التفاصيل البيبلوغرافية
| العنوان: |
Flip a coin: cell senescence at the maternal–fetal interface † |
| المؤلفون: |
Guang-Shun Gong, Kahindo P. Muyayalo, Yu-Jing Zhang, Xin-Xiu Lin, Ai-Hua Liao |
| المساهمون: |
Guang-Shun Gong, Kahindo P. Muyayalo, Yu-Jing Zhang, Xin-Xiu Lin, Ai-Hua Liao |
| المصدر: |
https://doi.org/10.1093/biolre/ioad071Test. |
| بيانات النشر: |
Society for the Study of Reproduction |
| سنة النشر: |
2023 |
| المجموعة: |
BioOne Online Journals |
| مصطلحات موضوعية: |
cell senescence, senescence-associated secretory phenotype |
| جغرافية الموضوع: |
world |
| الوصف: |
During pregnancy, cell senescence at the maternal–fetal interface is required for maternal well-being, placental development, and fetal growth. However, recent reports have shown that aberrant cell senescence is associated with multiple pregnancy-associated abnormalities, such as preeclampsia, fetal growth restrictions, recurrent pregnancy loss, and preterm birth. Therefore, the role and impact of cell senescence during pregnancy requires further comprehension. In this review, we discuss the principal role of cell senescence at the maternal–fetal interface, emphasizing its “bright side” during decidualization, placentation, and parturition. In addition, we highlight the impact of its deregulation and how this “dark side” promotes pregnancy-associated abnormalities. Furthermore, we discuss novel and less invasive therapeutic practices associated with the modulation of cell senescence during pregnancy. Summary Sentence An overview of the recent discoveries on the physiology role of cell senescence in successful pregnancies and pathology role of excessive cell senescence in complicated pregnancy. Graphical Abstract |
| نوع الوثيقة: |
text |
| وصف الملف: |
text/HTML |
| اللغة: |
English |
| DOI: |
10.1093/biolre/ioad071 |
| الإتاحة: |
https://doi.org/10.1093/biolre/ioad071Test |
| حقوق: |
All rights reserved. |
| رقم الانضمام: |
edsbas.421E5ECA |
| قاعدة البيانات: |
BASE |
