التفاصيل البيبلوغرافية
| العنوان: |
Structure–activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition |
| المؤلفون: |
Usuki, Yoshinosuke1 usuki@sci.osaka-cu.ac.jp, Adachi, Noriko1, Fujita, Ken-Ichi2, Ichimura, Akio3, Iio, Hideo1, Taniguchi, Makoto2 |
| المصدر: |
Bioorganic & Medicinal Chemistry Letters. Jun2006, Vol. 16 Issue 12, p3319-3322. 4p. |
| مصطلحات موضوعية: |
*ANTIFUNGAL agents, *ANTIBIOTICS, *STREPTOMYCES |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Abstract: Several open-chained analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were prepared for structure–activity studies. The in vitro antifungal activities of these compounds against Rhodotorula mucilaginosa IFO 0001 and the inhibition of uncoupler-stimulated respiration in bovine heart submitochondrial particles (SMP) were evaluated. Oxidative potentials were measured by cyclic voltammetry. An analogue prepared from dihexyl l-glutamate showed comparable inhibitory activity as UK-2A. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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