التفاصيل البيبلوغرافية
| العنوان: |
Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared. |
| المؤلفون: |
Wandeler, Gilles1,2 gilles.wandeler@ispm.unibe.ch, Mulenga, Lloyd3,4, Vinikoor, Michael J.3,5, Kovari, Helen6, Battegay, Manuel7, Calmy, Alexandra8, Cavassini, Matthias9, Bernasconi, Enos10, Schmid, Patrick11, Bolton-Moore, Carolyn3,5, Sinkala, Edford4, Chi, Benjamin H.3, Egger, Matthias2,12, Rauch, Andri1 |
| المصدر: |
International Journal of Infectious Diseases. Oct2016, Vol. 51, p97-102. 6p. |
| مصطلحات موضوعية: |
*FIBROSIS, *MIXED infections, *HIV-positive persons, *ASPARTATE aminotransferase, *HEPATITIS B virus, *COMPARATIVE studies, *THERAPEUTICS |
| مصطلحات جغرافية: |
ZAMBIA, SWITZERLAND |
| مستخلص: |
Summary Objective To examine the association between hepatitis B virus (HBV) infection and liver fibrosis in HIV-infected patients in Zambia and Switzerland. Methods HIV-infected adults starting antiretroviral therapy in two clinics in Zambia and Switzerland were included. Liver fibrosis was evaluated using the aspartate aminotransferase-to-platelet-ratio index (APRI), with a ratio >1.5 defining significant fibrosis and a ratio >2.0 indicating cirrhosis. The association between hepatitis B surface antigen (HBsAg) positivity, HBV replication, and liver fibrosis was examined using logistic regression. Results In Zambia, 96 (13.0%) of 739 patients were HBsAg-positive compared to 93 (4.5%) of 2058 in Switzerland. HBsAg-positive patients were more likely to have significant liver fibrosis than HBsAg-negative ones: the adjusted odds ratio (aOR) was 3.25 (95% confidence interval (CI) 1.44–7.33) in Zambia and 2.50 (95% CI 1.19–5.25) in Switzerland. Patients with a high HBV viral load (≥20 000 IU/ml) were more likely to have significant liver fibrosis compared to HBsAg-negative patients or patients with an undetectable viral load: aOR 3.85 (95% CI 1.29–11.44) in Zambia and 4.20 (95% CI 1.64–10.76) in Switzerland. In both settings, male sex was a strong risk factor for significant liver fibrosis. Conclusions Despite the differences in HBV natural history between Sub-Saharan Africa and Europe, the degree of liver fibrosis and the association with important risk factors were similar. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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