reference effect task in virtual reality (only in UHR, FEP, and CTRL). An interventional ancillary study will involve only healthy controls, in order to assess whether light hypnosis can modify the EEG microstate architecture in a direction opposite to what is seen in disease.Discussion: This transdiagnostic longitudinal ...

العلاقة: hal-04314404; https://hal.science/hal-04314404Test; https://hal.science/hal-04314404/documentTest; https://hal.science/hal-04314404/file/Lucarini%20et%20al.%20-%202023%20-%20Neurophysiological%20Explorations%20Across%20the%20Spectru.pdfTest

الإتاحة: https://doi.org/10.1186/s12888-023-05347-xTest
https://hal.science/hal-04314404Test
https://hal.science/hal-04314404/documentTest
https://hal.science/hal-04314404/file/Lucarini%20et%20al.%20-%202023%20-%20Neurophysiological%20Explorations%20Across%20the%20Spectru.pdfTest

المؤلفون: Rouy, Martin, Pereira, Michael, Saliou, Pauline, Sanchez, Rémi, El Mardi, Wassila, Sebban, Hanna, Baqué, Eugénie, Dezier, Childéric, Porte, Perrine, Micaux, Julia, de Gardelle, Vincent, Mamassian, Pascal, Moulin, Chris, J A, Dondé, Clément, Roux, Paul, Faivre, Nathan

المساهمون: Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB Université de Savoie Université de Chambéry )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des systèmes perceptifs (LSP), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), GIN Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), European Project: 803122,ERC-2018-STG,MetAction(2019)

المصدر: ISSN: 2334-265X ; npj Schizophrenia ; https://hal.science/hal-04203061Test ; npj Schizophrenia, 2023, 9 (1), pp.55. ⟨10.1038/s41537-023-00387-4⟩.

مصطلحات موضوعية: [SCCO]Cognitive science, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health

الوصف: International audience ; An effective way to quantify metacognitive performance is to ask participants to estimate their confidence in the accuracy of their response during a cognitive task. A recent meta-analysis 1 raised the issue that most assessments of metacognitive performance in schizophrenia spectrum disorders may be confounded with cognitive deficits, which are known to be present in this population. Therefore, it remains unclear whether the reported metacognitive deficits are metacognitive in nature or rather inherited from cognitive deficits. Arbitrating between these two possibilities requires equating task performance between experimental groups. Here, we aimed to characterize metacognitive performance among individuals with schizophrenia across three tasks (visual detection, familiarity, recollection) using a within-subject design while controlling experimentally for intra-individual task performance and statistically for between-subject task performance. In line with our hypotheses, we found no metacognitive deficit for visual detection and familiarity judgments. While we expected metacognition for recollection to be specifically impaired among individuals with schizophrenia, we found evidence in favor of an absence of a deficit in that domain also. We found no specific metacognitive deficit in schizophrenia spectrum disorder in the visual or memory domain. The clinical relevance of our findings is discussed in light of a hierarchical framework of metacognition.

العلاقة: info:eu-repo/grantAgreement//803122/EU/The motor hypothesis for self-monitoring: A new framework to understand and treat metacognitive failures/MetAction; hal-04203061; https://hal.science/hal-04203061Test; https://hal.science/hal-04203061/documentTest; https://hal.science/hal-04203061/file/s41537-023-00387-4-1.pdfTest

الإتاحة: https://doi.org/10.1038/s41537-023-00387-4Test
https://hal.science/hal-04203061Test
https://hal.science/hal-04203061/documentTest
https://hal.science/hal-04203061/file/s41537-023-00387-4-1.pdfTest

المؤلفون: Ayrolles, Anaël, Bargiacchi, Anne, Clarke, Julia, Michel, Morgane M.Magali, Baillin, Florence, Trebossen, Vincent, Kalifa, H. Poncet, Guilmin-Crépon, Sophie, Delorme, Richard, Godart, Nathalie T., Stordeur, Coline

المساهمون: Université Paris Cité (UPCité), Hôpital Robert Debré, Hôpital Robert Debré-Hôpital universitaire Robert Debré Reims (CHU Reims), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, PHRC, Programme Hospitalier de Recherche Clinique, Ministère de la Santé

المصدر: ISSN: 1471-244X ; BMC Psychiatry ; https://hal.science/hal-04271281Test ; BMC Psychiatry, 2023, 23 (1), ⟨10.1186/s12888-023-05222-9⟩.

مصطلحات موضوعية: Cost-effectiveness, Day-treatment, Early-onset anorexia nervosa, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health

الوصف: International audience ; Background: In children with early-onset anorexia nervosa (first symptoms before 13 years old, EO-AN), experts recommend initial outpatient treatment but in-patient treatment (IP) is frequently indicated due to acute medical instability or for those who have not improved with outpatient treatment. This IP can target either a partial weight restauration or a total weight normalization (return to the previous BMI growth trajectory). There are no evidence in the literature on which is the better therapeutic option in EOAN. But as long length of stay induce social isolation, with elevated costs, we wonder if a stepped-care model of daypatient treatment (DP) after short IP stabilisation may be a treatment option as effective as full-time IP to target weight normalization. We designed a two-arm randomised controlled trial testing the non-inferiority of a stepped-care model of DP after short IP stabilisation versus full-time IP. Methods: Eighty-eight children aged 8 to 13 years suffering from EOAN with initial severe undernutrition will be randomly allocated to either IP treatment as usual or a stepped care DP model both targeting weight normalization. Assessments will be conducted at inclusion, somatic stabilization, weight normalization, 6 months and 12 months post randomisation. The primary outcome will be BMI at 12 months post-randomisation. Secondaries outcomes will included clinical (tanner stage), biological (prealbumin, leptin, total ghrelin and IGF1) and radiological (bone mineralization and maturation) outcomes, eating symptomatology and psychiatric assessments, motivation to change, treatment acceptability and quality of life assessments, cost-utility and cost-effectiveness analyses. Discussion: COTIDEA will provide rigorous evaluation of treatment alternative to full-time inpatient treatment to allow a reduction of social iatrogenic link to hospital length of stay and associated costs. Trial registration: Trial is registered on ClinicalTrials.gov (NCT04479683).

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37817147; hal-04271281; https://hal.science/hal-04271281Test; https://hal.science/hal-04271281/documentTest; https://hal.science/hal-04271281/file/s12888-023-05222-9.pdfTest; PUBMED: 37817147

الإتاحة: https://doi.org/10.1186/s12888-023-05222-9Test
https://hal.science/hal-04271281Test
https://hal.science/hal-04271281/documentTest
https://hal.science/hal-04271281/file/s12888-023-05222-9.pdfTest

المؤلفون: Misdrahi, David, Dupuy, Maud, Dansou, Yecodji, Boyer, Laurent, Berna, Fabrice, Capdevielle, Delphine, Chereau, Isabelle, Coulon, Nathalie, D’amato, Thierry, Dubertret, Caroline, Leignier, Sylvain, Llorca, Pierre Michel, Lançon, Christophe, Mallet, Jasmina, Passerieux, Christine, Pignon, Baptiste, Rey, Romain, Schürhoff, Franck, Swendsen, Joel D., Urbach, Mathieu, Szöke, Andreï, Godin, Ophélia, Fond, Guillaume B., Andre, Myrtille, Andrieu-Haller, Christelle, Aouizerate, Bruno, Blanc, Olivier, Bourguignon, Evelien M., Clauss-Kobayashi, Julie M.E., Dassing, Romane, Dorey, Jean Michel, Esselin, Aurélie, Gabayet, Franck, Jarroir, Marine, Lacelle, Delphine, Leboyer, Marion, Mallet, Jacques J.B., Metairie, Emeline, Michel, Tanja Maria, Misdrahi, D., Petrucci, Jean, Pignon, B., Peri, Pauline, Portalier, Céline, Roman, Céline, Schorr, Benoît, Schürhoff, F., Tessier, Arnaud, Wachiche, G., Zinetti-Bertschy, Anna

المساهمون: Fondation FondaMental Créteil, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier Charles Perrens Bordeaux, CHU Henri Mondor Créteil, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Hôpital de la Colombière, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Louis Mourier - AP-HP Colombes, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier de Versailles André Mignot (CHV), CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Clermont-Ferrand, Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Université Sorbonne Paris Cité (USPC), Département Universitaire de Psychiatrie - Hôpital Sainte Marguerite - APHM (Hôpitaux Sud), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite CHU - APHM (Hôpitaux Sud ), Université de Bordeaux (UB), Hakim Laouamri, Fondation FondaMental, FFM, (ANR-10-COHO-10–01, ANR-11-IDEX-0004–02), ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010), ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011)

المصدر: ISSN: 2158-3188.

مصطلحات موضوعية: [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: International audience ; Schizophrenia is characterized by the most salient medication adherence problems among severe mental disorders, but limited prospective data are available to predict and improve adherence in this population. This investigation aims to identify predictors of medication adherence over a 1-year period in a large national cohort using clustering analysis. Outpatients were recruited from ten Schizophrenia Expert Centers and were evaluated with a day-long standardized battery including clinician and patient-rated medication adherence measures. A two-step cluster analysis and multivariate logistic regression were conducted to identify medication adherence profiles based on the Medication Adherence rating Scale (MARS) and baseline predictors. A total of 485 participants were included in the study and medication adherence was significantly improved at the 1-year follow-up. Higher depressive scores, lower insight, history of suicide attempt, younger age and alcohol use disorder were all associated with poorer adherence at 1 year. Among the 203 patients with initially poor adherence, 86 (42%) switched to good adherence at the 1-year follow-up, whereas 117 patients (58%) remained poorly adherent. Targeting younger patients with low insight, history of suicide, alcohol use disorder and depressive disorders should be prioritized through literacy and educational therapy programs. Adherence is a construct that can vary considerably from year to year in schizophrenia, and therefore may be amenable to interventions for its improvement. However, caution is also warranted as nearly one in five patients with initially good adherence experienced worsened adherence 1 year later.

العلاقة: hal-04294690; https://hal.science/hal-04294690Test; https://hal.science/hal-04294690/documentTest; https://hal.science/hal-04294690/file/s41398-023-02640-x.pdfTest

الإتاحة: https://doi.org/10.1038/s41398-023-02640-xTest
https://hal.science/hal-04294690Test
https://hal.science/hal-04294690/documentTest
https://hal.science/hal-04294690/file/s41398-023-02640-x.pdfTest

المؤلفون: Dobre, Daniela, Schwan, Raymund, Jansen, Claire, Schwitzer, Thomas, Martin, Olivier, Ligier, Fabienne, Rolland, Benjamin, Abdel-Ahad, Pierre, Capdevielle, Delphine, Corruble, Emmanuelle, Delamilleure, Pascal, Dollfus, Sonia, Drapier, Dominique, Bennabi, Djamila, Joubert, Fabien, Lecoeur, William, Massoubre, Catherine, Pelissolo, Antoine, Roser, Mathilde, Schmitt, Christophe, Teboul, Noé, Vansteene, Clément, Yekhlef, Wanda, Yrondi, Antoine, Haoui, Radoine, Gaillard, Raphaël, Leboyer, Marion, Thomas, Pierre, Gorwood, Philip, Laprevote, Vincent

المساهمون: Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS)-Les Hôpitaux Universitaires de Strasbourg (HUS), Centre Psychothérapique de Nancy Laxou (CPN), Faculté de Médecine Nancy, Université de Lorraine (UL), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), GHU Paris Psychiatrie et Neurosciences, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de psychiatrie adulte, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital La Colombière, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Comportement et noyaux gris centraux = Behavior and Basal Ganglia Rennes, Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou -Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier le Vinatier Bron, Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinique des maladies mentales et de l'encéphale (CMME - Service de psychiatrie), Hôpital Sainte-Anne-Université Paris Cité (UPCité), Service Psychiatrie et psychologie médicale CHU Toulouse, Pôle Psychiatrie CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Toulouse NeuroImaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Centre Hospitalier Gérard Marchant, Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)

المصدر: ISSN: 0033-2917.

مصطلحات موضوعية: COVID-19, Confusional state, Mental health, Psychiatry, [SDV]Life Sciences [q-bio], [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior

الوصف: International audience ; Background: Patients with psychiatric disorders are exposed to high risk of COVID-19 and increased mortality. In this study, we set out to assess the clinical features and outcomes of patients with current psychiatric disorders exposed to COVID-19.Methods: This multi-center prospective study was conducted in 22 psychiatric wards dedicated to COVID-19 inpatients between 28 February and 30 May 2020. The main outcomes were the number of patients transferred to somatic care units, the number of deaths, and the number of patients developing a confusional state. The risk factors of confusional state and transfer to somatic care units were assessed by a multivariate logistic model. The risk of death was analyzed by a univariate analysis.Results: In total, 350 patients were included in the study. Overall, 24 (7%) were transferred to medicine units, 7 (2%) died, and 51 (15%) patients presented a confusional state. Severe respiratory symptoms predicted the transfer to a medicine unit [odds ratio (OR) 17.1; confidence interval (CI) 4.9-59.3]. Older age, an organic mental disorder, a confusional state, and severe respiratory symptoms predicted mortality in univariate analysis. Age >55 (OR 4.9; CI 2.1-11.4), an affective disorder (OR 4.1; CI 1.6-10.9), and severe respiratory symptoms (OR 4.6; CI 2.2-9.7) predicted a higher risk, whereas smoking (OR 0.3; CI 0.1-0.9) predicted a lower risk of a confusional state.Conclusion: COVID-19 patients with severe psychiatric disorders have multiple somatic comorbidities and have a risk of developing a confusional state. These data underline the need for extreme caution given the risks of COVID-19 in patients hospitalized for psychiatric disorders.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33902760; hal-03224998; https://hal.science/hal-03224998Test; https://hal.science/hal-03224998/documentTest; https://hal.science/hal-03224998/file/div-class-title-clinical-features-and-outcomes-of-covid-19-patients-hospitalized-for-psychiatric-disorders-a-french-multi-centered-prospective-observational-study-div.pdfTest; PUBMED: 33902760; PUBMEDCENTRAL: PMC8144831

الإتاحة: https://doi.org/10.1017/S0033291721001537Test
https://hal.science/hal-03224998Test
https://hal.science/hal-03224998/documentTest
https://hal.science/hal-03224998/file/div-class-title-clinical-features-and-outcomes-of-covid-19-patients-hospitalized-for-psychiatric-disorders-a-french-multi-centered-prospective-observational-study-div.pdfTest

المؤلفون: Gouraud, Clément, Wiernik, Emmanuel, Matta, Joane, Melchior, Maria, Airagnes, Guillaume, Ouazana Vedrines, Charles, Robineau, Olivier, Carrat, Fabrice, Severi, Gianluca, Descatha, Alexis, Touvier, Mathilde, Goldberg, Marcel, Zins, Marie, Lemogne, Cédric

المساهمون: Hôpital Hôtel-Dieu Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Paris-Sud - Paris 11 (UP11), Santé Publique : épidémiologie et qualité des soins (EA 2694), Faculté de Médecine Henri Warembourg - Université de Lille-Centre d'Etudes et de Recherche en Informatique Médicale Lille (CERIM), Centre Hospitalier Tourcoing, Centre Hospitalier Gustave Dron Tourcoing, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hofstra University Hempstead, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Nutritional Epidemiology Research Team, Université Sorbonne Paris Nord-Centre for Research in Epidemiology and Statistics, Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche et d'études en sciences sociales (CRESS) (EA 1334 - UMB), The CONSTANCES cohort is supported by the Caisse Nationale d'Assurance Maladie des travailleurs salaries-CNAMTS. CONSTANCES is accredited as a “National Infrastructure for Biology and health” by the governmental Investissements d'avenir program and was funded by the Agence Nationale de la Recherche (ANR-11-INBS-0002 Grant). CONSTANCES also receives funding from MSD, AstraZeneca and Lundbeck managed by INSERM-Transfert. The funders did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.CL and CG are supported by a grant from “la Fondation de l'Assistance Publique - Hôpitaux de Paris”., ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011)

المصدر: ISSN: 0165-0327.

مصطلحات موضوعية: COVID, Cohort study, Depression, Distance working, Lockdown, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health

الوصف: International audience ; Background: Material conditions of lockdown and changes in regular functioning may have played a role on depressive manifestations. We aimed to examine the association between housing conditions and changes in professional activity and depression during the first COVID-19 outbreak in France.Method: Participants of the CONSTANCES cohort were followed online. A first questionnaire covered the lockdown period (assessing housing conditions and changes in professional activity), and a second the post-lockdown period (assessing depression using the Center of Epidemiologic Studies Depression-Scale (CES-D)). Incident depression was also estimated (with a previous CES-D measure). Logistic regression models were applied.Results: 22,042 participants (median age 46 years, 53.2 % women) were included and 20,534 had a previous CES-D measure. Depression was associated with female gender, lower household income and past history of depression. A negative gradient between the number of rooms and the likelihood of depression was consistently observed (OR = 1.55 95 % [1.19-2.00] for one room, OR = 0.76 [0.65-0.88] for seven rooms), while a U-shape relationship was observed with the number of people living together (OR = 1.62 [1.42-1.84] for living alone, OR = 1.44 [1.07-1.92] for six persons). These associations were also observed with incident depression. Changes in professional activity were associated with depression (Started distance working (OR = 1.33 [1.17-1.50]). Starting distance working was also associated with incident depression (OR = 1.27 [1.08-1.48]).Limitation: A cross-sectional design was used.Conclusion: The consequences of lockdown on depression may vary depending on living conditions and changes in professional activity, including distance working. These results could help to better identify vulnerable people to promote mental health.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37156279; hal-04098004; https://hal.science/hal-04098004Test; https://hal.science/hal-04098004/documentTest; https://hal.science/hal-04098004/file/Gouraud%20et%20al.%20-%202023%20-%20Housing%20conditions%20and%20changes%20in%20professional%20act.pdfTest; PUBMED: 37156279; WOS: 000999147200001

الإتاحة: https://doi.org/10.1016/j.jad.2023.05.004Test
https://hal.science/hal-04098004Test
https://hal.science/hal-04098004/documentTest
https://hal.science/hal-04098004/file/Gouraud%20et%20al.%20-%202023%20-%20Housing%20conditions%20and%20changes%20in%20professional%20act.pdfTest

المؤلفون: Estevez, Mégane, Oppenchaim, Nicolas, Rezzoug, Dalila, Laurent, Isaura, Domecq, Sandrine, Khireddine-Medouni, Imane, Thierry, Xavier, Galera, Cédric, de Stefano, Carla, Vandentorren, Stéphanie

المساهمون: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cités, Territoires, Environnement et Sociétés (CITERES), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Avicenne AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Ecole Nationale de la Statistique et de l'Analyse de l'Information Bruz (ENSAI), Santé publique France - French National Public Health Agency Saint-Maurice, France, Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier Charles Perrens Bordeaux, Université Paris 13 (UP13), Université Sorbonne Paris Nord, Centre National de Ressources et de Résilience Lille (CN2R), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Enguerrand Habran

المصدر: ISSN: 1471-2458.

مصطلحات موضوعية: Adolescents, Children, COVID-19, Living and housing conditions, Lockdown, Psychological distress, Social determinants, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health

الوصف: International audience ; Background: This study aimed to analyze the parental socio-demographic characteristics of children and adolescents aged 9 to 18 years old, as well as the living and housing conditions associated with the psychological distress in these two sub-populations during and after France’s first national COVID-19-related lockdown in spring 2020.Methods: We used data from the cross-sectional, observational, web-based study CONFEADO, which collected data on children and adolescents’ living and housing conditions and socio-demographic characteristics as well as those of their parents. It also collected data on children’s and adolescents’ health behaviors and psychological distress. We assessed psychological distress using the 10-item Children and Adolescents Psychological Distress Scale (CAPDS-10), and performed a multinomial logistic regression.Results: A total of 2882 children and adolescents were included in the present study. Factors associated with moderate psychological distress included being a female, parental financial difficulties, a lack of a private living space at home for the child/adolescent, and the following child health behaviors: no leisure or recreational activities with adults in the household, doing less than one hour of school homework a day, and not going outside during the lockdown. Severe psychological distress was associated with the parent’s occupation (especially essential frontline workers), a lack of a private living space at home for the child/adolescent, and the following child health behaviors: spending over 5 h a day on social media, doing less than one hour of school homework a day, and no leisure or recreational activities with adults in the household.Conclusions: This study emphasizes the impact of housing and living conditions, as well as parents’ socio-economic characteristics on children’s health behaviors and psychological needs during the first COVID-19-related lockdown in France. Our results suggest that health policies implemented during future pandemics ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37464340; hal-04190791; https://hal.science/hal-04190791Test; https://hal.science/hal-04190791/documentTest; https://hal.science/hal-04190791/file/12889_2023_Article_16284.pdfTest; PUBMED: 37464340; PUBMEDCENTRAL: PMC10353123

الإتاحة: https://doi.org/10.1186/s12889-023-16284-5Test
https://hal.science/hal-04190791Test
https://hal.science/hal-04190791/documentTest
https://hal.science/hal-04190791/file/12889_2023_Article_16284.pdfTest

المؤلفون: Baptista, Axel, Chambon, Valérian, Hoertel, Nicolas, Olfson, Mark, Blanco, Carlos V., Cohen, David, Jacquet, Pierre Olivier

المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Corentin Celton Issy-les-Moulineaux, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Columbia University New York, National Institute on Drug Abuse NIH, Bethesda, USA (NIDA), National Institutes of Health Bethesda, MD, USA (NIH), Institut des Systèmes Intelligents et de Robotique (ISIR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier de Versailles André Mignot (CHV), Laboratoire de Neurosciences Cognitives & Computationnelles (LNC2), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Agence Nationale de la Recherche, (ANR-19-CE37-0014-01, ANR-21-CE37-0020-02), Fondation de France, (00112563, ANR-10-IDEX-0001-02, ANR-17-EURE-0017, ANR-22-CE28-0012-01 eLIFUN), Fondation pour la Recherche Médicale, (SPF202209015876), Université Paris Cité, ANR-21-CE37-0020,Myelex,Implications de la myéline dans le contrôle executif à l'adolescence et à l'âge adulte(2021), ANR-22-CE28-0012,eLIFUN,Mesurer les effets de l'imprévisibilité et de la volatilité précoces sur le développement psychologique des individus.(2022), ANR-17-EURE-0017,FrontCog,Frontières en cognition(2017), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010)

المصدر: ISSN: 2168-622X.

مصطلحات موضوعية: [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: International audience ; Importance Borderline personality disorder (BPD) is often accompanied by a history of high-risk sexual behavior and somatic comorbidities. Yet, these features are most often considered in isolation and little is known about their underlying developmental pathways. Life history theory, a leading framework in evolutionary developmental biology, can help make sense of the wide range of behaviors and health issues found in BPD.Objective To examine whether the emergence of BPD is associated with the prioritization of immediate reproductive goals over longer-term somatic maintenance goals, a life strategy that can be viewed as a developmental response to adverse early life experiences, providing rapid reproductive benefits despite costs to health and well-being.Design, Setting, and Participants This study used cross-sectional data from the second wave of the National Epidemiologic Survey on Alcohol and Related Conditions in 2004-2005 (n = 34 653). Civilian, noninstitutionalized individuals in the US, 18 years or older, and those with and without a DSM-IV diagnosis of BPD were included. Analysis took place between August 2020 and June 2021.Main Outcomes and Measures Structural equation models were used to examine whether early life adversity was associated with the likelihood of a BPD diagnosis, either directly or indirectly through a life strategy whereby individuals trade somatic maintenance for immediate reproduction.Results Analyses were performed on a sample of 30 149 participants (females: 17 042 [52%]; mean [SE] age, 48.5 [0.09]; males: 12 747 [48%]; mean [SE] age, 47 [0.08]). Of these, 892 (2.7%) had a diagnosis of BPD and 29 257 (97.3%) did not have BPD. Mean early life adversity, metabolic disorder score, and body mass index were significantly higher among participants with a diagnosis of BPD. In an analysis adjusted for age, individuals with BPD reported having significantly more children than those without BPD (b =0.06; SE, 0.01; t = 4.09; P < .001). Having experienced greater ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37099311; hal-04191671; https://hal.science/hal-04191671Test; https://hal.science/hal-04191671/documentTest; https://hal.science/hal-04191671/file/jamapsychiatry_baptista_2023_oi_230017_1685127796.54504.pdfTest; PUBMED: 37099311; PUBMEDCENTRAL: PMC10134045

الإتاحة: https://doi.org/10.1001/jamapsychiatry.2023.0694Test
https://hal.science/hal-04191671Test
https://hal.science/hal-04191671/documentTest
https://hal.science/hal-04191671/file/jamapsychiatry_baptista_2023_oi_230017_1685127796.54504.pdfTest