التفاصيل البيبلوغرافية
| العنوان: |
Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa: a multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial. |
| المؤلفون: |
Chiaverini, Christine, Roger, Coralie, Fontas, Eric, Bourrat, Emmanuelle, Bourdon-Lanoy, Eva, Labrèze, Christine, Mazereeuw, Juliette, Vabres, Pierre, Bodemer, Christine, Lacour, Jean-Philippe |
| المصدر: |
Orphanet Journal of Rare Diseases; 3/25/2016, Vol. 11, p1-3, 3p |
| مصطلحات موضوعية: |
EPIGALLOCATECHIN gallate, EPIDERMOLYSIS bullosa, GREEN tea, METALLOPROTEINASES, ITCHING, THERAPEUTICS, PHENOLS, COMPARATIVE studies, CROSSOVER trials, FLAVONOIDS, RESEARCH methodology, MEDICAL cooperation, PROTEOLYTIC enzymes, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, BLIND experiment |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
Unlabelled: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genodermatosis with severe blistering. No curative treatment is available. Scientific data indicated that epigallocatechin-3-gallate (EGCG), a green tea extract, might improve the phenotype of RDEB patients. In a multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial, we evaluated a 4-month oral EGCG treatment regimen in 17 RDEB patients. We found that EGCG treatment was not more effective than placebo in modified intention to treat and per protocol analysis (n = 16; p = 0.78 and n = 10; p = 1 respectively). Tolerance was good. Specific organizational and technical difficulties of controlled randomized double-blind trials in EB patients are discussed.Trial Registration: US National Institutes of Health Clinical Trial Register ( NCT00951964 ). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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